WNT5A (Wnt family member 5A) - Rat Genome Database
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Gene: WNT5A (Wnt family member 5A) Homo sapiens
Analyze
Symbol: WNT5A
Name: Wnt family member 5A
RGD ID: 1353257
HGNC Page HGNC
Description: Exhibits frizzled binding activity and receptor tyrosine kinase-like orphan receptor binding activity. Involved in several processes, including animal organ development; positive regulation of macromolecule metabolic process; and positive regulation of response to external stimulus. Localizes to extracellular space and glutamatergic synapse. Colocalizes with collagen-containing extracellular matrix. Implicated in autosomal dominant Robinow syndrome 1. Biomarker of endometrial carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hWNT5A; protein Wnt-5a; wingless-type MMTV integration site family member 5A; wingless-type MMTV integration site family, member 5A; WNT-5A protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl355,465,715 - 55,490,539 (-)EnsemblGRCh38hg38GRCh38
GRCh38355,465,715 - 55,505,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37355,499,743 - 55,521,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36355,474,783 - 55,496,371 (-)NCBINCBI36hg18NCBI36
Build 34355,474,783 - 55,496,371NCBI
Celera355,465,957 - 55,488,272 (-)NCBI
Cytogenetic Map3p14.3NCBI
HuRef355,548,623 - 55,570,480 (-)NCBIHuRef
CHM1_1355,451,089 - 55,473,010 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (EXP)
calciol  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
casticin  (EXP)
CHIR 99021  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (EXP)
cyfluthrin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
glyphosate  (EXP,ISO)
homocysteine  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
isotretinoin  (EXP)
lipopolysaccharide  (EXP)
maneb  (ISO)
medroxyprogesterone acetate  (EXP)
mercury dibromide  (EXP)
methotrexate  (EXP)
methylmercury chloride  (EXP)
mifepristone  (EXP)
mitomycin C  (EXP)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
nitrofen  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
ozone  (EXP)
panobinostat  (EXP)
paraquat  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
phenytoin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (EXP)
progesterone  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
sunitinib  (EXP)
tamoxifen  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
tributylstannane  (EXP)
trichostatin A  (EXP)
troglitazone  (EXP)
tunicamycin  (EXP,ISO)
valproic acid  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IEA)
activation of JUN kinase activity  (IDA,IMP)
activation of MAPK activity  (IDA)
activation of protein kinase B activity  (IDA)
ameboidal-type cell migration  (ISO)
anterior/posterior axis specification, embryo  (IEA)
anterior/posterior pattern specification  (ISO)
atrial septum development  (IEA)
axis elongation  (ISO)
axon guidance  (ISS)
axonogenesis  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cartilage development  (IEA)
cell differentiation  (ISO)
cell fate commitment  (IBA)
cell migration  (ISO)
cellular protein localization  (IDA,ISO)
cellular response to calcium ion  (IEP)
cellular response to interferon-gamma  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to molecule of bacterial origin  (ISO)
cellular response to retinoic acid  (ISS)
cellular response to transforming growth factor beta stimulus  (IEP)
cervix development  (IEA,ISO)
chemoattraction of serotonergic neuron axon  (IEA)
chemorepulsion of dopaminergic neuron axon  (IEA)
cochlea morphogenesis  (IEA,ISO)
convergent extension  (ISO)
convergent extension involved in axis elongation  (IEA,ISO)
convergent extension involved in organogenesis  (IEA,ISO)
determination of left/right symmetry  (ISO)
development of primary male sexual characteristics  (ISO)
digestive tract morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (ISO)
embryonic skeletal system development  (IMP)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
epithelial to mesenchymal transition  (IEP)
establishment of epithelial cell apical/basal polarity  (IEA,ISO)
establishment of planar polarity  (IEA,ISO)
estrous cycle  (ISO)
excitatory synapse assembly  (TAS)
face development  (IMP)
genitalia development  (IMP)
heart looping  (IEA,ISO)
hematopoietic stem cell proliferation  (IDA,ISO)
hindgut morphogenesis  (IEA,ISO)
hypophysis morphogenesis  (IEA,ISO)
inhibitory synapse assembly  (TAS)
inner ear morphogenesis  (ISO)
JNK cascade  (ISO)
keratinocyte differentiation  (IEP)
kidney development  (IEA,ISO)
lateral sprouting involved in mammary gland duct morphogenesis  (IEA,ISO)
lens development in camera-type eye  (ISS)
limb morphogenesis  (ISO)
lung alveolus development  (ISO)
lung development  (IEA,ISO)
male gonad development  (IEP,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
melanocyte proliferation  (IEA)
membrane organization  (TAS)
mesenchymal-epithelial cell signaling  (IEA,ISO)
mesodermal to mesenchymal transition involved in gastrulation  (IEA,ISO)
midbrain development  (ISO)
midbrain dopaminergic neuron differentiation  (ISO)
midgut development  (IEA,ISO)
morphogenesis of an epithelium  (ISO)
multicellular organism development  (IEA)
negative chemotaxis  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of axon extension involved in axon guidance  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IGI,ISO)
negative regulation of cell proliferation in midbrain  (NAS)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of fat cell differentiation  (IMP)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of melanin biosynthetic process  (IEA)
negative regulation of mesenchymal cell proliferation  (IDA)
negative regulation of prostatic bud formation  (IEA,ISO)
negative regulation of synapse assembly  (IEA)
negative regulation of transcription, DNA-templated  (IDA)
neural tube closure  (ISO)
neural tube development  (ISO)
neurogenesis  (ISO)
neuron differentiation  (IBA,ISO,ISS)
neuron projection morphogenesis  (ISO)
non-canonical Wnt signaling pathway  (ISO,TAS)
non-canonical Wnt signaling pathway via JNK cascade  (IEA)
notochord morphogenesis  (IEA,ISO)
olfactory bulb interneuron development  (ISS)
optic cup formation involved in camera-type eye development  (ISS)
paraxial mesoderm formation  (IEA,ISO)
pericardium morphogenesis  (ISO)
planar cell polarity pathway involved in axis elongation  (IEA,ISO)
planar cell polarity pathway involved in axon guidance  (IEA)
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in cardiac right atrium morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in gastrula mediolateral intercalation  (IEA,ISO)
planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation  (TAS)
planar cell polarity pathway involved in neural tube closure  (IEA,ISO)
