LCN2 (lipocalin 2) - Rat Genome Database

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Gene: LCN2 (lipocalin 2) Homo sapiens
Analyze
Symbol: LCN2
Name: lipocalin 2
RGD ID: 69453
HGNC Page HGNC
Description: Exhibits enterobactin binding activity; identical protein binding activity; and iron ion binding activity. Involved in defense response to bacterium and sequestering of iron ion. Localizes to extracellular space. Biomarker of COVID-19; essential hypertension; hydronephrosis; hyperuricemia; and kidney disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin-2; migration-stimulating factor inhibitor; MSFI; neutrophil gelatinase-associated lipocalin; NGAL; oncogene 24p3; p25; siderocalin; siderocalin LCN2
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abscess  (ISO)
acute cystitis  (IEP)
acute kidney failure  (EXP,IEP,ISO)
adult respiratory distress syndrome  (EXP)
amyotrophic lateral sclerosis  (ISO)
Animal Hepatitis  (EXP)
autosomal dominant polycystic kidney disease  (IEP)
beta thalassemia  (EXP)
Brain Injuries, Traumatic  (ISO)
calcinosis  (EXP)
celiac disease  (EXP)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Chlamydophila Infections  (ISO)
chronic kidney disease  (EXP,ISO)
colon cancer  (ISO)
congenital diaphragmatic hernia  (IEP,ISO)
congenital disorder of glycosylation Iu  (IAGP)
contact dermatitis  (EXP)
Contrast-Induced Nephropathy  (ISO)
COVID-19  (IEP)
developmental and epileptic encephalopathy  (IAGP)
developmental and epileptic encephalopathy 31  (IAGP)
Diabetic Nephropathies  (IEP,ISO)
disease of cellular proliferation  (EXP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
early infantile epileptic encephalopathy  (IAGP)
end stage renal disease  (IEP)
Endotoxemia  (ISO)
Escherichia Coli Infections  (ISO)
essential hypertension  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Haemophilus Infections  (ISO)
heart valve disease  (EXP)
Helicobacter Infections  (IEP)
hidradenitis suppurativa  (IEP)
hydronephrosis  (IEP)
hyperuricemia  (IEP)
IgA glomerulonephritis  (IEP)
Inflammation  (EXP)
intrahepatic cholangiocarcinoma  (IEP,ISO)
kidney disease  (EXP,IEP)
Kidney Reperfusion Injury  (IEP,ISO)
Klebsiella pneumonia  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (EXP)
obesity  (IEP,ISO)
oral candidiasis  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (IEP)
primary coenzyme Q10 deficiency 7  (IAGP)
pulmonary hypertension  (IEP,ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries, Experimental  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
renovascular hypertension  (IEP)
retinal degeneration  (ISO)
rheumatoid arthritis  (EXP)
Sepsis  (ISO)
Streptococcal Infections  (ISO)
Stroke  (IEP)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IEP)
urinary tract infection  (IDA,IEP,ISO)
uveitis  (ISO)
West Nile encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (EXP)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (ISO)
Actein  (ISO)
adefovir  (ISO)
adefovir pivoxil  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
amphotericin B methyl ester  (ISO)
anthocyanin  (ISO)
aristolochic acid  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP,ISO)
cerium trichloride  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyanuric acid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dapagliflozin  (ISO)
decabromodiphenyl ether  (ISO)
deferasirox  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
enilconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
fluconazole  (ISO)
folic acid  (ISO)
fragrance  (EXP)
fructose  (ISO)
furan  (ISO)
gefitinib  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glafenine  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hydroquinone  (EXP)
