TUBB (tubulin beta class I) - Rat Genome Database

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Gene: TUBB (tubulin beta class I) Homo sapiens
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Symbol: TUBB
Name: tubulin beta class I
RGD ID: 1606428
HGNC Page HGNC:20778
Description: Enables MHC class I protein binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within odontoblast differentiation. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; microtubule cytoskeleton; and nuclear envelope lumen. Implicated in complex cortical dysplasia with other brain malformations 6 and congenital symmetric circumferential skin creases 1.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: beta 5-tubulin; beta Ib tubulin; beta-4 tubulin; beta1-tubulin; CDCBM6; class I beta-tubulin; CSCSC1; M40; MGC117247; MGC16435; OK/SW-cl.56; TUBB1; TUBB5; tubulin beta chain; tubulin beta polypeptide; tubulin beta-1 chain; tubulin beta-5 chain; tubulin, beta class I; tubulin, beta polypeptide
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: TUBBP1   TUBBP10   TUBBP11   TUBBP2   TUBBP3   TUBBP4   TUBBP5   TUBBP6   TUBBP7   TUBBP8   TUBBP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: TUBB1 (Gene ID: 81027) and TUBB (Gene ID: 203068) share the TUBB1 symbol/alias in common. TUBB (GeneID: 203068) also shares the TUBB symbol/alias in common with TUBB2A (Gene ID: 7280). [07 Feb 2019]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,720,352 - 30,725,422 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,717,435 - 30,725,538 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,688,129 - 30,693,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,796,136 - 30,801,178 (+)NCBINCBI36Build 36hg18NCBI36
Celera632,286,289 - 32,291,331 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,488,105 - 30,493,147 (+)NCBIHuRef
CHM1_1630,690,286 - 30,695,330 (+)NCBICHM1_1
T2T-CHM13v2.0630,584,554 - 30,589,624 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 29 rows
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Original Reference(s)
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:126726298|RGD:127286243|RGD:127327115|RGD:150468267|RGD:150556298|RGD:151350171|RGD:155266852|RGD:155644441|RGD:155795018|RGD:329847827|RGD:401750300|RGD:405870387|RGD:407480783|RGD:40886739|RGD:597714842|RGD:86578178554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:25741868
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:86578168554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:23246003|PMID:24833723|PMID:25741868|PMID:39825153
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:11345382|RGD:151663435|RGD:21071446|RGD:21074882|RGD:38598752|RGD:394566838554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVar 
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:408386069|RGD:4083860708554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:39825153
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:86578188554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:23246003|PMID:24833723|PMID:25741868|PMID:30738969|PMID:35183200
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:1267312578554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:23246003|PMID:25741868|PMID:26637975
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:2430573428554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:23246003|PMID:25741868|PMID:32085672|PMID:34211110
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:136128228554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:25741868|PMID:29671837|PMID:29706646
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGPRGD:1560524118554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 6ClinVarPMID:25741868|PMID:32085672
TUBBHumancongenital fibrosis of the extraocular muscles  IAGPRGD:4052803258554872ClinVar Annotator: match by term: Congenital fibrosis of extraocular musclesClinVarPMID:25741868|PMID:39033378
TUBBHumancongenital symmetric circumferential skin creases 1  IAGPRGD:127327115|RGD:150415589|RGD:150550389|RGD:405870387|RGD:40886739|RGD:86578178554872ClinVar Annotator: match by term: Symmetric circumferential skin creases, congenital, 1 | ClinVar Annotator: match more ...ClinVarPMID:25741868
TUBBHumancongenital symmetric circumferential skin creases 1  IAGPRGD:10766704|RGD:10766705|RGD:1529825568554872ClinVar Annotator: match by term: Symmetric circumferential skin creases, congenital, 1ClinVar 
TUBBHumancongenital symmetric circumferential skin creases 1  IAGPRGD:86578188554872ClinVar Annotator: match by term: Symmetric circumferential skin creases, congenital, 1ClinVarPMID:23246003|PMID:24833723|PMID:25741868|PMID:30738969|PMID:35183200
TUBBHumancongenital symmetric circumferential skin creases 1  IAGPRGD:1267312578554872ClinVar Annotator: match by term: Symmetric circumferential skin creases, congenital, 1ClinVarPMID:23246003|PMID:25741868|PMID:26637975
TUBBHumancongenital symmetric circumferential skin creases 1  IAGPRGD:136128228554872ClinVar Annotator: match by term: Symmetric circumferential skin creases, congenital, 1ClinVarPMID:25741868|PMID:29671837|PMID:29706646
TUBBHumanepilepsy  IAGPRGD:136128228554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868|PMID:29671837|PMID:29706646
TUBBHumangenetic disease  IAGPRGD:155795018|RGD:408867398554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868
TUBBHumangenetic disease  IAGPRGD:86578168554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23246003|PMID:24833723|PMID:25741868|PMID:39825153
TUBBHumangenetic disease  IAGPRGD:150556516|RGD:156040134|RGD:40887291|RGD:40887347|RGD:408874788554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
TUBBHumangenetic disease  IAGPRGD:86578188554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23246003|PMID:24833723|PMID:25741868|PMID:30738969|PMID:35183200
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Original Reference(s)
TUBBHumancongestive heart failure  ISORGD:162406311554173CTD Direct Evidence: marker/mechanismCTDPMID:16155095
TUBBHumandilated cardiomyopathy  ISORGD:162406311554173CTD Direct Evidence: marker/mechanismCTDPMID:16155095
TUBBHumanperinatal necrotizing enterocolitis  ISORGD:162406311554173CTD Direct Evidence: marker/mechanismCTDPMID:18806098
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Original Reference(s)
TUBBHumanmicrocephaly  ISSRGD:162406313592920OMIM:251200 | OMIM:604321 | OMIM:604804 | OMIM:608393 | OMIM:608716 | OMIM:612703MouseDO 
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Original Reference(s)
TUBBHumancomplex cortical dysplasia with other brain malformations 6  IAGP 7240710 OMIM 
TUBBHumancongenital symmetric circumferential skin creases 1  IAGP 7240710 OMIM 

