PDGFB (platelet derived growth factor subunit B) - Rat Genome Database

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Gene: PDGFB (platelet derived growth factor subunit B) Homo sapiens
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Symbol: PDGFB
Name: platelet derived growth factor subunit B
RGD ID: 737124
HGNC Page HGNC
Description: Enables several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of phosphorylation. Located in cell surface. Implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Biomarker of several diseases, including COVID-19; Kuhnt-Junius degeneration; clear cell renal cell carcinoma; diabetic retinopathy (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: becaplermin; c-sis; FLJ12858; IBGC5; PDGF subunit B; PDGF, B chain; PDGF-2; PDGF2; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit B; platelet-derived growth factor, B chain; Platelet-derived growth factor, beta polypeptide (oncogene SIS); proto-oncogene c-Sis; SIS; SSV
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2239,223,359 - 39,244,982 (-)EnsemblGRCh38hg38GRCh38
GRCh382239,223,359 - 39,244,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,619,364 - 39,640,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,949,665 - 37,970,936 (-)NCBINCBI36hg18NCBI36
Build 342237,944,218 - 37,961,419NCBI
Celera2223,421,845 - 23,443,115 (-)NCBI
Cytogenetic Map22q13.1ENTREZGENE
HuRef2222,586,719 - 22,607,974 (-)NCBIHuRef
CHM1_12239,578,202 - 39,599,467 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
AIDS Dementia Complex  (IEP)
Alzheimer's disease  (IEP)
asthma  (ISO)
background diabetic retinopathy  (IEP)
basal ganglia calcification  (IEA)
basal ganglia disease  (EXP)
brain infarction  (ISO)
Brain Injuries  (ISO)
calcinosis  (EXP)
cholestasis  (ISO)
choriocarcinoma  (IEP)
Chronic Allograft Nephropathy  (ISO)
clear cell renal cell carcinoma  (IDA,IEP)
COVID-19  (IEP)
dermatofibrosarcoma protuberans  (IAGP)
Diabetic Nephropathies  (IEP)
essential thrombocythemia  (EXP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial meningioma  (EXP,IAGP)
Fetal Growth Retardation  (IEP)
Fibrosis  (EXP,IDA,IEP,ISO)
Gingival Hyperplasia  (EXP)
glioblastoma  (IMP)
glomerulonephritis  (ISO)
Graft vs Host Disease  (IEP)
Head Injuries, Penetrating  (ISO)
hepatocellular carcinoma  (EXP)
hereditary breast ovarian cancer syndrome  (IAGP)
high grade glioma  (IEP,IMP)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Idiopathic Basal Ganglia Calcification 1  (EXP)
Idiopathic Basal Ganglia Calcification 5  (IAGP)
Inflammation  (IEP)
inflammatory bowel disease  (IEP)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (IEP)
leiomyoma  (IEP)
Leydig cell tumor  (IEP)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Lymphatic Metastasis  (IEP)
meningioma  (IAGP)
Neointima  (ISO)
Neoplasm Metastasis  (IEP)
oligohydramnios  (ISO)
Optic Nerve Injuries  (ISO)
pancreatitis  (IEP)
Periapical Diseases  (ISO)
proliferative diabetic retinopathy  (IEP)
prostate carcinoma  (ISO)
prostatic hypertrophy  (IMP)
pulmonary fibrosis  (EXP,ISO)
pulmonary hypertension  (IEP,ISO)
retinal disease  (EXP)
rheumatoid arthritis  (IEP)
sinusitis  (IEP)
Spinal Cord Injuries  (ISO)
Tibial Fractures  (IDA)
ureteral obstruction  (ISO)
visual epilepsy  (ISO)
Wounds and Injuries  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dihydromyricetin  (ISO)
(+)-taxifolin  (EXP)
(R)-mevalonic acid  (EXP)
(S)-nicotine  (EXP,ISO)
11-deoxycorticosterone  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6,7-dimethoxy-2-phenylquinoxaline  (EXP)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
ADP  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
anagrelide  (EXP)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
arotinoid acid  (EXP)
arsenite(3-)  (EXP,ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bivalirudin  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP,ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
carvedilol  (EXP)
chloroprene  (ISO)
choline  (ISO)
chondroitin sulfate  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
clopidogrel  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
cyanidin cation  (EXP)
cyclosporin A  (EXP)
deguelin  (EXP)
delphinidin  (EXP)
desferrioxamine B  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (ISO)
dihydrolipoic acid  (ISO)
dimethyl fumarate  (EXP)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
emodin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenhexamid  (EXP)
ferroheme b  (ISO)
folic acid  (ISO)
gadolinium trichloride  (ISO)
genistein  (EXP,ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
heme b  (ISO)
hemin  (EXP)
heparin  (ISO)
hydrogen peroxide  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
losartan  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
mabuterol  (ISO)
malvidin  (EXP)
medroxyprogesterone acetate  (EXP)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
morphine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodimethylamine  (ISO)
nebivolol  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP,ISO)
nitrofen  (ISO)
oleic acid  (EXP)
ozone  (ISO)
palbociclib  (EXP)
Panaxynol  (ISO)
paraquat  (ISO)
peonidin  (EXP)
peonidin chloride  (EXP)
perindopril  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
picoxystrobin  (EXP)
pioglitazone  (EXP)
potassium chromate  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP)
propanal  (EXP)
pyrimidifen  (EXP)
quercetin  (EXP,ISO)
ramipril  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sorafenib  (EXP)
sunitinib  (EXP)
tetrachloromethane  (ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
urethane  (EXP,ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vildagliptin  (ISO)