iomeprol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isocyanuric acid  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ketoconazole  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
maleic acid  (ISO)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (EXP)
melamine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
Natamycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
nystatin  (ISO)
ochratoxin A  (ISO)
Ondansetron  (ISO)
ozone  (ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (EXP)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quartz  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
zoledronic acid  (EXP)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA,ISO)
apoptotic process  (IEA)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to increased oxygen levels  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to nutrient levels  (ISO)
cellular response to oxygen-glucose deprivation  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to X-ray  (ISO)
defense response to bacterium  (IDA)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
innate immune response  (ISS)
long-term memory  (ISO)
negative regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell projection organization  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of endothelial tube morphogenesis  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of iron ion import across plasma membrane  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of neuron death  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
response to bacterium  (ISO)
response to blue light  (IEA,ISO)
response to drug  (IEA,ISO)
response to fructose  (ISO)
response to herbicide  (IEA,ISO)
response to iron(II) ion  (IEA,ISO)
response to mycotoxin  (IEA,ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to toxic substance  (ISO)
response to virus  (ISO)
sequestering of iron ion  (IDA)
short-term memory  (ISO)
siderophore transport  (ISS)

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
extracellular exosome  (HDA)
extracellular region  (HDA,IEA,ISS,TAS)
extracellular space  (HDA,IBA,IDA,ISO)
specific granule lumen  (TAS)

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1281792   PMID:7554268   PMID:7683678   PMID:7829063   PMID:7835423   PMID:7997842   PMID:8060329   PMID:8195592   PMID:8633182   PMID:8889548   PMID:9339356   PMID:9842963  
PMID:10339412   PMID:10475571   PMID:10529240   PMID:10684642   PMID:10737800   PMID:10777108   PMID:11486081   PMID:11986950   PMID:12473066   PMID:12477932   PMID:15084671   PMID:15342556  
PMID:15489334   PMID:15637066   PMID:15670845   PMID:15691834   PMID:15711640   PMID:16060857   PMID:16061852   PMID:16146540   PMID:16254208   PMID:16335952   PMID:16374475   PMID:16381001  
PMID:16502470   PMID:16671099   PMID:16733850   PMID:16740002   PMID:16798734   PMID:16827865   PMID:17114340   PMID:17229907   PMID:17253959   PMID:17294443   PMID:17360238   PMID:17530720  
PMID:17554627   PMID:17570904   PMID:17721627   PMID:17847728   PMID:17874137   PMID:17901710   PMID:17907186   PMID:17949711   PMID:18001501   PMID:18029348   PMID:18064607   PMID:18070344  
PMID:18275504   PMID:18287807   PMID:18317594   PMID:18337554   PMID:18362300   PMID:18375251   PMID:18392050   PMID:18393169   PMID:18398717   PMID:18437016   PMID:18464118   PMID:18600028  
PMID:18663364   PMID:18676832   PMID:18710473   PMID:18753796   PMID:18768801   PMID:18798264   PMID:18803290   PMID:18809975   PMID:18852336   PMID:18927283   PMID:19015448   PMID:19055468  
PMID:19056867   PMID:19092815   PMID:19148153   PMID:19148711   PMID:19176795   PMID:19201208   PMID:19237579   PMID:19249501   PMID:19249502   PMID:19287180   PMID:19308044   PMID:19321980  
