LCN2 (lipocalin 2) - Rat Genome Database

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Gene: LCN2 (lipocalin 2) Homo sapiens
Analyze
Symbol: LCN2
Name: lipocalin 2
RGD ID: 69453
HGNC Page HGNC:6526
Description: Enables several functions, including enterobactin binding activity; identical protein binding activity; and iron ion sequestering activity. Involved in defense response to bacterium. Located in extracellular space. Implicated in urinary tract infection. Biomarker of several diseases, including congenital diaphragmatic hernia; hidradenitis suppurativa; hydronephrosis; hypertension (multiple); and kidney disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin-2; migration-stimulating factor inhibitor; MSFI; neutrophil gelatinase-associated lipocalin; NGAL; oncogene 24p3; p25; siderocalin; siderocalin LCN2
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abscess  (ISO)
acute cystitis  (IEP)
acute kidney failure  (EXP,IEP,ISO)
adult respiratory distress syndrome  (EXP)
amyotrophic lateral sclerosis  (ISO)
Animal Hepatitis  (EXP)
autosomal dominant polycystic kidney disease  (IEP)
beta thalassemia  (EXP)
calcinosis  (EXP)
celiac disease  (EXP)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Chlamydophila Infections  (ISO)
chronic kidney disease  (EXP,ISO)
colon cancer  (ISO)
congenital diaphragmatic hernia  (IEP,ISO)
congenital disorder of glycosylation Iu  (IAGP)
contact dermatitis  (EXP)
Contrast-Induced Nephropathy  (ISO)
COVID-19  (IEP)
developmental and epileptic encephalopathy  (IAGP)
developmental and epileptic encephalopathy 31A  (IAGP)
Diabetic Nephropathies  (IEP,ISO)
disease of cellular proliferation  (EXP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
early infantile epileptic encephalopathy  (IAGP)
end stage renal disease  (IEP)
Endotoxemia  (ISO)
Escherichia Coli Infections  (ISO)
essential hypertension  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Radiation Injuries  (ISO)
genetic disease  (IAGP)
Haemophilus Infections  (ISO)
heart valve disease  (EXP)
Helicobacter Infections  (IEP)
hidradenitis suppurativa  (IEP)
hydronephrosis  (IEP)
hyperuricemia  (IEP)
IgA glomerulonephritis  (IEP)
Inflammation  (EXP)
intrahepatic cholangiocarcinoma  (IEP,ISO)
kidney disease  (EXP,IEP)
Kidney Reperfusion Injury  (IEP,ISO)
Klebsiella pneumonia  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (EXP)
obesity  (IEP,ISO)
oral candidiasis  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (IEP)
primary coenzyme Q10 deficiency 7  (IAGP)
pulmonary hypertension  (IEP,ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
renovascular hypertension  (IEP)
retinal degeneration  (ISO)
rheumatoid arthritis  (EXP)
Sepsis  (ISO)
Streptococcal Infections  (ISO)
Stroke  (IEP)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (IEP)
urinary tract infection  (IDA,IEP,ISO)
uveitis  (ISO)
West Nile encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (EXP)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (ISO)
Actein  (ISO)
adefovir  (ISO)
adefovir pivoxil  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
agomelatine  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
amphotericin B  (EXP)
amphotericin B methyl ester  (ISO)
anthocyanin  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (EXP,ISO)
carbon nanotube  (ISO)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyanuric acid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dapagliflozin  (ISO)
decabromodiphenyl ether  (ISO)
deferasirox  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
ferrostatin-1  (ISO)
fluconazole  (ISO)
folic acid  (ISO)
fragrance  (EXP)
fructose  (ISO)
furan  (ISO)
gefitinib  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glafenine  (ISO)
glucose  (ISO)
glycidol  (ISO)
glycidyl methacrylate  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hydroquinone  (EXP)
iomeprol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isocyanuric acid  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
maleic acid  (ISO)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (EXP)
melamine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
natamycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
nystatin  (ISO)
ochratoxin A  (ISO)