warfarin  (ISO)
Y-27632  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
activation of protein kinase activity  (IDA)
activation of protein kinase B activity  (IDA)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell chemotaxis  (IDA)
cell projection assembly  (ISO)
cellular response to angiotensin  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISS)
cellular response to platelet-derived growth factor stimulus  (ISO,ISS)
embryonic placenta development  (ISS)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
eye photoreceptor cell development  (ISO)
glial cell development  (ISO)
heart development  (ISS)
hemopoiesis  (IMP)
interleukin-18-mediated signaling pathway  (IDA)
male gonad development  (ISO)
metanephric glomerular endothelium development  (ISO)
metanephric glomerular mesangial cell development  (ISS)
metanephric glomerular mesangial cell proliferation involved in metanephros development  (ISO)
monocyte chemotaxis  (IDA)
negative regulation of cell migration  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of phosphatidylinositol biosynthetic process  (IDA)
negative regulation of platelet activation  (IDA)
negative regulation of pri-miRNA transcription by RNA polymerase II  (IDA)
negative regulation of protein binding  (IDA)
negative regulation of transcription, DNA-templated  (IDA)
negative regulation of vascular associated smooth muscle cell differentiation  (IDA)
neuron remodeling  (ISO)
paracrine signaling  (ISS)
peptidyl-serine phosphorylation  (IDA)
peptidyl-tyrosine phosphorylation  (IDA)
platelet-derived growth factor receptor signaling pathway  (IBA,IDA,ISO)
positive chemotaxis  (IEA)
positive regulation of blood vessel endothelial cell migration  (IDA)
positive regulation of calcium ion import  (IDA)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IBA,IDA,ISO)
positive regulation of cell population proliferation  (IBA,IDA,IEA)
positive regulation of cell-substrate adhesion  (IDA)
positive regulation of chemotaxis  (IDA)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IDA)
positive regulation of DNA biosynthetic process  (IDA)
positive regulation of DNA replication  (ISO)
positive regulation of endothelial cell proliferation  (IDA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (IDA,ISO,ISS)
positive regulation of glomerular filtration  (ISS)
positive regulation of glomerular mesangial cell proliferation  (IDA)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of hepatic stellate cell proliferation  (ISO)
positive regulation of hyaluronan biosynthetic process  (IDA)
positive regulation of MAP kinase activity  (IBA,IDA)
positive regulation of MAPK cascade  (IMP)
positive regulation of metanephric mesenchymal cell migration  (IDA)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (IDA)
positive regulation of mitotic cell cycle, embryonic  (ISO)
positive regulation of mitotic nuclear division  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase activity  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,IDA,ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA)
positive regulation of protein autophosphorylation  (IBA,IDA)
positive regulation of protein tyrosine kinase activity  (IDA)
positive regulation of reactive oxygen species metabolic process  (IDA)
positive regulation of smooth muscle cell migration  (IDA,ISO)
positive regulation of smooth muscle cell proliferation  (IDA,ISO,ISS)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of vascular associated smooth muscle cell dedifferentiation  (IDA)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
protein kinase C signaling  (IMP)
protein phosphorylation  (IDA)
reactive oxygen species metabolic process  (IMP)
regulation of cell population proliferation  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
response to axon injury  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to human chorionic gonadotropin  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to wounding  (IDA,NAS)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (ISO)
signal transduction  (IEA)
substrate-dependent cell migration  (ISO)
synapse assembly  (ISO)
wound healing  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal brain FDG positron emission tomography  (IAGP)
Abnormal central sensory function  (IAGP)
Abnormal cerebellum morphology  (IAGP)
Abnormal kinetic perimetry test  (IAGP)
Abnormal pyramidal sign  (IAGP)
Abnormality of neuronal migration  (IAGP)
Abnormality of the mediastinum  (IAGP)
Abnormality of the sense of smell  (IAGP)
Abnormality on pulmonary function testing  (IAGP)
Adult onset  (IAGP)
Amenorrhea  (IAGP)
Anxiety  (IAGP)
Apathy  (IAGP)
Ataxia  (IAGP)
Athetosis  (IAGP)
Autosomal dominant inheritance  (IAGP)
Back pain  (IAGP)
Basal ganglia calcification  (IAGP)
Bitemporal hemianopia  (IAGP)
Blindness  (IAGP)
Bradykinesia  (IAGP)
Brain stem compression  (IAGP)
Calcification of the small brain vessels  (IAGP)
Cerebral calcification  (IAGP)
Cerebral hemorrhage  (IAGP)
Chorea  (IAGP)
Chromosomal breakage induced by ionizing radiation  (IAGP)
Corneal opacity  (IAGP)
Decreased circulating ACTH level  (IAGP)
Decreased circulating cortisol level  (IAGP)
Decreased circulating follicle stimulating hormone concentration  (IAGP)
Decreased circulating luteinizing hormone level  (IAGP)
Decreased serum estradiol  (IAGP)
Decreased serum testosterone concentration  (IAGP)
Dementia  (IAGP)
Dense calcifications in the cerebellar dentate nucleus  (IAGP)
Depression  (IAGP)
Difficulty walking  (IAGP)
Dysarthria  (IAGP)
Dysdiadochokinesis  (IAGP)
Dyskinesia  (IAGP)
Dystonia  (IAGP)
Ear pain  (IAGP)
Emotional lability  (IAGP)
