SPARC (secreted protein acidic and cysteine rich) - Rat Genome Database

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Gene: SPARC (secreted protein acidic and cysteine rich) Homo sapiens
Analyze
Symbol: SPARC
Name: secreted protein acidic and cysteine rich
RGD ID: 731035
HGNC Page HGNC
Description: Enables calcium ion binding activity and collagen binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; and positive regulation of endothelial cell migration. Located in cell surface; nuclear matrix; and platelet alpha granule membrane. Implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Biomarker of calcinosis; ovary epithelial cancer; progressive osseous heteroplasia; renal cell carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: basement-membrane protein 40; BM-40; cysteine-rich protein; OI17; ON; ONT; osteonectin; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5151,661,096 - 151,686,975 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,040,657 - 151,066,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBINCBI36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-camphor  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP,ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
avobenzone  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
berberine  (EXP)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
buspirone  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
calciol  (EXP)
calcitriol  (ISO)
camphor  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
casticin  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cytarabine  (EXP)
D-glucose  (EXP)
DDT  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
Ethoxyacetic acid  (ISO)
fenamidone  (ISO)
fipronil  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
furan  (ISO)
furosemide  (ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-Oryzanol (TN)  (ISO)
genistein  (ISO)
glucose  (EXP)
glycerol 2-phosphate  (EXP)
indometacin  (ISO)
isoflavones  (EXP)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
magnesium atom  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
methylmercury(1+)  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
notoginsenoside R1  (EXP)
oxaliplatin  (ISO)
p-toluidine  (ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (EXP)
piroxicam  (EXP)
poly(vinylpyrrolidone)  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Trapidil  (ISO)
triacsin C  (EXP)
trichloroethene  (ISO)
triclosan  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. Au E, etal., J Neurosci. 2007 Jul 4;27(27):7208-21.
