PTPN3 (protein tyrosine phosphatase non-receptor type 3) - Rat Genome Database

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Gene: PTPN3 (protein tyrosine phosphatase non-receptor type 3) Homo sapiens
Analyze
Symbol: PTPN3
Name: protein tyrosine phosphatase non-receptor type 3
RGD ID: 1322781
HGNC Page HGNC
Description: Enables several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Involved in several processes, including negative regulation of membrane protein ectodomain proteolysis; protein dephosphorylation; and regulation of membrane depolarization during action potential. Located in cytoplasm and cytoplasmic side of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytoskeletal-associated protein tyrosine phosphatase; DKFZp686N0569; protein tyrosin phosphatase H1; protein-tyrosine phosphatase H1; PTP-H1; PTPH1; tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9109,375,466 - 109,498,313 (-)EnsemblGRCh38hg38GRCh38
GRCh389109,375,694 - 109,538,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379112,137,974 - 112,260,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369111,180,337 - 111,265,557 (-)NCBINCBI36hg18NCBI36
Build 349109,220,072 - 109,305,289NCBI
Celera982,637,279 - 82,759,899 (-)NCBI
Cytogenetic Map9q31.3NCBI
HuRef981,738,137 - 81,860,645 (-)NCBIHuRef
CHM1_19112,284,708 - 112,407,241 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
amiodarone  (EXP)
aristolochic acid  (EXP)
arsenite(3-)  (ISO)
belinostat  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
butanal  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calyculin a  (ISO)
cannabidiol  (ISO)
carmustine  (EXP)
choline  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clothianidin  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
crotonaldehyde  (EXP)
cyclosporin A  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (EXP)
finasteride  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
indometacin  (ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lapatinib  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
N(6)-dimethylallyladenine  (EXP)
N-nitrosodiethylamine  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
pirfenidone  (EXP)
potassium chromate  (EXP)
rac-lactic acid  (EXP)
rotenone  (EXP,ISO)
SB 431542  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
toluene  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (EXP)
vincristine  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal pain  (IAGP)
Acholic stools  (IAGP)
Anorexia  (IAGP)
Biliary tract neoplasm  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Jaundice  (IAGP)
Prostate cancer  (IAGP)
Pruritus  (IAGP)
References

Additional References at PubMed
PMID:1626183   PMID:1648725   PMID:7874267   PMID:8253532   PMID:9341175   PMID:10364224   PMID:10940933   PMID:11087817   PMID:12207026   PMID:12477932   PMID:12907755   PMID:14672952  
PMID:14702039   PMID:15161933   PMID:15588985   PMID:15778465   PMID:16344560   PMID:16930557   PMID:17166906   PMID:17353931   PMID:17588219   PMID:17921143   PMID:17947517   PMID:18978678  
PMID:19167335   PMID:20332238   PMID:20936779   PMID:21119599   PMID:21873635   PMID:22334442   PMID:22730326   PMID:24227889   PMID:24503127   PMID:25263444   PMID:25277244   PMID:25314968  
PMID:25416956   PMID:25640309   PMID:25728925   PMID:26053890   PMID:27432908   PMID:27833130   PMID:27880917   PMID:28330616   PMID:28514442   PMID:28675297   PMID:29117863   PMID:29395067  
PMID:29507755   PMID:29954144   PMID:30189107   PMID:30348936   PMID:30639242   PMID:30726710   PMID:30875834   PMID:31092861   PMID:31304624   PMID:31406243   PMID:31706106   PMID:31971989  
PMID:31972307   PMID:32169891   PMID:32296183   PMID:33137650   PMID:33441627   PMID:33961781  


Genomics

Comparative Map Data
PTPN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9109,375,466 - 109,498,313 (-)EnsemblGRCh38hg38GRCh38
GRCh389109,375,694 - 109,538,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379112,137,974 - 112,260,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369111,180,337 - 111,265,557 (-)NCBINCBI36hg18NCBI36
Build 349109,220,072 - 109,305,289NCBI
Celera982,637,279 - 82,759,899 (-)NCBI
Cytogenetic Map9q31.3NCBI
HuRef981,738,137 - 81,860,645 (-)NCBIHuRef
CHM1_19112,284,708 - 112,407,241 (-)NCBICHM1_1
Ptpn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,190,841 - 57,339,036 (-)NCBIGRCm39mm39
GRCm39 Ensembl457,190,841 - 57,301,837 (-)Ensembl
GRCm38457,190,841 - 57,339,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,190,841 - 57,301,837 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,203,713 - 57,314,709 (-)NCBIGRCm37mm9NCBIm37
MGSCv36457,284,895 - 57,394,944 (-)NCBImm8
Celera457,101,096 - 57,212,390 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.66NCBI
Ptpn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2571,908,520 - 72,027,323 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl571,911,135 - 72,065,443 (-)Ensembl
