MYBL2 (MYB proto-oncogene like 2) - Rat Genome Database

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Gene: MYBL2 (MYB proto-oncogene like 2) Homo sapiens
Analyze
Symbol: MYBL2
Name: MYB proto-oncogene like 2
RGD ID: 1318263
HGNC Page HGNC
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B-MYB; BMYB; MGC15600; myb-like protein 2; myb-related protein B; v-myb avian myeloblastosis viral oncogene homolog-like 2; v-myb myeloblastosis viral oncogene homolog-like 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2043,667,019 - 43,716,495 (+)EnsemblGRCh38hg38GRCh38
GRCh382043,667,114 - 43,716,482 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372042,295,754 - 42,345,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,729,123 - 41,778,536 (+)NCBINCBI36hg18NCBI36
Build 342041,729,122 - 41,778,536NCBI
Celera2039,003,174 - 39,052,551 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2039,030,966 - 39,080,488 (+)NCBIHuRef
CHM1_12042,199,374 - 42,248,808 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroxynon-2-enal  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
calcitriol  (EXP)
calyculin a  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorpromazine  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethyl maleate  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP)
Enterolactone  (EXP)
exemestane  (EXP)
fenvalerate  (ISO)
fipronil  (ISO)
folic acid  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
glycidol  (ISO)
Heliotrine  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP)
indometacin  (EXP)
L-ascorbic acid  (EXP)
Lasiocarpine  (EXP,ISO)
lipopolysaccharide  (ISO)
lucanthone  (EXP)
methotrexate  (ISO)
methylseleninic acid  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalene  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
oxaliplatin  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phytoestrogen  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
testosterone  (EXP)
thioacetamide  (ISO)
tioguanine  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
vorinostat  (EXP)
zaragozic acid A  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1376749   PMID:1717494   PMID:1984793   PMID:3060855   PMID:7642110   PMID:8062924   PMID:8123011   PMID:8125298   PMID:8142646   PMID:8314782   PMID:8812502   PMID:9012818  
PMID:9840932   PMID:10095772   PMID:10544265   PMID:10593981   PMID:10645009   PMID:10656684   PMID:10744766   PMID:10766737   PMID:10770937   PMID:10871850   PMID:11259168   PMID:11264176  
PMID:11423988   PMID:11522824   PMID:11733503   PMID:11780052   PMID:11973331   PMID:11997503   PMID:12439743   PMID:12475768   PMID:12477932   PMID:12645566   PMID:12673206   PMID:12748276  
PMID:12927788   PMID:12947099   PMID:14506250   PMID:14769798   PMID:15256398   PMID:15302935   PMID:15489334   PMID:15618219   PMID:16055500   PMID:16476973   PMID:16551698   PMID:17081983  
PMID:17098733   PMID:17159899   PMID:17531812   PMID:17563750   PMID:17588787   PMID:17671431   PMID:18026132   PMID:18548008   PMID:18676680   PMID:19016757   PMID:19043454   PMID:19170196  
PMID:19274049   PMID:19383908   PMID:19625176   PMID:19692168   PMID:19725879   PMID:19821490   PMID:20211142   PMID:20360068   PMID:20734103   PMID:20857481   PMID:20864510   PMID:21148321  
PMID:21187425   PMID:21304178   PMID:21367750   PMID:21419759   PMID:21480327   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22910183   PMID:23032261   PMID:23555285   PMID:23878725  
PMID:24141769   PMID:24199710   PMID:24515894   PMID:24981860   PMID:24999758   PMID:25368258   PMID:25502082   PMID:25557911   PMID:25609649   PMID:25917549   PMID:26186194   PMID:26308378  
PMID:26496610   PMID:26972000   PMID:27090638   PMID:27705803   PMID:28061449   PMID:28276478   PMID:28394947   PMID:28427077   PMID:28473536   PMID:28514442   PMID:28559119   PMID:28784180  
PMID:29049183   PMID:29268817   PMID:29274707   PMID:29395067   PMID:29772705   PMID:29893470   PMID:30021884   PMID:30082276   PMID:30206359   PMID:30224471   PMID:30305611   PMID:30321399  
PMID:30415952   PMID:30804394   PMID:30804502   PMID:30936457   PMID:31182584   PMID:31216474   PMID:31387917   PMID:31756170   PMID:31758653   PMID:32115147   PMID:32200471   PMID:32294305  
PMID:32439918   PMID:32853735   PMID:32951068   PMID:32979888   PMID:33058028   PMID:33073649   PMID:34079125  


