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Gene: LIF (LIF interleukin 6 family cytokine) Homo sapiens
Symbol: LIF
Name: LIF interleukin 6 family cytokine
Description: Exhibits cytokine activity; growth factor activity; and leukemia inhibitory factor receptor binding activity. Involved in several processes, including positive regulation of macrophage differentiation; positive regulation of protein modification process; and regulation of epithelial cell differentiation involved in kidney development. Localizes to cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDF; cholinergic differentiation factor; D factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; differentiation-inducing factor; differentiation-stimulating factor; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; LIF, interleukin 6 family cytokine; melanoma-derived LPL inhibitor; MLPLI
Mus musculus (house mouse) : Lif (leukemia inhibitory factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lif (LIF, interleukin 6 family cytokine)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lif (LIF interleukin 6 family cytokine)
Pan paniscus (bonobo/pygmy chimpanzee) : LIF (LIF interleukin 6 family cytokine)
Canis lupus familiaris (dog) : LIF (LIF interleukin 6 family cytokine)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lif (LIF interleukin 6 family cytokine)
Sus scrofa (pig) : LIF (LIF interleukin 6 family cytokine)
Chlorocebus sabaeus (African green monkey) : LIF (LIF interleukin 6 family cytokine)
Heterocephalus glaber (naked mole-rat) : Lif (LIF interleukin 6 family cytokine)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,240,453 - 30,257,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,636,436 - 30,642,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LIF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736774
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.