Ondansetron  (ISO)
ozone  (EXP,ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propanal  (EXP)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
Rhynchophylline  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tannic acid  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vanillin  (ISO)
vildagliptin  (ISO)
vinclozolin  (ISO)
xylazine  (ISO)
zoledronic acid  (EXP)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
apoptotic process  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to increased oxygen levels  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to X-ray  (ISO)
defense response to bacterium  (IDA)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
immune system process  (IEA)
innate immune response  (IEA,ISS)
iron ion transport  (IEA)
long-term memory  (ISO)
monoatomic ion transport  (IEA)
negative regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell projection organization  (ISO)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of iron ion import across plasma membrane  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
response to bacterium  (ISO)
response to blue light  (ISO)
response to fructose  (ISO)
response to herbicide  (ISO)
response to iron(II) ion  (ISO)
response to kainic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to toxic substance  (ISO)
response to virus  (ISO)
response to xenobiotic stimulus  (ISO)
short-term memory  (ISO)
siderophore transport  (ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. Abassi Z, etal., J Urol. 2013 Apr;189(4):1559-66. doi: 10.1016/j.juro.2012.10.029. Epub 2012 Oct 22.
2. Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori. Alpízar-Alpízar W, etal., Virchows Arch. 2009 Sep;455(3):225-33. doi: 10.1007/s00428-009-0825-8.
3. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Alter ML, etal., Clin Lab. 2012;58(7-8):659-71.
4. Fructose induces tubulointerstitial injury in the kidney of mice. Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
5. Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis. Bellmann-Weiler R, etal., Immunobiology. 2013 Jul;218(7):969-78. doi: 10.1016/j.imbio.2012.11.004. Epub 2012 Nov 21.
6. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Berger T, etal., Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. doi: 10.1073/pnas.0510847103. Epub 2006 Jan 30.
7. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Bhavsar NA, etal., Am J Kidney Dis. 2012 Aug;60(2):233-40. doi: 10.1053/j.ajkd.2012.02.336. Epub 2012 Apr 28.
8. Reactive astrocytes secrete lcn2 to promote neuron death. Bi F, etal., Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.
9. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
10. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. Chan YR, etal., J Immunol. 2009 Apr 15;182(8):4947-56. doi: 10.4049/jimmunol.0803282.
11. Chemopreventive and chemotherapeutic effect of dietary supplementation of vitamin D on cholangiocarcinoma in a Chemical-Induced animal model. Chiang KC, etal., Oncotarget. 2014 Jun 15;5(11):3849-61. doi: 10.18632/oncotarget.2000.
12. Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis. Dahl SL, etal., Front Immunol. 2018 Nov 26;9:2717. doi: 10.3389/fimmu.2018.02717. eCollection 2018.
13. The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats. De La Chesnaye E, etal., Mol Med Rep. 2020 Aug;22(2):1409-1419. doi: 10.3892/mmr.2020.11226. Epub 2020 Jun 12.
14. Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis. Ding L, etal., Circ J. 2010 Jan 7.
15. Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats. Dong M, etal., Brain Res. 2013 Apr 10;1505:86-92. doi: 10.1016/j.brainres.2013.02.008. Epub 2013 Feb 15.
16. Lipocalin 2 and Blood-Brain Barrier Disruption in White Matter after Experimental Subarachnoid Hemorrhage. Egashira Y, etal., Acta Neurochir Suppl. 2016;121:131-4. doi: 10.1007/978-3-319-18497-5_23.
17. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Eirin A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4153-61. doi: 10.1093/ndt/gfs370. Epub 2012 Aug 23.
18. Novel urinary biomarkers and the early detection of acute kidney injury after open cardiac surgeries. Elmedany SM, etal., J Crit Care. 2017 Aug;40:171-177. doi: 10.1016/j.jcrc.2017.03.029. Epub 2017 Apr 6.
19. Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis. Ferreira MC, etal., Infect Immun. 2014 Mar;82(3):1030-5. doi: 10.1128/IAI.01389-13. Epub 2013 Dec 16.
20. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
21. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Fu WJ, etal., Diabetes Res Clin Pract. 2012 Jan;95(1):105-9. doi: 10.1016/j.diabres.2011.09.031. Epub 2011 Oct 20.
22. Expression of acute-phase response proteins in retinal Muller cells in diabetes. Gerhardinger C, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):349-57.
23. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
24. Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Ip JP, etal., J Neuroinflammation. 2011 Sep 26;8:124. doi: 10.1186/1742-2094-8-124.
25. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Ko GJ, etal., Am J Physiol Renal Physiol. 2010 Jun;298(6):F1472-83. doi: 10.1152/ajprenal.00619.2009. Epub 2010 Feb 24.
26. Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and neutrophil extracellular traps. Li H, etal., Hepatology. 2018 Oct;68(4):1604-1620. doi: 10.1002/hep.29919. Epub 2018 May 10.
27. Urinary Biomarkers in Relapsing Antineutrophil Cytoplasmic Antibody-associated Vasculitis. Lieberthal JG, etal., J Rheumatol. 2013 May;40(5):674-683. Epub 2013 Apr 1.
28. Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain. Liu M, etal., Brain Res. 2018 Jan 15;1679:1-9. doi: 10.1016/j.brainres.2017.11.003. Epub 2017 Nov 6.
29. Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. Moreno-Navarrete JM, etal., Int J Obes (Lond). 2010 Feb;34(2):240-9. doi: 10.1038/ijo.2009.242. Epub 2009 Dec 1.
30. Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity. Nelson AL, etal., Cell Microbiol. 2005 Oct;7(10):1404-17. doi: 10.1111/j.1462-5822.2005.00566.x.
31. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
32. Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. Oh SW, etal., BMC Nephrol. 2013 May 17;14(1):105.
33. The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study. Panidis D, etal., Reprod Biol Endocrinol. 2010 Dec 9;8:151. doi: 10.1186/1477-7827-8-151.
34. α-Intercalated cells defend the urinary system from bacterial infection. Paragas N, etal., J Clin Invest. 2014 Jul;124(7):2963-76. doi: 10.1172/JCI71630. Epub 2014 Jun 17.
35. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Parikh CR, etal., Kidney Int. 2012 Apr;81(8):784-90. doi: 10.1038/ki.2011.465. Epub 2012 Jan 18.
36. High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy. Peters HP, etal., Nephrol Dial Transplant. 2011 Nov;26(11):3581-8. doi: 10.1093/ndt/gfr135. Epub 2011 Apr 5.
37. Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats. Quiros Y, etal., Toxicol Sci. 2013 Apr;132(2):493-501. doi: 10.1093/toxsci/kft007. Epub 2013 Jan 18.
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media. Rouse RL, etal., Toxicol Pathol. 2013;41(4):662-80. doi: 10.1177/0192623312464122. Epub 2012 Oct 19.
40. Time-dependent hemeoxygenase-1, lipocalin-2 and ferritin induction after non-contusion traumatic brain injury. Russell NH, etal., Brain Res. 2019 Dec 15;1725:146466. doi: 10.1016/j.brainres.2019.146466. Epub 2019 Sep 17.
41. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. Saiga H, etal., J Immunol. 2008 Dec 15;181(12):8521-7. doi: 10.4049/jimmunol.181.12.8521.
42. Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury. Seibert FS, etal., Acta Physiol (Oxf). 2013 Apr;207(4):700-8. doi: 10.1111/apha.12064. Epub 2013 Feb 14.
43. Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL and KIM-1. Sohotnik R, etal., Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1099-104. doi: 10.1152/ajprenal.00649.2012. Epub 2013 Jan 30.
44. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. Srinivasan G, etal., J Immunol. 2012 Aug 15;189(4):1911-9. doi: 10.4049/jimmunol.1200892. Epub 2012 Jul 11.
45. Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Steigedal M, etal., J Immunol. 2014 Dec 15;193(12):6081-9. doi: 10.4049/jimmunol.1401528. Epub 2014 Nov 14.
46. Serum Lipocalin2 is a potential biomarker of liver irradiation damage. Sultan S, etal., Liver Int. 2013 Mar;33(3):459-68. doi: 10.1111/liv.12073. Epub 2013 Jan 18.
47. LIPOCALIN-2 is a major acute-phase protein in a rat and mouse model of sterile abscess. Sultan S, etal., Shock. 2012 Feb;37(2):191-6. doi: 10.1097/SHK.0b013e31823918c2.
48. Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia. Sung HK, etal., J Cell Physiol. 2017 Aug;232(8):2125-2134. doi: 10.1002/jcp.25672. Epub 2017 Mar 24.
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50. Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration. Tang W, etal., Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):6014-6025. doi: 10.1167/iovs.18-25213.
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Additional References at PubMed
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Genomics

Comparative Map Data
LCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBIT2T-CHM13v2.0
Lcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)EnsemblGRCm39 Ensembl
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBIMGSCv36mm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Lcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Celera310,423,569 - 10,426,914 (-)NCBICelera
Cytogenetic Map3p12NCBI
LCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,940,799 - 127,944,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensemblpanpan1.1panPan2
LCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,328,118 - 55,342,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,328,133 - 55,332,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,522,898 - 54,537,231 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,250,316 - 56,264,670 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,250,331 - 56,254,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,010,191 - 55,024,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,324,906 - 55,339,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,416,588 - 55,430,934 (-)NCBIUU_Cfam_GSD_1.0
Lcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,953,204 - 195,956,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,721,684 - 15,728,221 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648715,721,752 - 15,725,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,609,887 - 268,614,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,609,975 - 268,614,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,600,679 - 302,609,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,976,278 - 9,981,087 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,976,614 - 9,980,870 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,251,600 - 6,256,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in LCN2
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:122792658-138124532)x3 copy number gain See cases [RCV000051040] Chr9:122792658..138124532 [GRCh38]
Chr9:125554937..141018984 [GRCh37]
Chr9:124594758..140138805 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9q33.3-34.11(chr9:125993583-129682375)x1 copy number loss See cases [RCV000052923] Chr9:125993583..129682375 [GRCh38]
Chr9:128755862..132444654 [GRCh37]
Chr9:127795683..131484475 [NCBI36]
Chr9:9q33.3-34.11		 pathogenic