planar cell polarity pathway involved in outflow tract morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in pericardium morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in ventricular septum morphogenesis  (IEA,ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell killing  (TAS)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (IEA,ISO)
positive regulation of chemokine production  (IMP)
positive regulation of cytokine production  (ISO)
positive regulation of cytokine production involved in immune response  (IMP)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of endothelial cell migration  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (ISS)
positive regulation of GTPase activity  (ISO)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of inflammatory response  (IMP)
positive regulation of interferon-gamma production  (IEA)
positive regulation of interleukin-1 beta production  (IMP,ISS)
positive regulation of interleukin-6 production  (IMP)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of JUN kinase activity  (ISO)
positive regulation of macrophage activation  (IMP)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of meiotic nuclear division  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of neuron death  (ISS)
positive regulation of neuron projection arborization  (ISS)
positive regulation of neuron projection development  (ISS)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of non-canonical Wnt signaling pathway  (IEA)
positive regulation of ossification  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of protein binding  (IEA)
positive regulation of protein catabolic process  (IGI)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase C activity  (IMP)
positive regulation of protein kinase C signaling  (IMP)
positive regulation of protein localization to synapse  (TAS)
positive regulation of protein phosphorylation  (ISO)
positive regulation of response to cytokine stimulus  (IDA)
positive regulation of T cell chemotaxis  (IMP)
positive regulation of thymocyte apoptotic process  (IEA,ISO)
positive regulation of timing of anagen  (IEA)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of transcription, DNA-templated  (IMP)
positive regulation of tumor necrosis factor production  (ISS)
positive regulation of type I interferon-mediated signaling pathway  (IDA)
post-anal tail morphogenesis  (IEA,ISO)
postsynapse assembly  (TAS)
presynapse assembly  (TAS)
primary heart field specification  (IEA)
primitive streak formation  (IEA,ISO)
prostate gland development  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of branching involved in mammary gland duct morphogenesis  (IEA,ISO)
regulation of cellular protein localization  (IEA)
regulation of I-kappaB kinase/NF-kappaB signaling  (ISS)
regulation of inflammatory response  (NAS)
regulation of postsynapse organization  (IDA,IMP)
regulation of postsynaptic cytosolic calcium ion concentration  (IDA,IMP)
regulation of protein localization  (ISO)
regulation of synapse organization  (IDA,IMP)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hyperoxia  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (IEP,ISO)
response to testosterone  (ISO)
secondary heart field specification  (IEA)
secondary palate development  (IMP)
somite development  (ISO)
somitogenesis  (IEA,ISO)
tube closure  (ISO)
type B pancreatic cell development  (IEA,ISO)
urinary bladder development  (IEA,ISO)
uterus development  (IEA,ISO)
vagina development  (IEA,ISO)
ventricular septum development  (ISO)
Wnt signaling pathway  (IDA,IEA,ISO,TAS)
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  (NAS)
Wnt signaling pathway, calcium modulating pathway  (IMP,ISO,NAS)
Wnt signaling pathway, planar cell polarity pathway  (ISO,TAS)
wound healing  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Alopecia  (IAGP)
Anodontia  (IAGP)
Anteverted nares  (IAGP)
Autosomal dominant inheritance  (IAGP)
Avascular necrosis of the capital femoral epiphysis  (IAGP)
Bifid distal phalanx of toe  (IAGP)
Bifid tongue  (IAGP)
Blue sclerae  (IAGP)
Brachydactyly  (IAGP)
Broad thumb  (IAGP)
Broad toe  (IAGP)
Camptodactyly of finger  (IAGP)
Capillary hemangioma  (IAGP)
Clinodactyly  (IAGP)
Clinodactyly of the 5th finger  (IAGP)
Clitoral hypoplasia  (IAGP)
Coxa valga  (IAGP)
Coxa vara  (IAGP)
Cryptorchidism  (IAGP)
Curly eyelashes  (IAGP)
Delayed eruption of teeth  (IAGP)
Delayed skeletal maturation  (IAGP)
Dental crowding  (IAGP)
Depressed nasal bridge  (IAGP)
Downslanted palpebral fissures  (IAGP)
Downturned corners of mouth  (IAGP)
Duplication of the distal phalanx of hand  (IAGP)
Elbow dislocation  (IAGP)
Epicanthus  (IAGP)
Epispadias  (IAGP)
Euryblepharon  (IAGP)
Femoral hernia  (IAGP)
Finger syndactyly  (IAGP)
Fingernail dysplasia  (IAGP)
Flat face  (IAGP)
Frontal bossing  (IAGP)
Gingival overgrowth  (IAGP)
Global developmental delay  (IAGP)
Hearing impairment  (IAGP)
Hemivertebrae  (IAGP)
High palate  (IAGP)
High, narrow palate  (IAGP)
Hip dislocation  (IAGP)
Hip dysplasia  (IAGP)
Hydronephrosis  (IAGP)
Hypertelorism  (IAGP)
Hypodontia  (IAGP)
Hypoplasia of penis  (IAGP)
Hypoplastic labia majora  (IAGP)
Hypoplastic labia minora  (IAGP)
Hypospadias  (IAGP)
Increased number of teeth  (IAGP)
Inguinal hernia  (IAGP)
Intellectual disability  (IAGP)
Long eyelashes  (IAGP)
Long palpebral fissure  (IAGP)
Long philtrum  (IAGP)
Low-set ears  (IAGP)
Macrocephaly  (IAGP)
Macroglossia  (IAGP)
Malar flattening  (IAGP)
Median cleft lip and palate  (IAGP)
Mesomelia  (IAGP)
Micrognathia  (IAGP)
Micromelia  (IAGP)
Micropenis  (IAGP)
Midface retrusion  (IAGP)
Naevus flammeus of the eyelid  (IAGP)
Nail dysplasia  (IAGP)
Narrow palate  (IAGP)
Nevus flammeus  (IAGP)
Oligodontia  (IAGP)
Onychogryposis of fingernail  (IAGP)
Open bite  (IAGP)
Oral cleft  (IAGP)
Pectus carinatum  (IAGP)
Pectus excavatum  (IAGP)
Posteriorly rotated ears  (IAGP)
Prominent forehead  (IAGP)
Proptosis  (IAGP)
Ptosis  (IAGP)
Radial deviation of finger  (IAGP)
Renal duplication  (IAGP)
Retrognathia  (IAGP)
Rhizomelia  (IAGP)
Ridged fingernail  (IAGP)
Right ventricular outlet tract obstruction  (IAGP)
Sacral dimple  (IAGP)
Scoliosis  (IAGP)
Severe short stature  (IAGP)
Short hard palate  (IAGP)
Short middle phalanx of the 5th finger  (IAGP)
Short neck  (IAGP)
Short nose  (IAGP)
Short palm  (IAGP)
Short philtrum  (IAGP)
Small hand  (IAGP)
Specific learning disability  (IAGP)
Strabismus  (IAGP)
Thin upper lip vermilion  (IAGP)
Triangular mouth  (IAGP)
Umbilical hernia  (IAGP)
Upslanted palpebral fissure  (IAGP)
Wide anterior fontanel  (IAGP)
Wide nasal bridge  (IAGP)
Wide nose  (IAGP)
References

Additional References at PubMed
PMID:8167409   PMID:8288227   PMID:8537388   PMID:8889548   PMID:9054360   PMID:9787155   PMID:10491302   PMID:10557084   PMID:11956659   PMID:12086864   PMID:12165812   PMID:12244165  