Enlarged pituitary gland  (IAGP)
Erythema  (IAGP)
Excessive daytime somnolence  (IAGP)
Facial palsy  (IAGP)
Fibrosarcoma  (IAGP)
Focal T2 hypointense thalamic lesion  (IAGP)
Focal-onset seizure  (IAGP)
Gait disturbance  (IAGP)
Headache  (IAGP)
Hemifacial spasm  (IAGP)
Hemiparesis  (IAGP)
Hepatomegaly  (IAGP)
Hydrocephalus  (IAGP)
Hyperreflexia  (IAGP)
Hypogonadotropic hypogonadism  (IAGP)
Hypothalamic hypothyroidism  (IAGP)
Impotence  (IAGP)
Incomplete penetrance  (IAGP)
Increased circulating prolactin concentration  (IAGP)
Increased intracranial pressure  (IAGP)
Increased sensitivity to ionizing radiation  (IAGP)
Intracranial meningioma  (IAGP)
Intrauterine growth retardation  (IAGP)
Limb dysmetria  (IAGP)
Lower limb muscle weakness  (IAGP)
Mask-like facies  (IAGP)
Memory impairment  (IAGP)
Meningioma  (IAGP)
Mental deterioration  (IAGP)
Microcephaly  (IAGP)
Micrographia  (IAGP)
Migraine  (IAGP)
Motor tics  (IAGP)
Nausea and vomiting  (IAGP)
Neoplasm of the anterior pituitary  (IAGP)
Neoplasm of the posterior pituitary  (IAGP)
Neoplasm of the skin  (IAGP)
Neoplasm of the tongue  (IAGP)
Neurofibromas  (IAGP)
Neurological speech impairment  (IAGP)
Obesity  (IAGP)
Oculomotor nerve palsy  (IAGP)
Ophthalmoplegia  (IAGP)
Papilledema  (IAGP)
Parkinsonism  (IAGP)
Pituitary hypothyroidism  (IAGP)
Postural instability  (IAGP)
Progressive  (IAGP)
Progressive pulmonary function impairment  (IAGP)
Proptosis  (IAGP)
Psychosis  (IAGP)
Reduced circulating prolactin concentration  (IAGP)
Rigidity  (IAGP)
Secondary growth hormone deficiency  (IAGP)
Seizure  (IAGP)
Skin ulcer  (IAGP)
Slow decrease in visual acuity  (IAGP)
Spinal meningioma  (IAGP)
Subcutaneous hemorrhage  (IAGP)
Subcutaneous nodule  (IAGP)
Syncope  (IAGP)
Thickened skin  (IAGP)
Thrombocytopenia  (IAGP)
Tinnitus  (IAGP)
Transient global amnesia  (IAGP)
Tremor  (IAGP)
Trigeminal neuralgia  (IAGP)
Upper limb muscle weakness  (IAGP)
Urinary incontinence  (IAGP)
Ventriculomegaly  (IAGP)
Vertigo  (IAGP)
Visual acuity test abnormality  (IAGP)
Weak extraocular muscles  (IAGP)
References

References - curated
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50. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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52. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
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Additional References at PubMed
PMID:287022   PMID:291037   PMID:1311092   PMID:1317862   PMID:1372091   PMID:1396586   PMID:1661670   PMID:1906887   PMID:2212004   PMID:2439522   PMID:2536956   PMID:2538439  
PMID:2544881   PMID:2836953   PMID:2845420   PMID:2991848   PMID:3023958   PMID:3275870   PMID:3456904   PMID:3472769   PMID:3517869   PMID:3969118   PMID:4033772   PMID:6091919  
PMID:6297002   PMID:6306471   PMID:6318322   PMID:6327048   PMID:6329745   PMID:6336312   PMID:6740330   PMID:6844921   PMID:7073684   PMID:7659502   PMID:7679113   PMID:7829517  
PMID:7896901   PMID:8174076   PMID:8647855   PMID:8697155   PMID:8780057   PMID:8889548   PMID:8900172   PMID:8988177   PMID:9057949   PMID:9334164   PMID:9409235   PMID:9677323  
PMID:9685360   PMID:9692901   PMID:9739761   PMID:10409733   PMID:10446987   PMID:10485711   PMID:10591208   PMID:10644978   PMID:10681572   PMID:10734101   PMID:10806482   PMID:11264163  
PMID:11297552   PMID:11331882   PMID:11498506   PMID:11788434   PMID:11811779   PMID:11854294   PMID:11903042   PMID:12023768   PMID:12034531   PMID:12070119   PMID:12127408   PMID:12176024  
PMID:12411321   PMID:12477932   PMID:12576295   PMID:12615918   PMID:12660034   PMID:12850807   PMID:12850832   PMID:12960151   PMID:14595114   PMID:14643521   PMID:14702039   PMID:14705808  
PMID:14760763   PMID:14997209   PMID:15081117   PMID:15461802   PMID:15489334   PMID:15496150   PMID:15522237   PMID:15695519   PMID:15767546   PMID:15826941   PMID:15897913   PMID:15915457  
PMID:15919668   PMID:15956925   PMID:16007151   PMID:16014047   PMID:16081426   PMID:16149045   PMID:16227675   PMID:16477226   PMID:16530387   PMID:16641085   PMID:16709185   PMID:16777970  
PMID:16843106   PMID:16847823   PMID:16893901   PMID:17074267   PMID:17157157   PMID:17227125   PMID:17229887   PMID:17292826   PMID:17324121   PMID:17338425   PMID:17341683   PMID:17395886  
PMID:17431412   PMID:17518657   PMID:17545544   PMID:17608589   PMID:17626901   PMID:17671690   PMID:17724602   PMID:17942966   PMID:17944929   PMID:17950782   PMID:17958740   PMID:17981115  
PMID:17991872   PMID:17998143   PMID:18069662   PMID:18075302   PMID:18239136   PMID:18300076   PMID:18310286   PMID:18325189   PMID:18326546   PMID:18420995   PMID:18456732   PMID:18471357  
PMID:18478301   PMID:18570917   PMID:18573259   PMID:18593464   PMID:18700164   PMID:18758297   PMID:18772331   PMID:18819098   PMID:18973553   PMID:19019919   PMID:19060904   PMID:19088079  
PMID:19091791   PMID:19126672   PMID:19219070   PMID:19447872   PMID:19451595   PMID:19498003   PMID:19576918   PMID:19584075   PMID:19628565   PMID:19635106   PMID:19696027   PMID:19728062  
PMID:19890351   PMID:19913121   PMID:19956642   PMID:20019669   PMID:20036421   PMID:20042679   PMID:20061935   PMID:20083221   PMID:20224347   PMID:20233927   PMID:20301334   PMID:20301594  
PMID:20406730   PMID:20452482   PMID:20485444   PMID:20534510   PMID:20577048   PMID:20624165   PMID:20628086   PMID:20628624   PMID:20673868   PMID:20681813   PMID:20694560   PMID:20717068  
PMID:20739660   PMID:20822908   PMID:20950212   PMID:21102276   PMID:21111450   PMID:21118571   PMID:21124835   PMID:21129745   PMID:21171016   PMID:21175804   PMID:21245381   PMID:21321938  
