CCN4 (cellular communication network factor 4) - Rat Genome Database

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Gene: CCN4 (cellular communication network factor 4) Homo sapiens
Analyze
Symbol: CCN4
Name: cellular communication network factor 4
RGD ID: 69487
HGNC Page HGNC
Description: Predicted to have heparin binding activity and integrin binding activity. Involved in positive regulation of inflammatory response; positive regulation of osteoblast differentiation; and regulation of cytokine production. Localizes to cytosol and extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCN family member 4; CTC-458A3.8; FLJ14388; WISP-1; WISP1; WISP1 3'UTR-associated RNA 1; WISP1 overlapping transcript 1; WISP1 overlapping transcript 1 (non-protein coding); WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc; Wnt-1 inducible signaling pathway protein 1; wnt-1 signaling pathway protein 1; wnt-1-induced secreted protein; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; WNT1-inducible-signaling pathway protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8133,191,039 - 133,231,690 (+)EnsemblGRCh38hg38GRCh38
GRCh388133,190,907 - 133,231,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378134,203,282 - 134,243,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,272,494 - 134,310,753 (+)NCBINCBI36hg18NCBI36
Build 348134,272,493 - 134,309,234NCBI
Celera8130,380,567 - 130,419,496 (+)NCBI
Cytogenetic Map8q24.22NCBI
HuRef8129,522,987 - 129,563,677 (+)NCBIHuRef
CHM1_18134,244,050 - 134,284,955 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
actinomycin D  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
chloroprene  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cycloheximide  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
graphite  (ISO)
homocysteine  (EXP)
indometacin  (EXP)
methotrexate  (EXP)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (ISO)
nitroprusside  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (ISO)
pentane-2,3-dione  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)

References

Additional References at PubMed
PMID:9843955   PMID:10716946   PMID:11571650   PMID:11598131   PMID:11751417   PMID:11782444   PMID:11855747   PMID:12477932   PMID:12529380   PMID:12717393   PMID:12805222   PMID:15489334  
PMID:15650268   PMID:16421571   PMID:17353931   PMID:17381509   PMID:17406949   PMID:17579708   PMID:17593496   PMID:17657846   PMID:18006828   PMID:18029348   PMID:18404666   PMID:18701807  
PMID:19069651   PMID:19180479   PMID:19238344   PMID:19240061   PMID:19282865   PMID:19287097   PMID:19339243   PMID:19453261   PMID:19926868   PMID:20010302   PMID:20074638   PMID:20372786  
PMID:20379614   PMID:20403915   PMID:20506641   PMID:20628624   PMID:20677014   PMID:20684029   PMID:21109017   PMID:21321938   PMID:21453685   PMID:21498727   PMID:21516124   PMID:21873635  
PMID:22715413   PMID:22778029   PMID:22873724   PMID:23300278   PMID:23313051   PMID:23316072   PMID:23343403   PMID:23612905   PMID:23977121   PMID:24036215   PMID:24402778   PMID:24426833  
PMID:24728101   PMID:24953558   PMID:25200494   PMID:25212236   PMID:25277191   PMID:25281430   PMID:25405734   PMID:25732125   PMID:25749038   PMID:25794425   PMID:26391330   PMID:26498181  
PMID:26555637   PMID:26823919   PMID:26824419   PMID:26867691   PMID:27267804   PMID:27321870   PMID:27391264   PMID:27403031   PMID:27409174   PMID:28406476   PMID:28426731   PMID:28618940  
PMID:28783045   PMID:28902353   PMID:29277583   PMID:29330021   PMID:29402200   PMID:29467324   PMID:29627497   PMID:29676528   PMID:29739999   PMID:29754289   PMID:29790184   PMID:29889892  
PMID:30341522   PMID:30353078   PMID:30548664   PMID:30649473   PMID:30686765   PMID:30998609   PMID:31023846   PMID:31294477   PMID:31636474   PMID:31689765   PMID:31689877   PMID:31800303  
PMID:32296183   PMID:32361708   PMID:32377270   PMID:32541784   PMID:32744779   PMID:33239617   PMID:33498604   PMID:33646053  