PMID:19419554   PMID:19454345   PMID:19466389   PMID:19474273   PMID:19540040   PMID:19549696   PMID:19638718   PMID:19649660   PMID:19661117   PMID:19680166   PMID:19708926   PMID:19714584  
PMID:19732769   PMID:19850388   PMID:19857721   PMID:19863663   PMID:19875582   PMID:19887608   PMID:19889214   PMID:19904630   PMID:19938135   PMID:19951994   PMID:20030526   PMID:20056755  
PMID:20068352   PMID:20072790   PMID:20086155   PMID:20101218   PMID:20123318   PMID:20179686   PMID:20208456   PMID:20306447   PMID:20332347   PMID:20363104   PMID:20373132   PMID:20412947  
PMID:20435938   PMID:20496473   PMID:20502037   PMID:20504246   PMID:20504881   PMID:20511727   PMID:20512104   PMID:20527084   PMID:20551266   PMID:20559153   PMID:20587610   PMID:20596614  
PMID:20620526   PMID:20628624   PMID:20680102   PMID:20703446   PMID:20802417   PMID:20819195   PMID:20853162   PMID:20870707   PMID:20960272   PMID:20961744   PMID:21030534   PMID:21031541  
PMID:21048034   PMID:21104585   PMID:21115620   PMID:21132267   PMID:21133718   PMID:21150136   PMID:21160226   PMID:21184133   PMID:21257679   PMID:21273640   PMID:21278918   PMID:21300375  
PMID:21307379   PMID:21334721   PMID:21403867   PMID:21412214   PMID:21420718   PMID:21439274   PMID:21442621   PMID:21457438   PMID:21463871   PMID:21511111   PMID:21518160   PMID:21545264  
PMID:21555394   PMID:21573795   PMID:21576334   PMID:21612443   PMID:21622717   PMID:21649922   PMID:21691251   PMID:21723753   PMID:21726963   PMID:21740336   PMID:21741997   PMID:21756081  
PMID:21756891   PMID:21763306   PMID:21836143   PMID:21836147   PMID:21855366   PMID:21872946   PMID:21873635   PMID:21874256   PMID:21885675   PMID:21947917   PMID:21978028   PMID:21986252  
PMID:22035911   PMID:22123561   PMID:22164937   PMID:22169111   PMID:22172816   PMID:22200895   PMID:22200942   PMID:22222228   PMID:22222353   PMID:22226205   PMID:22237710   PMID:22251225  
PMID:22291019   PMID:22292925   PMID:22325322   PMID:22340728   PMID:22371224   PMID:22371904   PMID:22404749   PMID:22441986   PMID:22469622   PMID:22500106   PMID:22505707   PMID:22515481  
PMID:22529161   PMID:22537138   PMID:22559235   PMID:22562534   PMID:22640376   PMID:22664934   PMID:22695331   PMID:22705926   PMID:22707293   PMID:22710694   PMID:22723447   PMID:22724477  
PMID:22728279   PMID:22749388   PMID:22767506   PMID:22800509   PMID:22811364   PMID:22820397   PMID:22835414   PMID:22851691   PMID:22876548   PMID:22876549   PMID:22928018   PMID:22932106  
PMID:22950345   PMID:22965758   PMID:22976261   PMID:22982376   PMID:23020231   PMID:23056218   PMID:23056397   PMID:23100449   PMID:23128339   PMID:23146921   PMID:23150684   PMID:23150981  
PMID:23167703   PMID:23179203   PMID:23207546   PMID:23242471   PMID:23318563   PMID:23327592   PMID:23332549   PMID:23343559   PMID:23344473   PMID:23349979   PMID:23376114   PMID:23376485  
PMID:23389669   PMID:23391290   PMID:23396290   PMID:23402494   PMID:23403985   PMID:23406465   PMID:23426707   PMID:23439619   PMID:23533145   PMID:23554037   PMID:23568978   PMID:23580616  
PMID:23627612   PMID:23633156   PMID:23668802   PMID:23668886   PMID:23684135   PMID:23696034   PMID:23712081   PMID:23726574   PMID:23735150   PMID:23736029   PMID:23754672   PMID:23775308  
PMID:23799122   PMID:23799980   PMID:23825078   PMID:23838135   PMID:23838697   PMID:23863624   PMID:23936859   PMID:23940770   PMID:23964619   PMID:23972287   PMID:23988549   PMID:24009223  
PMID:24022330   PMID:24052155   PMID:24052978   PMID:24054338   PMID:24060429   PMID:24118080   PMID:24123926   PMID:24133923   PMID:24149112   PMID:24165570   PMID:24172823   PMID:24182633  
PMID:24199457   PMID:24214285   PMID:24235082   PMID:24239146   PMID:24240113   PMID:24262504   PMID:24295718   PMID:24295734   PMID:24305547   PMID:24308223   PMID:24316309   PMID:24321290  