PMID:12477932   PMID:12482967   PMID:12805222   PMID:12839624   PMID:12841867   PMID:12952940   PMID:14702039   PMID:15040835   PMID:15067324   PMID:15389636   PMID:15588944   PMID:15592517  
PMID:15735754   PMID:16169547   PMID:16258938   PMID:16344560   PMID:16569699   PMID:16601243   PMID:16880514   PMID:16914445   PMID:16996564   PMID:17035633   PMID:17227781   PMID:17426020  
PMID:17458904   PMID:17463182   PMID:17486081   PMID:17525119   PMID:17546602   PMID:17709179   PMID:17848411   PMID:17937436   PMID:17952396   PMID:17956663   PMID:17967789   PMID:17976063  
PMID:17986384   PMID:17992121   PMID:18032022   PMID:18172252   PMID:18174174   PMID:18174455   PMID:18287027   PMID:18413325   PMID:18420933   PMID:18456733   PMID:18462958   PMID:18477650  
PMID:18541964   PMID:18615587   PMID:18632632   PMID:18656562   PMID:18703641   PMID:18794093   PMID:18986540   PMID:18990694   PMID:19048125   PMID:19061910   PMID:19063862   PMID:19074888  
PMID:19099253   PMID:19148501   PMID:19171330   PMID:19177143   PMID:19244247   PMID:19251946   PMID:19277043   PMID:19399181   PMID:19453261   PMID:19467340   PMID:19473452   PMID:19492056  
PMID:19520808   PMID:19561643   PMID:19582886   PMID:19651774   PMID:19696445   PMID:19760930   PMID:19802008   PMID:19847889   PMID:19849855   PMID:19874313   PMID:19878652   PMID:19910923  
PMID:19918918   PMID:19940551   PMID:19956879   PMID:20008136   PMID:20032469   PMID:20034610   PMID:20083703   PMID:20101234   PMID:20376066   PMID:20379614   PMID:20429785   PMID:20454608  
PMID:20518933   PMID:20525402   PMID:20554957   PMID:20603606   PMID:20628624   PMID:20634891   PMID:20639201   PMID:20890934   PMID:20955350   PMID:21069266   PMID:21115903   PMID:21165581  
PMID:21205070   PMID:21209903   PMID:21270611   PMID:21285942   PMID:21342370   PMID:21344486   PMID:21352264   PMID:21365928   PMID:21431850   PMID:21461571   PMID:21587258   PMID:21672426  
PMID:21816908   PMID:21857966   PMID:21871017   PMID:21873635   PMID:21918189   PMID:21980498   PMID:22039506   PMID:22101459   PMID:22124122   PMID:22128168   PMID:22162112   PMID:22293903  
PMID:22384081   PMID:22384249   PMID:22485170   PMID:22493546   PMID:22547701   PMID:22609948   PMID:22655072   PMID:22694338   PMID:22781592   PMID:22825874   PMID:22988876   PMID:23001722  
PMID:23046419   PMID:23054609   PMID:23075330   PMID:23159080   PMID:23178630   PMID:23250740   PMID:23254341   PMID:23265959   PMID:23266365   PMID:23271023   PMID:23278988   PMID:23342259  
PMID:23349696   PMID:23353182   PMID:23359789   PMID:23396967   PMID:23417837   PMID:23462101   PMID:23469623   PMID:23484019   PMID:23539626   PMID:23615002   PMID:23653377   PMID:23660959  
PMID:23679576   PMID:23716599   PMID:23748645   PMID:23764752   PMID:23947922   PMID:23963164   PMID:24091015   PMID:24139281   PMID:24156409   PMID:24185202   PMID:24260410   PMID:24293407  
PMID:24335906   PMID:24346141   PMID:24346691   PMID:24395444   PMID:24399733   PMID:24416340   PMID:24431302   PMID:24449494   PMID:24464650   PMID:24518599   PMID:24603290   PMID:24606488  
PMID:24621529   PMID:24626628   PMID:24647585   PMID:24658506   PMID:24696716   PMID:24706725   PMID:24716670   PMID:24750404   PMID:24766647   PMID:24796738   PMID:24833087   PMID:24840810  
PMID:24865425   PMID:24891513   PMID:24898696   PMID:24972966   PMID:24993819   PMID:24999479   PMID:25022753   PMID:25031739   PMID:25107489   PMID:25196330   PMID:25204426   PMID:25224731  
PMID:25240054   PMID:25240110   PMID:25241761   PMID:25303486   PMID:25308364   PMID:25337253   PMID:25382802   PMID:25401518   PMID:25407936   PMID:25410163   PMID:25413872   PMID:25424568  
PMID:25450290   PMID:25454492   PMID:25577943   PMID:25619716   PMID:25622531   PMID:25655430   PMID:25769722   PMID:25772239   PMID:25779663   PMID:25823923   PMID:25913759   PMID:25944911  
PMID:26054690   PMID:26118187   PMID:26186194   PMID:26202350   PMID:26240275   PMID:26278011   PMID:26281688   PMID:26305508   PMID:26316480   PMID:26342861   PMID:26462870   PMID:26511503  
PMID:26514730   PMID:26538547   PMID:26558991   PMID:26596412   PMID:26648282   PMID:26690702   PMID:26708300   PMID:26708384   PMID:26721633   PMID:26794322   PMID:26800561   PMID:26848991  
PMID:26934938   PMID:26939869   PMID:26978652   PMID:26997628   PMID:27090862   PMID:27156072   PMID:27159116   PMID:27184424   PMID:27191257   PMID:27214384   PMID:27297409   PMID:27311852  
PMID:27378423   PMID:27402827   PMID:27468699   PMID:27499692   PMID:27500936   PMID:27522468   PMID:27540134   PMID:27556044   PMID:27565656   PMID:27623766   PMID:27639333   PMID:27641635  
PMID:27688298   PMID:27863244   PMID:27876017   PMID:27895148   PMID:27932350   PMID:27979969   PMID:28011620   PMID:28051879   PMID:28057611   PMID:28100769   PMID:28131747   PMID:28205531  
PMID:28232477   PMID:28240050   PMID:28272483   PMID:28327460   PMID:28357477   PMID:28411232   PMID:28427201   PMID:28440495   PMID:28465528   PMID:28465529   PMID:28465645   PMID:28514442  
PMID:28536612   PMID:28546512   PMID:28559016   PMID:28600110   PMID:28615692   PMID:28627675   PMID:28627699   PMID:28641961   PMID:28662348   PMID:28681925   PMID:28748258   PMID:28756229  
PMID:28777797   PMID:28859077   PMID:28887323   PMID:29054966   PMID:29160937   PMID:29207169   PMID:29286164   PMID:29381686   PMID:29415994   PMID:29531296   PMID:29575631   PMID:29648538  
PMID:29674475   PMID:29678828   PMID:29709351   PMID:29869456   PMID:30085132   PMID:30117016   PMID:30137542   PMID:30172652   PMID:30177057   PMID:30257711   PMID:30322948   PMID:30406314  
PMID:30476907   PMID:30568170   PMID:30586764   PMID:30593464   PMID:30784283   PMID:30924074   PMID:30940800   PMID:31032853   PMID:31098409   PMID:31171711   PMID:31198984   PMID:31210281  
PMID:31218332   PMID:31268162   PMID:31436250   PMID:31510045   PMID:31534019   PMID:31593304   PMID:31645416   PMID:31700026   PMID:31894282   PMID:31929186   PMID:31932454   PMID:32023086  
PMID:32143829   PMID:32317758  


Genomics

Comparative Map Data
WNT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl355,465,715 - 55,490,539 (-)EnsemblGRCh38hg38GRCh38
GRCh38355,465,715 - 55,505,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37355,499,743 - 55,521,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36355,474,783 - 55,496,371 (-)NCBINCBI36hg18NCBI36
Build 34355,474,783 - 55,496,371NCBI
Celera355,465,957 - 55,488,272 (-)NCBI
Cytogenetic Map3p14.3NCBI
HuRef355,548,623 - 55,570,480 (-)NCBIHuRef
CHM1_1355,451,089 - 55,473,010 (-)NCBICHM1_1
Wnt5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391428,224,962 - 28,249,405 (+)NCBIGRCm39mm39
GRCm39 Ensembl1428,226,707 - 28,249,405 (+)Ensembl
GRCm381428,504,543 - 28,527,448 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1428,504,750 - 28,527,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv371429,318,659 - 29,338,620 (+)NCBIGRCm37mm9NCBIm37
