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Gene: SYP (synaptophysin) Homo sapiens
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Symbol: SYP
Name: synaptophysin
Description: Exhibits cholesterol binding activity. Predicted to be involved in endocytosis; regulation of neuronal synaptic plasticity; and regulation of opioid receptor signaling pathway. Localizes to the neuron projection. Implicated in non-syndromic X-linked intellectual disability. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: major synaptic vesicle protein P38; MRX96; MRXSYP
Orthologs:
Mus musculus (house mouse) : Syp (synaptophysin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Syp (synaptophysin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syp (synaptophysin)
Pan paniscus (bonobo/pygmy chimpanzee) : SYP (synaptophysin)
Canis lupus familiaris (dog) : SYP (synaptophysin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syp (synaptophysin)
Sus scrofa (pig) : SYP (synaptophysin)
Chlorocebus sabaeus (green monkey) : SYP (synaptophysin)
Heterocephalus glaber (naked mole-rat) : Syp (synaptophysin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX49,187,804 - 49,200,259 (-)Ensembl
GRCh38X49,187,812 - 49,200,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,044,263 - 49,056,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,931,209 - 48,943,605 (-)NCBINCBI36hg18NCBI36
Build 34X48,800,635 - 48,813,032NCBI
CeleraX52,607,708 - 52,620,104 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,701,336 - 46,713,608 (-)NCBIHuRef
CHM1_1X49,076,586 - 49,088,982 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SYP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737494
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.