LIF (LIF interleukin 6 family cytokine) - Rat Genome Database

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Gene: LIF (LIF interleukin 6 family cytokine) Homo sapiens
Analyze
Symbol: LIF
Name: LIF interleukin 6 family cytokine
RGD ID: 736774
HGNC Page HGNC
Description: Enables cytokine activity; growth factor activity; and leukemia inhibitory factor receptor binding activity. Involved in several processes, including leukemia inhibitory factor signaling pathway; positive regulation of protein modification process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDF; cholinergic differentiation factor; D factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; differentiation-inducing factor; differentiation-stimulating factor; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; LIF, interleukin 6 family cytokine; melanoma-derived LPL inhibitor; MLPLI
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,240,453 - 30,257,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (EXP)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
8-Br-cAMP  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
aripiprazole  (EXP)
aristolochic acid  (EXP)
arsenous acid  (EXP)
azathioprine  (EXP)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoates  (EXP)
benzyl alcohol  (EXP)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP)
cadmium atom  (EXP)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin a  (EXP)
carbon nanotube  (EXP,ISO)
carmustine  (EXP)
chlorambucil  (EXP)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clomiphene  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumaphos  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDT  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP,ISO)
Ethyl acrylate  (EXP)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (EXP)
fenamidone  (ISO)
fluoranthene  (ISO)
folic acid  (EXP)
formaldehyde  (EXP)
fulvestrant  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
geraniol  (EXP)
glucose  (EXP,ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (ISO)
hydrogen peroxide  (EXP)
imidacloprid  (ISO)
isoflavones  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
letrozole  (EXP)
limonene  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
MeIQx  (EXP)
menadione  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-Nitrosopyrrolidine  (EXP)
Nicardipine  (ISO)
nickel sulfate  (EXP)
nitric oxide  (ISO)
O-methyleugenol  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
physostigmine  (ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
quinolin-8-ol  (EXP)
resorcinol  (EXP)
resveratrol  (EXP)
ritonavir  (EXP)
SB 203580  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
succimer  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triclosan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP)
urethane  (EXP)
valproic acid  (EXP)
valsartan  (EXP)
vanadyl sulfate  (EXP)
verapamil  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte differentiation  (ISO)
blood vessel remodeling  (IEA,ISO)
decidualization  (IEA,ISO)
embryo implantation  (IEA,ISO)
immune response  (IEA)
leukemia inhibitory factor signaling pathway  (IBA,IDA)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
lung lobe morphogenesis  (IEA,ISO)
lung vasculature development  (IEA,ISO)
maternal process involved in female pregnancy  (ISO)
muscle organ morphogenesis  (IEA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of hormone secretion  (IDA)
negative regulation of meiotic nuclear division  (IEA,ISO)
neuron development  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IMP)
positive regulation of cell population proliferation  (IBA,IDA)
positive regulation of corticotropin secretion  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of histone H3-K27 acetylation  (IDA)
positive regulation of macrophage differentiation  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IDA)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IDA)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of protein localization to nucleus  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
regulation of cell differentiation  (IBA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (IDA)
regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
retina development in camera-type eye  (ISO)
spongiotrophoblast differentiation  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stem cell population maintenance  (IEA,ISO)
transdifferentiation  (ISO)
trophoblast giant cell differentiation  (IEA,ISO)
tyrosine phosphorylation of STAT protein  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1692837   PMID:1714745   PMID:2475312   PMID:2491897   PMID:2730639   PMID:3128791   PMID:3143916   PMID:3143918   PMID:7508917   PMID:7867561   PMID:7957045   PMID:8058719  
PMID:8207643   PMID:8489250   PMID:8999038   PMID:9349722   PMID:9593715   PMID:9847074   PMID:9920829   PMID:10205054   PMID:10591208   PMID:11448119   PMID:11587067   PMID:11811789  