PMID:21321954   PMID:21429937   PMID:21483469   PMID:21618276   PMID:21754979   PMID:21764712   PMID:21766497   PMID:21769672   PMID:21873635   PMID:21919032   PMID:21921666   PMID:21956466  
PMID:22021110   PMID:22038837   PMID:22104124   PMID:22133064   PMID:22174424   PMID:22200892   PMID:22619279   PMID:22688015   PMID:22711911   PMID:22805337   PMID:22908324   PMID:22922228  
PMID:23042547   PMID:23139410   PMID:23199263   PMID:23207290   PMID:23302418   PMID:23537647   PMID:23554459   PMID:23633549   PMID:23784143   PMID:23906294   PMID:23913003   PMID:23934686  
PMID:23979707   PMID:24008408   PMID:24063997   PMID:24084832   PMID:24282276   PMID:24331325   PMID:24423492   PMID:24454980   PMID:24463275   PMID:24502980   PMID:24524969   PMID:24605332  
PMID:24703957   PMID:24792185   PMID:24804810   PMID:24878758   PMID:24972450   PMID:25089138   PMID:25164676   PMID:25173753   PMID:25212438   PMID:25278706   PMID:25327457   PMID:25349036  
PMID:25498506   PMID:25550804   PMID:25683993   PMID:25738255   PMID:25816372   PMID:25924890   PMID:25940705   PMID:25945863   PMID:26129893   PMID:26320430   PMID:26353894   PMID:26371596  
PMID:26418719   PMID:26420039   PMID:26463591   PMID:26493107   PMID:26518873   PMID:26599395   PMID:26932148   PMID:26951930   PMID:27035566   PMID:27044757   PMID:27099350   PMID:27127135  
PMID:27147565   PMID:27150562   PMID:27289338   PMID:27465069   PMID:27503909   PMID:27633721   PMID:27742707   PMID:27807074   PMID:27989785   PMID:28011500   PMID:28162874   PMID:28267575  
PMID:28327358   PMID:28397199   PMID:28423550   PMID:28514442   PMID:28618254   PMID:28766166   PMID:28940884   PMID:29140881   PMID:29168174   PMID:29319128   PMID:29386225   PMID:29558627  
PMID:29680290   PMID:29685513   PMID:29955127   PMID:29991678   PMID:30014607   PMID:30195725   PMID:30383775   PMID:30755260   PMID:30765719   PMID:30894277   PMID:30952898   PMID:31386981  
PMID:31402636   PMID:31663419   PMID:31870844   PMID:32281291   PMID:32296183   PMID:32385763   PMID:32542608   PMID:32790267   PMID:32901105   PMID:33057010   PMID:33300045   PMID:33360224  
PMID:33416116   PMID:33421057   PMID:33846539   PMID:33961781   PMID:34407802  


Genomics

Comparative Map Data
PDGFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2239,223,359 - 39,244,982 (-)EnsemblGRCh38hg38GRCh38
GRCh382239,223,359 - 39,244,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,619,364 - 39,640,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,949,665 - 37,970,936 (-)NCBINCBI36hg18NCBI36
Build 342237,944,218 - 37,961,419NCBI
Celera2223,421,845 - 23,443,115 (-)NCBI
Cytogenetic Map22q13.1ENTREZGENE
HuRef2222,586,719 - 22,607,974 (-)NCBIHuRef
CHM1_12239,578,202 - 39,599,467 (-)NCBICHM1_1
Pdgfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,880,066 - 79,899,178 (-)NCBIGRCm39mm39
GRCm39 Ensembl1579,880,075 - 79,899,178 (-)Ensembl
GRCm381579,995,865 - 80,024,614 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,995,874 - 80,014,977 (-)EnsemblGRCm38mm10GRCm38
MGSCv371579,826,304 - 79,845,238 (-)NCBIGRCm37mm9NCBIm37
MGSCv361579,823,129 - 79,842,063 (-)NCBImm8
Celera1582,118,153 - 82,136,874 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Pdgfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27111,539,444 - 111,557,984 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7111,540,345 - 111,557,984 (-)Ensembl
Rnor_6.07121,215,458 - 121,233,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,214,628 - 121,232,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,205,505 - 121,223,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,244,385 - 118,262,021 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17118,279,553 - 118,295,832 (-)NCBI
Celera7107,869,873 - 107,887,412 (-)NCBICelera
Cytogenetic Map7q34NCBI
Pdgfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,148,062 - 25,166,987 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,150,702 - 25,166,987 (-)NCBIChiLan1.0ChiLan1.0
PDGFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12237,944,018 - 37,964,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,944,018 - 37,964,883 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02220,127,223 - 20,148,407 (-)NCBIMhudiblu_PPA_v0panPan3
PDGFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,798,877 - 25,819,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,798,938 - 25,817,746 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,734,794 - 25,753,108 (+)NCBI
ROS_Cfam_1.01026,550,122 - 26,571,489 (+)NCBI
UMICH_Zoey_3.11026,264,832 - 26,283,141 (+)NCBI
UNSW_CanFamBas_1.01026,584,490 - 26,602,860 (+)NCBI
UU_Cfam_GSD_1.01026,760,558 - 26,778,890 (+)NCBI
Pdgfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,343,420 - 9,358,195 (+)NCBI
SpeTri2.0NW_0049364922,353,840 - 2,368,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,986,461 - 9,007,446 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,330,898 - 6,333,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,865,792 - 21,888,068 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,863,768 - 21,886,395 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045103,877,990 - 103,890,183 (+)NCBIVero_WHO_p1.0
Pdgfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247529,072,471 - 9,088,289 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
GDB:190930  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,639,474 - 39,639,742UniSTSGRCh37
Build 362237,969,420 - 37,969,688RGDNCBI36
Celera2223,441,632 - 23,441,900RGD
Cytogenetic Map22q13.1UniSTS
HuRef2222,606,491 - 22,606,759UniSTS
GDB:452638  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,641,063 - 39,641,244UniSTSGRCh37
Build 362237,971,009 - 37,971,190RGDNCBI36
Celera2223,443,221 - 23,443,402RGD
Cytogenetic Map22q13.1UniSTS