2. Brown TJ, etal., Gynecol Oncol. 1999 Oct;75(1):25-33.
3. Camino AM, etal., J Gene Med. 2008 Sep;10(9):993-1004.
4. Gilbert RE, etal., Kidney Int. 1995 Oct;48(4):1216-25.
5. GOA_HUMAN data from the GO Consortium
6. Inagaki H, etal., Life Sci. 1996;58(11):927-34.
7. Jandeleit-Dahm K, etal., Microvasc Res. 2000 Jan;59(1):61-71.
8. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
9. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
10. Komatsubara I, etal., Cardiovasc Pathol. 2003 Jul-Aug;12(4):186-94.
11. Maeng HY, etal., Jpn J Cancer Res. 2002 Sep;93(9):960-7.
12. Nimphius W, etal., Virchows Arch. 2007 Feb;450(2):179-85.
13. Pichler RH, etal., Am J Pathol. 1996 Apr;148(4):1153-67.
14. Pichler RH, etal., Kidney Int. 1996 Dec;50(6):1978-89.
15. RGD automated import pipeline for gene-chemical interactions
16. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
17. Rodriguez-Jimenez FJ, etal., Oncol Rep. 2007 Jun;17(6):1301-7.
18. Said N, etal., Mol Cancer Res. 2007 Oct;5(10):1015-30.
19. Sakai N, etal., Hum Pathol. 2001 Oct;32(10):1064-70.
20. Socha MJ, etal., Am J Pathol. 2007 Oct;171(4):1104-12. Epub 2007 Aug 23.
21. Sova P, etal., Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23.
22. Tartare-Deckert S, etal., J Biol Chem. 2001 Jun 22;276(25):22231-7. Epub 2001 Apr 9.
23. Walpen S, etal., J Am Soc Nephrol. 2000 Mar;11(3):468-76.
24. Yamanaka M, etal., J Urol. 2001 Dec;166(6):2495-9.
Additional References at PubMed
PMID:1093755   PMID:1311092   PMID:1552170   PMID:1737102   PMID:2306517   PMID:2338025   PMID:2505905   PMID:2745554   PMID:2790009   PMID:2838412   PMID:3400777   PMID:3402455  
PMID:3410046   PMID:3489235   PMID:3581152   PMID:3597437   PMID:6368555   PMID:7034958   PMID:7559469   PMID:7563094   PMID:7721952   PMID:7730416   PMID:7821789   PMID:7829101  
PMID:7875683   PMID:7982919   PMID:8516290   PMID:8548457   PMID:8626499   PMID:8647860   PMID:8826089   PMID:9233787   PMID:9284812   PMID:9457905   PMID:9501084   PMID:9792673  
PMID:10567433   PMID:10756178   PMID:10801822   PMID:10880278   PMID:10937551   PMID:11445660   PMID:11554745   PMID:11716067   PMID:11782382   PMID:11856645   PMID:11956183   PMID:12169206  
PMID:12201246   PMID:12370830   PMID:12402984   PMID:12427131   PMID:12428242   PMID:12477932   PMID:12658547   PMID:12721366   PMID:12867428   PMID:12879219   PMID:14500371   PMID:14702039  
PMID:14718574   PMID:15014008   PMID:15034927   PMID:15246191   PMID:15389586   PMID:15469933   PMID:15480132   PMID:15489334   PMID:15546965   PMID:15558074   PMID:15609325   PMID:15641096  
PMID:15763438   PMID:15763439   PMID:15795937   PMID:15838642   PMID:16012759   PMID:16121393   PMID:16173048   PMID:16263253   PMID:16299239   PMID:16670288   PMID:16735494   PMID:16972886  
PMID:17022822   PMID:17213807   PMID:17235047   PMID:17343824   PMID:17397030   PMID:17435158   PMID:17490812   PMID:17586526   PMID:17625595   PMID:17638862   PMID:17681430   PMID:17724718  
PMID:17970686   PMID:17994631   PMID:18059024   PMID:18084690   PMID:18253934   PMID:18350569   PMID:18367635   PMID:18410576   PMID:18442048   PMID:18442089   PMID:18487610   PMID:18583538  
PMID:18787407   PMID:18796407   PMID:18808384   PMID:18813349   PMID:18813945   PMID:18949063   PMID:19011090   PMID:19177197   PMID:19236378   PMID:19403984   PMID:19448421   PMID:19453261  
PMID:19509023   PMID:19542224   PMID:19597474   PMID:19661316   PMID:19700761   PMID:19703125   PMID:19780053   PMID:19817957   PMID:19830689   PMID:19900269   PMID:19913121   PMID:19920824  
PMID:20061390   PMID:20070483   PMID:20087345   PMID:20132490   PMID:20195270   PMID:20210803   PMID:20338068   PMID:20339379   PMID:20369286   PMID:20393008   PMID:20452482   PMID:20525171  
PMID:20565704   PMID:20574156   PMID:20606036   PMID:20607658   PMID:20628086   PMID:20628624   PMID:20673868   PMID:20926826   PMID:20929508   PMID:20955243   PMID:21042566   PMID:21098700  
PMID:21152079   PMID:21173124   PMID:21192846   PMID:21264231   PMID:21308731   PMID:21339733   PMID:21349332   PMID:21672357   PMID:21685937   PMID:21725199   PMID:21778250   PMID:21798346  
PMID:21801304   PMID:21818290   PMID:21850018   PMID:21852239   PMID:21867537   PMID:21873635   PMID:21900206   PMID:21922274   PMID:21962567   PMID:21976959   PMID:22003835   PMID:22114076  
PMID:22136411   PMID:22145659   PMID:22157746   PMID:22206672   PMID:22222271   PMID:22246794   PMID:22247475   PMID:22308039   PMID:22321704   PMID:22422640   PMID:22491017   PMID:22542805  
PMID:22563191   PMID:22687753   PMID:22718352   PMID:22810586   PMID:22851666   PMID:22879971   PMID:22880013   PMID:22911700   PMID:22955913   PMID:22956186   PMID:22957090   PMID:23019342  
PMID:23023935   PMID:23050783   PMID:23114088   PMID:23123816   PMID:23249717   PMID:23321672   PMID:23383963   PMID:23390502   PMID:23516489   PMID:23532895   PMID:23599341   PMID:23638089  