MGSCv361427,332,339 - 27,352,300 (+)NCBImm8
Celera1424,754,276 - 24,774,180 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.8NCBI
Wnt5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2163,695,667 - 3,718,234 (+)NCBI
Rnor_6.0 Ensembl164,469,468 - 4,489,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0164,469,451 - 4,490,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0164,414,512 - 4,433,990 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,782,025 - 3,799,625 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1163,782,022 - 3,799,623 (+)NCBI
Celera163,644,605 - 3,665,720 (+)NCBICelera
Cytogenetic Map16p16NCBI
Wnt5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554305,304,745 - 5,325,684 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554305,304,817 - 5,325,684 (-)NCBIChiLan1.0ChiLan1.0
WNT5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1356,617,006 - 56,639,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl356,621,380 - 56,638,051 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0355,396,279 - 55,418,579 (-)NCBIMhudiblu_PPA_v0panPan3
WNT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12034,756,430 - 34,790,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2034,769,930 - 34,786,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2034,700,143 - 34,711,111 (+)NCBI
ROS_Cfam_1.02035,028,713 - 35,063,140 (+)NCBI
UMICH_Zoey_3.12034,490,948 - 34,501,920 (+)NCBI
UNSW_CanFamBas_1.02034,851,115 - 34,862,094 (+)NCBI
UU_Cfam_GSD_1.02035,066,932 - 35,077,922 (+)NCBI
Wnt5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118172,893,045 - 172,913,645 (-)NCBI
SpeTri2.0NW_0049364736,031,627 - 6,052,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1337,344,699 - 37,367,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11337,344,684 - 37,367,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21340,872,351 - 40,892,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT5A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12216,809,454 - 16,836,815 (-)NCBI
ChlSab1.1 Ensembl2216,809,451 - 16,825,048 (-)Ensembl
Wnt5a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248221,824,378 - 1,843,599 (+)NCBI

Position Markers
G35315  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37355,499,844 - 55,500,067UniSTSGRCh37
Build 36355,474,884 - 55,475,107RGDNCBI36
Celera355,466,058 - 55,466,281RGD
Cytogenetic Map3p21-p14UniSTS
HuRef355,548,724 - 55,548,947UniSTS
G15856  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37355,503,868 - 55,504,007UniSTSGRCh37
Build 36355,478,908 - 55,479,047RGDNCBI36
Celera355,470,084 - 55,470,223RGD
Cytogenetic Map3p21-p14UniSTS
HuRef355,552,748 - 55,552,887UniSTS
RH80790  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37355,503,901 - 55,504,132UniSTSGRCh37
Build 36355,478,941 - 55,479,172RGDNCBI36
Celera355,470,117 - 55,470,348RGD
Cytogenetic Map3p21-p14UniSTS
HuRef355,552,781 - 55,553,012UniSTS
GeneMap99-GB4 RH Map3189.12UniSTS
RH102004  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37355,499,803 - 55,499,886UniSTSGRCh37
Build 36355,474,843 - 55,474,926RGDNCBI36
Celera355,466,017 - 55,466,100RGD
Cytogenetic Map3p21-p14UniSTS
HuRef355,548,683 - 55,548,766UniSTS
GeneMap99-GB4 RH Map3184.53UniSTS
SHGC-77018  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37355,502,719 - 55,502,877UniSTSGRCh37
Build 36355,477,759 - 55,477,917RGDNCBI36
Celera355,468,935 - 55,469,093RGD
Cytogenetic Map3p21-p14UniSTS
HuRef355,551,599 - 55,551,757UniSTS
TNG Radiation Hybrid Map334442.0UniSTS
GeneMap99-GB4 RH Map3188.39UniSTS
NCBI RH Map3516.6UniSTS
RH78427  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p21-p14UniSTS
HuRef355,550,737 - 55,550,879UniSTS
GeneMap99-GB4 RH Map3189.96UniSTS
Wnt5a  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37355,513,482 - 55,514,935UniSTSGRCh37
Celera355,480,423 - 55,481,876UniSTS
HuRef355,562,307 - 55,563,760UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4519
Count of miRNA genes:1191
Interacting mature miRNAs:1472
Transcripts:ENST00000264634, ENST00000474267, ENST00000482079, ENST00000493406, ENST00000497027, ENST00000497817
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 110 16 109 65 50 27 62 91 97 96 550 262 42 21 6 1
Low 2232 1195 1499 484 705 362 3118 1542 3136 259 881 1293 126 917 1888 1 1
Below cutoff 26 1570 108 68 824 68 1162 558 474 61 16 42 2 1 266 891 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_031992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI634753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU118341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF218039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM728706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU742635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ970116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB224740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF028086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN095169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN368162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264634   ⟹   ENSP00000264634
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,465,716 - 55,487,642 (-)Ensembl
RefSeq Acc Id: ENST00000474267   ⟹   ENSP00000417310
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,465,715 - 55,489,945 (-)Ensembl
RefSeq Acc Id: ENST00000482079   ⟹   ENSP00000418184
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,474,334 - 55,481,196 (-)Ensembl
RefSeq Acc Id: ENST00000493406
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,469,388 - 55,470,141 (-)Ensembl
RefSeq Acc Id: ENST00000497027   ⟹   ENSP00000420104
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,469,993 - 55,481,393 (-)Ensembl
RefSeq Acc Id: ENST00000497817
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,479,040 - 55,480,920 (-)Ensembl
RefSeq Acc Id: ENST00000624674
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl355,489,155 - 55,490,539 (-)Ensembl
RefSeq Acc Id: NM_001256105   ⟹   NP_001243034
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,481,398 (-)NCBI
GRCh37355,499,743 - 55,521,670 (-)NCBI
HuRef355,548,623 - 55,570,480 (-)NCBI
CHM1_1355,451,089 - 55,466,770 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001377271   ⟹   NP_001364200
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,485,285 (-)NCBI
RefSeq Acc Id: NM_001377272   ⟹   NP_001364201
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,485,142 (-)NCBI
RefSeq Acc Id: NM_003392   ⟹   NP_003383
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,487,306 (-)NCBI
GRCh37355,499,743 - 55,521,670 (-)NCBI
Build 36355,474,783 - 55,496,371 (-)NCBI Archive
HuRef355,548,623 - 55,570,480 (-)NCBI
CHM1_1355,451,089 - 55,473,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534085   ⟹   XP_011532387