HuRef2222,608,080 - 22,608,261UniSTS
D22S1108  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,620,066 - 39,620,190UniSTSGRCh37
Build 362237,950,012 - 37,950,136RGDNCBI36
Celera2223,422,226 - 23,422,350RGD
Cytogenetic Map22q13.1UniSTS
HuRef2222,587,100 - 22,587,224UniSTS
GeneMap99-GB4 RH Map22133.76UniSTS
Whitehead-RH Map22143.9UniSTS
NCBI RH Map22157.4UniSTS
PDGFB_1020  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,620,546 - 39,621,271UniSTSGRCh37
Build 362237,950,492 - 37,951,217RGDNCBI36
Celera2223,422,706 - 23,423,431RGD
HuRef2222,587,580 - 22,588,305UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR146Bhsa-miR-146b-3pMirtarbaseexternal_infoELISA//Immunoblot//Microarray//qRT-PCRFunctional MTI (Weak)21266476

Predicted Target Of
Summary Value
Count of predictions:1993
Count of miRNA genes:829
Interacting mature miRNAs:981
Transcripts:ENST00000331163, ENST00000381551, ENST00000440375, ENST00000455790
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1719 1026 839 192 221 81 2620 1335 1590 284 681 1394 123 1201 1484 1
Low 692 1580 866 418 1098 371 1696 829 2085 129 763 173 48 3 1304 3
Below cutoff 14 377 18 12 517 13 24 21 36 4 13 30 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A37537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A37562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK022920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC077725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM983641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD386140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ858326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS172383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS172827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS367418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ901040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC040703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z81010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000331163   ⟹   ENSP00000330382
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2239,223,359 - 39,244,982 (-)Ensembl
RefSeq Acc Id: ENST00000381551   ⟹   ENSP00000370963
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2239,224,935 - 39,240,909 (-)Ensembl
RefSeq Acc Id: ENST00000440375   ⟹   ENSP00000405780
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2239,230,184 - 39,241,130 (-)Ensembl
RefSeq Acc Id: ENST00000455790   ⟹   ENSP00000402306
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2239,230,159 - 39,243,016 (-)Ensembl
RefSeq Acc Id: NM_002608   ⟹   NP_002599
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,223,359 - 39,244,982 (-)NCBI
GRCh372239,619,685 - 39,640,957 (-)ENTREZGENE
Build 362237,949,665 - 37,970,936 (-)NCBI Archive
HuRef2222,586,719 - 22,607,974 (-)ENTREZGENE
CHM1_12239,577,881 - 39,599,570 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033016   ⟹   NP_148937
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,223,359 - 39,240,909 (-)NCBI
GRCh372239,619,685 - 39,640,957 (-)ENTREZGENE
Build 362237,949,665 - 37,966,891 (-)NCBI Archive
HuRef2222,586,719 - 22,607,974 (-)ENTREZGENE
CHM1_12239,577,881 - 39,595,434 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_002599 (Get FASTA)   NCBI Sequence Viewer  
  NP_148937 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA60349 (Get FASTA)   NCBI Sequence Viewer  
  AAA60552 (Get FASTA)   NCBI Sequence Viewer  
  AAA60553 (Get FASTA)   NCBI Sequence Viewer  
  AAA98793 (Get FASTA)   NCBI Sequence Viewer  
  AAH29822 (Get FASTA)   NCBI Sequence Viewer  
  AAH77725 (Get FASTA)   NCBI Sequence Viewer  
  ADO22557 (Get FASTA)   NCBI Sequence Viewer  
  CAA02289 (Get FASTA)   NCBI Sequence Viewer  
  CAA02294 (Get FASTA)   NCBI Sequence Viewer  
  CAA25226 (Get FASTA)   NCBI Sequence Viewer  
  CAA25227 (Get FASTA)   NCBI Sequence Viewer  
  CAA25228 (Get FASTA)   NCBI Sequence Viewer  
  CAA25229 (Get FASTA)   NCBI Sequence Viewer  
  CAA25230 (Get FASTA)   NCBI Sequence Viewer  
  CAA26524 (Get FASTA)   NCBI Sequence Viewer  
  CAA26579 (Get FASTA)   NCBI Sequence Viewer  
  CAA27333 (Get FASTA)   NCBI Sequence Viewer  
  CAA58679 (Get FASTA)   NCBI Sequence Viewer  
  CAA67262 (Get FASTA)   NCBI Sequence Viewer  
  CAE82038 (Get FASTA)   NCBI Sequence Viewer  
  CAG30424 (Get FASTA)   NCBI Sequence Viewer  
  CAG46606 (Get FASTA)   NCBI Sequence Viewer  
  CAH23424 (Get FASTA)   NCBI Sequence Viewer  
  CAI06107 (Get FASTA)   NCBI Sequence Viewer  
  CAJ32895 (Get FASTA)   NCBI Sequence Viewer  
  CAJ32907 (Get FASTA)   NCBI Sequence Viewer  
  CAL32766 (Get FASTA)   NCBI Sequence Viewer  
  CBH30542 (Get FASTA)   NCBI Sequence Viewer  
  EAW60305 (Get FASTA)   NCBI Sequence Viewer  
  EAW60306 (Get FASTA)   NCBI Sequence Viewer  
  EAW60307 (Get FASTA)   NCBI Sequence Viewer  
  EAW60308 (Get FASTA)   NCBI Sequence Viewer  
  P01127 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_002599   ⟸   NM_002608
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P01127 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_148937   ⟸   NM_033016
- Peptide Label: isoform 2
- UniProtKB: P01127 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000330382   ⟸   ENST00000331163
RefSeq Acc Id: ENSP00000405780   ⟸   ENST00000440375
RefSeq Acc Id: ENSP00000402306   ⟸   ENST00000455790
RefSeq Acc Id: ENSP00000370963   ⟸   ENST00000381551
Protein Domains
PDGF_2

Promoters
RGD ID:6800206
Promoter ID:HG_KWN:42869
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:ENST00000381551,   OTTHUMT00000321044,   OTTHUMT00000321046
Position:
Human AssemblyChrPosition (strand)Source
Build 362237,967,051 - 37,967,872 (-)MPROMDB
