HMGN2 (high mobility group nucleosomal binding domain 2) - Rat Genome Database

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Gene: HMGN2 (high mobility group nucleosomal binding domain 2) Homo sapiens
Analyze
Symbol: HMGN2
Name: high mobility group nucleosomal binding domain 2
RGD ID: 1350424
HGNC Page HGNC:4986
Description: Enables RNA binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Located in cytoplasm; extracellular space; and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: high mobility group nucleosome-binding domain-containing protein 2; high mobility group protein N2; high-mobility group (nonhistone chromosomal) protein 17; high-mobility group nucleosomal binding domain 2; HMG17; MGC5629; MGC88718; non-histone chromosomal protein HMG-17; nonhistone chromosomal protein HMG-17
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HMGN2P1   HMGN2P10   HMGN2P11   HMGN2P12   HMGN2P13   HMGN2P14   HMGN2P15   HMGN2P16   HMGN2P17   HMGN2P18   HMGN2P19   HMGN2P2   HMGN2P20   HMGN2P21   HMGN2P22   HMGN2P23   HMGN2P24   HMGN2P25   HMGN2P26   HMGN2P27   HMGN2P28   HMGN2P29   HMGN2P3   HMGN2P30   HMGN2P31   HMGN2P32   HMGN2P33   HMGN2P34   HMGN2P35   HMGN2P36   HMGN2P37   HMGN2P38   HMGN2P39   HMGN2P4   HMGN2P40   HMGN2P41   HMGN2P42   HMGN2P43   HMGN2P44   HMGN2P45   HMGN2P46   HMGN2P47   HMGN2P48   HMGN2P5   HMGN2P6   HMGN2P7   HMGN2P8   HMGN2P9   LOC646853  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,472,440 - 26,476,642 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,472,440 - 26,476,642 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,798,931 - 26,803,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,671,489 - 26,675,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,483,055 - 26,486,603NCBI
Celera125,196,117 - 25,200,344 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,053,209 - 25,057,410 (+)NCBIHuRef
CHM1_1126,911,906 - 26,916,138 (+)NCBICHM1_1
T2T-CHM13v2.0126,310,460 - 26,314,663 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
Brodifacoum  (ISO)
buspirone  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
Cuprizon  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (ISO)
genistein  (EXP)
indometacin  (EXP)
L-methionine  (ISO)
lead(0)  (EXP)
leflunomide  (EXP,ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methidathion  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
propanal  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
sodium arsenite  (EXP)
sunitinib  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
tungsten  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA)
cytoplasm  (IDA,IEA)
extracellular space  (IDA)
female germ cell nucleus  (ISO)
nucleus  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:565710   PMID:2037294   PMID:2040281   PMID:2394451   PMID:2565024   PMID:3754870   PMID:4022776   PMID:7563062   PMID:9852141   PMID:10207070   PMID:10640150   PMID:10753971  
PMID:11246012   PMID:11337467   PMID:11410162   PMID:11438671   PMID:12032302   PMID:12477932   PMID:15489334   PMID:16204630   PMID:16710414   PMID:17474147   PMID:17709345   PMID:18029348  
PMID:18287527   PMID:18299391   PMID:19490893   PMID:19524541   PMID:20016921   PMID:20842856   PMID:21044950   PMID:21319273   PMID:21518253   PMID:21730181   PMID:21816901   PMID:21873635  
PMID:22267324   PMID:22681889   PMID:22898364   PMID:23314748   PMID:23403292   PMID:24872413   PMID:24981860   PMID:25060707   PMID:25156469   PMID:25530340   PMID:26167880   PMID:26514267  
PMID:26972000   PMID:27358110   PMID:27460641   PMID:28035005   PMID:28065597   PMID:28190768   PMID:28408162   PMID:28514442   PMID:28973435   PMID:29298432   PMID:29401165   PMID:29478914  
PMID:29568061   PMID:29777862   PMID:30021884   PMID:30110629   PMID:30196744   PMID:30415952   PMID:30425250   PMID:30463901   PMID:30725116   PMID:30804502   PMID:30890647   PMID:30952427  
PMID:30997501   PMID:31180492   PMID:31586073   PMID:31699896   PMID:31871319   PMID:31980649   PMID:32416067   PMID:32687490   PMID:32892371   PMID:33001583   PMID:33034909   PMID:33467898  
PMID:33545068   PMID:33589921   PMID:33838681   PMID:33916271   PMID:33961781   PMID:34079125   PMID:34537242   PMID:34709727   PMID:35271311   PMID:35583604   PMID:35831314   PMID:35844135  
PMID:35944360   PMID:36180891   PMID:36215168   PMID:36217030   PMID:36244648   PMID:36273042   PMID:36373674   PMID:36574265   PMID:37506885   PMID:38113892   PMID:38172120  


