Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of CST5 mRNA | CTD | PMID:14699072 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to CST5 promoter] and Estradiol promotes the reaction [ESR2 protein affects the expression of CST5 mRNA] | CTD | PMID:20404318 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA | CTD | PMID:28628672 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of CST5 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of CST5 exon | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of CST5 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | Cst5 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of CST5 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | Cst5 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of CST5 promoter | CTD | PMID:27312807 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CST5 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA | CTD | PMID:28628672 and PMID:31601247 | bisphenol F | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA | CTD | PMID:28628672 | carmustine | decreases expression | EXP | | 6480464 | Carmustine results in decreased expression of CST5 mRNA | CTD | PMID:15980968 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CST5 gene] | CTD | PMID:28238834 | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA | CTD | PMID:28628672 | fenvalerate | increases expression | ISO | Cst5 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of CST5 mRNA | CTD | PMID:30307764 | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CST5 gene | CTD | PMID:31601247 | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA | CTD | PMID:28628672 | N-acetyl-1,4-benzoquinone imine | affects response to substance | EXP | | 6480464 | CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine | CTD | PMID:21177773 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | decreases expression | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CST5 mRNA | CTD | PMID:31806706 | potassium dichromate | decreases expression | ISO | Cst5 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of CST5 mRNA | CTD | PMID:23608068 | titanium dioxide | decreases expression | ISO | Cst5 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CST5 mRNA | CTD | PMID:29264374 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of CST5 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | Cst5 (Mus musculus) | 6480464 | Valproic Acid affects the expression of CST5 mRNA | CTD | PMID:17963808 | |