STAM (signal transducing adaptor molecule) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: STAM (signal transducing adaptor molecule) Homo sapiens
Analyze
Symbol: STAM
Name: signal transducing adaptor molecule
RGD ID: 1320313
HGNC Page HGNC
Description: Enables ubiquitin-like protein ligase binding activity. Involved in positive regulation of exosomal secretion and regulation of extracellular exosome assembly. Located in intracellular membrane-bounded organelle. Part of ESCRT-0 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp686J2352; HSE1 homolog; signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM-1; STAM1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381017,644,151 - 17,716,824 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1017,644,151 - 17,716,824 (+)EnsemblGRCh38hg38GRCh38
GRCh371017,686,150 - 17,758,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361017,726,130 - 17,797,913 (+)NCBINCBI36hg18NCBI36
Build 341017,726,129 - 17,797,913NCBI
Celera1017,619,602 - 17,691,384 (+)NCBI
Cytogenetic Map10p12.33NCBI
HuRef1017,598,859 - 17,671,557 (+)NCBIHuRef
CHM1_11017,686,508 - 17,759,210 (+)NCBICHM1_1
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8780729   PMID:9133424   PMID:9407053   PMID:10383417   PMID:10899310   PMID:10982817   PMID:11031247   PMID:11390366   PMID:11687594   PMID:12477932   PMID:12551915   PMID:12745081  
PMID:12750381   PMID:12810066   PMID:12972556   PMID:13679051   PMID:14702039   PMID:15113837   PMID:15231748   PMID:15314065   PMID:15489334   PMID:15640163   PMID:15828871   PMID:15951569  
PMID:16189514   PMID:16344560   PMID:16385451   PMID:16431367   PMID:16520378   PMID:16716190   PMID:16730941   PMID:16760479   PMID:16771824   PMID:16964243   PMID:16964398   PMID:17078930  
PMID:17081983   PMID:17235283   PMID:17878339   PMID:18067320   PMID:18468998   PMID:19054391   PMID:19111546   PMID:19278655   PMID:20150893   PMID:20159979   PMID:20504764   PMID:20505072  
PMID:20588296   PMID:20736164   PMID:20927613   PMID:21187078   PMID:21873635   PMID:22275353   PMID:22626734   PMID:22939629   PMID:23035694   PMID:23080069   PMID:23314748   PMID:24105262  
PMID:24151880   PMID:24255178   PMID:24344129   PMID:24790097   PMID:25260751   PMID:25296754   PMID:25884766   PMID:25921289   PMID:26344197   PMID:26456826   PMID:26508657   PMID:26601948  
PMID:26638075   PMID:27226565   PMID:27789711   PMID:27880917   PMID:28190767   PMID:28218281   PMID:28514442   PMID:29509190   PMID:29568061   PMID:29604273   PMID:29742433   PMID:29778605  
PMID:29892012   PMID:29987050   PMID:31177093   PMID:31452512   PMID:31462741   PMID:31515488   PMID:31699778   PMID:31723608   PMID:31732153   PMID:31871319   PMID:32065482   PMID:32296183  
PMID:32753481   PMID:33001583   PMID:33277362   PMID:33545068   PMID:33916271   PMID:33961781   PMID:34079125   PMID:34102455   PMID:34702444   PMID:34709727   PMID:34795231   PMID:34831298  
PMID:35271311  


Genomics

Comparative Map Data
STAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381017,644,151 - 17,716,824 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1017,644,151 - 17,716,824 (+)EnsemblGRCh38hg38GRCh38
GRCh371017,686,150 - 17,758,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361017,726,130 - 17,797,913 (+)NCBINCBI36hg18NCBI36
Build 341017,726,129 - 17,797,913NCBI
Celera1017,619,602 - 17,691,384 (+)NCBI
Cytogenetic Map10p12.33NCBI
HuRef1017,598,859 - 17,671,557 (+)NCBIHuRef
CHM1_11017,686,508 - 17,759,210 (+)NCBICHM1_1
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Stam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39214,078,910 - 14,153,296 (+)NCBIGRCm39mm39
GRCm39 Ensembl214,078,909 - 14,154,445 (+)Ensembl
GRCm38214,073,962 - 14,148,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl214,074,098 - 14,149,634 (+)EnsemblGRCm38mm10GRCm38
MGSCv37213,995,739 - 14,069,965 (+)NCBIGRCm37mm9NCBIm37
MGSCv36213,991,866 - 14,066,092 (+)NCBImm8
Celera213,978,783 - 14,051,519 (+)NCBICelera
Cytogenetic Map2A2NCBI
Stam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21777,120,235 - 77,166,173 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1777,120,158 - 77,166,467 (+)Ensembl
Rnor_6.01781,209,795 - 81,256,111 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,209,867 - 81,255,808 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01782,954,327 - 83,002,657 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,276,082 - 88,321,955 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1776,453,145 - 76,499,077 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Stam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542910,306,957 - 10,366,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542910,306,957 - 10,366,072 (-)NCBIChiLan1.0ChiLan1.0
STAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11018,232,548 - 18,305,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1018,232,548 - 18,305,197 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01017,962,759 - 18,035,654 (+)NCBIMhudiblu_PPA_v0panPan3
STAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1219,264,392 - 19,344,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl219,266,055 - 19,344,045 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,365,991 - 16,445,808 (-)NCBI
ROS_Cfam_1.0219,553,884 - 19,634,156 (-)NCBI
ROS_Cfam_1.0 Ensembl219,553,652 - 19,652,382 (-)Ensembl
UMICH_Zoey_3.1216,756,688 - 16,836,708 (-)NCBI
UNSW_CanFamBas_1.0217,592,245 - 17,672,295 (-)NCBI
UU_Cfam_GSD_1.0218,212,306 - 18,292,067 (-)NCBI
Stam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934418,270,841 - 18,333,310 (+)NCBI
SpeTri2.0NW_0049365209,627,674 - 9,689,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1043,947,010 - 44,016,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11043,946,990 - 44,016,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21048,632,911 - 48,699,716 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1917,590,252 - 17,662,278 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl917,590,268 - 17,663,986 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605123,235,162 - 23,320,904 (+)NCBIVero_WHO_p1.0
Stam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479610,201,518 - 10,269,311 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462479610,195,897 - 10,269,311 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH70633  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,757,444 - 17,757,569UniSTSGRCh37
Build 361017,797,450 - 17,797,575RGDNCBI36
Celera1017,690,921 - 17,691,046RGD
Cytogenetic Map10p14-p13UniSTS
HuRef1017,670,178 - 17,670,303UniSTS
GeneMap99-GB4 RH Map10111.98UniSTS
NCBI RH Map10219.0UniSTS
SHGC-83385  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,731,058 - 17,731,341UniSTSGRCh37
Build 361017,771,064 - 17,771,347RGDNCBI36
Celera1017,664,535 - 17,664,818RGD
Cytogenetic Map10p14-p13UniSTS
HuRef1017,643,792 - 17,644,075UniSTS
TNG Radiation Hybrid Map109463.0UniSTS
STAM_850  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,757,272 - 17,758,100UniSTSGRCh37
Build 361017,797,278 - 17,798,106RGDNCBI36
Celera1017,690,749 - 17,691,577RGD
HuRef1017,670,004 - 17,670,834UniSTS
G22042  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,757,729 - 17,757,835UniSTSGRCh37
Build 361017,797,735 - 17,797,841RGDNCBI36
Celera1017,691,206 - 17,691,312RGD
Cytogenetic Map10p14-p13UniSTS
HuRef1017,670,463 - 17,670,569UniSTS
RH46555  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,729,345 - 17,729,466UniSTSGRCh37
Build 361017,769,351 - 17,769,472RGDNCBI36
Celera1017,662,822 - 17,662,943RGD
Cytogenetic Map10p14-p13UniSTS
GeneMap99-GB4 RH Map10115.15UniSTS
STS-H94886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,756,883 - 17,757,136UniSTSGRCh37
Build 361017,796,889 - 17,797,142RGDNCBI36
Celera1017,690,360 - 17,690,613RGD
Cytogenetic Map10p14-p13UniSTS
HuRef1017,669,615 - 17,669,868UniSTS
GeneMap99-GB4 RH Map10115.15UniSTS
NCBI RH Map10217.9UniSTS
RH45982  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,727,072 - 17,727,255UniSTSGRCh37
Build 361017,767,078 - 17,767,261RGDNCBI36
Celera1017,660,549 - 17,660,732RGD
Cytogenetic Map10p14-p13UniSTS
HuRef1017,639,806 - 17,639,989UniSTS
GeneMap99-GB4 RH Map10114.6UniSTS
NCBI RH Map10228.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:902
Count of miRNA genes:518
Interacting mature miRNAs:564
Transcripts:ENST00000377500, ENST00000377524, ENST00000445846, ENST00000486183, ENST00000494250, ENST00000540523
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1974 1922 1310 249 1133 123 4116 1647 2856 303 1371 1581 138 1112 2584 3
Low 464 1065 416 375 818 342 240 547 878 116 89 32 36 1 92 204 3 2
Below cutoff 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001324282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011519695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU118708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF445033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN344117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000377500   ⟹   ENSP00000366721