PMID:23648679   PMID:23666856   PMID:23840838   PMID:23846421   PMID:23846918   PMID:23904381   PMID:23935929   PMID:24018911   PMID:24309322   PMID:24349098   PMID:24396828   PMID:24474275  
PMID:24535175   PMID:24562449   PMID:24590286   PMID:24676680   PMID:24754275   PMID:24769035   PMID:24804200   PMID:24993904   PMID:25027401   PMID:25032754   PMID:25126876   PMID:25155283  
PMID:25252848   PMID:25262637   PMID:25311631   PMID:25331979   PMID:25355716   PMID:25374228   PMID:25516351   PMID:25556322   PMID:25786138   PMID:25802234   PMID:25921830   PMID:25925867  
PMID:26025968   PMID:26027498   PMID:26044224   PMID:26165695   PMID:26169969   PMID:26186194   PMID:26329007   PMID:26335014   PMID:26523779   PMID:26656750   PMID:26698404   PMID:26731428  
PMID:26851678   PMID:26890308   PMID:27068509   PMID:27069189   PMID:27230656   PMID:27421134   PMID:27759879   PMID:27776337   PMID:27908613   PMID:27909812   PMID:27916484   PMID:28009327  
PMID:28119265   PMID:28304139   PMID:28327460   PMID:28342122   PMID:28479157   PMID:28569190   PMID:28687963   PMID:28713937   PMID:28718842   PMID:28818666   PMID:28821297   PMID:29025374  
PMID:29075785   PMID:29077165   PMID:29207175   PMID:29237913   PMID:29277504   PMID:29295776   PMID:29335425   PMID:29374693   PMID:29660567   PMID:29756486   PMID:30021884   PMID:30227835  
PMID:30259245   PMID:30346081   PMID:30422339   PMID:30426491   PMID:30476717   PMID:30574760   PMID:30632279   PMID:30650425   PMID:30883351   PMID:31030335   PMID:31031331   PMID:31041810  
PMID:31062076   PMID:31127138   PMID:31243264   PMID:31352078   PMID:31536960   PMID:31597597   PMID:31695779   PMID:31727501   PMID:31753726   PMID:31830578   PMID:31857774   PMID:32113990  
PMID:32350057   PMID:32487602   PMID:32495004   PMID:32543919   PMID:32580473   PMID:32729304   PMID:32780451   PMID:32919020   PMID:32934754   PMID:33226850   PMID:33535026   PMID:33576452  
PMID:33579227   PMID:33596621   PMID:33627488   PMID:33675864   PMID:33758160   PMID:33781836   PMID:33843664   PMID:33907853   PMID:33910127   PMID:33955203   PMID:33961781   PMID:34000572  
PMID:34185677   PMID:34205668   PMID:34319830   PMID:34438040   PMID:34459016   PMID:34624572   PMID:35175782  


Genomics

Comparative Map Data
SPARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5151,661,096 - 151,686,975 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,040,657 - 151,066,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBINCBI36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBI
Sparc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,284,985 - 55,310,906 (-)NCBIGRCm39mm39
GRCm39 Ensembl1155,285,326 - 55,314,009 (-)Ensembl
GRCm381155,394,159 - 55,420,080 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,394,500 - 55,423,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,208,003 - 55,233,582 (-)NCBIGRCm37mm9NCBIm37
MGSCv361155,237,924 - 55,263,289 (-)NCBImm8
Celera1159,982,920 - 59,995,424 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.04NCBI
Sparc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)Ensembl
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
Sparc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,099,003 - 6,122,459 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,100,123 - 6,122,460 (-)NCBIChiLan1.0ChiLan1.0
SPARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15153,091,160 - 153,115,745 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,090,181 - 153,115,750 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05147,087,903 - 147,112,466 (-)NCBIMhudiblu_PPA_v0panPan3
SPARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,659,541 - 57,682,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBI
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBI
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)Ensembl
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBI
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBI
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBI
Sparc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,576,762 - 112,597,465 (+)NCBI
SpeTri2.0NW_00493651511,026,156 - 11,046,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,357,703 - 71,381,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,576,864 - 77,584,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,224,003 - 54,248,869 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,222,838 - 54,238,006 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603423,456,066 - 23,481,034 (+)NCBIVero_WHO_p1.0
Sparc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,338,284 - 37,369,804 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473337,348,993 - 37,369,804 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
STS-J03040  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,042,325 - 151,042,452UniSTSGRCh37
Build 365151,022,518 - 151,022,645RGDNCBI36
Celera5147,123,726 - 147,123,853RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,187,714 - 146,187,841UniSTS
GeneMap99-GB4 RH Map5584.07UniSTS