PMID:24325180   PMID:24359145   PMID:24375576   PMID:24383284   PMID:24384771   PMID:24390241   PMID:24391115   PMID:24395189   PMID:24438378   PMID:24475761   PMID:24480182   PMID:24491219  
PMID:24508993   PMID:24518531   PMID:24518829   PMID:24528623   PMID:24530115   PMID:24550181   PMID:24568505   PMID:24579085   PMID:24613364   PMID:24634297   PMID:24651681   PMID:24673459  
PMID:24687388   PMID:24721803   PMID:24742531   PMID:24755339   PMID:24764155   PMID:24801557   PMID:24803721   PMID:24804935   PMID:24821156   PMID:24851612   PMID:24885531   PMID:24920892  
PMID:24930480   PMID:24954627   PMID:24963810   PMID:24969771   PMID:24980968   PMID:24981860   PMID:24985156   PMID:25011070   PMID:25019387   PMID:25023056   PMID:25027586   PMID:25029806  
PMID:25040147   PMID:25049066   PMID:25066815   PMID:25088407   PMID:25112732   PMID:25153411   PMID:25195004   PMID:25199807   PMID:25205293   PMID:25283849   PMID:25284002   PMID:25311702  
PMID:25324306   PMID:25329716   PMID:25343379   PMID:25366893   PMID:25392341   PMID:25400814   PMID:25402375   PMID:25407832   PMID:25424376   PMID:25426620   PMID:25444221   PMID:25449518  
PMID:25473804   PMID:25479470   PMID:25509695   PMID:25522256   PMID:25531230   PMID:25542236   PMID:25566710   PMID:25591790   PMID:25599738   PMID:25607262   PMID:25611655   PMID:25645918  
PMID:25662930   PMID:25670719   PMID:25684463   PMID:25685783   PMID:25699275   PMID:25727405   PMID:25728945   PMID:25762211   PMID:25778333   PMID:25790277   PMID:25806716   PMID:25814363  
PMID:25832128   PMID:25861985   PMID:25864997   PMID:25890435   PMID:25893429   PMID:25894565   PMID:25895828   PMID:25919009   PMID:25936881   PMID:25939604   PMID:25940797   PMID:25943992  
PMID:25944130   PMID:25987661   PMID:25995665   PMID:25995666   PMID:26021263   PMID:26022238   PMID:26053382   PMID:26069091   PMID:26116587   PMID:26125566   PMID:26161663   PMID:26163623  
PMID:26186194   PMID:26190820   PMID:26200468   PMID:26212793   PMID:26259977   PMID:26266256   PMID:26278055   PMID:26296821   PMID:26324091   PMID:26350099   PMID:26350566   PMID:26351381  
PMID:26367277   PMID:26390966   PMID:26393328   PMID:26464627   PMID:26491688   PMID:26573874   PMID:26584598   PMID:26603784   PMID:26626454   PMID:26627016   PMID:26627265   PMID:26629810  
PMID:26632077   PMID:26635366   PMID:26673824   PMID:26682726   PMID:26702876   PMID:26729415   PMID:26745339   PMID:26757915   PMID:26773532   PMID:26810191   PMID:26840566   PMID:26849631  
PMID:26900638   PMID:26947538   PMID:26968114   PMID:26973291   PMID:26979478   PMID:27002756   PMID:27012045   PMID:27020372   PMID:27038000   PMID:27052061   PMID:27062515   PMID:27068509  
PMID:27161323   PMID:27166308   PMID:27168162   PMID:27173435   PMID:27175937   PMID:27194339   PMID:27207653   PMID:27251223   PMID:27288617   PMID:27288631   PMID:27339395   PMID:27353364  
PMID:27359090   PMID:27427417   PMID:27439687   PMID:27505067   PMID:27538670   PMID:27562389   PMID:27590891   PMID:27602760   PMID:27605390   PMID:27614682   PMID:27658322   PMID:27667450  
PMID:27680774   PMID:27716662   PMID:27744618   PMID:27771693   PMID:27780864   PMID:27782193   PMID:27787615   PMID:27796299   PMID:27819647   PMID:27836304   PMID:27862029   PMID:27863382  
PMID:27907168   PMID:27912767   PMID:27997859   PMID:28004483   PMID:28026019   PMID:28049882   PMID:28061889   PMID:28068947   PMID:28116808   PMID:28128223   PMID:28142264   PMID:28164508  
PMID:28207778   PMID:28210838   PMID:28249896   PMID:28255266   PMID:28255975   PMID:28279688   PMID:28324833   PMID:28338909   PMID:28342790   PMID:28389813   PMID:28397074   PMID:28409285  
