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Gene: PDE5A (phosphodiesterase 5A) Homo sapiens
Symbol: PDE5A
Name: phosphodiesterase 5A
Description: Exhibits 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in several processes, including cGMP catabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Predicted to localize to cytosol. Implicated in IgA glomerulonephritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; CN5A; PDE5; PDE5A1; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5
Mus musculus (house mouse) : Pde5a (phosphodiesterase 5A, cGMP-specific)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pde5a (phosphodiesterase 5A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde5a (phosphodiesterase 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE5A (phosphodiesterase 5A)
Canis lupus familiaris (dog) : PDE5A (phosphodiesterase 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde5a (phosphodiesterase 5A)
Sus scrofa (pig) : PDE5A (phosphodiesterase 5A)
Chlorocebus sabaeus (African green monkey) : PDE5A (phosphodiesterase 5A)
Heterocephalus glaber (naked mole-rat) : Pde5a (phosphodiesterase 5A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4119,494,397 - 119,628,804 (-)EnsemblGRCh38hg38GRCh38
GRCh384119,494,395 - 119,628,804 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374120,415,550 - 120,549,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,634,998 - 120,769,429 (-)NCBINCBI36hg18NCBI36
Build 344120,777,035 - 120,907,578NCBI
Celera4117,795,077 - 117,929,505 (-)NCBI
Cytogenetic Map4q26NCBI
HuRef4116,136,584 - 116,271,133 (-)NCBIHuRef
CHM1_14120,392,140 - 120,526,523 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDE5A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732674
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.