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,499,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534086   ⟹   XP_011532388
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,499,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534088   ⟹   XP_011532390
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,484,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534089   ⟹   XP_011532391
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,481,324 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017007127   ⟹   XP_016862616
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,505,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017007128   ⟹   XP_016862617
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,465,715 - 55,499,222 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003383   ⟸   NM_003392
- Peptide Label: isoform 1 precursor
- Sequence:
RefSeq Acc Id: NP_001243034   ⟸   NM_001256105
- Peptide Label: isoform 2 precursor
- UniProtKB: P41221 (UniProtKB/Swiss-Prot),   A0A024R316 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532388   ⟸   XM_011534086
- Peptide Label: isoform X2
- UniProtKB: P41221 (UniProtKB/Swiss-Prot),   A0A024R316 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532387   ⟸   XM_011534085
- Peptide Label: isoform X2
- UniProtKB: P41221 (UniProtKB/Swiss-Prot),   A0A024R316 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532390   ⟸   XM_011534088
- Peptide Label: isoform X2
- UniProtKB: P41221 (UniProtKB/Swiss-Prot),   A0A024R316 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532391   ⟸   XM_011534089
- Peptide Label: isoform X2
- UniProtKB: P41221 (UniProtKB/Swiss-Prot),   A0A024R316 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016862616   ⟸   XM_017007127
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016862617   ⟸   XM_017007128
- Peptide Label: isoform X2
- UniProtKB: P41221 (UniProtKB/Swiss-Prot),   A0A024R316 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001364200   ⟸   NM_001377271
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: NP_001364201   ⟸   NM_001377272
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: ENSP00000418184   ⟸   ENST00000482079
RefSeq Acc Id: ENSP00000420104   ⟸   ENST00000497027
RefSeq Acc Id: ENSP00000417310   ⟸   ENST00000474267
RefSeq Acc Id: ENSP00000264634   ⟸   ENST00000264634

Promoters
RGD ID:6864758
Promoter ID:EPDNEW_H5544
Type:initiation region
Name:WNT5A_2
Description:Wnt family member 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5545  EPDNEW_H5546  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,487,303 - 55,487,363EPDNEW
RGD ID:6864760
Promoter ID:EPDNEW_H5545
Type:initiation region
Name:WNT5A_3
Description:Wnt family member 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5544  EPDNEW_H5546  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,487,594 - 55,487,654EPDNEW
RGD ID:6801950
Promoter ID:HG_KWN:45311
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:UC003DHM.1,   UC010HMW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36355,490,061 - 55,490,561 (-)MPROMDB
RGD ID:6812303
Promoter ID:HG_ACW:54121
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:GLEEMOYBO.AAPR07-UNSPLICED,   WNT5A.DAPR07,   WNT5A.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36355,494,319 - 55,494,819 (+)MPROMDB
RGD ID:6801952
Promoter ID:HG_KWN:45312
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:NM_003392,   UC010HMX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36355,496,236 - 55,497,187 (-)MPROMDB
RGD ID:6864762
Promoter ID:EPDNEW_H5546
Type:single initiation site
Name:WNT5A_1
Description:Wnt family member 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5544  EPDNEW_H5545  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38355,505,261 - 55,505,321EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_003392.4(WNT5A):c.544T>C (p.Cys182Arg) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000022695] Chr3:55474477 [GRCh38]
Chr3:55508505 [GRCh37]
Chr3:3p14.3		 pathogenic
NM_003392.4(WNT5A):c.248G>C (p.Cys83Ser) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000022696] Chr3:55479457 [GRCh38]
Chr3:55513485 [GRCh37]
Chr3:3p14.3		 pathogenic
NM_003392.4(WNT5A):c.427G>A (p.Ala143Thr) single nucleotide variant not provided [RCV000729122] Chr3:55474594 [GRCh38]
Chr3:55508622 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.487_492dup (p.Gly163_Cys164dup) duplication Robinow syndrome, autosomal dominant 1 [RCV000577908] Chr3:55474528..55474529 [GRCh38]
Chr3:55508556..55508557 [GRCh37]
Chr3:3p14.3		 likely pathogenic
GRCh38/hg38 3p21.1-14.1(chr3:54045018-66060461)x1 copy number loss See cases [RCV000051081] Chr3:54045018..66060461 [GRCh38]
Chr3:54079045..66046136 [GRCh37]
Chr3:54054085..66021176 [NCBI36]
Chr3:3p21.1-14.1		 pathogenic
GRCh38/hg38 3p21.1-14.3(chr3:53287477-57025368)x1 copy number loss See cases [RCV000053929] Chr3:53287477..57025368 [GRCh38]
Chr3:53321495..57059396 [GRCh37]
Chr3:53296535..57034436 [NCBI36]
Chr3:3p21.1-14.3		 uncertain significance
NM_003392.4(WNT5A):c.588C>T (p.Phe196=) single nucleotide variant not provided [RCV000951253]|not specified [RCV000178191] Chr3:55474433 [GRCh38]
Chr3:55508461 [GRCh37]
Chr3:3p14.3		 benign|likely benign
NM_003392.4(WNT5A):c.140+14A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000147982] Chr3:55480771 [GRCh38]
Chr3:55514799 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.141-8C>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000147983]|not provided [RCV000924585] Chr3:55479572 [GRCh38]
Chr3:55513600 [GRCh37]
Chr3:3p14.3		 likely benign|uncertain significance
NM_003392.4(WNT5A):c.141-9C>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000147984]|not provided [RCV000897286] Chr3:55479573 [GRCh38]
Chr3:55513601 [GRCh37]
Chr3:3p14.3		 likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_003392.4(WNT5A):c.141-9C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000147985] Chr3:55479573 [GRCh38]
Chr3:55513601 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.391+11A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000147986] Chr3:55479303 [GRCh38]
Chr3:55513331 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.405G>T (p.Thr135=) single nucleotide variant not specified [RCV000147987] Chr3:55474616 [GRCh38]
Chr3:55508644 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.487G>C (p.Gly163Arg) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000147988] Chr3:55474534 [GRCh38]
Chr3:55508562 [GRCh37]
Chr3:3p14.3		 likely pathogenic|uncertain significance
NM_003392.4(WNT5A):c.257A>G (p.Tyr86Cys) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000169740] Chr3:55479448 [GRCh38]
Chr3:55513476 [GRCh37]
Chr3:3p14.3		 pathogenic|not provided