PMID:28419138   PMID:28424824   PMID:28430754   PMID:28445241   PMID:28467300   PMID:28482803   PMID:28514442   PMID:28522674   PMID:28545169   PMID:28575880   PMID:28581123   PMID:28583565  
PMID:28615213   PMID:28616656   PMID:28620620   PMID:28628361   PMID:28672747   PMID:28674715   PMID:28701593   PMID:28723856   PMID:28737526   PMID:28742104   PMID:28768458   PMID:28845433  
PMID:28859238   PMID:28943289   PMID:28954270   PMID:28958144   PMID:28980274   PMID:28988230   PMID:29033359   PMID:29073812   PMID:29082525   PMID:29098164   PMID:29098551   PMID:29100016  
PMID:29108879   PMID:29120575   PMID:29131707   PMID:29190605   PMID:29219172   PMID:29294226   PMID:29300232   PMID:29304747   PMID:29321030   PMID:29373174   PMID:29395573   PMID:29461590  
PMID:29473202   PMID:29509190   PMID:29528011   PMID:29532235   PMID:29533691   PMID:29550798   PMID:29572184   PMID:29580282   PMID:29602770   PMID:29673928   PMID:29749246   PMID:29782286  
PMID:29791495   PMID:29803740   PMID:29869714   PMID:29893703   PMID:29909502   PMID:29915849   PMID:29920228   PMID:29952418   PMID:29960862   PMID:30035656   PMID:30078006   PMID:30138675  
PMID:30174216   PMID:30221676   PMID:30257107   PMID:30268479   PMID:30284299   PMID:30308516   PMID:30325973   PMID:30424752   PMID:30504384   PMID:30511581   PMID:30513528   PMID:30533430  
PMID:30537724   PMID:30639197   PMID:30684630   PMID:30686015   PMID:30746716   PMID:30771300   PMID:30782844   PMID:30805373   PMID:30817778   PMID:30829613   PMID:30920848   PMID:30953748  
PMID:31035493   PMID:31062866   PMID:31078634   PMID:31090234   PMID:31092002   PMID:31115219   PMID:31129920   PMID:31140344   PMID:31147821   PMID:31162999   PMID:31164272   PMID:31175848  
PMID:31177884   PMID:31215304   PMID:31220528   PMID:31232043   PMID:31233712   PMID:31276730   PMID:31329371   PMID:31346523   PMID:31375084   PMID:31385242   PMID:31387110   PMID:31393997  
PMID:31414756   PMID:31422117   PMID:31461349   PMID:31500632   PMID:31601879   PMID:31606750   PMID:31615452   PMID:31639734   PMID:31653278   PMID:31676986   PMID:31729643   PMID:31772326  
PMID:31872282   PMID:31901947   PMID:31932215   PMID:31979726   PMID:31979742   PMID:32013365   PMID:32031713   PMID:32075600   PMID:32091174   PMID:32100329   PMID:32111073   PMID:32170733  
PMID:32174064   PMID:32184218   PMID:32198716   PMID:32207310   PMID:32222802   PMID:32296183   PMID:32304694   PMID:32307375   PMID:32369618   PMID:32441176   PMID:32457335   PMID:32479185  
PMID:32487561   PMID:32568173   PMID:32575507   PMID:32623432   PMID:32639539   PMID:32685458   PMID:32692467   PMID:32766690   PMID:32856853   PMID:32968110   PMID:32980390   PMID:33052454  
PMID:33119655   PMID:33184413   PMID:33214636   PMID:33231171   PMID:33242255   PMID:33277533   PMID:33548981   PMID:33796899   PMID:33799862   PMID:33824339   PMID:33832138  


Genomics

Comparative Map Data
LCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
Lcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)Ensembl
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIGRCm37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBImm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Lcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2315,680,688 - 15,684,033 (-)NCBI
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Celera310,423,569 - 10,426,914 (-)NCBICelera
Cytogenetic Map3p12NCBI
LCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19127,940,799 - 127,944,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0panPan3
LCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,328,118 - 55,342,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,328,133 - 55,332,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,522,898 - 54,537,231 (-)NCBI
ROS_Cfam_1.0956,250,316 - 56,264,670 (-)NCBI