RGD ID:6800207
Promoter ID:HG_KWN:42870
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000321045
Position:
Human AssemblyChrPosition (strand)Source
Build 362237,969,276 - 37,969,776 (-)MPROMDB
RGD ID:6800204
Promoter ID:HG_KWN:42871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000321043
Position:
Human AssemblyChrPosition (strand)Source
Build 362237,970,526 - 37,971,026 (-)MPROMDB
RGD ID:6850148
Promoter ID:EP11139
Type:single initiation site
Name:HS_PDGFB
Description:c-sis proto-oncogene, platelet-derived growth factor-2,PDGFB or C-SIS gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 50; Mammalian c-sis proto-oncogene
Tissues & Cell Lines:embryo, placenta, endothelial cells
Experiment Methods:Nuclease protection with homologous sequence ladder; Primer extension; Nuclease protection; experiments performed with closely related; gene
Position:
Human AssemblyChrPosition (strand)Source
Build 362237,970,933 - 37,970,993EPD
RGD ID:13604140
Promoter ID:EPDNEW_H28254
Type:initiation region
Name:PDGFB_3
Description:platelet derived growth factor subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28255  EPDNEW_H28256  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,244,621 - 39,244,681EPDNEW
RGD ID:13604142
Promoter ID:EPDNEW_H28255
Type:multiple initiation site
Name:PDGFB_1
Description:platelet derived growth factor subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28254  EPDNEW_H28256  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,244,767 - 39,244,827EPDNEW
RGD ID:13604144
Promoter ID:EPDNEW_H28256
Type:multiple initiation site
Name:PDGFB_2
Description:platelet derived growth factor subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28254  EPDNEW_H28255  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,244,982 - 39,245,042EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
PDGFB, 135-BP DEL, IVS5 deletion Meningioma [RCV000013429] Chr22:22q12.3-q13.1 pathogenic
PDGFB, PDGFB/COL1A1 FUSION variation Dermatofibrosarcoma protuberans [RCV000074299] Chr22:22q12.3-q13.1 pathogenic|other
GRCh38/hg38 22q12.3-13.1(chr22:36859030-39236985)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051366]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051366]|See cases [RCV000051366] Chr22:36859030..39236985 [GRCh38]
Chr22:37255072..39632990 [GRCh37]
Chr22:35585018..37962936 [NCBI36]
Chr22:22q12.3-13.1
pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:37061769-50738932)x3 copy number gain See cases [RCV000051684] Chr22:37061769..50738932 [GRCh38]
Chr22:37457809..51177360 [GRCh37]
Chr22:35787755..49524226 [NCBI36]
Chr22:22q12.3-13.33
pathogenic
GRCh38/hg38 22q13.1-13.2(chr22:37721797-40860953)x3 copy number gain See cases [RCV000051685] Chr22:37721797..40860953 [GRCh38]
Chr22:38117804..41256957 [GRCh37]
Chr22:36447750..39586903 [NCBI36]
Chr22:22q13.1-13.2
pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3 copy number gain See cases [RCV000051682] Chr22:33768441..50739977 [GRCh38]
Chr22:34164428..51178405 [GRCh37]
Chr22:32494428..49525271 [NCBI36]
Chr22:22q12.3-13.33
pathogenic
GRCh38/hg38 22q13.1(chr22:38951259-39371142)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053628]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053628]|See cases [RCV000053628] Chr22:38951259..39371142 [GRCh38]
Chr22:39347264..39767147 [GRCh37]
Chr22:37677210..38097093 [NCBI36]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.433C>T (p.Gln145Ter) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV000066212] Chr22:39231645 [GRCh38]
Chr22:39627650 [GRCh37]
Chr22:22q13.1
pathogenic
NM_002608.4(PDGFB):c.356T>C (p.Leu119Pro) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV000066214] Chr22:39231722 [GRCh38]
Chr22:39627727 [GRCh37]
Chr22:22q13.1
pathogenic
NM_002608.4(PDGFB):c.726G>C (p.Ter242Tyr) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV000066216] Chr22:39225723 [GRCh38]
Chr22:39621728 [GRCh37]
Chr22:22q13.1
pathogenic
NM_002608.4(PDGFB):c.445C>T (p.Arg149Ter) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV000066218] Chr22:39231633 [GRCh38]
Chr22:39627638 [GRCh37]
Chr22:22q13.1
pathogenic
NM_002608.4(PDGFB):c.3G>A (p.Met1Ile) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV000066220] Chr22:39243961 [GRCh38]
Chr22:39639966 [GRCh37]
Chr22:22q13.1
pathogenic
NM_002608.2(PDGFB):c.722C>T (p.Ala241Val) single nucleotide variant Malignant melanoma [RCV000072973] Chr22:39225727 [GRCh38]
Chr22:39621732 [GRCh37]
Chr22:37951678 [NCBI36]
Chr22:22q13.1
not provided
NM_002608.2(PDGFB):c.633G>A (p.Arg211=) single nucleotide variant Malignant melanoma [RCV000063915] Chr22:39225816 [GRCh38]
Chr22:39621821 [GRCh37]
Chr22:37951767 [NCBI36]
Chr22:22q13.1
not provided
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
NM_002608.4(PDGFB):c.716T>C (p.Leu239Pro) single nucleotide variant Meningioma, familial [RCV001195858] Chr22:39225733 [GRCh38]
Chr22:39621738 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_002608.4(PDGFB):c.635C>T (p.Thr212Met) single nucleotide variant Dermatofibrosarcoma protuberans [RCV000625215]|not provided [RCV000960323]|not specified [RCV001579660] Chr22:39225814 [GRCh38]
Chr22:39621819 [GRCh37]
Chr22:22q13.1
benign|likely benign|conflicting interpretations of pathogenicity
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.3-13.33(chr22:35728929-51220961)x3 copy number gain See cases [RCV000240469] Chr22:35728929..51220961 [GRCh37]
Chr22:22q12.3-13.33
pathogenic
NM_002608.4(PDGFB):c.512C>T (p.Thr171Met) single nucleotide variant not provided [RCV001269835] Chr22:39230173 [GRCh38]
Chr22:39626178 [GRCh37]
Chr22:22q13.1
likely pathogenic