Genomics

Comparative Map Data
CCN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8133,191,039 - 133,231,690 (+)EnsemblGRCh38hg38GRCh38
GRCh388133,190,907 - 133,231,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378134,203,282 - 134,243,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,272,494 - 134,310,753 (+)NCBINCBI36hg18NCBI36
Build 348134,272,493 - 134,309,234NCBI
Celera8130,380,567 - 130,419,496 (+)NCBI
Cytogenetic Map8q24.22NCBI
HuRef8129,522,987 - 129,563,677 (+)NCBIHuRef
CHM1_18134,244,050 - 134,284,955 (+)NCBICHM1_1
Ccn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,763,218 - 66,795,054 (+)NCBIGRCm39mm39
GRCm39 Ensembl1566,763,169 - 66,795,050 (+)Ensembl
GRCm381566,891,369 - 66,923,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,891,320 - 66,923,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371566,722,955 - 66,754,761 (+)NCBIGRCm37mm9NCBIm37
MGSCv361566,721,062 - 66,752,868 (+)NCBImm8
Celera1568,424,047 - 68,455,874 (+)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
Ccn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2798,645,238 - 98,677,253 (+)NCBI
Rnor_6.0 Ensembl7107,695,215 - 107,723,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07107,695,227 - 107,723,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07107,644,976 - 107,673,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47104,263,089 - 104,291,621 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17104,297,318 - 104,325,846 (+)NCBI
Celera795,196,524 - 95,225,037 (+)NCBICelera
Cytogenetic Map7q34NCBI
Ccn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554617,748,005 - 7,780,427 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554617,748,399 - 7,780,359 (+)NCBIChiLan1.0ChiLan1.0
CCN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18132,818,397 - 132,858,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,818,397 - 132,858,861 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08129,842,580 - 129,884,528 (+)NCBIMhudiblu_PPA_v0panPan3
CCN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11329,648,720 - 29,683,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1329,648,639 - 29,679,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1329,622,701 - 29,661,265 (+)NCBI
ROS_Cfam_1.01330,004,803 - 30,043,373 (+)NCBI
UMICH_Zoey_3.11329,731,434 - 29,769,975 (+)NCBI
UNSW_CanFamBas_1.01329,830,792 - 29,869,352 (+)NCBI
UU_Cfam_GSD_1.01330,180,453 - 30,219,020 (+)NCBI
Ccn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053038,682,581 - 8,708,143 (-)NCBI
SpeTri2.0NW_00493647016,110,492 - 16,134,065 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,078,156 - 8,110,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.148,078,163 - 8,110,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,188,614 - 8,216,061 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCN4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18127,620,635 - 127,658,132 (+)NCBI
ChlSab1.1 Ensembl8127,642,598 - 127,661,462 (+)Ensembl
Ccn4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473522,789,784 - 22,819,527 (-)NCBI