PMID:11855863   PMID:12089333   PMID:12153570   PMID:12218157   PMID:12477932   PMID:12574225   PMID:12579339   PMID:12601009   PMID:12643274   PMID:12707269   PMID:12764151   PMID:12807438  
PMID:14527405   PMID:14557674   PMID:14647442   PMID:14687743   PMID:14715713   PMID:15044601   PMID:15146197   PMID:15180980   PMID:15341921   PMID:15342941   PMID:15489334   PMID:15543003  
PMID:15670782   PMID:15731310   PMID:15837065   PMID:15905624   PMID:16051226   PMID:16263181   PMID:16295654   PMID:16341766   PMID:16489116   PMID:16545901   PMID:16648972   PMID:16759928  
PMID:16949591   PMID:17000646   PMID:17054938   PMID:17332938   PMID:17411373   PMID:17652170   PMID:17671691   PMID:17681328   PMID:17702963   PMID:17848619   PMID:17966612   PMID:17979974  
PMID:18029348   PMID:18047677   PMID:18048043   PMID:18258286   PMID:18298054   PMID:18317962   PMID:18468598   PMID:18492704   PMID:18540977   PMID:18637760   PMID:18639869   PMID:18684446  
PMID:18953658   PMID:19011087   PMID:19086053   PMID:19213836   PMID:19251277   PMID:19255255   PMID:19342253   PMID:19361790   PMID:19374770   PMID:19453261   PMID:19470478   PMID:19495417  
PMID:19541590   PMID:19545488   PMID:19548631   PMID:19550366   PMID:19647472   PMID:19704963   PMID:19751193   PMID:19879916   PMID:19913121   PMID:19915574   PMID:20074285   PMID:20237496  
PMID:20396801   PMID:20570039   PMID:20587610   PMID:20597819   PMID:20618183   PMID:20624457   PMID:20628086   PMID:20734064   PMID:20851233   PMID:21129244   PMID:21155043   PMID:21178106  
PMID:21191816   PMID:21399633   PMID:21527666   PMID:21570299   PMID:21613225   PMID:21726338   PMID:21745467   PMID:21873635   PMID:21966484   PMID:21987111   PMID:22142941   PMID:22252755  
PMID:22285730   PMID:22323722   PMID:22341639   PMID:22436290   PMID:22520363   PMID:22537815   PMID:22649064   PMID:22698642   PMID:22712053   PMID:22720020   PMID:22783022   PMID:22835519  
PMID:22905257   PMID:23122949   PMID:23128233   PMID:23541977   PMID:23628981   PMID:23687977   PMID:23729555   PMID:23831429   PMID:23867815   PMID:23876532   PMID:23963683   PMID:24074901  
PMID:24270418   PMID:24310780   PMID:24664722   PMID:24690239   PMID:24857661   PMID:25128195   PMID:25179300   PMID:25277705   PMID:25323535   PMID:25514345   PMID:25790555   PMID:25879318  
PMID:25885043   PMID:26187859   PMID:26271643   PMID:26296968   PMID:26615902   PMID:26716902   PMID:26723254   PMID:26776907   PMID:26817395   PMID:26817565   PMID:26984928   PMID:27082016  
PMID:27304912   PMID:28064096   PMID:28246407   PMID:28247842   PMID:28391028   PMID:28432985   PMID:28466814   PMID:28512205   PMID:28577574   PMID:28729093   PMID:28755912   PMID:29038846  
PMID:29063331   PMID:29269518   PMID:29393372   PMID:29397316   PMID:29605252   PMID:30213486   PMID:30242886   PMID:30305729   PMID:30383471   PMID:30565675   PMID:30611552   PMID:30664218  
PMID:30996350   PMID:31296870   PMID:31586768   PMID:31615908   PMID:31854204   PMID:31916327   PMID:32045772   PMID:32296183   PMID:32324266   PMID:32504404   PMID:32540613   PMID:32827446  
PMID:32914874   PMID:33004621   PMID:33410420   PMID:33914392   PMID:34074039  


Genomics

Candidate Gene Status
LIF is a candidate Gene for QTL GLUCO97_H
Comparative Map Data
LIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,240,453 - 30,257,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
Lif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,207,568 - 4,222,514 (+)NCBIGRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Lif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)Ensembl
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
Lif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,489,421 - 4,497,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,489,515 - 4,505,439 (-)NCBIChiLan1.0ChiLan1.0
LIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,078,862 - 29,095,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,078,862 - 29,095,608 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02211,276,576 - 11,282,972 (-)NCBIMhudiblu_PPA_v0panPan3
LIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
Lif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,317,865 - 116,334,346 (-)NCBI
SpeTri2.0NW_004936904410,043 - 413,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,121,261 - 13,127,663 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,121,297 - 13,127,679 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045113,007,597 - 113,025,154 (+)NCBIVero_WHO_p1.0
Lif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247476,558,872 - 6,565,207 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH27829  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,638,785 - 30,639,089UniSTSGRCh37
Build 362228,968,785 - 28,969,089RGDNCBI36
Celera2214,438,468 - 14,438,772RGD
Cytogenetic Map22q12.2UniSTS
HuRef2213,600,565 - 13,600,869UniSTS
SHGC-145300  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,640,002 - 30,640,318UniSTSGRCh37
Build 362228,970,002 - 28,970,318RGDNCBI36
Celera2214,439,685 - 14,440,001RGD
Cytogenetic Map22q12.2UniSTS
HuRef2213,601,782 - 13,602,098UniSTS