Rnor_6.0574,248,996 - 74,368,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl574,248,996 - 74,368,186 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0578,399,259 - 78,528,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,106,880 - 75,222,735 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1575,111,995 - 75,139,197 (-)NCBI
Celera570,758,167 - 70,876,826 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ptpn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541917,493,518 - 17,645,477 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541917,560,664 - 17,645,420 (+)NCBIChiLan1.0ChiLan1.0
PTPN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19108,699,761 - 108,787,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9108,699,761 - 108,787,464 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0980,528,896 - 80,651,629 (-)NCBIMhudiblu_PPA_v0panPan3
PTPN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11164,486,293 - 64,595,416 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1164,489,446 - 64,630,004 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1162,886,334 - 63,029,951 (-)NCBI
ROS_Cfam_1.01165,619,500 - 65,763,908 (-)NCBI
ROS_Cfam_1.0 Ensembl1165,619,501 - 65,764,431 (-)Ensembl
UMICH_Zoey_3.11164,139,495 - 64,283,404 (-)NCBI
UNSW_CanFamBas_1.01164,160,914 - 64,305,281 (-)NCBI
UU_Cfam_GSD_1.01164,851,489 - 64,995,173 (-)NCBI
Ptpn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947179,719,264 - 179,830,375 (-)NCBI
SpeTri2.0NW_0049365593,436,114 - 3,547,316 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,418,132 - 250,583,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,418,131 - 250,583,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTPN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11230,048,941 - 30,168,816 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1230,083,128 - 30,171,473 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,966 (-)NCBIVero_WHO_p1.0
Ptpn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247582,011,998 - 2,170,096 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
A009V09  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,138,019 - 112,138,131UniSTSGRCh37
Build 369111,177,840 - 111,177,952RGDNCBI36
Celera982,637,324 - 82,637,436RGD
Cytogenetic Map9q31UniSTS
HuRef981,738,182 - 81,738,294UniSTS
GeneMap99-GB4 RH Map9350.7UniSTS
STS-W15441  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,140,553 - 112,140,734UniSTSGRCh37
Build 369111,180,374 - 111,180,555RGDNCBI36
Celera982,639,858 - 82,640,039RGD
Cytogenetic Map9q31UniSTS
HuRef981,740,716 - 81,740,897UniSTS
GeneMap99-GB4 RH Map9350.6UniSTS
RH91146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,138,026 - 112,138,198UniSTSGRCh37
Build 369111,177,847 - 111,178,019RGDNCBI36
Celera982,637,331 - 82,637,503RGD
Cytogenetic Map9q31UniSTS
HuRef981,738,189 - 81,738,361UniSTS
GeneMap99-GB4 RH Map9348.88UniSTS
D9S1760  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,138,079 - 112,138,201UniSTSGRCh37
Build 369111,177,900 - 111,178,022RGDNCBI36
Celera982,637,384 - 82,637,506RGD
Cytogenetic Map9q31UniSTS
HuRef981,738,242 - 81,738,364UniSTS
GeneMap99-GB4 RH Map9346.14UniSTS
NCBI RH Map9974.8UniSTS
SHGC-149695  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,224,464 - 112,224,759UniSTSGRCh37
Build 369111,264,285 - 111,264,580RGDNCBI36
Celera982,723,772 - 82,724,067RGD
Cytogenetic Map9q31UniSTS
HuRef981,824,657 - 81,824,952UniSTS
PTPN3_2445  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,140,548 - 112,141,244UniSTSGRCh37
Build 369111,180,369 - 111,181,065RGDNCBI36
Celera982,639,853 - 82,640,549RGD
HuRef981,740,711 - 81,741,407UniSTS
RH48492  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,246,818 - 112,246,947UniSTSGRCh37
Build 369111,286,639 - 111,286,768RGDNCBI36
Celera982,746,126 - 82,746,255RGD
Cytogenetic Map9q31UniSTS
HuRef981,846,931 - 81,847,060UniSTS
GeneMap99-GB4 RH Map9339.78UniSTS
D9S58  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710111,637,030 - 111,637,119UniSTSGRCh37
GRCh379112,139,649 - 112,139,781UniSTSGRCh37
Build 369111,179,470 - 111,179,602RGDNCBI36
Celera10105,368,714 - 105,368,803UniSTS
Celera982,638,954 - 82,639,086RGD
Cytogenetic Map9q31UniSTS
Cytogenetic Map10q25.3UniSTS
HuRef10105,268,114 - 105,268,203UniSTS
HuRef981,739,812 - 81,739,944UniSTS
RH78381  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,140,684 - 112,140,823UniSTSGRCh37
Build 369111,180,505 - 111,180,644RGDNCBI36
Celera982,639,989 - 82,640,128RGD
Cytogenetic Map9q31UniSTS
HuRef981,740,847 - 81,740,986UniSTS
GeneMap99-GB4 RH Map9350.7UniSTS
WI-10390  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,173,091 - 112,173,242UniSTSGRCh37
Build 369111,212,912 - 111,213,063RGDNCBI36
Celera982,672,400 - 82,672,551RGD
Cytogenetic Map9q31UniSTS