Genomics

Comparative Map Data
MYBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2043,667,019 - 43,716,495 (+)EnsemblGRCh38hg38GRCh38
GRCh382043,667,114 - 43,716,482 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372042,295,754 - 42,345,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,729,123 - 41,778,536 (+)NCBINCBI36hg18NCBI36
Build 342041,729,122 - 41,778,536NCBI
Celera2039,003,174 - 39,052,551 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2039,030,966 - 39,080,488 (+)NCBIHuRef
CHM1_12042,199,374 - 42,248,808 (+)NCBICHM1_1
Mybl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Build 34646,205,870 - 46,222,237NCBI
GRCm392162,896,246 - 162,926,608 (+)NCBIGRCm39mm39
GRCm39 Ensembl2162,896,607 - 162,926,608 (+)Ensembl
GRCm382163,054,327 - 163,084,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,054,687 - 163,084,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv372162,880,371 - 162,910,423 (+)NCBIGRCm37mm9NCBIm37
MGSCv362162,746,076 - 162,776,128 (+)NCBImm8
Celera2169,001,317 - 169,031,320 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map284.0NCBI
Mybl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23151,705,254 - 151,733,714 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl3159,421,671 - 159,450,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03159,421,638 - 159,450,087 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03165,617,173 - 165,645,610 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43153,925,908 - 153,954,323 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13153,831,924 - 153,858,958 (+)NCBI
Celera3150,362,664 - 150,391,069 (+)NCBICelera
Cytogenetic Map3q42NCBI
Mybl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544513,496,919 - 13,530,689 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544513,496,919 - 13,530,689 (-)NCBIChiLan1.0ChiLan1.0
MYBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12041,099,325 - 41,146,822 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2041,099,368 - 41,146,423 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02040,005,482 - 40,053,324 (+)NCBIMhudiblu_PPA_v0panPan3
MYBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12431,339,570 - 31,382,626 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2431,343,997 - 31,382,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2430,983,123 - 31,025,849 (+)NCBI
ROS_Cfam_1.02432,046,538 - 32,089,827 (+)NCBI
UMICH_Zoey_3.12431,310,869 - 31,353,896 (+)NCBI
UNSW_CanFamBas_1.02431,422,213 - 31,465,277 (+)NCBI
UU_Cfam_GSD_1.02431,963,002 - 32,006,311 (+)NCBI
Mybl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640180,352,693 - 180,387,306 (+)NCBI
SpeTri2.0NW_0049365302,918,924 - 2,953,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,256,257 - 46,287,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11746,256,245 - 46,287,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21751,696,566 - 51,726,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1220,097,179 - 20,148,998 (-)NCBI
ChlSab1.1 Ensembl220,097,108 - 20,148,926 (-)Ensembl
Vero_WHO_p1.0NW_02366605068,828,866 - 68,880,606 (-)NCBI
Mybl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479010,629,771 - 10,665,187 (-)NCBI

Position Markers
STS-X13293  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372042,344,738 - 42,344,933UniSTSGRCh37
Build 362041,778,152 - 41,778,347RGDNCBI36
Celera2039,052,167 - 39,052,362RGD
Cytogenetic Map20q13.1UniSTS
HuRef2039,080,090 - 39,080,285UniSTS
GeneMap99-GB4 RH Map20238.34UniSTS
WI-7535  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372042,344,759 - 42,345,084UniSTSGRCh37
Build 362041,778,173 - 41,778,498RGDNCBI36
Celera2039,052,188 - 39,052,513RGD
Cytogenetic Map20q13.1UniSTS
HuRef2039,080,111 - 39,080,436UniSTS
Whitehead-YAC Contig Map20 UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR429hsa-miR-429OncomiRDBexternal_infoNANA22101269
MIR200Bhsa-miR-200b-3pOncomiRDBexternal_infoNANA22101269
MIR149hsa-miR-149-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI20623644
MIR200Chsa-miR-200c-3pOncomiRDBexternal_infoNANA22101269

Predicted Target Of
Summary Value
Count of predictions:659
Count of miRNA genes:376
Interacting mature miRNAs:418
Transcripts:ENST00000217026, ENST00000396863
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 6 1 1
Medium 408 230 129 103 1233 106 329 62 131 101 691 352 10 11 15 3
Low 781 1065 832 319 688 172 1898 197 311 181 374 955 149 1 754 869 3 2
Below cutoff 1173 1631 763 201 24 186 1991 1784 3116 127 365 306 15 437 1768

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000217026   ⟹   ENSP00000217026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2043,667,114 - 43,716,482 (+)Ensembl
RefSeq Acc Id: ENST00000396863   ⟹   ENSP00000380072
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2043,667,019 - 43,716,495 (+)Ensembl
RefSeq Acc Id: NM_001278610   ⟹   NP_001265539
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,667,114 - 43,716,482 (+)NCBI
GRCh372042,295,659 - 42,345,136 (+)NCBI
HuRef2039,030,966 - 39,080,488 (+)NCBI
CHM1_12042,199,374 - 42,248,808 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002466   ⟹   NP_002457
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,667,114 - 43,716,482 (+)NCBI
GRCh372042,295,659 - 42,345,136 (+)NCBI
Build 362041,729,123 - 41,778,536 (+)NCBI Archive
HuRef2039,030,966 - 39,080,488 (+)NCBI
CHM1_12042,199,374 - 42,248,808 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002457   ⟸   NM_002466
- Peptide Label: isoform 1
- UniProtKB: P10244 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265539   ⟸   NM_001278610
- Peptide Label: isoform 2
- UniProtKB: P10244 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000217026   ⟸   ENST00000217026
RefSeq Acc Id: ENSP00000380072   ⟸   ENST00000396863
Protein Domains
HTH myb-type