SHGC-7772  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,639,662 - 30,639,939UniSTSGRCh37
Build 362228,969,662 - 28,969,939RGDNCBI36
Celera2214,439,345 - 14,439,622RGD
Cytogenetic Map22q12.2UniSTS
HuRef2213,601,442 - 13,601,719UniSTS
Stanford-G3 RH Map22649.0UniSTS
NCBI RH Map22131.4UniSTS
GeneMap99-G3 RH Map22649.0UniSTS
GDB:624823  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,639,591 - 30,640,802UniSTSGRCh37
Celera2214,439,274 - 14,440,485UniSTS
Cytogenetic Map22q12.2UniSTS
HuRef2213,601,371 - 13,602,582UniSTS
GDB:625815  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,639,613 - 30,640,782UniSTSGRCh37
Celera2214,439,296 - 14,440,465UniSTS
Cytogenetic Map22q12.2UniSTS
HuRef2213,601,393 - 13,602,562UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR637hsa-miR-637OncomiRDBexternal_infoNANA21809363
MIR346hsa-miR-346Mirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI19011087
MIR346hsa-miR-346Mirecordsexternal_infoNANA19011087
MIR26A1hsa-miR-26a-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
MIR125B1hsa-miR-125b-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
MIR26A2hsa-miR-26a-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
MIR199A1hsa-miR-199a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI19011087
MIR125Ahsa-miR-125a-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
MIR125B2hsa-miR-125b-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087

Predicted Target Of
Summary Value
Count of predictions:2391
Count of miRNA genes:963
Interacting mature miRNAs:1187
Transcripts:ENST00000249075, ENST00000403987
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 1 2 1
Medium 606 521 439 107 332 83 731 167 261 179 339 773 35 401 390 1
Low 1787 1602 1171 418 996 293 2736 1097 1398 223 1035 802 130 1 748 1567 3
Below cutoff 46 819 112 95 455 86 881 922 1970 17 83 32 9 53 826 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024452239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024452240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI796373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK819709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN409458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000249075   ⟹   ENSP00000249075
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)Ensembl
RefSeq Acc Id: ENST00000403987   ⟹   ENSP00000384450
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,243,533 - 30,246,739 (-)Ensembl
RefSeq Acc Id: NM_001257135   ⟹   NP_001244064
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,240,453 - 30,246,759 (-)NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBI
CHM1_12230,595,573 - 30,601,977 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002309   ⟹   NP_002300
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,240,453 - 30,246,759 (-)NCBI
GRCh372230,636,436 - 30,642,840 (-)NCBI
Build 362228,966,441 - 28,972,748 (-)NCBI Archive
HuRef2213,598,220 - 13,604,620 (-)NCBI
CHM1_12230,595,573 - 30,601,977 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024452239   ⟹   XP_024308007
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,240,453 - 30,257,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024452240   ⟹   XP_024308008
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,240,453 - 30,249,190 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002300   ⟸   NM_002309
- Peptide Label: isoform 1 precursor
- UniProtKB: P15018 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001244064   ⟸   NM_001257135
- Peptide Label: isoform 2
- UniProtKB: P15018 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024308007   ⟸   XM_024452239
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024308008   ⟸   XM_024452240
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000384450   ⟸   ENST00000403987
RefSeq Acc Id: ENSP00000249075   ⟸   ENST00000249075

Promoters
RGD ID:6800089
Promoter ID:HG_KWN:42292
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:ENST00000403987,   OTTHUMT00000320508
Position:
Human AssemblyChrPosition (strand)Source
Build 362228,972,471 - 28,972,971 (-)MPROMDB
RGD ID:13603660
Promoter ID:EPDNEW_H28015
Type:initiation region
Name:LIF_1
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28016  EPDNEW_H28017  EPDNEW_H28018  EPDNEW_H28019  EPDNEW_H28020  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,246,757 - 30,246,817EPDNEW
RGD ID:13603664
Promoter ID:EPDNEW_H28016
Type:initiation region
Name:LIF_6
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28015  EPDNEW_H28017  EPDNEW_H28018  EPDNEW_H28019  EPDNEW_H28020  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,247,170 - 30,247,230EPDNEW
RGD ID:13603666
Promoter ID:EPDNEW_H28017
Type:initiation region
Name:LIF_5
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28015  EPDNEW_H28016  EPDNEW_H28018  EPDNEW_H28019  EPDNEW_H28020  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,249,223 - 30,249,283EPDNEW
RGD ID:13603668
Promoter ID:EPDNEW_H28018
Type:initiation region
Name:LIF_2