NCBI RH Map5891.6UniSTS
D5S444E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,042,901 - 151,043,064UniSTSGRCh37
Build 365151,023,094 - 151,023,257RGDNCBI36
Celera5147,124,302 - 147,124,465RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,188,290 - 146,188,453UniSTS
TNG Radiation Hybrid Map570331.0UniSTS
GeneMap99-G3 RH Map55654.0UniSTS
SHGC-84435  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,046,042 - 151,046,255UniSTSGRCh37
Build 365151,026,235 - 151,026,448RGDNCBI36
Celera5147,127,443 - 147,127,656RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,191,431 - 146,191,644UniSTS
TNG Radiation Hybrid Map570331.0UniSTS
GDB:201800  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,053,462 - 151,053,638UniSTSGRCh37
Build 365151,033,655 - 151,033,831RGDNCBI36
Celera5147,134,864 - 147,135,040RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,198,852 - 146,199,024UniSTS
GDB:294200  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,042,647 - 151,042,901UniSTSGRCh37
Build 365151,022,840 - 151,023,094RGDNCBI36
Celera5147,124,048 - 147,124,302RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,188,036 - 146,188,290UniSTS
A007I34  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,041,047 - 151,041,298UniSTSGRCh37
Build 365151,021,240 - 151,021,491RGDNCBI36
Celera5147,122,445 - 147,122,696RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,186,433 - 146,186,684UniSTS
GeneMap99-GB4 RH Map5583.96UniSTS
D5S2386  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,041,060 - 151,041,149UniSTSGRCh37
Build 365151,021,253 - 151,021,342RGDNCBI36
Celera5147,122,458 - 147,122,547RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,186,446 - 146,186,535UniSTS
GeneMap99-G3 RH Map55648.0UniSTS
234  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,042,867 - 151,042,931UniSTSGRCh37
Build 365151,023,060 - 151,023,124RGDNCBI36
Celera5147,124,268 - 147,124,332RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,188,256 - 146,188,320UniSTS
GeneMap99-GB4 RH Map5576.76UniSTS
D5S2416  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,041,065 - 151,041,388UniSTSGRCh37
Build 365151,021,258 - 151,021,581RGDNCBI36
Celera5147,122,463 - 147,122,786RGD
Cytogenetic Map5q31.3-q32UniSTS
Whitehead-YAC Contig Map5 UniSTS
RH68620  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,042,103 - 151,042,244UniSTSGRCh37
Build 365151,022,296 - 151,022,437RGDNCBI36
Celera5147,123,504 - 147,123,645RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,187,492 - 146,187,633UniSTS
GeneMap99-GB4 RH Map5584.79UniSTS
RH65614  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,060,138 - 151,060,247UniSTSGRCh37
Build 365151,040,331 - 151,040,440RGDNCBI36
Celera5147,141,549 - 147,141,658RGD
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,205,534 - 146,205,643UniSTS
GeneMap99-GB4 RH Map5584.07UniSTS
NCBI RH Map5891.6UniSTS
SPARC_1369  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,041,963 - 151,042,800UniSTSGRCh37
Build 365151,022,156 - 151,022,993RGDNCBI36
Celera5147,123,364 - 147,124,201RGD
HuRef5146,187,352 - 146,188,189UniSTS
RH47515  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.3-q32UniSTS
GeneMap99-GB4 RH Map8397.88UniSTS
RH41219  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,187,408 - 146,187,618UniSTS
RH71413  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375151,051,196 - 151,052,772UniSTSGRCh37
Celera5147,132,598 - 147,134,174UniSTS
Cytogenetic Map5q31.3-q32UniSTS
HuRef5146,196,586 - 146,198,162UniSTS
GeneMap99-GB4 RH Map5583.96UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR29Ahsa-miR-29a-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)22864815
MIR29Ahsa-miR-29a-3pMirecordsexternal_infoNANA18390668

Predicted Target Of
Summary Value
Count of predictions:2895
Count of miRNA genes:1180
Interacting mature miRNAs:1470
Transcripts:ENST00000231061, ENST00000520687, ENST00000521327, ENST00000521569, ENST00000522348, ENST00000524277, ENST00000537849, ENST00000538026, ENST00000539687
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 167 1182 75 9 16 10 1807 53 949 95 225 373 3 794 1205 1
Medium 2159 1712 1633 602 1617 440 2548 2134 2759 312 1170 1116 165 1 410 1583 4
Low 46 92 12 12 197 12 1 9 19 9 45 66 6 1 2
Below cutoff 42 3 6 1 86 3 1 5 2 14 42 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_042174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL540785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL541830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY545555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI602719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ018477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U65081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000231061   ⟹   ENSP00000231061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,661,096 - 151,686,915 (-)Ensembl
RefSeq Acc Id: ENST00000520687
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,662,488 - 151,667,654 (-)Ensembl