HuRef981,773,270 - 81,773,421UniSTS
Whitehead-RH Map9414.4UniSTS
D9S1693  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,138,020 - 112,138,198UniSTSGRCh37
Build 369111,177,841 - 111,178,019RGDNCBI36
Celera982,637,325 - 82,637,503RGD
Cytogenetic Map9q31UniSTS
HuRef981,738,183 - 81,738,361UniSTS
Whitehead-YAC Contig Map9 UniSTS
G32870  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379112,138,019 - 112,138,131UniSTSGRCh37
Celera982,637,324 - 82,637,436UniSTS
Cytogenetic Map9q31UniSTS
HuRef981,738,182 - 81,738,294UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5214
Count of miRNA genes:1055
Interacting mature miRNAs:1303
Transcripts:ENST00000262539, ENST00000374541, ENST00000394827, ENST00000412145, ENST00000446349, ENST00000497739
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 363 663 919 372 77 333 2293 922 47 314 388 870 51 24 1633 6 2
Low 1967 1549 798 250 501 130 2043 1169 2583 101 1013 739 124 1 1178 1145
Below cutoff 106 734 6 1 1187 1 19 103 1091 4 56 1 2 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_026918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017014955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017014956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017014957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK096975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL450025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU624870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB173093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB306298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC342461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ104439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG828775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S39392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W15441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262539   ⟹   ENSP00000262539
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9109,375,694 - 109,498,313 (-)Ensembl
RefSeq Acc Id: ENST00000374541   ⟹   ENSP00000363667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9109,375,700 - 109,498,307 (-)Ensembl
RefSeq Acc Id: ENST00000412145   ⟹   ENSP00000416654
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9109,375,694 - 109,451,384 (-)Ensembl
RefSeq Acc Id: ENST00000446349   ⟹   ENSP00000395384
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9109,375,694 - 109,451,384 (-)Ensembl
RefSeq Acc Id: ENST00000447271
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9109,375,466 - 109,378,980 (-)Ensembl
RefSeq Acc Id: ENST00000497739
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9109,389,237 - 109,397,770 (-)Ensembl
RefSeq Acc Id: NM_001145368   ⟹   NP_001138840
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,700 - 109,498,307 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,407,241 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001145369   ⟹   NP_001138841
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,700 - 109,451,384 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,360,384 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001145370   ⟹   NP_001138842
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,700 - 109,451,384 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,360,384 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001145371   ⟹   NP_001138843
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,700 - 109,428,972 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,338,044 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001145372   ⟹   NP_001138844
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,700 - 109,428,972 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,338,044 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002829   ⟹   NP_002820
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,700 - 109,498,307 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
Build 369111,180,337 - 111,265,557 (-)NCBI Archive
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,407,241 (-)NCBI
Sequence:
RefSeq Acc Id: NR_026918
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,694 - 109,417,783 (-)NCBI
GRCh379112,137,974 - 112,260,593 (-)ENTREZGENE
HuRef981,738,137 - 81,860,645 (-)ENTREZGENE
CHM1_19112,284,708 - 112,326,784 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006717197   ⟹   XP_006717260
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,476,172 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006717199   ⟹   XP_006717262
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,497,891 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006717201   ⟹   XP_006717264
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,498,333 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006717202   ⟹   XP_006717265
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,454,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006717203   ⟹   XP_006717266