Position Markers
RH76344  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378134,243,629 - 134,243,840UniSTSGRCh37
Build 368134,312,811 - 134,313,022RGDNCBI36
Celera8130,421,554 - 130,421,765RGD
Cytogenetic Map8q24.22UniSTS
HuRef8129,563,373 - 129,563,584UniSTS
RH102883  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378134,243,615 - 134,243,781UniSTSGRCh37
Build 368134,312,797 - 134,312,963RGDNCBI36
Celera8130,421,540 - 130,421,706RGD
Cytogenetic Map8q24.22UniSTS
HuRef8129,563,359 - 129,563,525UniSTS
GeneMap99-GB4 RH Map8515.77UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1897
Count of miRNA genes:864
Interacting mature miRNAs:991
Transcripts:ENST00000220856, ENST00000250160, ENST00000377862, ENST00000377863, ENST00000517423, ENST00000519433
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 558 695 208 14 41 15 430 418 98 80 359 263 1 103 398 1
Low 1557 1340 1278 440 511 297 2776 847 1037 283 999 1064 146 1 911 1666 2 2
Below cutoff 220 666 212 157 513 137 1002 893 2516 27 46 142 21 190 721 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_037944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB034725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF100779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF192304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF223404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI347990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW291472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY196486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY196487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY196488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ009791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX476382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN997366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF025923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC344835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000220856   ⟹   ENSP00000220856
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8133,191,137 - 133,228,064 (+)Ensembl
RefSeq Acc Id: ENST00000250160   ⟹   ENSP00000250160
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8133,191,039 - 133,231,690 (+)Ensembl
RefSeq Acc Id: ENST00000377862   ⟹   ENSP00000367093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8133,191,039 - 133,228,360 (+)Ensembl
RefSeq Acc Id: ENST00000517423   ⟹   ENSP00000427744
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8133,191,084 - 133,227,716 (+)Ensembl
RefSeq Acc Id: ENST00000519433   ⟹   ENSP00000429185
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8133,191,069 - 133,227,810 (+)Ensembl
RefSeq Acc Id: NM_001204869   ⟹   NP_001191798
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,191,039 - 133,231,690 (+)NCBI
GRCh378134,203,282 - 134,243,933 (+)ENTREZGENE
HuRef8129,522,987 - 129,563,677 (+)ENTREZGENE
CHM1_18134,244,050 - 134,284,955 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001204870   ⟹   NP_001191799
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,191,039 - 133,231,690 (+)NCBI
GRCh378134,203,282 - 134,243,933 (+)ENTREZGENE
HuRef8129,522,987 - 129,563,677 (+)ENTREZGENE
CHM1_18134,244,050 - 134,284,955 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003882   ⟹   NP_003873
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,191,039 - 133,231,690 (+)NCBI
GRCh378134,203,282 - 134,243,933 (+)ENTREZGENE
Build 368134,272,494 - 134,310,753 (+)NCBI Archive
HuRef8129,522,987 - 129,563,677 (+)ENTREZGENE
CHM1_18134,244,050 - 134,284,955 (+)NCBI
Sequence:
RefSeq Acc Id: NM_080838   ⟹   NP_543028
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,191,039 - 133,231,690 (+)NCBI
GRCh378134,203,282 - 134,243,933 (+)ENTREZGENE
Build 368134,272,494 - 134,309,235 (+)NCBI Archive
HuRef8129,522,987 - 129,563,677 (+)ENTREZGENE
CHM1_18134,244,050 - 134,284,955 (+)NCBI
Sequence:
RefSeq Acc Id: NR_037944
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,191,039 - 133,231,690 (+)NCBI
GRCh378134,203,282 - 134,243,933 (+)ENTREZGENE
HuRef8129,522,987 - 129,563,677 (+)ENTREZGENE
CHM1_18134,244,050 - 134,284,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024447319   ⟹   XP_024303087
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,190,907 - 133,231,596 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024447320   ⟹   XP_024303088
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,190,911 - 133,231,596 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024447321   ⟹   XP_024303089
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,224,893 - 133,231,596 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003873   ⟸   NM_003882
- Peptide Label: isoform 1 precursor
- UniProtKB: O95388 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_543028   ⟸   NM_080838
- Peptide Label: isoform 2 precursor
- UniProtKB: O95388 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001191798   ⟸   NM_001204869
- Peptide Label: isoform 3 precursor
- UniProtKB: O95388 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001191799   ⟸   NM_001204870
- Peptide Label: isoform 4 precursor
- UniProtKB: O95388 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024303087   ⟸   XM_024447319
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024303088   ⟸   XM_024447320
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024303089   ⟸   XM_024447321
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000427744   ⟸   ENST00000517423
RefSeq Acc Id: ENSP00000429185   ⟸   ENST00000519433
RefSeq Acc Id: ENSP00000367093   ⟸   ENST00000377862
RefSeq Acc Id: ENSP00000220856   ⟸   ENST00000220856
RefSeq Acc Id: ENSP00000250160   ⟸   ENST00000250160
Protein Domains
CTCK   IGFBP N-terminal   TSP type-1   VWFC