RefSeq Acc Id: ENST00000521327
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,672,597 - 151,686,975 (-)Ensembl
RefSeq Acc Id: ENST00000521569   ⟹   ENSP00000428119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,666,477 - 151,686,968 (-)Ensembl
RefSeq Acc Id: ENST00000522348   ⟹   ENSP00000429152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,673,178 - 151,686,963 (-)Ensembl
RefSeq Acc Id: ENST00000524277
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,667,474 - 151,671,829 (-)Ensembl
RefSeq Acc Id: ENST00000537849
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,666,425 - 151,667,584 (-)Ensembl
RefSeq Acc Id: ENST00000538026   ⟹   ENSP00000440127
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,666,373 - 151,686,963 (-)Ensembl
RefSeq Acc Id: ENST00000539687   ⟹   ENSP00000444998
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5151,671,570 - 151,685,230 (-)Ensembl
RefSeq Acc Id: NM_001309443   ⟹   NP_001296372
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,661,096 - 151,686,915 (-)NCBI
CHM1_15150,473,070 - 150,499,042 (-)NCBI
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001309444   ⟹   NP_001296373
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,661,096 - 151,686,915 (-)NCBI
CHM1_15150,473,070 - 150,499,042 (-)NCBI
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003118   ⟹   NP_003109
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,661,096 - 151,686,915 (-)NCBI
GRCh375151,040,657 - 151,066,615 (-)NCBI
Build 365151,021,201 - 151,046,710 (-)NCBI Archive
HuRef5146,186,043 - 146,212,010 (-)NCBI
CHM1_15150,473,070 - 150,499,042 (-)NCBI
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003109   ⟸   NM_003118
- Peptide Label: isoform 1 precursor
- UniProtKB: P09486 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001296372   ⟸   NM_001309443
- Peptide Label: isoform 2 precursor
- UniProtKB: P09486 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001296373   ⟸   NM_001309444
- Peptide Label: isoform 3 precursor
- UniProtKB: P09486 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000231061   ⟸   ENST00000231061
RefSeq Acc Id: ENSP00000428119   ⟸   ENST00000521569
RefSeq Acc Id: ENSP00000429152   ⟸   ENST00000522348
RefSeq Acc Id: ENSP00000440127   ⟸   ENST00000538026
RefSeq Acc Id: ENSP00000444998   ⟸   ENST00000539687
Protein Domains
EF-hand   Follistatin-like   Kazal-like   SPARC_Ca_bdg

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09486-F1-model_v2 AlphaFold P09486 1-303 view protein structure

Promoters
RGD ID:6803573
Promoter ID:HG_KWN:51575
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252430
Position:
Human AssemblyChrPosition (strand)Source
Build 365151,046,416 - 151,046,916 (-)MPROMDB
RGD ID:6851736
Promoter ID:EP73673
Type:initiation region
Name:HS_SPARC
Description:Secreted protein, acidic, cysteine-rich (osteonectin).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 365151,046,669 - 151,046,729EPD
RGD ID:6871330
Promoter ID:EPDNEW_H8830
Type:initiation region
Name:SPARC_1
Description:secreted protein acidic and cysteine rich
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8832  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,686,915 - 151,686,975EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
NM_003118.4(SPARC):c.657C>A (p.Asp219Glu) single nucleotide variant not provided [RCV000734316] Chr5:151666438 [GRCh38]
Chr5:151045999 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.787G>A (p.Glu263Lys) single nucleotide variant Osteogenesis imperfecta type 17 [RCV000412523] Chr5:151664183 [GRCh38]
Chr5:151043744 [GRCh37]
Chr5:5q33.1		 pathogenic
NM_003118.4(SPARC):c.497G>A (p.Arg166His) single nucleotide variant Osteogenesis imperfecta type 17 [RCV000412625] Chr5:151667555 [GRCh38]
Chr5:151047116 [GRCh37]
Chr5:5q33.1		 pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_003118.4(SPARC):c.66A>G (p.Glu22=) single nucleotide variant Osteogenesis imperfecta type 17 [RCV001810280]|not provided [RCV001708670] Chr5:151674666 [GRCh38]
Chr5:151054227 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.55C>T (p.Pro19Ser) single nucleotide variant not provided [RCV001724507] Chr5:151676134 [GRCh38]
Chr5:151055695 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.114G>A (p.Val38=) single nucleotide variant not provided [RCV000980316] Chr5:151674618 [GRCh38]
Chr5:151054179 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.121-142G>A single nucleotide variant not provided [RCV001666680] Chr5:151673358 [GRCh38]
Chr5:151052919 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.120+5G>A single nucleotide variant not provided [RCV000900537] Chr5:151674607 [GRCh38]
Chr5:151054168 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.120+8G>T single nucleotide variant not provided [RCV000884315] Chr5:151674604 [GRCh38]
Chr5:151054165 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.733G>A (p.Gly245Arg) single nucleotide variant not provided [RCV000966976] Chr5:151666362 [GRCh38]
