MED1 (mediator complex subunit 1) - Rat Genome Database
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Gene: MED1 (mediator complex subunit 1) Homo sapiens
Analyze
Symbol: MED1
Name: mediator complex subunit 1
RGD ID: 1351174
HGNC Page HGNC
Description: Exhibits several functions, including LBD domain binding activity; mediator complex binding activity; and nuclear hormone receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to hormone stimulus; and positive regulation of cell differentiation. Localizes to mediator complex and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activator-recruited cofactor 205 kDa component; ARC205; CRSP1; CRSP200; DRIP205; DRIP230; mediator of RNA polymerase II transcription subunit 1; MGC71488; p53 regulatory protein RB18A; PBP; peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPAR-binding protein; PPARBP; PPARG binding protein; PPARGBP; RB18A; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; thyroid receptor-interacting protein 2; TR-interacting protein 2; TRAP220; TRIP-2; TRIP2; vitamin D receptor-interacting protein 230 kD; vitamin D receptor-interacting protein complex component DRIP205
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1739,404,285 - 39,451,272 (-)EnsemblGRCh38hg38GRCh38
GRCh381739,404,285 - 39,451,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,560,538 - 37,607,516 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371737,560,538 - 37,607,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,814,064 - 34,861,053 (-)NCBINCBI36hg18NCBI36
Build 341734,816,379 - 34,861,030NCBI
Celera1734,221,470 - 34,268,494 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,354,022 - 33,401,237 (-)NCBIHuRef
CHM1_11737,796,744 - 37,843,728 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (EXP)
10H-phenothiazine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID  (ISO)
alfacalcidol  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amphetamine  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
butamben  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP,ISO)
carmustine  (EXP)
chloroethene  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clemizole  (EXP)
clopidogrel  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
cyproterone acetate  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
Falecalcitriol  (EXP)
folic acid  (ISO)
furan  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodiethylamine  (ISO)
okadaic acid  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP)
pentobarbital  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phthalic acid  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
rac-lactic acid  (EXP)
rifampicin  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
sulconazole  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
tunicamycin  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen biosynthetic process  (IMP)
angiogenesis  (ISO,ISS)
animal organ morphogenesis  (ISO)
animal organ regeneration  (IEA,ISO)
brain development  (IEA,ISO)
camera-type eye development  (ISO)
cell morphogenesis  (IMP)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to steroid hormone stimulus  (IDA)
cellular response to thyroid hormone stimulus  (IBA,IDA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
enucleate erythrocyte development  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
erythrocyte development  (ISO,ISS)
fat cell differentiation  (IDA,ISO)
heart development  (ISO)
in utero embryonic development  (ISO)
intracellular steroid hormone receptor signaling pathway  (IDA)
keratinocyte differentiation  (IMP)
lactation  (IEA,ISO)
lens development in camera-type eye  (ISO,ISS)
liver development  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
mammary gland epithelial cell proliferation  (ISO)
megakaryocyte development  (ISO,ISS)
monocyte differentiation  (IEA,ISO)
mRNA transcription by RNA polymerase II  (ISO,ISS)
multicellular organism development  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of keratinocyte proliferation  (IMP)
negative regulation of neuron differentiation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of G0 to G1 transition  (IEA,ISO)
positive regulation of gene expression  (IDA,IMP)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of interferon-gamma-mediated signaling pathway  (IEA,ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
positive regulation of keratinocyte differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (IDA)