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28015  EPDNEW_H28016  EPDNEW_H28017  EPDNEW_H28019  EPDNEW_H28020  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,257,443 - 30,257,503EPDNEW
RGD ID:13603670
Promoter ID:EPDNEW_H28019
Type:initiation region
Name:LIF_4
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28015  EPDNEW_H28016  EPDNEW_H28017  EPDNEW_H28018  EPDNEW_H28020  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,257,723 - 30,257,783EPDNEW
RGD ID:13603672
Promoter ID:EPDNEW_H28020
Type:initiation region
Name:LIF_3
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28015  EPDNEW_H28016  EPDNEW_H28017  EPDNEW_H28018  EPDNEW_H28019  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,257,992 - 30,258,052EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.3(chr22:26979579-33992220)x3 copy number gain See cases [RCV000050553] Chr22:26979579..33992220 [GRCh38]
Chr22:27375542..34388209 [GRCh37]
Chr22:25705542..32718209 [NCBI36]
Chr22:22q12.1-12.3
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28278805-31742328)x1 copy number loss See cases [RCV000052870] Chr22:28278805..31742328 [GRCh38]
Chr22:28674793..32138314 [GRCh37]
Chr22:27004793..30468314 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28441035-30276511)x1 copy number loss See cases [RCV000052871] Chr22:28441035..30276511 [GRCh38]
Chr22:28837023..30672500 [GRCh37]
Chr22:27167023..29002500 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3 copy number gain See cases [RCV000138172] Chr22:23279231..36247369 [GRCh38]
Chr22:23621418..36643415 [GRCh37]
Chr22:21951418..34973361 [NCBI36]
Chr22:22q11.23-12.3
pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:26451042-31451926)x1 copy number loss See cases [RCV000143415] Chr22:26451042..31451926 [GRCh38]
Chr22:26847008..31847912 [GRCh37]
Chr22:25177008..30177912 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.1-12.2(chr22:29537064-30994320)x3 copy number gain See cases [RCV000448504] Chr22:29537064..30994320 [GRCh37]
Chr22:22q12.1-12.2
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.2(chr22:30323089-31092425)x3 copy number gain See cases [RCV000448760] Chr22:30323089..31092425 [GRCh37]
Chr22:22q12.2
uncertain significance
NM_002309.5(LIF):c.256G>A (p.Val86Met) single nucleotide variant not specified [RCV000455358] Chr22:30244004 [GRCh38]
Chr22:30639993 [GRCh37]
Chr22:22q12.2
benign
GRCh37/hg19 22q12.1-12.3(chr22:28349854-33013062)x3 copy number gain See cases [RCV000510523] Chr22:28349854..33013062 [GRCh37]
Chr22:22q12.1-12.3
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3 copy number gain See cases [RCV000511098] Chr22:23637907..36614412 [GRCh37]
Chr22:22q11.23-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.2(chr22:29644625-31051719)x1 copy number loss not provided [RCV000684497] Chr22:29644625..31051719 [GRCh37]
Chr22:22q12.2
pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3 copy number gain not provided [RCV000684530] Chr22:22460754..35198232 [GRCh37]
Chr22:22q11.22-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
inv(22)(q12.2q12.2) inversion Anaplastic ependymoma [RCV000785873] Chr22:29684716..31740655 [GRCh37]
Chr22:22q12.2
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6596 AgrOrtholog
COSMIC LIF COSMIC
Ensembl Genes ENSG00000128342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000249075 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000384450 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000249075 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000403987 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000128342 GTEx
HGNC ID HGNC:6596 ENTREZGENE
Human Proteome Map LIF Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  Leukemia_IF UniProtKB/Swiss-Prot
  Leukemia_IF/oncostatin UniProtKB/Swiss-Prot
  Leukemia_IF/oncostatin_CS UniProtKB/Swiss-Prot
KEGG Report hsa:3976 UniProtKB/Swiss-Prot
NCBI Gene 3976 ENTREZGENE
OMIM 159540 OMIM
PANTHER PTHR10633 UniProtKB/Swiss-Prot
Pfam LIF_OSM UniProtKB/Swiss-Prot
PharmGKB PA30370 PharmGKB
PRINTS LEUKAEMIAIF UniProtKB/Swiss-Prot
PROSITE LIF_OSM UniProtKB/Swiss-Prot
SMART LIF_OSM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt LIF_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RCW7 UniProtKB/Swiss-Prot
  B5MC23 UniProtKB/Swiss-Prot
  Q52LZ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 LIF  LIF interleukin 6 family cytokine    LIF, interleukin 6 family cytokine  Symbol and/or name change 5135510 APPROVED
2017-03-21 LIF  LIF, interleukin 6 family cytokine    leukemia inhibitory factor  Symbol and/or name change 5135510 APPROVED
2012-03-20 LIF  leukemia inhibitory factor  LIF  leukemia inhibitory factor  Symbol and/or name change 5135510 APPROVED
2012-02-14 LIF  leukemia inhibitory factor  LIF  leukemia inhibitory factor (cholinergic differentiation factor)  Symbol and/or name change 5135510 APPROVED
2011-08-16 LIF  leukemia inhibitory factor (cholinergic differentiation factor)  LIF  leukemia inhibitory factor (cholinergic differentiation factor)  Symbol and/or name change 5135510 APPROVED