UMICH_Zoey_3.1955,010,191 - 55,024,522 (-)NCBI
UNSW_CanFamBas_1.0955,324,906 - 55,339,237 (-)NCBI
UU_Cfam_GSD_1.0955,416,588 - 55,430,934 (-)NCBI
Lcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,953,204 - 195,956,869 (+)NCBI
SpeTri2.0NW_00493648715,721,752 - 15,725,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11268,609,975 - 268,614,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,600,679 - 302,609,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,976,278 - 9,981,087 (-)NCBI
ChlSab1.1 Ensembl129,976,614 - 9,980,870 (-)Ensembl
Vero_WHO_p1.0NW_0236660796,251,600 - 6,256,754 (+)NCBI

Position Markers
RH93784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379130,914,190 - 130,914,488UniSTSGRCh37
Build 369129,954,011 - 129,954,309RGDNCBI36
Celera9101,565,082 - 101,565,380RGD
Cytogenetic Map9q34UniSTS
HuRef9100,527,860 - 100,528,158UniSTS
GeneMap99-GB4 RH Map9389.68UniSTS
PMC152639P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379130,914,475 - 130,914,559UniSTSGRCh37
Build 369129,954,296 - 129,954,380RGDNCBI36
Celera9101,565,367 - 101,565,451RGD
Cytogenetic Map9q34UniSTS
HuRef9100,528,145 - 100,528,229UniSTS
STS-X99133  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379130,915,401 - 130,915,580UniSTSGRCh37
Build 369129,955,222 - 129,955,401RGDNCBI36
Celera9101,566,293 - 101,566,472RGD
Cytogenetic Map9q34UniSTS
HuRef9100,529,071 - 100,529,250UniSTS
GeneMap99-GB4 RH Map9389.89UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3345
Count of miRNA genes:801
Interacting mature miRNAs:987
Transcripts:ENST00000277480, ENST00000372998, ENST00000373013, ENST00000373017, ENST00000470902, ENST00000487719, ENST00000488391, ENST00000494317, ENST00000540948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 68 127 6 76 133 6 4 1 5 83 17 72
Medium 679 638 433 283 908 195 584 56 116 120 470 747 97 36 257
Low 990 906 1141 241 228 240 2003 805 1314 186 627 735 4 1 716 1176 1 2
Below cutoff 656 1196 132 21 151 21 1582 1224 2099 89 259 76 430 1234 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK301694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW778875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF354583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM977724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP272828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX644845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA454137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU644752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  N79823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S75256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000277480   ⟹   ENSP00000277480
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,149,453 - 128,153,453 (+)Ensembl
RefSeq Acc Id: ENST00000372998   ⟹   ENSP00000362089
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,149,518 - 128,153,139 (+)Ensembl
RefSeq Acc Id: ENST00000373017   ⟹   ENSP00000362108
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,149,071 - 128,153,133 (+)Ensembl
RefSeq Acc Id: ENST00000470902
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,149,441 - 128,153,453 (+)Ensembl
RefSeq Acc Id: ENST00000487719
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,149,472 - 128,150,609 (+)Ensembl
RefSeq Acc Id: ENST00000488391
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,151,500 - 128,153,328 (+)Ensembl
RefSeq Acc Id: ENST00000494317
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,151,669 - 128,153,453 (+)Ensembl
RefSeq Acc Id: NM_005564   ⟹   NP_005555
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389128,149,453 - 128,153,453 (+)NCBI
GRCh379130,911,732 - 130,915,734 (+)ENTREZGENE
Build 369129,951,553 - 129,955,555 (+)NCBI Archive