Chr5:151045923 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.816C>A (p.Thr272=) single nucleotide variant not provided [RCV000923799] Chr5:151664154 [GRCh38]
Chr5:151043715 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.204G>A (p.Ala68=) single nucleotide variant not provided [RCV000900413] Chr5:151673133 [GRCh38]
Chr5:151052694 [GRCh37]
Chr5:5q33.1		 benign|likely benign
NM_003118.4(SPARC):c.186C>T (p.Thr62=) single nucleotide variant not provided [RCV000941178] Chr5:151673151 [GRCh38]
Chr5:151052712 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.120+36T>G single nucleotide variant not provided [RCV001648109] Chr5:151674576 [GRCh38]
Chr5:151054137 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.208+127A>G single nucleotide variant not provided [RCV001651975] Chr5:151673002 [GRCh38]
Chr5:151052563 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.452-332G>A single nucleotide variant not provided [RCV001641593] Chr5:151667932 [GRCh38]
Chr5:151047493 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.585+298T>C single nucleotide variant not provided [RCV001676137] Chr5:151667169 [GRCh38]
Chr5:151046730 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.884-53C>T single nucleotide variant not provided [RCV001717868] Chr5:151663652 [GRCh38]
Chr5:151043213 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.120+42T>C single nucleotide variant Osteogenesis imperfecta type 17 [RCV001810296]|not provided [RCV001724495] Chr5:151674570 [GRCh38]
Chr5:151054131 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.483C>G (p.Thr161=) single nucleotide variant not provided [RCV000902624] Chr5:151667569 [GRCh38]
Chr5:151047130 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.357C>T (p.Phe119=) single nucleotide variant not provided [RCV000921038] Chr5:151669758 [GRCh38]
Chr5:151049319 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.891C>T (p.Ile297=) single nucleotide variant not provided [RCV000909199] Chr5:151663592 [GRCh38]
Chr5:151043153 [GRCh37]
Chr5:5q33.1		 pathogenic|likely benign
NM_003118.4(SPARC):c.861C>T (p.Ala287=) single nucleotide variant not provided [RCV000908620] Chr5:151664109 [GRCh38]
Chr5:151043670 [GRCh37]
Chr5:5q33.1		 benign|likely benign
NM_003118.4(SPARC):c.513C>G (p.Leu171=) single nucleotide variant not provided [RCV000907321] Chr5:151667539 [GRCh38]
Chr5:151047100 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.489C>T (p.Phe163=) single nucleotide variant not provided [RCV000931198] Chr5:151667563 [GRCh38]
Chr5:151047124 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.438C>T (p.Ile146=) single nucleotide variant not provided [RCV000906142] Chr5:151669677 [GRCh38]
Chr5:151049238 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.702G>A (p.Gln234=) single nucleotide variant not provided [RCV000915260] Chr5:151666393 [GRCh38]
Chr5:151045954 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.209A>G (p.Asn70Ser) single nucleotide variant not provided [RCV000888987] Chr5:151671694 [GRCh38]
Chr5:151051255 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.810C>T (p.Phe270=) single nucleotide variant not provided [RCV000888592] Chr5:151664160 [GRCh38]
Chr5:151043721 [GRCh37]
Chr5:5q33.1		 benign|likely benign
NM_003118.4(SPARC):c.633C>T (p.His211=) single nucleotide variant not provided [RCV000908974] Chr5:151666462 [GRCh38]
Chr5:151046023 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.585+100G>A single nucleotide variant not provided [RCV001635708] Chr5:151667367 [GRCh38]
Chr5:151046928 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.*29C>G single nucleotide variant not provided [RCV001678745] Chr5:151663542 [GRCh38]
Chr5:151043103 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.331-59T>G single nucleotide variant not provided [RCV001672077] Chr5:151669843 [GRCh38]
Chr5:151049404 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.-13-281C>T single nucleotide variant not provided [RCV001679688] Chr5:151676482 [GRCh38]
Chr5:151056043 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.*55C>G single nucleotide variant Osteogenesis imperfecta type 17 [RCV001335095] Chr5:151663516 [GRCh38]
Chr5:151043077 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.209-234C>G single nucleotide variant not provided [RCV001541438] Chr5:151671928 [GRCh38]
Chr5:151051489 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.208+153G>C single nucleotide variant not provided [RCV001648763] Chr5:151672976 [GRCh38]
Chr5:151052537 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.452-69T>G single nucleotide variant not provided [RCV001724492] Chr5:151667669 [GRCh38]
Chr5:151047230 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.586-268G>A single nucleotide variant not provided [RCV001724511] Chr5:151666777 [GRCh38]
Chr5:151046338 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.57+56G>C single nucleotide variant not provided [RCV001693890] Chr5:151676076 [GRCh38]