GRCh38/hg38 9q34.11(chr9:127874581-130421811)x1 copy number loss See cases [RCV000052934] Chr9:127874581..130421811 [GRCh38]
Chr9:130636860..133297198 [GRCh37]
Chr9:129676681..132287019 [NCBI36]
Chr9:9q34.11		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9q34.11(chr9:127919476-130079974)x3 copy number gain See cases [RCV000053777] Chr9:127919476..130079974 [GRCh38]
Chr9:130681755..132842253 [GRCh37]
Chr9:129721576..131882074 [NCBI36]
Chr9:9q34.11		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9q33.3-34.11(chr9:125055865-128637946)x1 copy number loss See cases [RCV000137787] Chr9:125055865..128637946 [GRCh38]
Chr9:127818144..131400225 [GRCh37]
Chr9:126857965..130440046 [NCBI36]
Chr9:9q33.3-34.11		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q33.3-34.3(chr9:128652785-141044751)x3 copy number gain See cases [RCV000447080] Chr9:128652785..141044751 [GRCh37]
Chr9:9q33.3-34.3		 pathogenic
GRCh37/hg19 9q34.11(chr9:130390139-132760275)x1 copy number loss See cases [RCV000445837] Chr9:130390139..132760275 [GRCh37]
Chr9:9q34.11		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q33.2-34.3(chr9:124642754-141146461)x3 copy number gain See cases [RCV000448784] Chr9:124642754..141146461 [GRCh37]
Chr9:9q33.2-34.3		 pathogenic
NM_005564.5(LCN2):c.356-15C>G single nucleotide variant not specified [RCV000454689] Chr9:128151891 [GRCh38]
Chr9:130914170 [GRCh37]
Chr9:9q34.11		 benign
NM_005564.5(LCN2):c.526T>C (p.Ser176Pro) single nucleotide variant Inborn genetic diseases [RCV003276530] Chr9:128152233 [GRCh38]
Chr9:130914512 [GRCh37]
Chr9:9q34.11		 uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NC_000009.11:g.(?_130911805)_(131302617_?)dup duplication Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome [RCV000708297] Chr9:128149526..128540338 [GRCh38]
Chr9:130911805..131302617 [GRCh37]
Chr9:9q34.11		 uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q33.3-34.12(chr9:129370440-133866894)x1 copy number loss not provided [RCV000748671] Chr9:129370440..133866894 [GRCh37]
Chr9:9q33.3-34.12		 pathogenic
GRCh37/hg19 9q33.3-34.11(chr9:129522693-131410039)x1 copy number loss not provided [RCV000748677] Chr9:129522693..131410039 [GRCh37]
Chr9:9q33.3-34.11		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NM_005564.5(LCN2):c.355+8T>C single nucleotide variant not provided [RCV000906726] Chr9:128151725 [GRCh38]
Chr9:130914004 [GRCh37]
Chr9:9q34.11		 benign
NM_005564.5(LCN2):c.356-3C>A single nucleotide variant not provided [RCV000906727] Chr9:128151903 [GRCh38]
Chr9:130914182 [GRCh37]
Chr9:9q34.11		 benign
NM_005564.5(LCN2):c.371C>T (p.Thr124Met) single nucleotide variant not provided [RCV000906728] Chr9:128151921 [GRCh38]
Chr9:130914200 [GRCh37]
Chr9:9q34.11		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NM_005564.5(LCN2):c.93A>G (p.Pro31=) single nucleotide variant not provided [RCV000930329] Chr9:128149618 [GRCh38]
Chr9:130911897 [GRCh37]
Chr9:9q34.11		 likely benign
NC_000009.12:g.(?_127612384)_(128566997_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV000819894]|Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome [RCV001387712] Chr9:127612384..128566997 [GRCh38]
Chr9:130374663..131329276 [GRCh37]
Chr9:9q34.11		 pathogenic|uncertain significance
NC_000009.11:g.(?_130216797)_(130953151_?)dup duplication Congenital muscular dystrophy with intellectual disability and severe epilepsy [RCV000821291] Chr9:127454518..128190872 [GRCh38]
Chr9:130216797..130953151 [GRCh37]
Chr9:9q33.3-34.11		 uncertain significance
NM_005564.5(LCN2):c.26G>T (p.Gly9Val) single nucleotide variant not provided [RCV000961058] Chr9:128149551 [GRCh38]
Chr9:130911830 [GRCh37]
Chr9:9q34.11		 likely benign