positive regulation of transcription, DNA-templated  (IDA)
protein import into nucleus  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
regulation of lipid metabolic process  (TAS)
regulation of RNA biosynthetic process  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription initiation from RNA polymerase II promoter  (TAS)
regulation of transcription, DNA-templated  (ISO)
regulation of vitamin D receptor signaling pathway  (IEA,ISO)
retinal pigment epithelium development  (IEA,ISO)
thyroid hormone generation  (IEA,ISO)
thyroid hormone mediated signaling pathway  (IMP)
transcription initiation from RNA polymerase II promoter  (TAS)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
mediator complex  (IBA,IDA,IMP,ISO)
membrane  (HDA)
nucleolus  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (IDA,ISO)
protein-DNA complex  (IEA,ISO)
ubiquitin ligase complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7776974   PMID:8710870   PMID:9325263   PMID:9444950   PMID:9653119   PMID:9989412   PMID:10024883   PMID:10037764   PMID:10198638   PMID:10235266   PMID:10235267   PMID:10478845  
PMID:10485914   PMID:10508170   PMID:10733574   PMID:10753860   PMID:10760302   PMID:10770935   PMID:10882111   PMID:10935544   PMID:11027271   PMID:11117530   PMID:11118038   PMID:11266503  
PMID:11438648   PMID:11500849   PMID:11724781   PMID:11840331   PMID:11867769   PMID:11877444   PMID:11912212   PMID:12037571   PMID:12082103   PMID:12089346   PMID:12101254   PMID:12130544  
PMID:12145330   PMID:12189208   PMID:12218053   PMID:12356758   PMID:12403843   PMID:12477932   PMID:12556447   PMID:12562779   PMID:12584197   PMID:12738788   PMID:12796488   PMID:14636573  
PMID:14638676   PMID:14657022   PMID:14983011   PMID:15026545   PMID:15095040   PMID:15175163   PMID:15187081   PMID:15302935   PMID:15342556   PMID:15471764   PMID:15572376   PMID:15604093  
PMID:15848166   PMID:15863722   PMID:15886699   PMID:15919092   PMID:15989967   PMID:16055720   PMID:16204234   PMID:16239144   PMID:16239257   PMID:16314496   PMID:16396960   PMID:16434701  
PMID:16554032   PMID:16574658   PMID:16723356   PMID:16799563   PMID:16934225   PMID:16964243   PMID:17011503   PMID:17081983   PMID:17082781   PMID:17117180   PMID:17132730   PMID:17223341  
PMID:17254542   PMID:17392787   PMID:17468099   PMID:17478428   PMID:17502350   PMID:17641689   PMID:17704298   PMID:17786964   PMID:17827210   PMID:17967894   PMID:18003614   PMID:18339625  
PMID:18391015   PMID:18418385   PMID:18660489   PMID:18691967   PMID:18950845   PMID:19127118   PMID:19183483   PMID:19243021   PMID:19255064   PMID:19322201   PMID:19497978   PMID:19521987  
PMID:19596656   PMID:19766566   PMID:19786558   PMID:19913121   PMID:19946888   PMID:20098423   PMID:20133760   PMID:20160030   PMID:20398753   PMID:20473893   PMID:20508642   PMID:20520624  
PMID:20534441   PMID:20628086   PMID:21292004   PMID:21326907   PMID:21454576   PMID:21478865   PMID:21556051   PMID:21729782   PMID:21868449   PMID:21873635   PMID:21988832   PMID:22070604  
PMID:22102282   PMID:22331469   PMID:22342682   PMID:22343046   PMID:22869146   PMID:22939629   PMID:22964581   PMID:23160722   PMID:23178929   PMID:23275444   PMID:23322298   PMID:23538858  
PMID:23563140   PMID:23602568   PMID:23824909   PMID:23936234   PMID:24245781   PMID:24390342   PMID:24418047   PMID:24871463   PMID:24882805   PMID:24969180   PMID:24981860   PMID:25281560  
PMID:25303530   PMID:25481872   PMID:25644605   PMID:25720964   PMID:25921289   PMID:26130665   PMID:26186194   PMID:26344197   PMID:26469385   PMID:26496610   PMID:26760575   PMID:26849466  
PMID:27173435   PMID:27248496   PMID:27684187   PMID:27739523   PMID:28291257   PMID:28430840   PMID:28514442   PMID:28533407   PMID:28611094   PMID:28794006   PMID:28813667   PMID:29187405  
PMID:29507755   PMID:29511261   PMID:29568061   PMID:29656893   PMID:29845934   PMID:29997176   PMID:30021884   PMID:30033366   PMID:30087366   PMID:30196744   PMID:30217970   PMID:30404004  
PMID:30575522   PMID:30585729   PMID:30595551   PMID:30651555   PMID:30804502   PMID:30890647   PMID:31090264   PMID:31135261   PMID:31239290   PMID:31527615   PMID:31570834   PMID:31586073  
PMID:32203489   PMID:32367578   PMID:32416067   PMID:32694731   PMID:32990725   PMID:33005030  


Genomics

Comparative Map Data
MED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1739,404,285 - 39,451,272 (-)EnsemblGRCh38hg38GRCh38