Chr5:151055637 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.208+31C>T single nucleotide variant Osteogenesis imperfecta type 17 [RCV001810253]|not provided [RCV001688065] Chr5:151673098 [GRCh38]
Chr5:151052659 [GRCh37]
Chr5:5q33.1		 benign
NM_003118.4(SPARC):c.*148T>A single nucleotide variant not provided [RCV001769775] Chr5:151663423 [GRCh38]
Chr5:151042984 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.884-140G>A single nucleotide variant not provided [RCV001774846] Chr5:151663739 [GRCh38]
Chr5:151043300 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.585+124G>A single nucleotide variant not provided [RCV001774862] Chr5:151667343 [GRCh38]
Chr5:151046904 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.586-37A>G single nucleotide variant not provided [RCV001757728] Chr5:151666546 [GRCh38]
Chr5:151046107 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.734+276G>A single nucleotide variant not provided [RCV001759321] Chr5:151666085 [GRCh38]
Chr5:151045646 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.-13-120T>C single nucleotide variant not provided [RCV001769674] Chr5:151676321 [GRCh38]
Chr5:151055882 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.735-252G>A single nucleotide variant not provided [RCV001752898] Chr5:151664487 [GRCh38]
Chr5:151044048 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.208+143G>A single nucleotide variant not provided [RCV001776544] Chr5:151672986 [GRCh38]
Chr5:151052547 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.883+106G>C single nucleotide variant not provided [RCV001757669] Chr5:151663981 [GRCh38]
Chr5:151043542 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.331-3C>T single nucleotide variant not provided [RCV001896253] Chr5:151669787 [GRCh38]
Chr5:151049348 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.212C>A (p.Pro71His) single nucleotide variant not provided [RCV002042910] Chr5:151671691 [GRCh38]
Chr5:151051252 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.751G>A (p.Glu251Lys) single nucleotide variant not provided [RCV001872519] Chr5:151664219 [GRCh38]
Chr5:151043780 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.706G>A (p.Gly236Ser) single nucleotide variant not provided [RCV001874034] Chr5:151666389 [GRCh38]
Chr5:151045950 [GRCh37]
Chr5:5q33.1		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
NM_003118.4(SPARC):c.36C>T (p.Ala12=) single nucleotide variant not provided [RCV002077330]|not specified [RCV001844581] Chr5:151676153 [GRCh38]
Chr5:151055714 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.484G>A (p.Glu162Lys) single nucleotide variant not provided [RCV002040120] Chr5:151667568 [GRCh38]
Chr5:151047129 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.34G>T (p.Ala12Ser) single nucleotide variant not provided [RCV001872986] Chr5:151676155 [GRCh38]
Chr5:151055716 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.652C>T (p.Arg218Trp) single nucleotide variant not provided [RCV001894447] Chr5:151666443 [GRCh38]
Chr5:151046004 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.157G>A (p.Gly53Arg) single nucleotide variant not provided [RCV002041679] Chr5:151673180 [GRCh38]
Chr5:151052741 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.778A>G (p.Ile260Val) single nucleotide variant not provided [RCV002041818] Chr5:151664192 [GRCh38]
Chr5:151043753 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.803G>A (p.Arg268His) single nucleotide variant not provided [RCV001871354] Chr5:151664167 [GRCh38]
Chr5:151043728 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.553AAC[1] (p.Asn186del) microsatellite not provided [RCV001947478] Chr5:151667494..151667496 [GRCh38]
Chr5:151047055..151047057 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.358G>A (p.Asp120Asn) single nucleotide variant not provided [RCV001909910] Chr5:151669757 [GRCh38]
Chr5:151049318 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.520G>A (p.Val174Ile) single nucleotide variant not provided [RCV002020291] Chr5:151667532 [GRCh38]
Chr5:151047093 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.250G>A (p.Glu84Lys) single nucleotide variant not provided [RCV002032342] Chr5:151671653 [GRCh38]
Chr5:151051214 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.604A>T (p.Asn202Tyr) single nucleotide variant not provided [RCV001934278] Chr5:151666491 [GRCh38]
Chr5:151046052 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.280G>A (p.Val94Met) single nucleotide variant not provided [RCV001940806] Chr5:151671623 [GRCh38]
Chr5:151051184 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.155_157del (p.Val52del) deletion not provided [RCV001933353] Chr5:151673180..151673182 [GRCh38]
Chr5:151052741..151052743 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.811G>A (p.Glu271Lys) single nucleotide variant not provided [RCV002013829] Chr5:151664159 [GRCh38]