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3		 pathogenic
NM_005564.5(LCN2):c.139-9C>A single nucleotide variant not provided [RCV000879017] Chr9:128150229 [GRCh38]
Chr9:130912508 [GRCh37]
Chr9:9q34.11		 likely benign
NC_000009.12:g.(?_127815672)_(128541180_?)del deletion not provided [RCV001032461] Chr9:130577951..131303459 [GRCh37]
Chr9:9q34.11		 pathogenic
NC_000009.11:g.(?_130374663)_(131329276_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV001304269] Chr9:130374663..131329276 [GRCh37]
Chr9:9q34.11		 uncertain significance
GRCh37/hg19 9q34.11(chr9:130412438-131423964)x1 copy number loss Infantile epilepsy syndrome [RCV001265154] Chr9:130412438..131423964 [GRCh37]
Chr9:9q34.11		 pathogenic
NC_000009.11:g.(?_129376729)_(131016993_?)del deletion Developmental and epileptic encephalopathy, 31 [RCV001364955]|Early infantile epileptic encephalopathy with suppression bursts [RCV001383155] Chr9:129376729..131016993 [GRCh37]
Chr9:9q33.3-34.11		 pathogenic|uncertain significance
NC_000009.11:g.(?_130216797)_(130953151_?)dup duplication Congenital disorder of glycosylation type 1u [RCV001323033] Chr9:130216797..130953151 [GRCh37]
Chr9:9q33.3-34.11		 uncertain significance
GRCh37/hg19 9q33.3-34.11(chr9:128523763-132604808)x3 copy number gain not provided [RCV001832977] Chr9:128523763..132604808 [GRCh37]
Chr9:9q33.3-34.11		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q32-34.11(chr9:116422275-131713233) copy number gain not specified [RCV002052831] Chr9:116422275..131713233 [GRCh37]
Chr9:9q32-34.11		 pathogenic
GRCh37/hg19 9q34.11(chr9:130390139-132760275) copy number loss not specified [RCV002052848] Chr9:130390139..132760275 [GRCh37]
Chr9:9q34.11		 pathogenic
NC_000009.11:g.(?_130216807)_(130953136_?)del deletion Congenital muscular dystrophy with intellectual disability and severe epilepsy [RCV001972646] Chr9:130216807..130953136 [GRCh37]
Chr9:9q33.3-34.11		 pathogenic
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
NM_005564.5(LCN2):c.73T>A (p.Ser25Thr) single nucleotide variant Inborn genetic diseases [RCV003282816] Chr9:128149598 [GRCh38]
Chr9:130911877 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.201C>A (p.Asp67Glu) single nucleotide variant Inborn genetic diseases [RCV002879440] Chr9:128150300 [GRCh38]
Chr9:130912579 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.19T>C (p.Trp7Arg) single nucleotide variant Inborn genetic diseases [RCV002924552] Chr9:128149544 [GRCh38]
Chr9:130911823 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.328G>A (p.Gly110Ser) single nucleotide variant Inborn genetic diseases [RCV002693545] Chr9:128151690 [GRCh38]
Chr9:130913969 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.589G>A (p.Asp197Asn) single nucleotide variant Inborn genetic diseases [RCV002641897] Chr9:128153111 [GRCh38]
Chr9:130915390 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.130G>A (p.Asp44Asn) single nucleotide variant Inborn genetic diseases [RCV002713860] Chr9:128149655 [GRCh38]
Chr9:130911934 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.569T>A (p.Val190Asp) single nucleotide variant Inborn genetic diseases [RCV002677854] Chr9:128152276 [GRCh38]
Chr9:130914555 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.44C>A (p.Ala15Asp) single nucleotide variant Inborn genetic diseases [RCV003207424] Chr9:128149569 [GRCh38]
Chr9:130911848 [GRCh37]
Chr9:9q34.11		 uncertain significance
NM_005564.5(LCN2):c.11G>A (p.Gly4Asp) single nucleotide variant Inborn genetic diseases [RCV003178647] Chr9:128149536 [GRCh38]
Chr9:130911815 [GRCh37]
Chr9:9q34.11		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3345
Count of miRNA genes:801