Promoters
RGD ID:6812060
Promoter ID:HG_ACW:49344
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:MYBL2.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 362041,719,264 - 41,719,764 (+)MPROMDB
RGD ID:6798853
Promoter ID:HG_KWN:39504
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000080408,   UC002XLA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362041,728,911 - 41,729,411 (+)MPROMDB
RGD ID:6812062
Promoter ID:HG_ACW:49346
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:MYBL2.IAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 362041,743,236 - 41,744,137 (+)MPROMDB
RGD ID:13206969
Promoter ID:EPDNEW_H27065
Type:initiation region
Name:MYBL2_2
Description:MYB proto-oncogene like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27066  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,657,556 - 43,657,616EPDNEW
RGD ID:13206971
Promoter ID:EPDNEW_H27066
Type:initiation region
Name:MYBL2_1
Description:MYB proto-oncogene like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27065  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,667,114 - 43,667,174EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001278610.1(MYBL2):c.207+282G>T single nucleotide variant Lung cancer [RCV000101600] Chr20:43683168 [GRCh38]
Chr20:42311808 [GRCh37]
Chr20:20q13.12
uncertain significance
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_002466.4(MYBL2):c.1022A>G (p.Asn341Ser) single nucleotide variant not provided [RCV000885927] Chr20:43702560 [GRCh38]
Chr20:42331200 [GRCh37]
Chr20:20q13.12
benign
NM_002466.4(MYBL2):c.117C>T (p.Asp39=) single nucleotide variant not provided [RCV000959625] Chr20:43681786 [GRCh38]
Chr20:42310426 [GRCh37]
Chr20:20q13.12
benign
NM_002466.4(MYBL2):c.691G>T (p.Val231Phe) single nucleotide variant not provided [RCV000963207] Chr20:43699784 [GRCh38]
Chr20:42328424 [GRCh37]
Chr20:20q13.12
benign
NM_002466.4(MYBL2):c.1783G>A (p.Val595Met) single nucleotide variant not provided [RCV000958069] Chr20:43713065 [GRCh38]
Chr20:42341705 [GRCh37]
Chr20:20q13.12
benign
NM_002466.4(MYBL2):c.572G>A (p.Ser191Asn) single nucleotide variant not provided [RCV000890415] Chr20:43692228 [GRCh38]
Chr20:42320868 [GRCh37]
Chr20:20q13.12
benign
Single allele deletion Focal seizures [RCV001004039] Chr20:34980430..46806549 [GRCh37]
Chr20:20q11.23-13.13
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7548 AgrOrtholog
COSMIC MYBL2 COSMIC
Ensembl Genes ENSG00000101057 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000217026 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380072 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000217026 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000396863 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000101057 GTEx
HGNC ID HGNC:7548 ENTREZGENE
Human Proteome Map MYBL2 Human Proteome Map
InterPro C-myb_C UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Myb_dom UniProtKB/Swiss-Prot
  MYBL2 UniProtKB/Swiss-Prot
  SANT/Myb UniProtKB/Swiss-Prot
KEGG Report hsa:4605 UniProtKB/Swiss-Prot
NCBI Gene 4605 ENTREZGENE
OMIM 601415 OMIM
PANTHER PTHR45614:SF30 UniProtKB/Swiss-Prot
Pfam Cmyb_C UniProtKB/Swiss-Prot
  Myb_DNA-binding UniProtKB/Swiss-Prot
PharmGKB PA31348 PharmGKB
PROSITE HTH_MYB UniProtKB/Swiss-Prot
SMART SANT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt MYBB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RBS5 UniProtKB/Swiss-Prot
  B7Z8D9 UniProtKB/Swiss-Prot
  F8W6N6 UniProtKB/Swiss-Prot
  Q53F07 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 MYBL2  MYB proto-oncogene like 2    v-myb avian myeloblastosis viral oncogene homolog-like 2  Symbol and/or name change 5135510 APPROVED
2013-07-16 MYBL2  v-myb avian myeloblastosis viral oncogene homolog-like 2    v-myb myeloblastosis viral oncogene homolog (avian)-like 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 MYBL2  v-myb myeloblastosis viral oncogene homolog (avian)-like 2  MYBL2  v-myb myeloblastosis viral oncogene homolog (avian)-like 2  Symbol and/or name change 5135510 APPROVED