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Gene: HCFC1 (host cell factor C1) Homo sapiens
Symbol: HCFC1
Name: host cell factor C1
Description: Exhibits several functions, including activating transcription factor binding activity; identical protein binding activity; and transcription coactivator activity. Contributes to histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); and histone acetyltransferase activity (H4-K8 specific). Involved in several processes, including histone H4 acetylation; positive regulation of transcription, DNA-templated; and protein stabilization. Localizes to the cytoplasm; neuronal cell body; and nucleoplasm. Colocalizes with the Ada2/Gcn5/Ada3 transcription activator complex and SAGA-type complex. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C1 factor; CFF; HCF; HCF-1; HCF1; HFC1; host cell factor 1; mental retardation, X-linked 3; MGC70925; MRX3; PPP1R89; VCAF; VP16 accessory protein
Mus musculus (house mouse) : Hcfc1 (host cell factor C1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hcfc1 (host cell factor C1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hcfc1 (host cell factor C1)
Pan paniscus (bonobo/pygmy chimpanzee) : HCFC1 (host cell factor C1)
Canis lupus familiaris (dog) : HCFC1 (host cell factor C1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hcfc1 (host cell factor C1)
Sus scrofa (pig) : HCFC1 (host cell factor C1)
Chlorocebus sabaeus (African green monkey) : HCFC1 (host cell factor C1)
Heterocephalus glaber (naked mole-rat) : Hcfc1 (host cell factor C1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX153,947,557 - 153,971,818 (-)Ensembl
GRCh38X153,947,556 - 153,972,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,213,008 - 153,237,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,866,202 - 152,890,013 (-)NCBINCBI36hg18NCBI36
Build 34X152,733,854 - 152,751,024NCBI
CeleraX153,446,719 - 153,470,530 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,865,579 - 141,889,655 (-)NCBIHuRef
CHM1_1X153,087,420 - 153,111,232 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HCFC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345622
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.