LAD1 (ladinin 1) - Rat Genome Database

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Gene: LAD1 (ladinin 1) Homo sapiens
Analyze
Symbol: LAD1
Name: ladinin 1
RGD ID: 1321680
HGNC Page HGNC:6472
Description: Enables cadherin binding activity. Located in actin cytoskeleton.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: lad-1; LadA; ladinin-1; linear IgA bullous dermatosis antigen; linear IgA disease antigen homolog; MGC10355
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,380,833 - 201,399,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,380,833 - 201,399,915 (-)EnsemblGRCh38hg38GRCh38
GRCh371201,349,961 - 201,368,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,616,589 - 199,635,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 341198,081,623 - 198,100,326NCBI
Celera1174,473,817 - 174,492,312 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,516,212 - 172,534,694 (-)NCBIHuRef
CHM1_11202,772,133 - 202,790,834 (-)NCBICHM1_1
T2T-CHM13v2.01200,638,642 - 200,657,124 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-Nitrobenzanthrone  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
antirheumatic drug  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
butan-1-ol  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
cyclosporin A  (EXP)
DDE  (EXP)
dexamethasone  (EXP)
dimethylarsinic acid  (ISO)
ethylparaben  (EXP)
fenvalerate  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
gentamycin  (ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (EXP)
methimazole  (ISO)
methylarsonic acid  (ISO)
methylphenidate  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (EXP)
sulfadimethoxine  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
tetrachloromethane  (ISO)
trametinib  (EXP)
triptonide  (ISO)
uranium atom  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8618013   PMID:8618014   PMID:8983017   PMID:9119369   PMID:9665393   PMID:9804354   PMID:12477932   PMID:15778465   PMID:16083285   PMID:18029348   PMID:18570454   PMID:20830310  
PMID:21832049   PMID:24457600   PMID:25468996   PMID:25605789   PMID:25754235   PMID:27460703   PMID:27684187   PMID:29382783   PMID:29509190   PMID:31324722   PMID:31980649   PMID:32457219  
PMID:33111431   PMID:33961781   PMID:34516317   PMID:35748872   PMID:35831314   PMID:35944360   PMID:36217030   PMID:36244648   PMID:36526897   PMID:36604567   PMID:36613882   PMID:36770773  
PMID:37039823   PMID:38334954   PMID:39147351   PMID:39354061  