Genomics

Comparative Map Data
HMGN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,472,440 - 26,476,642 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,472,440 - 26,476,642 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,798,931 - 26,803,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,671,489 - 26,675,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,483,055 - 26,486,603NCBI
Celera125,196,117 - 25,200,344 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,053,209 - 25,057,410 (+)NCBIHuRef
CHM1_1126,911,906 - 26,916,138 (+)NCBICHM1_1
T2T-CHM13v2.0126,310,460 - 26,314,663 (+)NCBIT2T-CHM13v2.0
Hmgn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,692,050 - 133,695,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,692,049 - 133,695,961 (-)EnsemblGRCm39 Ensembl
GRCm384133,964,739 - 133,967,991 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,964,738 - 133,968,650 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,520,654 - 133,523,906 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364133,236,815 - 133,240,067 (-)NCBIMGSCv36mm8
Celera4132,142,295 - 132,145,551 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.47NCBI
Hmgn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,475,907 - 151,479,361 (-)NCBIGRCr8
mRatBN7.25146,192,126 - 146,195,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1630,622,845 - 30,634,512 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl5146,192,126 - 146,195,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,895,254 - 148,898,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,664,873 - 150,668,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,651,441 - 150,654,896 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05152,195,359 - 152,198,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5152,195,361 - 152,198,813 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,878,876 - 155,881,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,712,158 - 152,715,493 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,722,662 - 152,722,956 (-)NCBI
Celera5144,612,205 - 144,615,712 (-)NCBICelera
Cytogenetic Map5q36NCBI
Hmgn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554525,846,085 - 5,849,996 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554525,846,085 - 5,849,996 (+)NCBIChiLan1.0ChiLan1.0
HMGN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21200,392,724 - 200,396,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,493,472 - 199,497,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,736,429 - 25,739,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,801,607 - 26,804,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,801,607 - 26,804,333 (+)Ensemblpanpan1.1panPan2
HMGN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,579,042 - 73,582,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,579,042 - 73,610,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha270,155,762 - 70,159,506 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,142,182 - 74,145,929 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,139,249 - 74,174,423 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,967,003 - 70,970,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,972,747 - 71,976,493 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,976,197 - 72,979,941 (-)NCBIUU_Cfam_GSD_1.0
HMGN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,858,177 - 83,861,905 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,857,114 - 83,861,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,401,654 - 77,406,199 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Hmgn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476410,477,276 - 10,480,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p36.11(chr1:26603699-26903828)x3 copy number gain not provided [RCV000847959] Chr1:26603699..26903828 [GRCh37]
Chr1:1p36.11		 uncertain significance
GRCh37/hg19 1p36.11(chr1:26246213-27044118)x3 copy number gain not provided [RCV001829142] Chr1:26246213..27044118 [GRCh37]
Chr1:1p36.11		 uncertain significance
NC_000001.10:g.(?_25870190)_(27278871_?)dup duplication Retinitis pigmentosa 59 [RCV003122734] Chr1:25870190..27278871 [GRCh37]
Chr1:1p36.11		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR23Ahsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23437179