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1017,644,208 - 17,700,221 (+)Ensembl
RefSeq Acc Id: ENST00000377524   ⟹   ENSP00000366746
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1017,644,151 - 17,716,824 (+)Ensembl
RefSeq Acc Id: ENST00000445846   ⟹   ENSP00000400025
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1017,644,208 - 17,693,281 (+)Ensembl
RefSeq Acc Id: ENST00000486183
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1017,684,785 - 17,688,157 (+)Ensembl
RefSeq Acc Id: ENST00000494250
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1017,694,926 - 17,700,241 (+)Ensembl
RefSeq Acc Id: NM_001324282   ⟹   NP_001311211
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324283   ⟹   NP_001311212
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324284   ⟹   NP_001311213
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324285   ⟹   NP_001311214
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324286   ⟹   NP_001311215
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324287   ⟹   NP_001311216
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324288   ⟹   NP_001311217
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324289   ⟹   NP_001311218
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003473   ⟹   NP_003464
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,716,824 (+)NCBI
GRCh371017,686,124 - 17,758,823 (+)ENTREZGENE
GRCh371017,686,124 - 17,758,823 (+)NCBI
Build 361017,726,130 - 17,797,913 (+)NCBI Archive
HuRef1017,598,859 - 17,671,557 (+)ENTREZGENE
CHM1_11017,686,508 - 17,759,210 (+)NCBI
T2T-CHM13v2.01017,662,652 - 17,736,129 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011519695   ⟹   XP_011517997
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,715,910 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003464   ⟸   NM_003473
- Peptide Label: isoform a
- UniProtKB: Q92783 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011517997   ⟸   XM_011519695
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001311213   ⟸   NM_001324284
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001311214   ⟸   NM_001324285
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001311217   ⟸   NM_001324288
- Peptide Label: isoform f
- Sequence:
RefSeq Acc Id: NP_001311211   ⟸   NM_001324282
- Peptide Label: isoform e
- Sequence:
RefSeq Acc Id: NP_001311216   ⟸   NM_001324287
- Peptide Label: isoform b
- UniProtKB: B4DZT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001311218   ⟸   NM_001324289
- Peptide Label: isoform f
- Sequence:
RefSeq Acc Id: NP_001311212   ⟸   NM_001324283
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001311215   ⟸   NM_001324286
- Peptide Label: isoform d
- Sequence:
RefSeq Acc Id: ENSP00000366746   ⟸   ENST00000377524
RefSeq Acc Id: ENSP00000366721   ⟸   ENST00000377500
RefSeq Acc Id: ENSP00000400025   ⟸   ENST00000445846
Protein Domains
ITAM   SH3   UIM   VHS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q92783-F1-model_v2 AlphaFold Q92783 1-540 view protein structure

Promoters
RGD ID:7217093
Promoter ID:EPDNEW_H14292
Type:initiation region
Name:STAM_1
Description:signal transducing adaptor molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14293  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,151 - 17,644,211EPDNEW
RGD ID:7217095
Promoter ID:EPDNEW_H14293
Type:initiation region
Name:STAM_2
Description:signal transducing adaptor molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14292  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,644,253 - 17,644,313EPDNEW
RGD ID:6787584
Promoter ID:HG_KWN:8753
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000377500,   OTTHUMT00000047039,   OTTHUMT00000047040,   OTTHUMT00000047044,   OTTHUMT00000047045
Position:
Human AssemblyChrPosition (strand)Source
Build 361017,725,761 - 17,726,302 (+)MPROMDB
RGD ID:6788279
Promoter ID:HG_KWN:8754
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000047042
Position:
Human AssemblyChrPosition (strand)Source
Build 361017,766,186 - 17,766,737 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10p15.3-12.31(chr10:69261-19184047)x3 copy number gain See cases [RCV000053507] Chr10:69261..19184047 [GRCh38]
Chr10:224406..19472976 [GRCh37]
Chr10:105201..19512982 [NCBI36]
Chr10:10p15.3-12.31
pathogenic
GRCh38/hg38 10p15.3-12.2(chr10:90221-22567425)x3 copy number gain See cases [RCV000053508] Chr10:90221..22567425 [GRCh38]