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Original Reference(s)
TUBBHuman(-)-demecolcine decreases expressionEXP 6480464Demecolcine results in decreased expression of TUBB mRNACTDPMID:23649840
TUBBHuman(1->4)-beta-D-glucan multiple interactionsISORGD:16240636480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TUBB5 mRNACTDPMID:36331819
TUBBHuman(S)-colchicine decreases expressionISORGD:6285966480464Colchicine results in decreased expression of TUBB5 mRNACTDPMID:20624997
TUBBHuman(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of TUBB mRNACTDPMID:16949557
TUBBHuman1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISORGD:6285966480464o,p'-DDT results in increased expression of TUBB5 mRNACTDPMID:24096037
TUBBHuman1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISORGD:16240636480464o,p'-DDT results in increased expression of TUBB5 mRNACTDPMID:24096037
TUBBHuman1,1-dichloroethene increases expressionISORGD:16240636480464vinylidene chloride results in increased expression of TUBB mRNACTDPMID:26682919
TUBBHuman1,2-dimethylhydrazine increases expressionISORGD:162406364804641,2-Dimethylhydrazine results in increased expression of TUBB5 mRNACTDPMID:22206623
TUBBHuman1,2-dimethylhydrazine multiple interactionsISORGD:16240636480464Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TUBB5 mRNA]CTDPMID:22206623
TUBBHuman1-naphthyl isothiocyanate increases expressionISORGD:62859664804641-Naphthylisothiocyanate results in increased expression of TUBB5 mRNACTDPMID:30723492
TUBBHuman17alpha-ethynylestradiol increases expressionISORGD:6285966480464Ethinyl Estradiol results in increased expression of TUBB5 mRNACTDPMID:16174780|PMID:17108234|PMID:24096037
TUBBHuman17alpha-ethynylestradiol increases expressionISORGD:16240636480464Ethinyl Estradiol results in increased expression of TUBB5 mRNACTDPMID:16174780|PMID:17942748|PMID:24096037
TUBBHuman17alpha-ethynylestradiol multiple interactionsISORGD:16240636480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB5 mRNACTDPMID:17942748
TUBBHuman17alpha-ethynylestradiol affects expressionISORGD:16240636480464Ethinyl Estradiol affects the expression of TUBB5 mRNACTDPMID:17555576
TUBBHuman17beta-estradiol decreases expressionISORGD:6285966480464Estradiol results in decreased expression of TUBB5 proteinCTDPMID:32145629
TUBBHuman17beta-estradiol decreases expressionISORGD:16240636480464Estradiol results in decreased expression of TUBB5 mRNACTDPMID:39298647
TUBBHuman17beta-estradiol affects expressionISORGD:6285966480464Estradiol affects the expression of TUBB5 mRNACTDPMID:32145629
TUBBHuman17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expressionEXP 6480464Metribolone results in decreased expression of TUBB proteinCTDPMID:17152098
TUBBHuman2,2',4,4',5,5'-hexachlorobiphenyl decreases expressionISORGD:62859664804642,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TUBB5 mRNACTDPMID:20959002
TUBBHuman2,3',4,4',5-Pentachlorobiphenyl increases expressionISORGD:162406364804642,3',4,4',5-pentachlorobiphenyl results in increased expression of TUBB5 mRNACTDPMID:31388691

