Exhibits several functions, including molecular function regulator; platelet-derived growth factor binding activity; and protein dimerization activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of cellular metabolic process. Localizes to cell surface. Implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Biomarker of several diseases, including COVID-19; Kuhnt-Junius degeneration; bone disease (multiple); diabetic retinopathy (multiple); and reproductive organ cancer (multiple).
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]], geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]
Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein] more ...
Tretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein] more ...
1-Butanol inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA], 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFB more ...
Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein], Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]
[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFB mRNA, SHH protein affects the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFB mRNA]
cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species], cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species], delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
ARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA], Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]
Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFB more ...
Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein] more ...
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein] more ...
salvianolic acid A inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide], salvianolic acid B inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]
Cysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein], Cysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Methionine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein], Methionine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFB more ...
lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein], PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA], Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]
2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein] more ...
2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]
[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of PDGFB mRNA
Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]] more ...
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]] more ...
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]], Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of PDGFB mRNA
[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFB mRNA, SHH protein affects the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFB mRNA]
[Estradiol co-treated with Progesterone] results in decreased expression of PDGFB mRNA, [Progesterone co-treated with Estradiol] results in decreased expression of PDGFB mRNA
Quercetin inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates], Quercetin results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]
resveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates] more ...
Rotenone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of MMP9 protein], Rotenone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]
salvianolic acid A inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide], salvianolic acid A inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]
SB 203580 inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein], SB 203580 results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]] more ...
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein], Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051366]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051366]|See cases [RCV000051366]
Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053628]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053628]|See cases [RCV000053628]