Chr5:151043720 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.802C>T (p.Arg268Cys) single nucleotide variant not provided [RCV002010131] Chr5:151664168 [GRCh38]
Chr5:151043729 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.142G>T (p.Val48Phe) single nucleotide variant not provided [RCV001989870] Chr5:151673195 [GRCh38]
Chr5:151052756 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.585+1G>T single nucleotide variant not provided [RCV002018805] Chr5:151667466 [GRCh38]
Chr5:151047027 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.826G>A (p.Asp276Asn) single nucleotide variant not provided [RCV002029937] Chr5:151664144 [GRCh38]
Chr5:151043705 [GRCh37]
Chr5:5q33.1		 uncertain significance
NM_003118.4(SPARC):c.121-20T>C single nucleotide variant not provided [RCV002205050] Chr5:151673236 [GRCh38]
Chr5:151052797 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.735-19C>T single nucleotide variant not provided [RCV002168909] Chr5:151664254 [GRCh38]
Chr5:151043815 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.783C>T (p.Pro261=) single nucleotide variant not provided [RCV002191137] Chr5:151664187 [GRCh38]
Chr5:151043748 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.771T>C (p.Ala257=) single nucleotide variant not provided [RCV002107992] Chr5:151664199 [GRCh38]
Chr5:151043760 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.420G>A (p.Lys140=) single nucleotide variant not provided [RCV002085934] Chr5:151669695 [GRCh38]
Chr5:151049256 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.734+8C>G single nucleotide variant not provided [RCV002173157] Chr5:151666353 [GRCh38]
Chr5:151045914 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.120+17C>T single nucleotide variant not provided [RCV002135215] Chr5:151674595 [GRCh38]
Chr5:151054156 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.261G>A (p.Glu87=) single nucleotide variant not provided [RCV002152721] Chr5:151671642 [GRCh38]
Chr5:151051203 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.586-18C>T single nucleotide variant not provided [RCV002194685] Chr5:151666527 [GRCh38]
Chr5:151046088 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.666G>A (p.Lys222=) single nucleotide variant not provided [RCV002151140] Chr5:151666429 [GRCh38]
Chr5:151045990 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.331-14_331-13del microsatellite not provided [RCV002196045] Chr5:151669797..151669798 [GRCh38]
Chr5:151049358..151049359 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.795C>T (p.Cys265=) single nucleotide variant not provided [RCV002142211] Chr5:151664175 [GRCh38]
Chr5:151043736 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.187G>A (p.Glu63Lys) single nucleotide variant not provided [RCV002163580] Chr5:151673150 [GRCh38]
Chr5:151052711 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.734+11A>C single nucleotide variant not provided [RCV002161877] Chr5:151666350 [GRCh38]
Chr5:151045911 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.209-11C>G single nucleotide variant not provided [RCV002184563] Chr5:151671705 [GRCh38]
Chr5:151051266 [GRCh37]
Chr5:5q33.1		 likely benign
NM_003118.4(SPARC):c.870C>T (p.Phe290=) single nucleotide variant not provided [RCV002122568] Chr5:151664100 [GRCh38]
Chr5:151043661 [GRCh37]
Chr5:5q33.1		 likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11219 AgrOrtholog
COSMIC SPARC COSMIC
Ensembl Genes ENSG00000113140 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000231061 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428119 UniProtKB/TrEMBL
  ENSP00000429152 UniProtKB/TrEMBL
  ENSP00000440127 UniProtKB/TrEMBL
  ENSP00000444998 UniProtKB/TrEMBL
Ensembl Transcript ENST00000231061 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000521569 UniProtKB/TrEMBL
  ENST00000522348 UniProtKB/TrEMBL
  ENST00000538026 UniProtKB/TrEMBL
  ENST00000539687 UniProtKB/TrEMBL
GTEx ENSG00000113140 GTEx
HGNC ID HGNC:11219 ENTREZGENE
Human Proteome Map SPARC Human Proteome Map
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteonectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC/Testican_Ca-bd-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6678 UniProtKB/Swiss-Prot
NCBI Gene 6678 ENTREZGENE
OMIM 182120 OMIM
  616507 OMIM
PANTHER PTHR13866:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC_Ca_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36055 PharmGKB
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DQH8_HUMAN UniProtKB/TrEMBL
  E5RJA5_HUMAN UniProtKB/TrEMBL
  E5RK62_HUMAN UniProtKB/TrEMBL
  F5GY03_HUMAN UniProtKB/TrEMBL
  F5H4E2_HUMAN UniProtKB/TrEMBL
  P09486 ENTREZGENE
  Q6QE20_HUMAN UniProtKB/TrEMBL
  SPRC_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary D3DQH9 UniProtKB/Swiss-Prot
  Q6IBK4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 SPARC  secreted protein acidic and cysteine rich    secreted protein, acidic, cysteine-rich (osteonectin)  Symbol and/or name change 5135510 APPROVED