GRCh381739,404,285 - 39,451,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,560,538 - 37,607,516 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371737,560,538 - 37,607,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,814,064 - 34,861,053 (-)NCBINCBI36hg18NCBI36
Build 341734,816,379 - 34,861,030NCBI
Celera1734,221,470 - 34,268,494 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,354,022 - 33,401,237 (-)NCBIHuRef
CHM1_11737,796,744 - 37,843,728 (-)NCBICHM1_1
Med1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,042,980 - 98,084,121 (-)NCBIGRCm39mm39
GRCm381198,152,154 - 98,193,313 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,152,154 - 98,193,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,013,468 - 98,054,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv361197,968,244 - 98,009,350 (-)NCBImm8
Celera11107,807,134 - 107,848,278 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Med1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,145,538 - 83,189,260 (-)NCBI
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01086,101,560 - 86,145,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01085,899,172 - 85,942,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,917,525 - 86,959,080 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1081,896,663 - 81,937,929 (-)NCBICelera
Cytogenetic Map10q31NCBI
Med1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,202,744 - 14,237,797 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,204,326 - 14,237,809 (-)NCBIChiLan1.0ChiLan1.0
MED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11718,050,250 - 18,096,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,050,474 - 18,095,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,836,350 - 17,883,610 (+)NCBIMhudiblu_PPA_v0panPan3
MED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl922,989,301 - 23,019,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1922,989,257 - 23,019,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Med1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649014,625,201 - 14,663,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,839,005 - 22,872,407 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,830,405 - 22,872,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,283,204 - 23,325,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,719,393 - 66,764,902 (+)NCBI
ChlSab1.1 Ensembl1666,719,423 - 66,762,896 (+)Ensembl
Med1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247953,572,025 - 3,605,675 (+)NCBI

Position Markers
SHGC-36242  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,560,893 - 37,561,020UniSTSGRCh37
Build 361734,814,419 - 34,814,546RGDNCBI36
Celera1734,221,825 - 34,221,952RGD
Cytogenetic Map17q12UniSTS
HuRef1733,354,377 - 33,354,504UniSTS
Stanford-G3 RH Map171460.0UniSTS
NCBI RH Map17464.7UniSTS
GeneMap99-G3 RH Map171961.0UniSTS
RH12583  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,560,659 - 37,560,833UniSTSGRCh37
Build 361734,814,185 - 34,814,359RGDNCBI36
Celera1734,221,591 - 34,221,765RGD
Cytogenetic Map17q12UniSTS
HuRef1733,354,143 - 33,354,317UniSTS
GeneMap99-GB4 RH Map17307.34UniSTS
NCBI RH Map17468.9UniSTS
RH79708  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,564,006 - 37,564,251UniSTSGRCh37
Build 361734,817,532 - 34,817,777RGDNCBI36
Celera1734,224,938 - 34,225,183RGD
Cytogenetic Map17q12UniSTS
HuRef1733,357,490 - 33,357,735UniSTS
GeneMap99-GB4 RH Map17303.45UniSTS
RH91484  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,561,954 - 37,562,084UniSTSGRCh37
Build 361734,815,480 - 34,815,610RGDNCBI36
Celera1734,222,886 - 34,223,016RGD
Cytogenetic Map17q12UniSTS
HuRef1733,355,438 - 33,355,568UniSTS
GeneMap99-GB4 RH Map17307.04UniSTS
G64397  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371265,259,522 - 65,259,713UniSTSGRCh37
Build 361263,545,789 - 63,545,980RGDNCBI36
Celera1264,924,990 - 64,925,181RGD
HuRef1733,363,983 - 33,364,270UniSTS
HuRef1262,310,331 - 62,310,522UniSTS
SGC32796  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,560,888 - 37,561,014UniSTSGRCh37
Build 361734,814,414 - 34,814,540RGDNCBI36
Celera1734,221,820 - 34,221,946RGD
Cytogenetic Map17q12UniSTS
HuRef1733,354,372 - 33,354,498UniSTS
GeneMap99-GB4 RH Map17309.33UniSTS
Whitehead-RH Map17330.7UniSTS
NCBI RH Map17506.0UniSTS
RH11014  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,561,792 - 37,561,973UniSTSGRCh37
Build 361734,815,318 - 34,815,499RGDNCBI36
Celera1734,222,724 - 34,222,905RGD
Cytogenetic Map17q12UniSTS
HuRef1733,355,276 - 33,355,457UniSTS
GeneMap99-GB4 RH Map17307.34UniSTS
NCBI RH Map17468.9UniSTS