NM_003392.4(WNT5A):c.206G>A (p.Cys69Tyr) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000169741] Chr3:55479499 [GRCh38]
Chr3:55513527 [GRCh37]
Chr3:3p14.3		 pathogenic|uncertain significance|not provided
NM_003392.4(WNT5A):c.-393C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000264674] Chr3:55487378 [GRCh38]
Chr3:55521406 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*810del deletion Robinow syndrome, autosomal dominant 1 [RCV000263502] Chr3:55469282 [GRCh38]
Chr3:55503310 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.545G>C (p.Cys182Ser) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000192022] Chr3:55474476 [GRCh38]
Chr3:55508504 [GRCh37]
Chr3:3p14.3		 pathogenic
NM_003392.4(WNT5A):c.141-8C>T single nucleotide variant not provided [RCV000317209] Chr3:55479572 [GRCh38]
Chr3:55513600 [GRCh37]
Chr3:3p14.3		 likely benign|uncertain significance
GRCh37/hg19 3p21.2-14.2(chr3:52086599-59689209)x1 copy number loss See cases [RCV000239886] Chr3:52086599..59689209 [GRCh37]
Chr3:3p21.2-14.2		 pathogenic
NM_003392.4(WNT5A):c.-329C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000268067] Chr3:55487314 [GRCh38]
Chr3:55521342 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*2655G>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000285963] Chr3:55467437 [GRCh38]
Chr3:55501465 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*2728del deletion Robinow syndrome, autosomal dominant 1 [RCV000282387] Chr3:55467364 [GRCh38]
Chr3:55501392 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*3473T>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000268534] Chr3:55466619 [GRCh38]
Chr3:55500647 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1655G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000284419] Chr3:55468437 [GRCh38]
Chr3:55502465 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*2945A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000275582] Chr3:55467147 [GRCh38]
Chr3:55501175 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*1952_*1953del deletion Robinow syndrome, autosomal dominant 1 [RCV000277253] Chr3:55468139..55468140 [GRCh38]
Chr3:55502167..55502168 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*564C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000267296] Chr3:55469528 [GRCh38]
Chr3:55503556 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1103C>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000298819] Chr3:55468989 [GRCh38]
Chr3:55503017 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1277G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000314069] Chr3:55468815 [GRCh38]
Chr3:55502843 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*3721C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000299951] Chr3:55466371 [GRCh38]
Chr3:55500399 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1657T>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000376073] Chr3:55468435 [GRCh38]
Chr3:55502463 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*3661C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000398532] Chr3:55466431 [GRCh38]
Chr3:55500459 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1177T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000399225] Chr3:55468915 [GRCh38]
Chr3:55502943 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.-592G>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000316025] Chr3:55487577 [GRCh38]
Chr3:55521605 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*3864T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000334930] Chr3:55466228 [GRCh38]
Chr3:55500256 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1869C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000354502] Chr3:55468223 [GRCh38]
Chr3:55502251 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*2010C>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000399300] Chr3:55468082 [GRCh38]
Chr3:55502110 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*978G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000355932] Chr3:55469114 [GRCh38]
Chr3:55503142 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.983C>T (p.Thr328Met) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000289666] Chr3:55470252 [GRCh38]
Chr3:55504280 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*3647T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000303615] Chr3:55466445 [GRCh38]
Chr3:55500473 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1684T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000319620] Chr3:55468408 [GRCh38]
Chr3:55502436 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*3712A>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000338759] Chr3:55466380 [GRCh38]
Chr3:55500408 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*579A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000359632] Chr3:55469513 [GRCh38]
Chr3:55503541 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*38C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000381735] Chr3:55470054 [GRCh38]
Chr3:55504082 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*2711_*2713del deletion Robinow syndrome, autosomal dominant 1 [RCV000339679] Chr3:55467379..55467381 [GRCh38]
Chr3:55501407..55501409 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*3577G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000360699] Chr3:55466515 [GRCh38]
Chr3:55500543 [GRCh37]
Chr3:3p14.3		 likely benign
NM_001256105.1(WNT5A):c.*1428_*1429TA[6] microsatellite Robinow syndrome, autosomal dominant 1 [RCV000291354] Chr3:55468651..55468652 [GRCh38]
Chr3:55502679..55502680 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*598A>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000321198] Chr3:55469494 [GRCh38]
Chr3:55503522 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*3118C>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000385334] Chr3:55466974 [GRCh38]
Chr3:55501002 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*1561G>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000323048] Chr3:55468531 [GRCh38]
Chr3:55502559 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.-292G>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000362902] Chr3:55487277 [GRCh38]
Chr3:55521305 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*3420T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000307258] Chr3:55466672 [GRCh38]
Chr3:55500700 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*245A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000324765] Chr3:55469847 [GRCh38]
Chr3:55503875 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*3195del deletion Robinow syndrome, autosomal dominant 1 [RCV000364401] Chr3:55466897 [GRCh38]
Chr3:55500925 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*2011G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000365142] Chr3:55468081 [GRCh38]