NM_002608.4(PDGFB):c.386G>A (p.Arg129His) single nucleotide variant not specified [RCV000413661] Chr22:39231692 [GRCh38]
Chr22:39627697 [GRCh37]
Chr22:22q13.1
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q13.1(chr22:38871571-39704938)x1 copy number loss See cases [RCV000446194] Chr22:38871571..39704938 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_002608.4(PDGFB):c.2T>G (p.Met1Arg) single nucleotide variant not provided [RCV000441852] Chr22:39243962 [GRCh38]
Chr22:39639967 [GRCh37]
Chr22:22q13.1
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_000085.5(CLCNKB):c.101-50G>C single nucleotide variant Dermatofibrosarcoma protuberans [RCV000625216]|not provided [RCV001683618] Chr22:39235763 [GRCh38]
Chr22:39631768 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.670C>T (p.Arg224Trp) single nucleotide variant Dermatofibrosarcoma protuberans [RCV000625214]|not provided [RCV000899280] Chr22:39225779 [GRCh38]
Chr22:39621784 [GRCh37]
Chr22:22q13.1
benign|likely benign|uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
Single allele duplication not provided [RCV000678009] Chr22:39537009..39713845 [GRCh37]
Chr22:22q13.1
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q13.1(chr22:39592181-39663296)x3 copy number gain not provided [RCV000741977] Chr22:39592181..39663296 [GRCh37]
Chr22:22q13.1
benign
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
null single nucleotide variant not provided [RCV001610138] Chr22:39233324 [GRCh38]
Chr22:39629329 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001708339] Chr22:39235708 [GRCh38]
Chr22:39631713 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.453C>G (p.Val151=) single nucleotide variant not provided [RCV001548175]|not specified [RCV001579578] Chr22:39231625 [GRCh38]
Chr22:39627630 [GRCh37]
Chr22:22q13.1
benign|likely benign
null single nucleotide variant not provided [RCV001581847] Chr22:39230537 [GRCh38]
Chr22:39626542 [GRCh37]
Chr22:22q13.1
likely benign
NM_014053.4(FLVCR1):c.663C>T (p.Pro221=) single nucleotide variant not provided [RCV001648140] Chr22:39243848 [GRCh38]
Chr22:39639853 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.558A>G (p.Ala186=) single nucleotide variant not provided [RCV000879943] Chr22:39230127 [GRCh38]
Chr22:39626132 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.262A>G (p.Ile88Val) single nucleotide variant not provided [RCV000899986] Chr22:39231816 [GRCh38]
Chr22:39627821 [GRCh37]
Chr22:22q13.1
benign
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33
pathogenic
NM_002608.4(PDGFB):c.457-1G>C single nucleotide variant not provided [RCV000997932] Chr22:39230229 [GRCh38]
Chr22:39626234 [GRCh37]
Chr22:22q13.1
likely pathogenic
NM_002608.4(PDGFB):c.169G>A (p.Gly57Arg) single nucleotide variant not provided [RCV001568291] Chr22:39233516 [GRCh38]
Chr22:39629521 [GRCh37]
Chr22:22q13.1
uncertain significance
Single allele single nucleotide variant not provided [RCV001550810] Chr22:39245256 [GRCh38]
Chr22:39641261 [GRCh37]
Chr22:22q13.1
likely benign
null microsatellite not provided [RCV001612095] Chr22:39240894..39240895 [GRCh38]
Chr22:39636899..39636900 [GRCh37]
Chr22:22q13.1
benign
NM_201384.3(PLEC):c.1956C>T (p.Thr652=) single nucleotide variant not provided [RCV001720352] Chr22:39240925 [GRCh38]
Chr22:39636930 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.572G>A (p.Arg191Gln) single nucleotide variant not provided [RCV001576492] Chr22:39230113 [GRCh38]
Chr22:39626118 [GRCh37]
Chr22:22q13.1
likely benign
NM_002055.5(GFAP):c.469G>A (p.Asp157Asn) microsatellite not provided [RCV001661021] Chr22:39244733..39244739 [GRCh38]
Chr22:39640738..39640744 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001669712] Chr22:39233604 [GRCh38]
Chr22:39629609 [GRCh37]
Chr22:22q13.1
benign
null microsatellite not provided [RCV001615745] Chr22:39225700..39225701 [GRCh38]
Chr22:39621705..39621706 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001620319] Chr22:39240923 [GRCh38]
Chr22:39636928 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001676468] Chr22:39225574 [GRCh38]
Chr22:39621579 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001589670] Chr22:39240848 [GRCh38]
Chr22:39636853 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.-132A>G single nucleotide variant not provided [RCV001566199] Chr22:39244095 [GRCh38]
Chr22:39640100 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.157G>A (p.Gly53Arg) single nucleotide variant not provided [RCV000881167] Chr22:39235781 [GRCh38]
Chr22:39631786 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.456+248C>A single nucleotide variant not provided [RCV001539565] Chr22:39231374 [GRCh38]
Chr22:39627379 [GRCh37]
Chr22:22q13.1
likely benign
GRCh37/hg19 22q13.1(chr22:39629440-39639968)x1 copy number loss not provided [RCV001171732] Chr22:39629440..39639968 [GRCh37]
Chr22:22q13.1
likely pathogenic
NM_002608.4(PDGFB):c.393C>T (p.Ser131=) single nucleotide variant not provided [RCV000933843] Chr22:39231685 [GRCh38]
Chr22:39627690 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.296C>T (p.Thr99Met) single nucleotide variant not provided [RCV000912297] Chr22:39231782 [GRCh38]
Chr22:39627787 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.657C>A (p.Pro219=) single nucleotide variant not provided [RCV000958221] Chr22:39225792 [GRCh38]
Chr22:39621797 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.137G>A (p.Arg46His) single nucleotide variant not provided [RCV000958222] Chr22:39235801 [GRCh38]
Chr22:39631806 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.35G>T (p.Cys12Phe) single nucleotide variant not provided [RCV000890207] Chr22:39243929 [GRCh38]
Chr22:39639934 [GRCh37]
Chr22:22q13.1
benign