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Biological Process
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Original Reference(s)
TUBBHumancell division involved_inTAS 150520179 PMID:12090300BHF-UCLPMID:12090300
TUBBHumancytoskeleton organization involved_inIEAGO:0005200150520179 GOCGO_REF:0000108
TUBBHumancytoskeleton-dependent intracellular transport involved_inTAS 150520179 PMID:12090300BHF-UCLPMID:12090300
TUBBHumanmicrotubule cytoskeleton organization involved_inIBAFB:FBgn0003885|FB:FBgn0010097|FB:FBgn0052396|FB:FBgn0087040|FB:FBgn0260639|MGI:101834|MGI:107812|MGI:107814|MGI:98869|PANTHER:PTN000172598|PomBase:SPBC16A3.15c|PomBase:SPBC26H8.07c|PomBase:SPBC32F12.04|PomBase:SPBC800.05c|SGD:S000001857|SGD:S000004202|TAIR:locus:2076750|TAIR:locus:2166469|TAIR:locus:3439219|UniProtKB:A0A644F0Y1|UniProtKB:D6XD01|UniProtKB:P10653|UniProtKB:P18695|UniProtKB:P24633|UniProtKB:P54401|UniProtKB:P68363|UniProtKB:Q13509|UniProtKB:Q3ZCM7|UniProtKB:Q4QQZ8|WB:WBGene00003171|WB:WBGene00006528|WB:WBGene00006529|WB:WBGene00006537|WB:WBGene00006540150520179 GO_CentralGO_REF:0000033
TUBBHumanmicrotubule-based process involved_inTAS 150520179 PMID:12090300BHF-UCLPMID:12090300
TUBBHumanmicrotubule-based process acts_upstream_of_or_withinIEAUniProtKB:P99024|ensembl:ENSMUSP00000001566150520179 EnsemblGO_REF:0000107
TUBBHumanmicrotubule-based process involved_inIEAInterPro:IPR000217|InterPro:IPR002453|InterPro:IPR017975150520179 InterProGO_REF:0000002
TUBBHumanmitotic cell cycle involved_inIBAFB:FBgn0087040|FB:FBgn0260639|PANTHER:PTN000172598|PomBase:SPBC26H8.07c|PomBase:SPBC32F12.04|PomBase:SPBC800.05c|SGD:S000001857|SGD:S000004202|SGD:S000004550|TAIR:locus:2076750|TAIR:locus:2166469|UniProtKB:A0A644F0Y1|UniProtKB:P10653|UniProtKB:P18695|WB:WBGene00006528|WB:WBGene00006529|WB:WBGene00006540150520179 GO_CentralGO_REF:0000033
TUBBHumannatural killer cell mediated cytotoxicity involved_inNAS 150520179 PMID:11120798UniProtPMID:11120798
TUBBHumanodontoblast differentiation acts_upstream_of_or_withinIDA 150520179 PMID:19567321GO_CentralPMID:19567321
TUBBHumanregulation of synapse organization involved_inIEAUniProtKB:P99024|ensembl:ENSMUSP00000001566150520179 EnsemblGO_REF:0000107
TUBBHumanspindle assembly acts_upstream_of_or_withinIEAUniProtKB:P99024|ensembl:ENSMUSP00000001566150520179 EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
TUBBHumanazurophil granule lumen located_inTAS 150520179 ReactomeReactome:R-HSA-6798751
TUBBHumancell body located_inIDA 150520179 PMID:19567321DFLATPMID:19567321
TUBBHumancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
TUBBHumancytoplasm is_active_inIBAFB:FBgn0003884|FB:FBgn0003885|FB:FBgn0003886|FB:FBgn0010097|FB:FBgn0087040|FB:FBgn0260639|MGI:101834|MGI:107804|MGI:107813|MGI:107848|MGI:1095409|MGI:1858225|MGI:1891826|MGI:2144208|MGI:98869|PANTHER:PTN000172598|PomBase:SPBC26H8.07c|PomBase:SPBC32F12.04|TAIR:locus:2076750|UniProtKB:A0A644F0Y1|UniProtKB:D6XD01|UniProtKB:P04350|UniProtKB:P07437|UniProtKB:P10653|UniProtKB:P23258|UniProtKB:P24633|UniProtKB:P68371|UniProtKB:Q71U36|UniProtKB:Q9H4B7|UniProtKB:Q9UJT1|WB:WBGene00006531|WB:WBGene00006538|WB:WBGene00006540|dictyBase:DDB_G0271738150520179 GO_CentralGO_REF:0000033
TUBBHumancytoplasm located_inIDA 150520179 PMID:23178297CAFAPMID:23178297
TUBBHumancytoplasmic ribonucleoprotein granule located_inIDA 150520179 PMID:15121898ParkinsonsUK-UCLPMID:15121898
TUBBHumancytoskeleton located_inIEAUniProtKB-KW:KW-0206150520179 UniProtGO_REF:0000043
TUBBHumancytoskeleton located_inTAS 150520179 PMID:16130169UniProtPMID:16130169
TUBBHumancytoskeleton located_inIEAUniProtKB-SubCell:SL-0090150520179 UniProtGO_REF:0000044
TUBBHumancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-9685830
TUBBHumanextracellular exosome located_inHDA 150520179 PMID:12519789, PMID:21362503, PMID:23533145UniProtPMID:12519789|PMID:21362503|PMID:23533145
TUBBHumanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-2574840|Reactome:R-HSA-2574845|Reactome:R-HSA-3000310|Reactome:R-HSA-3000319|Reactome:R-HSA-380272|Reactome:R-HSA-380283|Reactome:R-HSA-380294|Reactome:R-HSA-380303|Reactome:R-HSA-380311|Reactome:R-HSA-380316|Reactome:R-HSA-380455|Reactome:R-HSA-380508|Reactome:R-HSA-5617816|Reactome:R-HSA-5626220|Reactome:R-HSA-5626223|Reactome:R-HSA-5626227|Reactome:R-HSA-5626228|Reactome:R-HSA-5626681|Reactome:R-HSA-5626699|Reactome:R-HSA-5638009|Reactome:R-HSA-6798751|Reactome:R-HSA-8853405|Reactome:R-HSA-8853419
TUBBHumanintercellular bridge located_inIEAARBA:ARBA00028413150520179 UniProtGO_REF:0000117
TUBBHumanintercellular bridge located_inIDA 150520179 HPAGO_REF:0000052
TUBBHumanmembrane raft located_inIEAUniProtKB:P69897|ensembl:ENSRNOP00000072090150520179 EnsemblGO_REF:0000107
TUBBHumanmicrotubule located_inIEAUniProtKB-KW:KW-0493150520179 UniProtGO_REF:0000043
TUBBHumanmicrotubule is_active_inIBACGD:CAL0000176403|FB:FBgn0003884|FB:FBgn0003886|FB:FBgn0003888|FB:FBgn0052396|FB:FBgn0087040|FB:FBgn0260639|FB:FBgn0284243|MGI:101834|MGI:107804|MGI:107812|MGI:107814|MGI:1095406|MGI:1095409|MGI:2144208|MGI:98869|PANTHER:PTN000172598|PomBase:SPBC26H8.07c|PomBase:SPBC800.05c|TAIR:locus:2076750|TAIR:locus:2166469|TAIR:locus:3439219|UniProtKB:A0A1D8PTV4|UniProtKB:P04350|UniProtKB:P07437|UniProtKB:P10653|UniProtKB:P23258|UniProtKB:P24633|UniProtKB:P68363|UniProtKB:P68366|UniProtKB:P68371|UniProtKB:Q13509|UniProtKB:Q13885|UniProtKB:Q71U36|UniProtKB:Q9BUF5|UniProtKB:Q9BVA1|UniProtKB:Q9NRH3|WB:WBGene00003175|WB:WBGene00006531|WB:WBGene00006536|WB:WBGene00006537|WB:WBGene00006538|dictyBase:DDB_G0269196|dictyBase:DDB_G0287689150520179 GO_CentralGO_REF:0000033
TUBBHumanmicrotubule located_inTAS 150520179 PMID:12090300BHF-UCLPMID:12090300
TUBBHumanmicrotubule located_inIEAUniProtKB:P99024|ensembl:ENSMUSP00000001566150520179 EnsemblGO_REF:0000107
TUBBHumanmicrotubule located_inIEAInterPro:IPR000217|InterPro:IPR002453|InterPro:IPR017975150520179 InterProGO_REF:0000002
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Molecular Function
1 to 20 of 33 rows