Chr3:55502109 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*2053C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000308183] Chr3:55468039 [GRCh38]
Chr3:55502067 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*4075A>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000388446] Chr3:55466017 [GRCh38]
Chr3:55500045 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*4339A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000326383] Chr3:55465753 [GRCh38]
Chr3:55499781 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*2878T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000389778] Chr3:55467214 [GRCh38]
Chr3:55501242 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*3125T>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000328427] Chr3:55466967 [GRCh38]
Chr3:55500995 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.807G>A (p.Lys269=) single nucleotide variant not provided [RCV000943395] Chr3:55470428 [GRCh38]
Chr3:55504456 [GRCh37]
Chr3:3p14.3		 benign|likely benign
NM_003392.4(WNT5A):c.-61G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000348054] Chr3:55487046 [GRCh38]
Chr3:55521074 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1276T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000371070] Chr3:55468816 [GRCh38]
Chr3:55502844 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*2276dup duplication Robinow syndrome, autosomal dominant 1 [RCV000394572] Chr3:55467815..55467816 [GRCh38]
Chr3:55501843..55501844 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.*2711del deletion Robinow syndrome, autosomal dominant 1 [RCV000394544] Chr3:55467381 [GRCh38]
Chr3:55501409 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.110C>G (p.Ala37Gly) single nucleotide variant not provided [RCV000900737] Chr3:55480815 [GRCh38]
Chr3:55514843 [GRCh37]
Chr3:3p14.3		 benign|likely benign
NM_003392.4(WNT5A):c.*3745C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000395466] Chr3:55466347 [GRCh38]
Chr3:55500375 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*1357A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000396020] Chr3:55468735 [GRCh38]
Chr3:55502763 [GRCh37]
Chr3:3p14.3		 likely benign
NM_001256105.1(WNT5A):c.*1428_*1429TA[8] microsatellite Robinow syndrome, autosomal dominant 1 [RCV000396024] Chr3:55468650..55468651 [GRCh38]
Chr3:55502678..55502679 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-575G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000260654] Chr3:55487560 [GRCh38]
Chr3:55521588 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*3157G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000272157] Chr3:55466935 [GRCh38]
Chr3:55500963 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1953dup duplication Robinow syndrome, autosomal dominant 1 [RCV000312477] Chr3:55468138..55468139 [GRCh38]
Chr3:55502166..55502167 [GRCh37]
Chr3:3p14.3		 conflicting interpretations of pathogenicity
NM_003392.4(WNT5A):c.839G>A (p.Ser280Asn) single nucleotide variant not provided [RCV000381699] Chr3:55470396 [GRCh38]
Chr3:55504424 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1791G>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000262083] Chr3:55468301 [GRCh38]
Chr3:55502329 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1952_*1953dup duplication Robinow syndrome, autosomal dominant 1 [RCV000369418] Chr3:55468138..55468139 [GRCh38]
Chr3:55502166..55502167 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_001256105.1(WNT5A):c.*1452_*1457AATATA[4] microsatellite Robinow syndrome, autosomal dominant 1 [RCV000379984] Chr3:55468622..55468623 [GRCh38]
Chr3:55502650..55502651 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.*4179dup duplication Robinow syndrome, autosomal dominant 1 [RCV000384915] Chr3:55465912..55465913 [GRCh38]
Chr3:55499940..55499941 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.14T>C (p.Ile5Thr) single nucleotide variant not provided [RCV000964936]|not specified [RCV000363742] Chr3:55480911 [GRCh38]
Chr3:55514939 [GRCh37]
Chr3:3p14.3		 benign|likely benign
NM_003392.4(WNT5A):c.*2811C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000279036] Chr3:55467281 [GRCh38]
Chr3:55501309 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.819G>A (p.Ala273=) single nucleotide variant not provided [RCV000299406] Chr3:55470416 [GRCh38]
Chr3:55504444 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*4356T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000268946] Chr3:55465736 [GRCh38]
Chr3:55499764 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1446T>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000345172] Chr3:55468646 [GRCh38]
Chr3:55502674 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*4142G>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000292883] Chr3:55465950 [GRCh38]
Chr3:55499978 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-150C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000401988] Chr3:55487135 [GRCh38]
Chr3:55521163 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-383G>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000304743] Chr3:55487368 [GRCh38]
Chr3:55521396 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*2918A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000332932] Chr3:55467174 [GRCh38]
Chr3:55501202 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*1440T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000349029] Chr3:55468652 [GRCh38]
Chr3:55502680 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.685A>G (p.Thr229Ala) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000385244] Chr3:55470550 [GRCh38]
Chr3:55504578 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*4127C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000350261] Chr3:55465965 [GRCh38]
Chr3:55499993 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-503C>T single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000319832] Chr3:55487488 [GRCh38]
Chr3:55521516 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_001256105.1(WNT5A):c.*3932_*3933CT[3] microsatellite Robinow syndrome, autosomal dominant 1 [RCV000296270] Chr3:55466153..55466154 [GRCh38]
Chr3:55500181..55500182 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-150C>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000308217] Chr3:55487135 [GRCh38]
Chr3:55521163 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*2731dup duplication Robinow syndrome, autosomal dominant 1 [RCV000336309] Chr3:55467360..55467361 [GRCh38]
Chr3:55501388..55501389 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.141-14T>C single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000351528] Chr3:55479578 [GRCh38]
Chr3:55513606 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_001256105.1(WNT5A):c.*1444_*1445TA[5] microsatellite Robinow syndrome, autosomal dominant 1 [RCV000287801] Chr3:55468640..55468641 [GRCh38]