Interacting mature miRNAs:987
Transcripts:ENST00000277480, ENST00000372998, ENST00000373013, ENST00000373017, ENST00000470902, ENST00000487719, ENST00000488391, ENST00000494317, ENST00000540948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH93784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379130,914,190 - 130,914,488UniSTSGRCh37
Build 369129,954,011 - 129,954,309RGDNCBI36
Celera9101,565,082 - 101,565,380RGD
Cytogenetic Map9q34UniSTS
HuRef9100,527,860 - 100,528,158UniSTS
GeneMap99-GB4 RH Map9389.68UniSTS
PMC152639P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379130,914,475 - 130,914,559UniSTSGRCh37
Build 369129,954,296 - 129,954,380RGDNCBI36
Celera9101,565,367 - 101,565,451RGD
Cytogenetic Map9q34UniSTS
HuRef9100,528,145 - 100,528,229UniSTS
STS-X99133  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379130,915,401 - 130,915,580UniSTSGRCh37
Build 369129,955,222 - 129,955,401RGDNCBI36
Celera9101,566,293 - 101,566,472RGD
Cytogenetic Map9q34UniSTS
HuRef9100,529,071 - 100,529,250UniSTS
GeneMap99-GB4 RH Map9389.89UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 68 127 6 76 133 6 4 1 5 83 17 72
Medium 679 638 433 283 908 195 584 56 116 120 470 747 97 36 257
Low 990 906 1141 241 228 240 2003 805 1314 186 627 735 4 1 716 1176 1 2
Below cutoff 656 1196 132 21 151 21 1582 1224 2099 89 259 76 430 1234 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054362963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK301694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW778875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF354583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM977724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP272828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX644845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA454137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU644752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  N79823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S75256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000277480   ⟹   ENSP00000277480
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,149,453 - 128,153,453 (+)Ensembl
RefSeq Acc Id: ENST00000372998   ⟹   ENSP00000362089
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,149,518 - 128,153,139 (+)Ensembl
RefSeq Acc Id: ENST00000373017   ⟹   ENSP00000362108
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,149,071 - 128,153,133 (+)Ensembl
RefSeq Acc Id: ENST00000470902
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,149,441 - 128,153,453 (+)Ensembl
RefSeq Acc Id: ENST00000487719
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,149,472 - 128,150,609 (+)Ensembl
RefSeq Acc Id: ENST00000488391
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,151,500 - 128,153,328 (+)Ensembl
RefSeq Acc Id: ENST00000494317
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9128,151,669 - 128,153,453 (+)Ensembl
RefSeq Acc Id: NM_005564   ⟹   NP_005555
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389128,149,453 - 128,153,453 (+)NCBI
GRCh379130,911,732 - 130,915,734 (+)ENTREZGENE
Build 369129,951,553 - 129,955,555 (+)NCBI Archive
HuRef9100,525,402 - 100,529,404 (+)ENTREZGENE
CHM1_19131,062,719 - 131,066,744 (+)NCBI
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047423376   ⟹   XP_047279332
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389128,149,453 - 128,153,453 (+)NCBI
RefSeq Acc Id: XM_054362963   ⟹   XP_054218938
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_005555   ⟸   NM_005564
- Peptide Label: precursor