  
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TUBBHumanGTP binding enablesIEAInterPro:IPR002453|InterPro:IPR003008|InterPro:IPR017975150520179 InterProGO_REF:0000002
TUBBHumanGTP binding enablesIBAFB:FBgn0010097|FB:FBgn0260639|MGI:98869|PANTHER:PTN000172598|UniProtKB:P68363|UniProtKB:Q13509150520179 GO_CentralGO_REF:0000033
TUBBHumanGTP binding enablesIEAUniProtKB-KW:KW-0342150520179 UniProtGO_REF:0000043
TUBBHumanGTP binding enablesIEAUniRule:UR000000085150520179 UniProtGO_REF:0000104
TUBBHumanGTPase activating protein binding  ISORGD:6216659068941 RGDPMID:16820281|REF_RGD_ID:7207368
TUBBHumanGTPase activating protein binding enablesIEAUniProtKB:P69897|ensembl:ENSRNOP00000072090150520179 EnsemblGO_REF:0000107
TUBBHumanGTPase activity enablesIEAInterPro:IPR002453150520179 InterProGO_REF:0000002
TUBBHumanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
TUBBHumanMHC class I protein binding enablesIDA 150520179 PMID:11120798UniProtPMID:11120798
TUBBHumannucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
TUBBHumanprotein binding enablesIPIUniProtKB:P05067150520179 PMID:16049941IntActPMID:16049941
TUBBHumanprotein binding enablesIPIUniProtKB:P10636-8|UniProtKB:Q71U36150520179 PMID:30274285IntActPMID:30274285
TUBBHumanprotein binding enablesIPIUniProtKB:P10636-8150520179 PMID:35063084IntActPMID:35063084
TUBBHumanprotein binding enablesIPIUniProtKB:Q5S007150520179 PMID:24275654, PMID:24947832, PMID:31046837IntActPMID:24275654|PMID:24947832|PMID:31046837
TUBBHumanprotein binding enablesIPIUniProtKB:Q8AZK7150520179 PMID:18457437IntActPMID:18457437
TUBBHumanprotein binding enablesIPIUniProtKB:Q15843150520179 PMID:21145461IntActPMID:21145461
TUBBHumanprotein binding enablesIPIUniProtKB:P51114150520179 PMID:21653829IntActPMID:21653829
TUBBHumanprotein binding enablesIPIUniProtKB:Q9BSI4150520179 PMID:21044950IntActPMID:21044950
TUBBHumanprotein binding enablesIPIUniProtKB:O14737|UniProtKB:P48643150520179 PMID:24375412UniProtPMID:24375412
TUBBHumanprotein binding enablesIPIUniProtKB:P05412150520179 PMID:20195357, PMID:25609649IntActPMID:20195357|PMID:25609649
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Imported Annotations - KEGG (archival)