Chr3:55502668..55502669 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-574C>A single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000374099] Chr3:55487559 [GRCh38]
Chr3:55521587 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*2728_*2730del deletion Robinow syndrome, autosomal dominant 1 [RCV000374621] Chr3:55467362..55467364 [GRCh38]
Chr3:55501390..55501392 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.41T>C (p.Leu14Ser) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000311901] Chr3:55480884 [GRCh38]
Chr3:55514912 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.*2485A>G single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000342999] Chr3:55467607 [GRCh38]
Chr3:55501635 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.-393_-391del deletion Robinow syndrome, autosomal dominant 1 [RCV000359450] Chr3:55487376..55487378 [GRCh38]
Chr3:55521404..55521406 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.417C>T (p.Tyr139=) single nucleotide variant not provided [RCV000596243] Chr3:55474604 [GRCh38]
Chr3:55508632 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.496C>T (p.Arg166Cys) single nucleotide variant not provided [RCV000733923] Chr3:55474525 [GRCh38]
Chr3:55508553 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.779G>T (p.Arg260Leu) single nucleotide variant not provided [RCV000733943] Chr3:55470456 [GRCh38]
Chr3:55504484 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.1052A>T (p.Gln351Leu) single nucleotide variant not provided [RCV000434129] Chr3:55470183 [GRCh38]
Chr3:55504211 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.4(WNT5A):c.479C>G (p.Ser160Cys) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV000577882] Chr3:55474542 [GRCh38]
Chr3:55508570 [GRCh37]
Chr3:3p14.3		 likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_003392.4(WNT5A):c.104C>T (p.Ser35Phe) single nucleotide variant not provided [RCV000595735] Chr3:55480821 [GRCh38]
Chr3:55514849 [GRCh37]
Chr3:3p14.3		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_003392.4(WNT5A):c.822G>A (p.Ala274=) single nucleotide variant not provided [RCV000900517] Chr3:55470413 [GRCh38]
Chr3:55504441 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.441G>A (p.Val147=) single nucleotide variant not provided [RCV000915733] Chr3:55474580 [GRCh38]
Chr3:55508608 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.291G>A (p.Ala97=) single nucleotide variant not provided [RCV000906932] Chr3:55479414 [GRCh38]
Chr3:55513442 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.1047C>T (p.Thr349=) single nucleotide variant not provided [RCV000918861] Chr3:55470188 [GRCh38]
Chr3:55504216 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.951G>A (p.Ser317=) single nucleotide variant not provided [RCV000917231] Chr3:55470284 [GRCh38]
Chr3:55504312 [GRCh37]
Chr3:3p14.3		 likely benign
NM_003392.4(WNT5A):c.850T>C (p.Leu284=) single nucleotide variant not provided [RCV000956106] Chr3:55470385 [GRCh38]
Chr3:55504413 [GRCh37]
Chr3:3p14.3		 benign
NM_003392.4(WNT5A):c.502G>A (p.Ala168Thr) single nucleotide variant not provided [RCV000956107] Chr3:55474519 [GRCh38]
Chr3:55508547 [GRCh37]
Chr3:3p14.3		 benign
NC_000003.12:g.(?_55470092)_(55486985_?)dup duplication not provided [RCV001033474] Chr3:55504120..55521013 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.115G>C (p.Val39Leu) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV001254609] Chr3:55480810 [GRCh38]
Chr3:55514838 [GRCh37]
Chr3:3p14.3		 uncertain significance
NC_000003.11:g.(?_55504120)_(55521013_?)dup duplication not provided [RCV001319586] Chr3:55504120..55521013 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.503C>T (p.Ala168Val) single nucleotide variant not provided [RCV001316247] Chr3:55474518 [GRCh38]
Chr3:55508546 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.991G>T (p.Gly331Cys) single nucleotide variant not provided [RCV001325372] Chr3:55470244 [GRCh38]
Chr3:55504272 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.641C>G (p.Ala214Gly) single nucleotide variant not provided [RCV001309038] Chr3:55474380 [GRCh38]
Chr3:55508408 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.634G>A (p.Glu212Lys) single nucleotide variant not provided [RCV001350914] Chr3:55474387 [GRCh38]
Chr3:55508415 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.547G>A (p.Gly183Ser) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV001270765] Chr3:55474474 [GRCh38]
Chr3:55508502 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.463_486del (p.Arg155_Cys162del) deletion not provided [RCV001323406] Chr3:55474535..55474558 [GRCh38]
Chr3:55508563..55508586 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.461G>T (p.Cys154Phe) single nucleotide variant Robinow syndrome, autosomal dominant 1 [RCV001334139] Chr3:55474560 [GRCh38]
Chr3:55508588 [GRCh37]
Chr3:3p14.3		 uncertain significance
NM_003392.7(WNT5A):c.1123G>A (p.Asp375Asn) single nucleotide variant not provided [RCV001323469] Chr3:55470112 [GRCh38]
Chr3:55504140 [GRCh37]
Chr3:3p14.3		 uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12784 AgrOrtholog
COSMIC WNT5A COSMIC
Ensembl Genes ENSG00000114251 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000264634 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417310 UniProtKB/Swiss-Prot
  ENSP00000418184 UniProtKB/TrEMBL
  ENSP00000420104 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264634 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000474267 UniProtKB/Swiss-Prot
  ENST00000482079 UniProtKB/TrEMBL
  ENST00000497027 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000114251 GTEx
HGNC ID HGNC:12784 ENTREZGENE
Human Proteome Map WNT5A Human Proteome Map
InterPro Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt5a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7474 ENTREZGENE
OMIM 164975 OMIM
  180700 OMIM
PANTHER PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12027:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37385 PharmGKB
PRINTS WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R316 ENTREZGENE, UniProtKB/TrEMBL
  A0A384N611_HUMAN UniProtKB/TrEMBL
  A0FKN4_HUMAN UniProtKB/TrEMBL
  B3KQX9_HUMAN UniProtKB/TrEMBL
  C9J8I8_HUMAN UniProtKB/TrEMBL
  P41221 ENTREZGENE
  Q6DK41_HUMAN UniProtKB/TrEMBL
  WNT5A_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8K4A4 UniProtKB/Swiss-Prot
  E7ETR6 UniProtKB/TrEMBL
  Q6P278 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 WNT5A  Wnt family member 5A    wingless-type MMTV integration site family member 5A  Symbol and/or name change 5135510 APPROVED
2015-11-24 WNT5A  wingless-type MMTV integration site family member 5A    wingless-type MMTV integration site family, member 5A  Symbol and/or name change 5135510 APPROVED