Promoters
RGD ID:7214219
Promoter ID:EPDNEW_H12855
Type:initiation region
Name:WISP1_1
Description:WNT1 inducible signaling pathway protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388133,191,039 - 133,191,099EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q24.21-24.22(chr8:129176782-134170188)x1 copy number loss See cases [RCV000050751] Chr8:129176782..134170188 [GRCh38]
Chr8:130189028..135182431 [GRCh37]
Chr8:130258210..135251613 [NCBI36]
Chr8:8q24.21-24.22
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.21-24.23(chr8:126626164-137169427)x1 copy number loss See cases [RCV000054306] Chr8:126626164..137169427 [GRCh38]
Chr8:127638409..138181670 [GRCh37]
Chr8:127707591..138250852 [NCBI36]
Chr8:8q24.21-24.23
pathogenic
GRCh38/hg38 8q24.21-24.3(chr8:130115518-141228210)x3 copy number gain See cases [RCV000133621] Chr8:130115518..141228210 [GRCh38]
Chr8:131127764..142238309 [GRCh37]
Chr8:131196946..142307491 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.22(chr8:132935590-133815152)x3 copy number gain See cases [RCV000143529] Chr8:132935590..133815152 [GRCh38]
Chr8:133947835..134827395 [GRCh37]
Chr8:134017017..134896577 [NCBI36]
Chr8:8q24.22
uncertain significance
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.22(chr8:134201586-134851366)x3 copy number gain not provided [RCV000682993] Chr8:134201586..134851366 [GRCh37]
Chr8:8q24.22
uncertain significance
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:133621137-140433338)x1 copy number loss not provided [RCV000747861] Chr8:133621137..140433338 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
NM_003882.4(CCN4):c.855C>T (p.Phe285=) single nucleotide variant not provided [RCV000969224] Chr8:133227461 [GRCh38]
Chr8:134239704 [GRCh37]
Chr8:8q24.22
benign
NM_003882.4(CCN4):c.291G>A (p.Arg97=) single nucleotide variant not provided [RCV000966206] Chr8:133213085 [GRCh38]
Chr8:134225328 [GRCh37]
Chr8:8q24.22
benign
NM_003882.4(CCN4):c.726C>T (p.Asn242=) single nucleotide variant not provided [RCV000905803] Chr8:133225505 [GRCh38]
Chr8:134237748 [GRCh37]
Chr8:8q24.22
likely benign
NM_003882.4(CCN4):c.297C>T (p.Leu99=) single nucleotide variant not provided [RCV000965087] Chr8:133213091 [GRCh38]
Chr8:134225334 [GRCh37]
Chr8:8q24.22
benign
NM_003882.4(CCN4):c.444C>T (p.Asp148=) single nucleotide variant not provided [RCV000916846] Chr8:133220675 [GRCh38]
Chr8:134232918 [GRCh37]
Chr8:8q24.22
likely benign
GRCh37/hg19 8q24.13-24.3(chr8:126892814-143750028)x1 copy number loss not provided [RCV001006144] Chr8:126892814..143750028 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NC_000008.10:g.(?_133141489)_(134296574_?)dup duplication Charcot-Marie-Tooth disease type 4 [RCV000804620] Chr8:133141489..134296574 [GRCh37]
Chr8:8q24.22
uncertain significance
GRCh37/hg19 8q24.13-24.22(chr8:124120772-135265846)x1 copy number loss not provided [RCV000848438] Chr8:124120772..135265846 [GRCh37]
Chr8:8q24.13-24.22
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.22(chr8:131915430-135240074)x1 copy number loss not provided [RCV000845974] Chr8:131915430..135240074 [GRCh37]
Chr8:8q24.22
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_003882.4(CCN4):c.611-9C>T single nucleotide variant not provided [RCV000888705] Chr8:133225381 [GRCh38]
Chr8:134237624 [GRCh37]
Chr8:8q24.22
likely benign
NM_003882.4(CCN4):c.434C>T (p.Thr145Met) single nucleotide variant not provided [RCV000894485] Chr8:133220665 [GRCh38]
Chr8:134232908 [GRCh37]
Chr8:8q24.22
likely benign
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12769 AgrOrtholog
COSMIC CCN4 COSMIC
Ensembl Genes ENSG00000104415 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000220856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000250160 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000367093 UniProtKB/TrEMBL
  ENSP00000427744 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429185 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000220856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000250160 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000377862 UniProtKB/TrEMBL
  ENST00000517423 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000519433 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot
GTEx ENSG00000104415 GTEx
HGNC ID HGNC:12769 ENTREZGENE
Human Proteome Map CCN4 Human Proteome Map
InterPro Cys_knot_C UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_CNN UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  TSP1_CCN UniProtKB/Swiss-Prot
  TSP1_rpt UniProtKB/Swiss-Prot
  TSP1_rpt_sf UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report hsa:8840 UniProtKB/Swiss-Prot
NCBI Gene 8840 ENTREZGENE
OMIM 603398 OMIM
Pfam Cys_knot UniProtKB/Swiss-Prot
  IGFBP UniProtKB/Swiss-Prot
  TSP1_CCN UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
PharmGKB PA37372 PharmGKB
PIRSF IGFBP_rP_CNN UniProtKB/Swiss-Prot
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
SMART SM00041 UniProtKB/Swiss-Prot
  SM00121 UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF82895 UniProtKB/Swiss-Prot
UniProt E5RG88_HUMAN UniProtKB/TrEMBL
  O95388 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8KAG6 UniProtKB/Swiss-Prot
  E7EMM5 UniProtKB/Swiss-Prot
  Q5JBS6 UniProtKB/Swiss-Prot
  Q5JBS7 UniProtKB/Swiss-Prot
  Q5JBS8 UniProtKB/Swiss-Prot
  Q9HCS3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-16 CCN4  cellular communication network factor 4  WISP1  WNT1 inducible signaling pathway protein 1  Symbol and/or name change 5135510 APPROVED
2017-10-26 WISP1  WNT1 inducible signaling pathway protein 1  WISP1-OT1  WISP1 overlapping transcript 1  Data Merged 737654 PROVISIONAL