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TUBBHumanpathogenic Escherichia coli infection pathway  IEA 6907045 KEGGhsa:05130
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Original Reference(s)
TUBBHumanAbnormal pinna morphology  IAGP 8699517 HPOORPHA:2505
TUBBHumanAbnormal scrotum morphology  IAGP 8699517 HPOORPHA:2505
TUBBHumanAbnormality of the face  IAGP 8699517 HPOORPHA:2505
TUBBHumanAbnormality of the musculature  IAGP 8699517 HPOORPHA:2505
TUBBHumanAtaxia  IAGP 8699517 HPOMIM:615771|PMID:23246003
TUBBHumanAutosomal dominant inheritance  IAGP 8699517 HPOMIM:156610|PMID:26637975|MIM:615771|PMID:23246003
TUBBHumanBlepharophimosis  IAGP 8699517 HPOMIM:156610|PMID:26637975
TUBBHumanBrachycephaly  IAGP 8699517 HPOMIM:156610|PMID:26637975
TUBBHumanCerebellar vermis atrophy  IAGP 8699517 HPOMIM:156610
TUBBHumanCerebellar vermis hypoplasia  IAGP 8699517 HPOMIM:615771|PMID:23246003
TUBBHumanCircumferential skin creases on extremities  IAGP 8699517 HPOMIM:156610|PMID:26637975
TUBBHumanCleft palate  IAGP 8699517 HPOMIM:156610|PMID:26637975|ORPHA:2505
TUBBHumanCongenital onset  IAGP 8699517 HPOMIM:615771|PMID:23246003
TUBBHumanCongestive heart failure  IAGP 8699517 HPOORPHA:2505
TUBBHumanCortical dysplasia  IAGP 8699517 HPOMIM:615771|PMID:23246003
TUBBHumanCryptorchidism  IAGP 8699517 HPOORPHA:2505
TUBBHumanDandy-Walker malformation  IAGP 8699517 HPOMIM:156610|PMID:26637975
TUBBHumanDelayed speech and language development  IAGP 8699517 HPOMIM:156610|MIM:615771|PMID:23246003
TUBBHumanDepressed nasal bridge  IAGP 8699517 HPOMIM:156610|PMID:26637975
TUBBHumanDilated fourth ventricle  IAGP 8699517 HPOMIM:615771|PMID:23246003
1 to 20 of 68 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TUBBHumanAbnormal brain morphology  IAGPRGD:1272862438554872ClinVar Annotator: match by term: Abnormality of brain morphologyClinVarPMID:25741868
TUBBHumanCongenital fibrosis of extraocular muscles  IAGPRGD:4052803258554872ClinVar Annotator: match by term: Congenital fibrosis of extraocular musclesClinVarPMID:25741868|PMID:39033378
TUBBHumanHypoplasia of the corpus callosum  IAGPRGD:1272744848554872ClinVar Annotator: match by term: Hypoplasia of the corpus callosumClinVarPMID:25741868
TUBBHumanLissencephaly  IAGPRGD:136128228554872ClinVar Annotator: match by term: LissencephalyClinVarPMID:25741868|PMID:29671837|PMID:29706646
TUBBHumanMegacolon  IAGPRGD:414076048554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
TUBBHumanSeizure  IAGPRGD:136128228554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868|PMID:29671837|PMID:29706646

#
Reference Title
Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
1 to 10 of 41 rows
PMID:1629950   PMID:3007184   PMID:3405308   PMID:3782288   PMID:6688039   PMID:6865944   PMID:6893015   PMID:6946435   PMID:7556643   PMID:7744867   PMID:8103323   PMID:8270253  
PMID:8530437   PMID:8619474   PMID:8700896   PMID:8895530   PMID:9110174   PMID:9553134   PMID:9581762   PMID:9629920   PMID:9880513   PMID:9886087   PMID:9922135   PMID:9973324  
PMID:10022909   PMID:10191277   PMID:10220577   PMID:10561216   PMID:10722852   PMID:11120798   PMID:11278895   PMID:11504633   PMID:11590136   PMID:11698390   PMID:11750707   PMID:11870213  
PMID:11964161   PMID:12134159   PMID:12209587   PMID:12353262   PMID:12417652   PMID:12477932   PMID:12519789   PMID:12606581   PMID:12639940   PMID:12639963   PMID:12716939   PMID:12771190  
PMID:12826311   PMID:12852856   PMID:12855424   PMID:12872123   PMID:12884273   PMID:12893435   PMID:12963728   PMID:12966166   PMID:14532270   PMID:14583623   PMID:14594945   PMID:14603253  
PMID:14634002   PMID:14744259   PMID:14760703   PMID:15003198   PMID:15014504   PMID:15047060   PMID:15120663   PMID:15121898   PMID:15129282   PMID:15161933   PMID:15188402   PMID:15304323  
PMID:15324660   PMID:15331440   PMID:15331635   PMID:15489334   PMID:15556606   PMID:15592455   PMID:15878338   PMID:15959508   PMID:16027165   PMID:16039987   PMID:16049941   PMID:16095531  
PMID:16130169   PMID:16371510   PMID:16380805   PMID:16455083   PMID:16462731   PMID:16526095   PMID:16702430   PMID:16824193   PMID:16879614   PMID:16941085   PMID:16944923   PMID:17043677  
PMID:17266347   PMID:17360745   PMID:17373842   PMID:17488662   PMID:17569113   PMID:17620599   PMID:17869412   PMID:17955473   PMID:18029348   PMID:18214993   PMID:18320585   PMID:18457437  
PMID:18458804   PMID:19019082   PMID:19041431   PMID:19074767   PMID:19167051   PMID:19322201   PMID:19380743   PMID:19394292   PMID:19405953   PMID:19481056   PMID:19503101   PMID:19545277  
1 to 10 of 41 rows