RH47206  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,560,870 - 37,560,996UniSTSGRCh37
Build 361734,814,396 - 34,814,522RGDNCBI36
Celera1734,221,802 - 34,221,928RGD
Cytogenetic Map17q12UniSTS
HuRef1733,354,354 - 33,354,480UniSTS
GeneMap99-GB4 RH Map17307.34UniSTS
NCBI RH Map17468.9UniSTS
RH64892  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,564,057 - 37,564,181UniSTSGRCh37
Build 361734,817,583 - 34,817,707RGDNCBI36
Celera1734,224,989 - 34,225,113RGD
Cytogenetic Map17q12UniSTS
HuRef1733,357,541 - 33,357,665UniSTS
GeneMap99-GB4 RH Map17307.34UniSTS
NCBI RH Map17468.9UniSTS
MARC_12057-12058:1004548952:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371737,565,471 - 37,565,825UniSTSGRCh37
Build 361734,818,997 - 34,819,351RGDNCBI36
Celera1734,226,403 - 34,226,757RGD
HuRef1733,358,955 - 33,359,309UniSTS
PPARBP_2041  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef1733,356,325 - 33,357,214UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR205hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20065103
MIR205hsa-miR-205-5pMirecordsexternal_infoNANA20065103
MIR205hsa-miR-205-5pOncomiRDBexternal_infoNANA22869146

Predicted Target Of
Summary Value
Count of predictions:3426
Count of miRNA genes:1225
Interacting mature miRNAs:1559
Transcripts:ENST00000300651, ENST00000394287, ENST00000577831, ENST00000581334, ENST00000584308
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1143 777 525 111 915 82 2525 608 971 212 1062 964 43 752 1440 3
Low 1296 2191 1201 513 1016 383 1831 1586 2762 207 398 649 132 1 452 1348 3 2
Below cutoff 23 20 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_046996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005257465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC009283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF055994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF283812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP357374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L40366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000300651   ⟹   ENSP00000300651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,404,285 - 39,451,263 (-)Ensembl
RefSeq Acc Id: ENST00000394287   ⟹   ENSP00000377828
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,404,285 - 39,451,268 (-)Ensembl
RefSeq Acc Id: ENST00000577831   ⟹   ENSP00000463307
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,407,714 - 39,451,272 (-)Ensembl
RefSeq Acc Id: ENST00000581334   ⟹   ENSP00000462441
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,443,550 - 39,451,272 (-)Ensembl
RefSeq Acc Id: ENST00000584308
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1739,427,446 - 39,431,236 (-)Ensembl
RefSeq Acc Id: NM_004774   ⟹   NP_004765
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,404,285 - 39,451,263 (-)NCBI
GRCh371737,560,538 - 37,607,527 (-)ENTREZGENE
GRCh371737,560,538 - 37,607,527 (-)NCBI
Build 361734,814,064 - 34,861,053 (-)NCBI Archive
HuRef1733,354,022 - 33,401,237 (-)ENTREZGENE
CHM1_11737,796,744 - 37,843,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005257465   ⟹   XP_005257522
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,404,285 - 39,451,281 (-)NCBI
GRCh371737,560,538 - 37,607,527 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006721957   ⟹   XP_006722020
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,404,285 - 39,451,274 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017024779   ⟹   XP_016880268
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,404,285 - 39,451,265 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004765   ⟸   NM_004774
- UniProtKB: Q15648 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005257522   ⟸   XM_005257465
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006722020   ⟸   XM_006721957
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016880268   ⟸   XM_017024779
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000462441   ⟸   ENST00000581334
RefSeq Acc Id: ENSP00000463307   ⟸   ENST00000577831
RefSeq Acc Id: ENSP00000300651   ⟸   ENST00000300651
RefSeq Acc Id: ENSP00000377828   ⟸   ENST00000394287

Promoters
RGD ID:6794309
Promoter ID:HG_KWN:25985
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004774,   OTTHUMT00000256944
Position:
Human AssemblyChrPosition (strand)Source
Build 361734,860,806 - 34,861,306 (-)MPROMDB
RGD ID:7234831
Promoter ID:EPDNEW_H23161
Type:initiation region
Name:MED1_1