HuRef9100,525,402 - 100,529,404 (+)ENTREZGENE
CHM1_19131,062,719 - 131,066,744 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005555   ⟸   NM_005564
- Peptide Label: precursor
- UniProtKB: P80188 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000362089   ⟸   ENST00000372998
RefSeq Acc Id: ENSP00000362108   ⟸   ENST00000373017
RefSeq Acc Id: ENSP00000277480   ⟸   ENST00000277480
Protein Domains
Lipocln_cytosolic_FA-bd_dom

Promoters
RGD ID:7216249
Promoter ID:EPDNEW_H13871
Type:initiation region
Name:LCN2_1
Description:lipocalin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13870  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389128,149,453 - 128,149,513EPDNEW
RGD ID:6807839
Promoter ID:HG_KWN:65099
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000372998,   ENST00000373013,   ENST00000373017,   NM_005564,   OTTHUMT00000054376,   UC010MXQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369129,951,106 - 129,951,606 (+)MPROMDB
RGD ID:6807837
Promoter ID:HG_KWN:65100
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:OTTHUMT00000054377,   OTTHUMT00000054378
Position:
Human AssemblyChrPosition (strand)Source
Build 369129,952,676 - 129,953,176 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:122792658-138124532)x3 copy number gain See cases [RCV000051040] Chr9:122792658..138124532 [GRCh38]
Chr9:125554937..141018984 [GRCh37]
Chr9:124594758..140138805 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q33.3-34.11(chr9:125993583-129682375)x1 copy number loss See cases [RCV000052923] Chr9:125993583..129682375 [GRCh38]
Chr9:128755862..132444654 [GRCh37]
Chr9:127795683..131484475 [NCBI36]
Chr9:9q33.3-34.11
pathogenic
GRCh38/hg38 9q34.11(chr9:127874581-130421811)x1 copy number loss See cases [RCV000052934] Chr9:127874581..130421811 [GRCh38]
Chr9:130636860..133297198 [GRCh37]
Chr9:129676681..132287019 [NCBI36]
Chr9:9q34.11
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q34.11(chr9:127919476-130079974)x3 copy number gain See cases [RCV000053777] Chr9:127919476..130079974 [GRCh38]
Chr9:130681755..132842253 [GRCh37]
Chr9:129721576..131882074 [NCBI36]
Chr9:9q34.11
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q33.3-34.11(chr9:125055865-128637946)x1 copy number loss See cases [RCV000137787] Chr9:125055865..128637946 [GRCh38]
Chr9:127818144..131400225 [GRCh37]
Chr9:126857965..130440046 [NCBI36]
Chr9:9q33.3-34.11
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q33.3-34.3(chr9:128652785-141044751)x3 copy number gain See cases [RCV000447080] Chr9:128652785..141044751 [GRCh37]
Chr9:9q33.3-34.3
pathogenic
GRCh37/hg19 9q34.11(chr9:130390139-132760275)x1 copy number loss See cases [RCV000445837] Chr9:130390139..132760275 [GRCh37]
Chr9:9q34.11
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q33.2-34.3(chr9:124642754-141146461)x3 copy number gain See cases [RCV000448784] Chr9:124642754..141146461 [GRCh37]
Chr9:9q33.2-34.3
pathogenic
NM_005564.5(LCN2):c.356-15C>G single nucleotide variant not specified [RCV000454689] Chr9:128151891 [GRCh38]
Chr9:130914170 [GRCh37]
Chr9:9q34.11
benign
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NC_000009.11:g.(?_130911805)_(131302617_?)dup duplication Coenzyme Q10 deficiency, primary, 7 [RCV000708297] Chr9:128149526..128540338 [GRCh38]
Chr9:130911805..131302617 [GRCh37]
Chr9:9q34.11
uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q33.3-34.12(chr9:129370440-133866894)x1 copy number loss not provided [RCV000748671] Chr9:129370440..133866894 [GRCh37]
Chr9:9q33.3-34.12
pathogenic
GRCh37/hg19 9q33.3-34.11(chr9:129522693-131410039)x1 copy number loss not provided [RCV000748677] Chr9:129522693..131410039 [GRCh37]
Chr9:9q33.3-34.11
benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_005564.5(LCN2):c.355+8T>C single nucleotide variant not provided [RCV000906726] Chr9:128151725 [GRCh38]
Chr9:130914004 [GRCh37]
Chr9:9q34.11
benign
NM_005564.5(LCN2):c.356-3C>A single nucleotide variant not provided [RCV000906727] Chr9:128151903 [GRCh38]
Chr9:130914182 [GRCh37]
Chr9:9q34.11
benign
NM_005564.5(LCN2):c.371C>T (p.Thr124Met) single nucleotide variant not provided [RCV000906728] Chr9:128151921 [GRCh38]
Chr9:130914200 [GRCh37]
Chr9:9q34.11
benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_005564.5(LCN2):c.93A>G (p.Pro31=) single nucleotide variant not provided [RCV000930329] Chr9:128149618 [GRCh38]
Chr9:130911897 [GRCh37]
Chr9:9q34.11
likely benign
NC_000009.12:g.(?_127612384)_(128566997_?)del deletion Coenzyme Q10 deficiency, primary, 7 [RCV001387712]|Early infantile epileptic encephalopathy with suppression bursts [RCV000819894] Chr9:127612384..128566997 [GRCh38]
Chr9:130374663..131329276 [GRCh37]
Chr9:9q34.11
pathogenic|uncertain significance
NC_000009.11:g.(?_130216797)_(130953151_?)dup duplication Congenital disorder of glycosylation type 1u [RCV000821291] Chr9:127454518..128190872 [GRCh38]
Chr9:130216797..130953151 [GRCh37]
Chr9:9q33.3-34.11
uncertain significance
NM_005564.5(LCN2):c.26G>T (p.Gly9Val) single nucleotide variant not provided [RCV000961058] Chr9:128149551 [GRCh38]
Chr9:130911830 [GRCh37]
Chr9:9q34.11
likely benign
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
NM_005564.5(LCN2):c.139-9C>A single nucleotide variant not provided [RCV000879017] Chr9:128150229 [GRCh38]
Chr9:130912508 [GRCh37]
Chr9:9q34.11
likely benign
NC_000009.12:g.(?_127815672)_(128541180_?)del deletion not provided [RCV001032461] Chr9:130577951..131303459 [GRCh37]
Chr9:9q34.11
pathogenic
NC_000009.11:g.(?_130374663)_(131329276_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV001304269] Chr9:130374663..131329276 [GRCh37]
Chr9:9q34.11
uncertain significance
GRCh37/hg19 9q34.11(chr9:130412438-131423964)x1 copy number loss Infantile epilepsy syndrome [RCV001265154] Chr9:130412438..131423964 [GRCh37]
Chr9:9q34.11
pathogenic
NC_000009.11:g.(?_129376729)_(131016993_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV001383155]|Epileptic encephalopathy, early infantile, 31 [RCV001364955] Chr9:129376729..131016993 [GRCh37]
Chr9:9q33.3-34.11
pathogenic|uncertain significance
NC_000009.11:g.(?_130216797)_(130953151_?)dup duplication Congenital disorder of glycosylation type 1u [RCV001323033] Chr9:130216797..130953151 [GRCh37]
Chr9:9q33.3-34.11
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6526 AgrOrtholog
COSMIC LCN2 COSMIC
Ensembl Genes ENSG00000148346 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000277480 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000362089 UniProtKB/TrEMBL
  ENSP00000362108 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000277480 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000372998 UniProtKB/TrEMBL
  ENST00000373017 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000148346 GTEx
HGNC ID HGNC:6526 ENTREZGENE
Human Proteome Map LCN2 Human Proteome Map
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCN2/LCN12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3934 UniProtKB/Swiss-Prot
NCBI Gene 3934 ENTREZGENE
OMIM 600181 OMIM
PANTHER PTHR11430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LCN2 RGD, PharmGKB
PRINTS NGELATINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NGAL_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  X6R8F3_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6NII8 UniProtKB/Swiss-Prot
  B4DWV4 UniProtKB/Swiss-Prot
  B7ZAA2 UniProtKB/Swiss-Prot
  P30150 UniProtKB/Swiss-Prot
  Q5SYV9 UniProtKB/Swiss-Prot
  Q5SYW0 UniProtKB/Swiss-Prot
  Q6FGL5 UniProtKB/Swiss-Prot
  Q92683 UniProtKB/Swiss-Prot