TUBB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,720,352 - 30,725,422 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,717,435 - 30,725,538 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,688,129 - 30,693,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,796,136 - 30,801,178 (+)NCBINCBI36Build 36hg18NCBI36
Celera632,286,289 - 32,291,331 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,488,105 - 30,493,147 (+)NCBIHuRef
CHM1_1630,690,286 - 30,695,330 (+)NCBICHM1_1
T2T-CHM13v2.0630,584,554 - 30,589,624 (+)NCBIT2T-CHM13v2.0
Tubb5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,144,812 - 36,149,193 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,144,813 - 36,149,198 (-)EnsemblGRCm39 Ensembl
GRCm381735,833,920 - 35,838,301 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,833,921 - 35,838,306 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,970,865 - 35,975,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,442,858 - 35,446,260 (-)NCBIMGSCv36mm8
Celera1739,343,980 - 39,348,363 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Tubb5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,917,577 - 2,921,726 (+)NCBIGRCr8
mRatBN7.2202,912,779 - 2,916,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,912,778 - 2,916,940 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,964,208 - 2,968,352 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,969,189 - 2,973,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,995,550 - 2,999,694 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,422,448 - 3,426,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,422,461 - 3,426,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,519,551 - 5,523,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,060,224 - 3,090,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,060,491 - 3,065,012 (+)NCBI
Celera20338,700 - 342,843 (+)NCBICelera
Cytogenetic Map20p12NCBI
Tubb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583704,750 - 718,649 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955583704,811 - 715,742 (+)NCBIChiLan1.0ChiLan1.0
TUBB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,280,026 - 45,285,423 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,243,801 - 41,248,269 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,465,367 - 30,470,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,333,985 - 31,339,739 (+)NCBIpanpan1.1PanPan1.1panPan2
TUBB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112512,738 - 517,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12650,056 - 654,417 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012655,875 - 660,238 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12655,834 - 693,258 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112513,860 - 518,216 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012582,704 - 587,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012651,287 - 655,647 (+)NCBIUU_Cfam_GSD_1.0
Tubb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,015,619 - 34,019,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837380,879 - 384,748 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837380,880 - 384,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,247,736 - 23,252,240 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,247,827 - 23,252,240 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,969,793 - 26,974,207 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TUBB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,728,103 - 41,733,206 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,729,143 - 41,733,243 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,417,844 - 30,423,077 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tubb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,001,552 - 25,005,464 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,001,555 - 25,005,459 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in TUBB
97 total Variants

1 to 10 of 118 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_178014.4(TUBB):c.961A>G (p.Met321Val) single nucleotide variant Abnormal brain morphology [RCV001526664]|Complex cortical dysplasia with other brain malformations 6 [RCV003154188] Chr6:30724023 [GRCh38]
Chr6:30691800 [GRCh37]
Chr6:6p21.33
pathogenic
NM_178014.4(TUBB):c.647A>G (p.Lys216Arg) single nucleotide variant not provided [RCV000656301] Chr6:30723709 [GRCh38]
Chr6:30691486 [GRCh37]
Chr6:6p21.33
likely pathogenic
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
NM_178014.4(TUBB):c.895A>G (p.Met299Val) single nucleotide variant Complex cortical dysplasia with other brain malformations 6 [RCV000115018]|Inborn genetic diseases [RCV003162533]|not provided [RCV003319319] Chr6:30723957 [GRCh38]
Chr6:30691734 [GRCh37]
Chr6:6p21.33
pathogenic
NM_178014.4(TUBB):c.1057G>A (p.Val353Ile) single nucleotide variant Complex cortical dysplasia with other brain malformations 6 [RCV000115019]|Multiple benign circumferential skin creases on limbs 1 [RCV004796020]|TUBB-related disorder [RCV004730874] Chr6:30724119 [GRCh38]
Chr6:30691896 [GRCh37]
Chr6:6p21.33
pathogenic|likely pathogenic
NM_178014.4(TUBB):c.1201G>A (p.Glu401Lys) single nucleotide variant Complex cortical dysplasia with other brain malformations 6 [RCV000115020]|Inborn genetic diseases [RCV000624500]|Multiple benign circumferential skin creases on limbs 1 [RCV002274914]|not provided [RCV004772839] Chr6:30724263 [GRCh38]
Chr6:30692040 [GRCh37]
Chr6:6p21.33
pathogenic
NM_178014.4(TUBB):c.599A>G (p.Tyr200Cys) single nucleotide variant Complex cortical dysplasia with other brain malformations 6 [RCV001331890]|not provided [RCV001664832] Chr6:30723661 [GRCh38]
Chr6:30691438 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
NM_178014.4(TUBB):c.665A>T (p.Tyr222Phe) single nucleotide variant Multiple benign circumferential skin creases on limbs 1 [RCV000203277] Chr6:30723727 [GRCh38]
Chr6:30691504 [GRCh37]
Chr6:6p21.33
pathogenic
NM_178014.4(TUBB):c.43C>A (p.Gln15Lys) single nucleotide variant Multiple benign circumferential skin creases on limbs 1 [RCV000203282] Chr6:30720549 [GRCh38]
Chr6:30688326 [GRCh37]
Chr6:6p21.33
pathogenic
1 to 10 of 118 rows