- UniProtKB: Q6FGL5 (UniProtKB/Swiss-Prot),   Q5SYW0 (UniProtKB/Swiss-Prot),   Q5SYV9 (UniProtKB/Swiss-Prot),   P30150 (UniProtKB/Swiss-Prot),   B7ZAA2 (UniProtKB/Swiss-Prot),   B4DWV4 (UniProtKB/Swiss-Prot),   A6NII8 (UniProtKB/Swiss-Prot),   Q92683 (UniProtKB/Swiss-Prot),   P80188 (UniProtKB/Swiss-Prot),   B2ZDQ1 (UniProtKB/TrEMBL),   X6R8F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000362089   ⟸   ENST00000372998
RefSeq Acc Id: ENSP00000362108   ⟸   ENST00000373017
RefSeq Acc Id: ENSP00000277480   ⟸   ENST00000277480
RefSeq Acc Id: XP_047279332   ⟸   XM_047423376
- Peptide Label: isoform X1
- UniProtKB: Q6FGL5 (UniProtKB/Swiss-Prot),   Q5SYW0 (UniProtKB/Swiss-Prot),   Q5SYV9 (UniProtKB/Swiss-Prot),   P80188 (UniProtKB/Swiss-Prot),   P30150 (UniProtKB/Swiss-Prot),   B7ZAA2 (UniProtKB/Swiss-Prot),   B4DWV4 (UniProtKB/Swiss-Prot),   A6NII8 (UniProtKB/Swiss-Prot),   Q92683 (UniProtKB/Swiss-Prot),   B2ZDQ1 (UniProtKB/TrEMBL),   X6R8F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054218938   ⟸   XM_054362963
- Peptide Label: isoform X1
- UniProtKB: Q6FGL5 (UniProtKB/Swiss-Prot),   Q5SYW0 (UniProtKB/Swiss-Prot),   Q5SYV9 (UniProtKB/Swiss-Prot),   P80188 (UniProtKB/Swiss-Prot),   P30150 (UniProtKB/Swiss-Prot),   B7ZAA2 (UniProtKB/Swiss-Prot),   B4DWV4 (UniProtKB/Swiss-Prot),   A6NII8 (UniProtKB/Swiss-Prot),   Q92683 (UniProtKB/Swiss-Prot),   B2ZDQ1 (UniProtKB/TrEMBL),   X6R8F3 (UniProtKB/TrEMBL)
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80188-F1-model_v2 AlphaFold P80188 1-198 view protein structure

Promoters
RGD ID:7216249
Promoter ID:EPDNEW_H13871
Type:initiation region
Name:LCN2_1
Description:lipocalin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13870  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389128,149,453 - 128,149,513EPDNEW
RGD ID:6807839
Promoter ID:HG_KWN:65099
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000372998,   ENST00000373013,   ENST00000373017,   NM_005564,   OTTHUMT00000054376,   UC010MXQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369129,951,106 - 129,951,606 (+)MPROMDB
RGD ID:6807837
Promoter ID:HG_KWN:65100
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:OTTHUMT00000054377,   OTTHUMT00000054378
Position:
Human AssemblyChrPosition (strand)Source
Build 369129,952,676 - 129,953,176 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6526 AgrOrtholog
COSMIC LCN2 COSMIC
Ensembl Genes ENSG00000148346 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000277480 ENTREZGENE
  ENST00000277480.7 UniProtKB/Swiss-Prot
  ENST00000372998.1 UniProtKB/TrEMBL
  ENST00000373017 ENTREZGENE
  ENST00000373017.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000148346 GTEx
HGNC ID HGNC:6526 ENTREZGENE
Human Proteome Map LCN2 Human Proteome Map
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCN2/LCN12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3934 UniProtKB/Swiss-Prot
NCBI Gene 3934 ENTREZGENE
OMIM 600181 OMIM
PANTHER NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LCN2 RGD, PharmGKB
PRINTS LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGELATINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6NII8 ENTREZGENE
  B2ZDQ1 ENTREZGENE, UniProtKB/TrEMBL
  B4DWV4 ENTREZGENE
  B7ZAA2 ENTREZGENE
  NGAL_HUMAN UniProtKB/Swiss-Prot
  P30150 ENTREZGENE
  P80188 ENTREZGENE
  Q5SYV9 ENTREZGENE
  Q5SYW0 ENTREZGENE
  Q6FGL5 ENTREZGENE
  Q92683 ENTREZGENE
  X6R8F3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6NII8 UniProtKB/Swiss-Prot
  B4DWV4 UniProtKB/Swiss-Prot
  B7ZAA2 UniProtKB/Swiss-Prot
  P30150 UniProtKB/Swiss-Prot
  Q5SYV9 UniProtKB/Swiss-Prot
  Q5SYW0 UniProtKB/Swiss-Prot
  Q6FGL5 UniProtKB/Swiss-Prot
  Q92683 UniProtKB/Swiss-Prot