Genomics

Comparative Map Data
LAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,380,833 - 201,399,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,380,833 - 201,399,915 (-)EnsemblGRCh38hg38GRCh38
GRCh371201,349,961 - 201,368,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,616,589 - 199,635,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 341198,081,623 - 198,100,326NCBI
Celera1174,473,817 - 174,492,312 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,516,212 - 172,534,694 (-)NCBIHuRef
CHM1_11202,772,133 - 202,790,834 (-)NCBICHM1_1
T2T-CHM13v2.01200,638,642 - 200,657,124 (-)NCBIT2T-CHM13v2.0
Lad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,746,336 - 135,761,079 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,746,336 - 135,761,080 (+)EnsemblGRCm39 Ensembl
GRCm381135,818,598 - 135,833,341 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,818,598 - 135,833,342 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,715,175 - 137,729,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,635,009 - 137,649,752 (+)NCBIMGSCv36mm8
Celera1138,453,423 - 138,468,147 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.3NCBI
Lad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,801,347 - 49,815,709 (+)NCBIGRCr8
mRatBN7.21347,249,605 - 47,263,967 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,249,605 - 47,263,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,857,617 - 49,871,977 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,145,682 - 51,160,042 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,409,583 - 48,423,948 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,645,257 - 52,659,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,645,257 - 52,659,619 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,693,625 - 57,707,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,850,260 - 48,864,622 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,868,513 - 48,878,662 (+)NCBI
Celera1347,566,704 - 47,581,066 (+)NCBICelera
Cytogenetic Map13q13NCBI
Lad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,510,298 - 37,526,225 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,510,675 - 37,526,178 (-)NCBIChiLan1.0ChiLan1.0
LAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,981,935 - 48,000,468 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,946,623 - 47,965,159 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,979,109 - 176,997,837 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,280,503 - 181,298,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,281,294 - 181,298,732 (-)Ensemblpanpan1.1panPan2
LAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.171,623,839 - 1,639,314 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl71,624,056 - 1,641,104 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,541,200 - 1,556,676 (+)NCBIDog10K_Boxer_Tasha
Lad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,799,094 - 73,814,231 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,033,672 - 3,048,943 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,033,750 - 3,048,921 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,766,872 - 23,778,654 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,767,204 - 23,779,743 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,176,646 - 28,189,027 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,013,713 - 28,032,481 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,013,826 - 28,031,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,810,799 - 28,829,755 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,316,457 - 9,328,485 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248079,315,172 - 9,329,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LAD1
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q32.1(chr1:201226425-202014204)x3 copy number gain See cases [RCV000051558] Chr1:201226425..202014204 [GRCh38]
Chr1:201195553..201983332 [GRCh37]
Chr1:199462176..200249955 [NCBI36]
Chr1:1q32.1		 uncertain significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
GRCh38/hg38 1q32.1(chr1:200144603-203112078)x1 copy number loss See cases [RCV000133625] Chr1:200144603..203112078 [GRCh38]
Chr1:200113731..203081206 [GRCh37]
Chr1:198380354..201347829 [NCBI36]
Chr1:1q32.1		 pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13		 pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q32.1(chr1:200873507-201947585)x3 copy number gain not provided [RCV000684686] Chr1:200873507..201947585 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
NM_005558.4(LAD1):c.591C>T (p.Ser197=) single nucleotide variant not provided [RCV000946547] Chr1:201386770 [GRCh38]
Chr1:201355898 [GRCh37]
Chr1:1q32.1		 benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
NM_005558.4(LAD1):c.483_484del (p.Leu161fs) deletion not provided [RCV000961343] Chr1:201386877..201386878 [GRCh38]
Chr1:201356005..201356006 [GRCh37]
Chr1:1q32.1		 benign
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2		 not provided
NM_005558.4(LAD1):c.990G>A (p.Pro330=) single nucleotide variant not provided [RCV000974495] Chr1:201386371 [GRCh38]
Chr1:201355499 [GRCh37]
Chr1:1q32.1		 benign
NM_005558.4(LAD1):c.191G>A (p.Ser64Asn) single nucleotide variant not provided [RCV000951236] Chr1:201387170 [GRCh38]
Chr1:201356298 [GRCh37]
Chr1:1q32.1		 benign
NM_005558.4(LAD1):c.864G>A (p.Glu288=) single nucleotide variant not provided [RCV000955831] Chr1:201386497 [GRCh38]
Chr1:201355625 [GRCh37]
Chr1:1q32.1		 benign
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737) copy number loss not specified [RCV002053780] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
NC_000001.10:g.(?_200522516)_(206945780_?)dup duplication Epilepsy, familial adult myoclonic, 5 [RCV003116306] Chr1:200522516..206945780 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_200522516)_(208391267_?)dup duplication Hypokalemic periodic paralysis, type 1 [RCV003119239]|not provided [RCV003119240] Chr1:200522516..208391267 [GRCh37]
Chr1:1q32.1-32.2		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_005558.4(LAD1):c.1154C>T (p.Ser385Leu) single nucleotide variant not specified [RCV004193049] Chr1:201384813 [GRCh38]
Chr1:201353941 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_005558.4(LAD1):c.143T>G (p.Leu48Arg) single nucleotide variant not specified [RCV004082372] Chr1:201389199 [GRCh38]
Chr1:201358327 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_005558.4(LAD1):c.28G>A (p.Ala10Thr) single nucleotide variant not specified [RCV004103860] Chr1:201399279 [GRCh38]
Chr1:201368407 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_005558.4(LAD1):c.159C>A (p.Asp53Glu) single nucleotide variant not specified [RCV004247032] Chr1:201389183 [GRCh38]
Chr1:201358311 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_005558.4(LAD1):c.1184T>G (p.Met395Arg) single nucleotide variant not specified [RCV004202275] Chr1:201383381 [GRCh38]
Chr1:201352509 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_005558.4(LAD1):c.127G>A (p.Asp43Asn) single nucleotide variant not specified [RCV004089961] Chr1:201389215 [GRCh38]
Chr1:201358343 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-32.1(chr1:197216705-203683110)x1 copy number loss not specified [RCV003986384] Chr1:197216705..203683110 [GRCh37]
Chr1:1q31.3-32.1		 likely pathogenic
GRCh37/hg19 1q32.1(chr1:199373229-204335027)x3 copy number gain not specified [RCV003986684] Chr1:199373229..204335027 [GRCh37]
Chr1:1q32.1		 likely pathogenic
NM_005558.4(LAD1):c.103C>T (p.Arg35Cys) single nucleotide variant not specified [RCV004407164] Chr1:201389239 [GRCh38]
Chr1:201358367 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_005558.4(LAD1):c.1102C>T (p.Arg368Cys) single nucleotide variant not specified [RCV004407165] Chr1:201385730 [GRCh38]
Chr1:201354858 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_190829412)_(216061974_?)del deletion not provided [RCV004579260] Chr1:190829412..216061974 [GRCh37]
Chr1:1q31.2-41		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2231
Count of miRNA genes:834
Interacting mature miRNAs:984
Transcripts:ENST00000367313, ENST00000391967, ENST00000475136, ENST00000488842, ENST00000503578
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406941634GWAS590610_HQRS-T angle QTL GWAS590610 (human)4e-09heart excitatory physiology trait (VT:0000231)1201384699201384700Human
406999211GWAS648187_Htriglyceride measurement QTL GWAS648187 (human)2e-17triglyceride measurementblood triglyceride level (CMO:0000118)1201386525201386526Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1189 2421 2780 2221 4519 1702 2323 6 621 1717 462 2248 7032 6198 31 3296 1 845 1725 1590 174 1