Predicted Target Of
Summary Value
Count of predictions:2591
Count of miRNA genes:577
Interacting mature miRNAs:626
Transcripts:ENST00000327892, ENST00000330914, ENST00000396384, ENST00000396389, ENST00000435534
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
597218507GWAS1314581_HBMI-adjusted waist-hip ratio QTL GWAS1314581 (human)1e-08body size trait (VT:0100005)63072065030720651Human
597247277GWAS1343351_HBMI-adjusted waist-hip ratio QTL GWAS1343351 (human)3e-08body size trait (VT:0100005)63072065030720651Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
597205505GWAS1301579_Hhandedness QTL GWAS1301579 (human)6e-25handedness63072065030720651Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human

1 to 10 of 11 rows



adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2434 2788 2247 4963 1723 2347 5 622 1949 464 2269 7292 6462 52 3725 851 1740 1613 174 1


1 to 30 of 65 rows
RefSeq Transcripts NG_034142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_120608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB062393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB088100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB103606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB202098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF141349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 65 rows

Ensembl Acc Id: ENST00000327892   ⟹   ENSP00000339001
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,720,352 - 30,725,422 (+)Ensembl
Ensembl Acc Id: ENST00000330914   ⟹   ENSP00000365578
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,721,574 - 30,725,426 (+)Ensembl
Ensembl Acc Id: ENST00000396384   ⟹   ENSP00000379668
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,721,699 - 30,725,426 (+)Ensembl
Ensembl Acc Id: ENST00000396389   ⟹   ENSP00000379672
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,721,667 - 30,725,426 (+)Ensembl
Ensembl Acc Id: ENST00000680530
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,721,618 - 30,725,409 (+)Ensembl
Ensembl Acc Id: ENST00000681421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,721,686 - 30,725,408 (+)Ensembl
Ensembl Acc Id: ENST00000681435   ⟹   ENSP00000506665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,717,435 - 30,725,538 (+)Ensembl
RefSeq Acc Id: NM_001293212   ⟹   NP_001280141
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,721,638 - 30,725,422 (+)NCBI
CHM1_1630,691,455 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,585,840 - 30,589,624 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001293213   ⟹   NP_001280142
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,720,352 - 30,725,422 (+)NCBI
CHM1_1630,690,107 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,584,554 - 30,589,624 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001293214   ⟹   NP_001280143
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,720,352 - 30,725,422 (+)NCBI
CHM1_1630,690,107 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,584,554 - 30,589,624 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001293215   ⟹   NP_001280144
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,721,638 - 30,725,422 (+)NCBI
CHM1_1630,691,455 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,585,840 - 30,589,624 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001293216   ⟹   NP_001280145
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,721,638 - 30,725,422 (+)NCBI
CHM1_1630,691,455 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,585,840 - 30,589,624 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178014   ⟹   NP_821133
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,720,352 - 30,725,422 (+)NCBI
GRCh37630,688,012 - 30,693,199 (+)NCBI
Build 36630,796,136 - 30,801,178 (+)NCBI Archive
HuRef630,488,105 - 30,493,147 (+)ENTREZGENE
CHM1_1630,690,107 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,584,554 - 30,589,624 (+)NCBI
Sequence:
RefSeq Acc Id: NR_120608
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,720,352 - 30,725,422 (+)NCBI
CHM1_1630,690,107 - 30,695,334 (+)NCBI
T2T-CHM13v2.0630,584,554 - 30,589,624 (+)NCBI
Sequence:
1 to 30 of 57 rows
Protein RefSeqs NP_001280141 (Get FASTA)   NCBI Sequence Viewer  
  NP_001280142 (Get FASTA)   NCBI Sequence Viewer  
  NP_001280143 (Get FASTA)   NCBI Sequence Viewer  
  NP_001280144 (Get FASTA)   NCBI Sequence Viewer  
  NP_001280145 (Get FASTA)   NCBI Sequence Viewer  
  NP_821133 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB59507 (Get FASTA)   NCBI Sequence Viewer  
  AAC28642 (Get FASTA)   NCBI Sequence Viewer  
  AAC28650 (Get FASTA)   NCBI Sequence Viewer  
  AAC28654 (Get FASTA)   NCBI Sequence Viewer  
  AAD33873 (Get FASTA)   NCBI Sequence Viewer  
  AAH01896 (Get FASTA)   NCBI Sequence Viewer  
  AAH01938 (Get FASTA)   NCBI Sequence Viewer  
  AAH02347 (Get FASTA)   NCBI Sequence Viewer  
  AAH05838 (Get FASTA)   NCBI Sequence Viewer  
  AAH07605 (Get FASTA)   NCBI Sequence Viewer  
  AAH13374 (Get FASTA)   NCBI Sequence Viewer  
  AAH15889 (Get FASTA)   NCBI Sequence Viewer  
  AAH19924 (Get FASTA)   NCBI Sequence Viewer  
  AAH20946 (Get FASTA)   NCBI Sequence Viewer  
  AAH21909 (Get FASTA)   NCBI Sequence Viewer  
  AAH62532 (Get FASTA)   NCBI Sequence Viewer  
  AAH70326 (Get FASTA)   NCBI Sequence Viewer  
  AAI03747 (Get FASTA)   NCBI Sequence Viewer  
  ABE96641 (Get FASTA)   NCBI Sequence Viewer  
  ABO65095 (Get FASTA)   NCBI Sequence Viewer  
  ADO22487 (Get FASTA)   NCBI Sequence Viewer  
  BAB63321 (Get FASTA)   NCBI Sequence Viewer  
  BAB93480 (Get FASTA)   NCBI Sequence Viewer  
  BAC54932 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 57 rows
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_821133   ⟸   NM_178014
- Peptide Label: isoform b
- UniProtKB: Q8WUC1 (UniProtKB/Swiss-Prot),   P05218 (UniProtKB/Swiss-Prot),   Q9CY33 (UniProtKB/Swiss-Prot),   P07437 (UniProtKB/Swiss-Prot),   Q5SU16 (UniProtKB/TrEMBL),   A0A384NYT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280142   ⟸   NM_001293213
- Peptide Label: isoform c
- UniProtKB: B4DMJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280143   ⟸   NM_001293214
- Peptide Label: isoform d
- UniProtKB: B7ZAK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280141   ⟸   NM_001293212
- Peptide Label: isoform a
- UniProtKB: B4DY90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280144   ⟸   NM_001293215
- Peptide Label: isoform e
- UniProtKB: Q5ST81 (UniProtKB/TrEMBL),   B7ZAK1 (UniProtKB/TrEMBL)
- Sequence:
Name Modeler Protein Id AA Range Protein Structure
AF-P07437-F1-model_v2 AlphaFold P07437 1-444 view protein structure