Chr10:224406..22856354 [GRCh37]
Chr10:126161..22896360 [NCBI36]
Chr10:10p15.3-12.2
pathogenic
GRCh38/hg38 10p15.3-12.1(chr10:90421-29058318)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|See cases [RCV000053512] Chr10:90421..29058318 [GRCh38]
Chr10:224406..29347247 [GRCh37]
Chr10:126361..29387253 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
GRCh38/hg38 10p14-12.31(chr10:7428770-21587752)x1 copy number loss See cases [RCV000137307] Chr10:7428770..21587752 [GRCh38]
Chr10:7470732..21876681 [GRCh37]
Chr10:7510738..21916687 [NCBI36]
Chr10:10p14-12.31
pathogenic|uncertain significance
GRCh38/hg38 10p12.33(chr10:17632287-17934423)x1 copy number loss See cases [RCV000137899] Chr10:17632287..17934423 [GRCh38]
Chr10:17714292..18263358 [NCBI36]
Chr10:10p12.33
likely benign
GRCh38/hg38 10p15.3-12.1(chr10:90205-26339978)x3 copy number gain See cases [RCV000138428] Chr10:90205..26339978 [GRCh38]
Chr10:224406..26628907 [GRCh37]
Chr10:126145..26668913 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22
benign
GRCh38/hg38 10p15.3-12.31(chr10:54086-19336980)x1 copy number loss See cases [RCV000143703] Chr10:54086..19336980 [GRCh38]
Chr10:100026..19625909 [GRCh37]
Chr10:90026..19665915 [NCBI36]
Chr10:10p15.3-12.31
pathogenic|likely pathogenic
GRCh37/hg19 10p15.3-11.23(chr10:100026-30278548)x3 copy number gain See cases [RCV000447131] Chr10:100026..30278548 [GRCh37]
Chr10:10p15.3-11.23
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p13-12.31(chr10:15966534-19063585)x1 copy number loss See cases [RCV000510639] Chr10:15966534..19063585 [GRCh37]
Chr10:10p13-12.31
uncertain significance
GRCh37/hg19 10p13-12.31(chr10:16624071-19846248)x3 copy number gain See cases [RCV000511935] Chr10:16624071..19846248 [GRCh37]
Chr10:10p13-12.31
uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p12.33(chr10:17450489-18106263)x3 copy number gain See cases [RCV000510818] Chr10:17450489..18106263 [GRCh37]
Chr10:10p12.33
uncertain significance
GRCh37/hg19 10p15.3-q11.23(chr10:100026-50961640)x3 copy number gain See cases [RCV000510893] Chr10:100026..50961640 [GRCh37]
Chr10:10p15.3-q11.23
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
Single allele deletion Hypoparathyroidism, deafness, renal disease syndrome [RCV000735901] Chr10:4689760..19120882 [GRCh37]
Chr10:10p15.1-12.31
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_003473.4(STAM):c.728+4A>G single nucleotide variant not provided [RCV000963500] Chr10:17695245 [GRCh38]
Chr10:17737244 [GRCh37]
Chr10:10p12.33
benign
NM_003473.4(STAM):c.123T>C (p.Thr41=) single nucleotide variant not provided [RCV000958615] Chr10:17660546 [GRCh38]
Chr10:17702545 [GRCh37]
Chr10:10p12.33
benign
GRCh37/hg19 10p15.3-q11.22(chr10:135655-47688677)x4 copy number gain Mosaic supernumerary isodicentric chromosome 10 [RCV001825164] Chr10:135655..47688677 [GRCh37]
Chr10:10p15.3-q11.22
not provided
GRCh37/hg19 10p15.1-11.21(chr10:6273934-34732521) copy number gain not specified [RCV002052863] Chr10:6273934..34732521 [GRCh37]
Chr10:10p15.1-11.21
pathogenic
NC_000010.10:g.(?_16866974)_(18828653_?)dup duplication Imerslund-Grasbeck syndrome [RCV001916289] Chr10:16866974..18828653 [GRCh37]
Chr10:10p13-12.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11357 AgrOrtholog
COSMIC STAM COSMIC
Ensembl Genes ENSG00000136738 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000366721 UniProtKB/TrEMBL
  ENSP00000366746 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000400025 UniProtKB/TrEMBL
Ensembl Transcript ENST00000377500 UniProtKB/TrEMBL
  ENST00000377524 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000445846 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000136738 GTEx
HGNC ID HGNC:11357 ENTREZGENE
Human Proteome Map STAM Human Proteome Map
InterPro ENTH_VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAM1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8027 UniProtKB/Swiss-Prot
NCBI Gene 8027 ENTREZGENE
OMIM 601899 OMIM
Pfam SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36179 PharmGKB
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6NMU3_HUMAN UniProtKB/TrEMBL
  B4DZT2 ENTREZGENE, UniProtKB/TrEMBL
  C9J1E5_HUMAN UniProtKB/TrEMBL
  Q92783 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B0YJ99 UniProtKB/Swiss-Prot
  D3DRU5 UniProtKB/Swiss-Prot
  Q8N6D9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 STAM  signal transducing adaptor molecule    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1  Symbol and/or name change 5135510 APPROVED