Sequence


Ensembl Acc Id: ENST00000367313   ⟹   ENSP00000356282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,381,207 - 201,399,548 (-)Ensembl
Ensembl Acc Id: ENST00000391967   ⟹   ENSP00000375829
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,380,833 - 201,399,324 (-)Ensembl
Ensembl Acc Id: ENST00000475136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,382,284 - 201,383,208 (-)Ensembl
Ensembl Acc Id: ENST00000488842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,382,686 - 201,383,573 (-)Ensembl
Ensembl Acc Id: ENST00000631576   ⟹   ENSP00000488829
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,386,811 - 201,399,915 (-)Ensembl
Ensembl Acc Id: ENST00000632743   ⟹   ENSP00000487828
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,386,847 - 201,397,316 (-)Ensembl
Ensembl Acc Id: ENST00000633953   ⟹   ENSP00000487726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1201,386,893 - 201,399,309 (-)Ensembl
RefSeq Acc Id: NM_005558   ⟹   NP_005549
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381201,380,833 - 201,399,324 (-)NCBI
GRCh371201,349,966 - 201,368,669 (-)RGD
Build 361199,616,589 - 199,635,292 (-)NCBI Archive
Celera1174,473,817 - 174,492,312 (-)RGD
HuRef1172,516,212 - 172,534,694 (-)ENTREZGENE
CHM1_11202,772,133 - 202,790,834 (-)NCBI
T2T-CHM13v2.01200,638,642 - 200,657,124 (-)NCBI
Sequence:
RefSeq Acc Id: NP_005549   ⟸   NM_005558
- UniProtKB: O95614 (UniProtKB/Swiss-Prot),   Q96GD8 (UniProtKB/Swiss-Prot),   O00515 (UniProtKB/Swiss-Prot),   Q6IPJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000375829   ⟸   ENST00000391967
Ensembl Acc Id: ENSP00000356282   ⟸   ENST00000367313
Ensembl Acc Id: ENSP00000488829   ⟸   ENST00000631576
Ensembl Acc Id: ENSP00000487828   ⟸   ENST00000632743
Ensembl Acc Id: ENSP00000487726   ⟸   ENST00000633953

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00515-F1-model_v2 AlphaFold O00515 1-517 view protein structure

Promoters
RGD ID:6858532
Promoter ID:EPDNEW_H2431
Type:initiation region
Name:LAD1_2
Description:ladinin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2432  EPDNEW_H2433  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381201,399,324 - 201,399,384EPDNEW
RGD ID:6858534
Promoter ID:EPDNEW_H2432
Type:initiation region
Name:LAD1_1
Description:ladinin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2431  EPDNEW_H2433  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381201,399,532 - 201,399,592EPDNEW
RGD ID:6858536
Promoter ID:EPDNEW_H2433
Type:multiple initiation site
Name:LAD1_3
Description:ladinin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2431  EPDNEW_H2432  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381201,399,915 - 201,399,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6472 AgrOrtholog
COSMIC LAD1 COSMIC
Ensembl Genes ENSG00000159166 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000367313.4 UniProtKB/TrEMBL
  ENST00000391967 ENTREZGENE
  ENST00000391967.7 UniProtKB/Swiss-Prot
  ENST00000631576.1 UniProtKB/TrEMBL
  ENST00000632743.1 UniProtKB/TrEMBL
  ENST00000633953.1 UniProtKB/TrEMBL
GTEx ENSG00000159166 GTEx
HGNC ID HGNC:6472 ENTREZGENE
Human Proteome Map LAD1 Human Proteome Map
InterPro Ladinin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3898 UniProtKB/Swiss-Prot
NCBI Gene 3898 ENTREZGENE
OMIM 602314 OMIM
PANTHER LADININ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30263 PharmGKB
PIRSF Ladinin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YVY2_HUMAN UniProtKB/TrEMBL
  A0A0J9YW63_HUMAN UniProtKB/TrEMBL
  A0A0J9YYF6_HUMAN UniProtKB/TrEMBL
  E9PDI4_HUMAN UniProtKB/TrEMBL
  LAD1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  O95614 ENTREZGENE
  Q6IPJ9 ENTREZGENE, UniProtKB/TrEMBL
  Q96GD8 ENTREZGENE
UniProt Secondary O95614 UniProtKB/Swiss-Prot
  Q96GD8 UniProtKB/Swiss-Prot