NM_002055.5(GFAP):c.469G>A (p.Asp157Asn) single nucleotide variant not provided [RCV001660869] Chr22:39226053 [GRCh38]
Chr22:39622058 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001595441] Chr22:39235542 [GRCh38]
Chr22:39631547 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.602-244G>A single nucleotide variant not provided [RCV001552711] Chr22:39226091 [GRCh38]
Chr22:39622096 [GRCh37]
Chr22:22q13.1
likely benign
Single allele duplication not provided [RCV001549556] Chr22:39245080..39245081 [GRCh38]
Chr22:39641085..39641086 [GRCh37]
Chr22:22q13.1
likely benign
null single nucleotide variant not provided [RCV001593442] Chr22:39233368 [GRCh38]
Chr22:39629373 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.601+65G>A single nucleotide variant not provided [RCV001539884] Chr22:39230019 [GRCh38]
Chr22:39626024 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001673251] Chr22:39244698 [GRCh38]
Chr22:39640703 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001595448] Chr22:39240943 [GRCh38]
Chr22:39636948 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.273G>A (p.Pro91=) single nucleotide variant not provided [RCV001580117] Chr22:39231805 [GRCh38]
Chr22:39627810 [GRCh37]
Chr22:22q13.1
likely benign
NM_014053.4(FLVCR1):c.663C>T (p.Pro221=) single nucleotide variant not provided [RCV001649583] Chr22:39235958 [GRCh38]
Chr22:39631963 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001621244] Chr22:39235742 [GRCh38]
Chr22:39631747 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001693229] Chr22:39225540 [GRCh38]
Chr22:39621545 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001614011] Chr22:39240581 [GRCh38]
Chr22:39636586 [GRCh37]
Chr22:22q13.1
benign
null microsatellite not provided [RCV001690449] Chr22:39240921..39240922 [GRCh38]
Chr22:39636926..39636927 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001614740] Chr22:39230370 [GRCh38]
Chr22:39626375 [GRCh37]
Chr22:22q13.1
benign
null single nucleotide variant not provided [RCV001696333] Chr22:39233413 [GRCh38]
Chr22:39629418 [GRCh37]
Chr22:22q13.1
benign
NM_002608.4(PDGFB):c.63+2960TG[9] microsatellite not provided [RCV001540826] Chr22:39240922..39240923 [GRCh38]
Chr22:39636927..39636928 [GRCh37]
Chr22:22q13.1
likely benign
NM_002608.4(PDGFB):c.1A>G (p.Met1Val) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV001253677] Chr22:39243963 [GRCh38]
Chr22:39639968 [GRCh37]
Chr22:22q13.1
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_002608.4(PDGFB):c.71C>A (p.Pro24His) single nucleotide variant Idiopathic basal ganglia calcification 5 [RCV001330744] Chr22:39235867 [GRCh38]
Chr22:39631872 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_002608.4(PDGFB):c.540T>G (p.Cys180Trp) single nucleotide variant Hereditary breast and ovarian cancer syndrome [RCV001374552] Chr22:39230145 [GRCh38]
Chr22:39626150 [GRCh37]
Chr22:22q13.1
uncertain significance
null single nucleotide variant not provided [RCV001617183] Chr22:39230414 [GRCh38]
Chr22:39626419 [GRCh37]
Chr22:22q13.1
benign
null microsatellite not provided [RCV001619100] Chr22:39240942..39240943 [GRCh38]
Chr22:39636947..39636948 [GRCh37]
Chr22:22q13.1
benign
NM_014053.4(FLVCR1):c.663C>T (p.Pro221=) deletion not provided [RCV001651762] Chr22:39240940..39240943 [GRCh38]
Chr22:39636945..39636948 [GRCh37]
Chr22:22q13.1
benign
null microsatellite not provided [RCV001612089] Chr22:39240919..39240920 [GRCh38]
Chr22:39636924..39636925 [GRCh37]
Chr22:22q13.1
benign
NM_002055.5(GFAP):c.469G>A (p.Asp157Asn) single nucleotide variant not provided [RCV001652700] Chr22:39225888 [GRCh38]
Chr22:39621893 [GRCh37]
Chr22:22q13.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8800 AgrOrtholog
COSMIC PDGFB COSMIC
Ensembl Genes ENSG00000100311 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000330382 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000370963 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000402306 UniProtKB/TrEMBL
  ENSP00000405780 UniProtKB/TrEMBL
Ensembl Transcript ENST00000331163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000381551 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000440375 UniProtKB/TrEMBL
  ENST00000455790 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000100311 GTEx
HGNC ID HGNC:8800 ENTREZGENE
Human Proteome Map PDGFB Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PD_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF/VEGF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_suB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5155 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5155 ENTREZGENE
OMIM 190040 OMIM
  607174 OMIM
  607907 OMIM
  615483 OMIM
PANTHER PTHR11633:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33145 PharmGKB
PROSITE PDGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R1R5_HUMAN UniProtKB/TrEMBL
  A0A384NYY3_HUMAN UniProtKB/TrEMBL
  A9UJN9_HUMAN UniProtKB/TrEMBL
  A9UJP0_HUMAN UniProtKB/TrEMBL
  P01127 ENTREZGENE
  P78450_HUMAN UniProtKB/TrEMBL
  PDGFB_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary G3XAG8 UniProtKB/Swiss-Prot
  P78431 UniProtKB/Swiss-Prot
  Q15354 UniProtKB/Swiss-Prot
  Q6FHE7 UniProtKB/Swiss-Prot
  Q9UF23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 PDGFB  platelet derived growth factor subunit B    platelet-derived growth factor beta polypeptide  Symbol and/or name change 5135510 APPROVED
2011-08-16 PDGFB  platelet-derived growth factor beta polypeptide  PDGFB  platelet-derived growth factor beta polypeptide  Symbol and/or name change 5135510 APPROVED
2011-07-27 PDGFB  platelet-derived growth factor beta polypeptide  PDGFB  platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)  Symbol and/or name change 5135510 APPROVED