Description:mediator complex subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381739,451,262 - 39,451,322EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31		 pathogenic
GRCh38/hg38 17q12(chr17:39365569-39612092)x3 copy number gain See cases [RCV000054044] Chr17:39365569..39612092 [GRCh38]
Chr17:37521822..37768345 [GRCh37]
Chr17:34775348..35021871 [NCBI36]
Chr17:17q12		 uncertain significance
NM_004774.3(MED1):c.2545C>T (p.Pro849Ser) single nucleotide variant Malignant melanoma [RCV000071434] Chr17:39409676 [GRCh38]
Chr17:37565929 [GRCh37]
Chr17:34819455 [NCBI36]
Chr17:17q12		 not provided
NM_004774.3(MED1):c.2978G>A (p.Gly993Glu) single nucleotide variant Malignant melanoma [RCV000063202] Chr17:39409243 [GRCh38]
Chr17:37565496 [GRCh37]
Chr17:34819022 [NCBI36]
Chr17:17q12		 not provided
NM_004774.4(MED1):c.632T>G (p.Leu211Arg) single nucleotide variant Malignant tumor of prostate [RCV000149160] Chr17:39431132 [GRCh38]
Chr17:37587385 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:39036037-39694679)x3 copy number gain See cases [RCV000140753] Chr17:39036037..39694679 [GRCh38]
Chr17:37192290..37850932 [GRCh37]
Chr17:34445816..35104458 [NCBI36]
Chr17:17q12		 likely benign|uncertain significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17q12(chr17:37381717-37596822)x3 copy number gain See cases [RCV000445661] Chr17:37381717..37596822 [GRCh37]
Chr17:17q12		 benign
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q12(chr17:37313691-37868516)x3 copy number gain See cases [RCV000512247] Chr17:37313691..37868516 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q12(chr17:36972794-38033708)x4 copy number gain not provided [RCV000683933] Chr17:36972794..38033708 [GRCh37]
Chr17:17q12		 uncertain significance
NM_004774.4(MED1):c.3680C>T (p.Ser1227Leu) single nucleotide variant Intellectual disability [RCV001251837] Chr17:39408541 [GRCh38]
Chr17:37564794 [GRCh37]
Chr17:17q12		 likely benign
NM_004774.4(MED1):c.2195C>T (p.Thr732Met) single nucleotide variant Intellectual disability [RCV001251838] Chr17:39410026 [GRCh38]
Chr17:37566279 [GRCh37]
Chr17:17q12		 likely benign
NM_004774.4(MED1):c.1113G>T (p.Gln371His) single nucleotide variant Intellectual disability [RCV001251840] Chr17:39419901 [GRCh38]
Chr17:37576154 [GRCh37]
Chr17:17q12		 likely benign
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q12(chr17:37387413-37879941)x3 copy number gain not provided [RCV000739510] Chr17:37387413..37879941 [GRCh37]
Chr17:17q12		 benign
NM_004774.4(MED1):c.1053C>T (p.Asp351=) single nucleotide variant not provided [RCV000969684] Chr17:39423369 [GRCh38]
Chr17:37579622 [GRCh37]
Chr17:17q12		 benign
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2		 pathogenic
GRCh37/hg19 17q12(chr17:37190609-37868002)x3 copy number gain not provided [RCV000849616] Chr17:37190609..37868002 [GRCh37]
Chr17:17q12		 uncertain significance
NM_004774.4(MED1):c.638C>T (p.Pro213Leu) single nucleotide variant Intellectual disability [RCV001251839] Chr17:39431126 [GRCh38]
Chr17:37587379 [GRCh37]
Chr17:17q12		 likely benign
NM_004774.4(MED1):c.763G>A (p.Ala255Thr) single nucleotide variant Intellectual disability [RCV001251836] Chr17:39424715 [GRCh38]
Chr17:37580968 [GRCh37]
Chr17:17q12		 likely benign
NM_004774.4(MED1):c.429-7C>T single nucleotide variant Intellectual disability [RCV001251835] Chr17:39434327 [GRCh38]
Chr17:37590580 [GRCh37]
Chr17:17q12		 likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9234 AgrOrtholog
COSMIC MED1 COSMIC
Ensembl Genes ENSG00000125686 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000300651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377828 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000462441 UniProtKB/TrEMBL
  ENSP00000463307 UniProtKB/TrEMBL
Ensembl Transcript ENST00000300651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000394287 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000577831 UniProtKB/TrEMBL
  ENST00000581334 UniProtKB/TrEMBL
GTEx ENSG00000125686 GTEx
HGNC ID HGNC:9234 ENTREZGENE
Human Proteome Map MED1 Human Proteome Map
InterPro Mediator_Med1 UniProtKB/Swiss-Prot
KEGG Report hsa:5469 UniProtKB/Swiss-Prot
NCBI Gene 5469 ENTREZGENE
OMIM 604311 OMIM
Pfam Med1 UniProtKB/Swiss-Prot
PharmGKB PA33556 PharmGKB
UniProt J3KSD7_HUMAN UniProtKB/TrEMBL
  J3QKZ7_HUMAN UniProtKB/TrEMBL
  MED1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RRQ6 UniProtKB/Swiss-Prot
  O43810 UniProtKB/Swiss-Prot
  O75447 UniProtKB/Swiss-Prot
  Q6P9H7 UniProtKB/Swiss-Prot
  Q6PK58 UniProtKB/Swiss-Prot
  Q9HD39 UniProtKB/Swiss-Prot