RGD ID:6872418
Promoter ID:EPDNEW_H9374
Type:initiation region
Name:TUBB_1
Description:tubulin beta class I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,720,352 - 30,720,412EPDNEW
RGD ID:6804912
Promoter ID:HG_KWN:52855
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000076074,   UC003NRK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,795,181 - 30,796,207 (+)MPROMDB
RGD ID:6804116
Promoter ID:HG_KWN:52856
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000330914,   ENST00000396384,   ENST00000396389
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,796,791 - 30,797,442 (+)MPROMDB


1 to 40 of 76 rows
Database
Acc Id
Source(s)
COSMIC TUBB COSMIC
Ensembl Genes ENSG00000183311 UniProtKB/Swiss-Prot
  ENSG00000196230 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000224156 UniProtKB/Swiss-Prot
  ENSG00000227739 UniProtKB/Swiss-Prot
  ENSG00000229684 UniProtKB/Swiss-Prot
  ENSG00000232421 UniProtKB/Swiss-Prot
  ENSG00000232575 UniProtKB/Swiss-Prot
  ENSG00000235067 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000327892 ENTREZGENE
  ENST00000327892.13 UniProtKB/Swiss-Prot
  ENST00000330914 ENTREZGENE
  ENST00000383564.8 UniProtKB/Swiss-Prot
  ENST00000396389 ENTREZGENE
  ENST00000419792.6 UniProtKB/Swiss-Prot
  ENST00000421473.6 UniProtKB/Swiss-Prot
  ENST00000422650.6 UniProtKB/Swiss-Prot
  ENST00000422674.6 UniProtKB/Swiss-Prot
  ENST00000432462.6 UniProtKB/Swiss-Prot
  ENST00000436628.6 UniProtKB/Swiss-Prot
  ENST00000681435 ENTREZGENE
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
GTEx ENSG00000183311 GTEx
  ENSG00000196230 GTEx
  ENSG00000224156 GTEx
  ENSG00000227739 GTEx
  ENSG00000229684 GTEx
  ENSG00000232421 GTEx
  ENSG00000232575 GTEx
  ENSG00000235067 GTEx
HGNC ID HGNC:20778 ENTREZGENE
Human Proteome Map TUBB Human Proteome Map
InterPro Beta-tubulin_BS UniProtKB/Swiss-Prot
  Beta_tubulin UniProtKB/Swiss-Prot
  Tub_FtsZ_C UniProtKB/Swiss-Prot
  Tubulin UniProtKB/Swiss-Prot
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
1 to 40 of 76 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 TUBB  tubulin beta class I    tubulin, beta class I  Symbol and/or name change 5135510 APPROVED
2011-10-18 TUBB  tubulin, beta class I  TUBB  tubulin, beta  Symbol and/or name change 5135510 APPROVED