Predicted Target Of
Summary Value
Count of predictions:1342
Count of miRNA genes:615
Interacting mature miRNAs:685
Transcripts:ENST00000361427, ENST00000460563, ENST00000463817, ENST00000464888, ENST00000466194, ENST00000467700, ENST00000468388, ENST00000479815, ENST00000493418
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-74438  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37126,800,488 - 26,800,768UniSTSGRCh37
Build 36126,673,075 - 26,673,355RGDNCBI36
Celera125,197,699 - 25,197,979RGD
Cytogenetic Map1p36.1UniSTS
HuRef125,054,765 - 25,055,045UniSTS
TNG Radiation Hybrid Map111204.0UniSTS
GeneMap99-GB4 RH Map188.41UniSTS
NCBI RH Map1142.5UniSTS
ECD09439  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map14q23.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 37 7 3 109 3 19 18 25 10 96 100 5
Medium 2402 2939 1718 620 1841 461 4337 2128 3694 407 1362 1512 170 1 1204 2787 6 2
Low 52 1 1 1 1 1 51 15 2 2 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK026562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL513365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU100588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU074476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000361427   ⟹   ENSP00000355228
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,440 - 26,476,642 (+)Ensembl
RefSeq Acc Id: ENST00000460563
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,477 - 26,475,432 (+)Ensembl
RefSeq Acc Id: ENST00000463817
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,511 - 26,475,568 (+)Ensembl
RefSeq Acc Id: ENST00000464888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,506 - 26,475,158 (+)Ensembl
RefSeq Acc Id: ENST00000466194
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,473,206 - 26,475,565 (+)Ensembl
RefSeq Acc Id: ENST00000467700
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,517 - 26,475,626 (+)Ensembl
RefSeq Acc Id: ENST00000468388
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,450 - 26,474,128 (+)Ensembl
RefSeq Acc Id: ENST00000479815
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,463 - 26,475,228 (+)Ensembl
RefSeq Acc Id: ENST00000493418
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,473,429 - 26,475,360 (+)Ensembl
RefSeq Acc Id: ENST00000619352   ⟹   ENSP00000481160
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,472,515 - 26,475,970 (+)Ensembl
RefSeq Acc Id: NM_005517   ⟹   NP_005508
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,472,440 - 26,476,642 (+)NCBI
GRCh37126,798,902 - 26,803,133 (+)ENTREZGENE
Build 36126,671,489 - 26,675,720 (+)NCBI Archive
HuRef125,053,209 - 25,057,410 (+)ENTREZGENE
CHM1_1126,911,906 - 26,916,138 (+)NCBI
T2T-CHM13v2.0126,310,460 - 26,314,663 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_005508   ⟸   NM_005517
- UniProtKB: Q6FGI5 (UniProtKB/Swiss-Prot),   Q0VGD5 (UniProtKB/Swiss-Prot),   Q96C64 (UniProtKB/Swiss-Prot),   P05204 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000355228   ⟸   ENST00000361427
RefSeq Acc Id: ENSP00000481160   ⟸   ENST00000619352

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05204-F1-model_v2 AlphaFold P05204 1-90 view protein structure

Promoters
RGD ID:6854634
Promoter ID:EPDNEW_H482
Type:initiation region
Name:HMGN2_1
Description:high mobility group nucleosomal binding domain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,472,506 - 26,472,566EPDNEW
RGD ID:6785727
Promoter ID:HG_KWN:1508
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005517,   OTTHUMT00000009902,   OTTHUMT00000009903,   OTTHUMT00000009904,   OTTHUMT00000009905,   OTTHUMT00000009906,   OTTHUMT00000096887,   UC009VSK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,670,536 - 26,671,697 (+)MPROMDB
RGD ID:6849410
Promoter ID:EP31009
Type:single initiation site
Name:HS_HMGN2
Description:High mobility group chromosomal protein-17.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 185; Mammalian, avian HMG-17 protein.
Tissues & Cell Lines:housekeeping gene
Experiment Methods:Primer extension with homologous sequence ladder
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,671,584 - 26,671,644EPD
RGD ID:6785730
Promoter ID:HG_KWN:1509
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000096888,   OTTHUMT00000096889,   UC001BMQ.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36126,671,706 - 26,673,187 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4986 AgrOrtholog
COSMIC HMGN2 COSMIC
Ensembl Genes ENSG00000198830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000361427 ENTREZGENE
  ENST00000361427.6 UniProtKB/Swiss-Prot
GTEx ENSG00000198830 GTEx
HGNC ID HGNC:4986 ENTREZGENE
Human Proteome Map HMGN2 Human Proteome Map
InterPro HMGN_fam UniProtKB/Swiss-Prot
KEGG Report hsa:3151 UniProtKB/Swiss-Prot
NCBI Gene 3151 ENTREZGENE
OMIM 163910 OMIM
PANTHER NON-HISTONE CHROMOSOMAL PROTEIN HMG-17 UniProtKB/Swiss-Prot
  NONHISTONE CHROMOSOMAL PROTEIN HMG UniProtKB/Swiss-Prot
Pfam HMG14_17 UniProtKB/Swiss-Prot
PharmGKB PA35089 PharmGKB
PRINTS NONHISHMG17 UniProtKB/Swiss-Prot
PROSITE HMG14_17 UniProtKB/Swiss-Prot
SMART HMG17 UniProtKB/Swiss-Prot
UniProt HMGN2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VGD5 ENTREZGENE
  Q6FGI5 ENTREZGENE
  Q96C64 ENTREZGENE
UniProt Secondary Q0VGD5 UniProtKB/Swiss-Prot
  Q6FGI5 UniProtKB/Swiss-Prot
  Q96C64 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 HMGN2  high mobility group nucleosomal binding domain 2  HMGN2  high-mobility group nucleosomal binding domain 2  Symbol and/or name change 5135510 APPROVED