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,454,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006717204   ⟹   XP_006717267
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,498,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011518888   ⟹   XP_011517190
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,538,395 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011518889   ⟹   XP_011517191
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,499,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017014955   ⟹   XP_016870444
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,478,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017014956   ⟹   XP_016870445
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,498,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017014957   ⟹   XP_016870446
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,375,696 - 109,498,313 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001138840 (Get FASTA)   NCBI Sequence Viewer  
  NP_001138841 (Get FASTA)   NCBI Sequence Viewer  
  NP_001138842 (Get FASTA)   NCBI Sequence Viewer  
  NP_001138843 (Get FASTA)   NCBI Sequence Viewer  
  NP_001138844 (Get FASTA)   NCBI Sequence Viewer  
  NP_002820 (Get FASTA)   NCBI Sequence Viewer  
  XP_006717260 (Get FASTA)   NCBI Sequence Viewer  
  XP_006717262 (Get FASTA)   NCBI Sequence Viewer  
  XP_006717264 (Get FASTA)   NCBI Sequence Viewer  
  XP_006717265 (Get FASTA)   NCBI Sequence Viewer  
  XP_006717266 (Get FASTA)   NCBI Sequence Viewer  
  XP_006717267 (Get FASTA)   NCBI Sequence Viewer  
  XP_011517190 (Get FASTA)   NCBI Sequence Viewer  
  XP_011517191 (Get FASTA)   NCBI Sequence Viewer  
  XP_016870444 (Get FASTA)   NCBI Sequence Viewer  
  XP_016870445 (Get FASTA)   NCBI Sequence Viewer  
  XP_016870446 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35647 (Get FASTA)   NCBI Sequence Viewer  
  AAB22439 (Get FASTA)   NCBI Sequence Viewer  
  AAB33583 (Get FASTA)   NCBI Sequence Viewer  
  AAH33716 (Get FASTA)   NCBI Sequence Viewer  
  AAI26118 (Get FASTA)   NCBI Sequence Viewer  
  AAI43849 (Get FASTA)   NCBI Sequence Viewer  
  AAZ20185 (Get FASTA)   NCBI Sequence Viewer  
  BAH12211 (Get FASTA)   NCBI Sequence Viewer  
  BAH12296 (Get FASTA)   NCBI Sequence Viewer  
  BAH12339 (Get FASTA)   NCBI Sequence Viewer  
  BAH13995 (Get FASTA)   NCBI Sequence Viewer  
  BAH14184 (Get FASTA)   NCBI Sequence Viewer  
  BAH14437 (Get FASTA)   NCBI Sequence Viewer  
  BAH14489 (Get FASTA)   NCBI Sequence Viewer  
  CAH18062 (Get FASTA)   NCBI Sequence Viewer  
  EAW59045 (Get FASTA)   NCBI Sequence Viewer  
  EAW59046 (Get FASTA)   NCBI Sequence Viewer  
  EAW59047 (Get FASTA)   NCBI Sequence Viewer  
  P26045 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001138840   ⟸   NM_001145368
- Peptide Label: isoform 2
- UniProtKB: P26045 (UniProtKB/Swiss-Prot),   B7Z9V1 (UniProtKB/TrEMBL),   Q8N4S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002820   ⟸   NM_002829
- Peptide Label: isoform 1
- UniProtKB: P26045 (UniProtKB/Swiss-Prot),   B7Z9V1 (UniProtKB/TrEMBL),   Q8N4S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138842   ⟸   NM_001145370
- Peptide Label: isoform 4
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001138841   ⟸   NM_001145369
- Peptide Label: isoform 3
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001138844   ⟸   NM_001145372
- Peptide Label: isoform 6
- UniProtKB: B7ZA03 (UniProtKB/TrEMBL),   Q8N4S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138843   ⟸   NM_001145371
- Peptide Label: isoform 5
- UniProtKB: P26045 (UniProtKB/Swiss-Prot),   B7Z3V3 (UniProtKB/TrEMBL),   Q8N4S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006717264   ⟸   XM_006717201
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006717267   ⟸   XM_006717204
- Peptide Label: isoform X6
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006717262   ⟸   XM_006717199
- Peptide Label: isoform X3
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006717260   ⟸   XM_006717197
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006717266   ⟸   XM_006717203
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006717265   ⟸   XM_006717202
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011517190   ⟸   XM_011518888
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011517191   ⟸   XM_011518889
- Peptide Label: isoform X3
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016870445   ⟸   XM_017014956
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016870446   ⟸   XM_017014957
- Peptide Label: isoform X8
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016870444   ⟸   XM_017014955
- Peptide Label: isoform X3
- UniProtKB: P26045 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000416654   ⟸   ENST00000412145
RefSeq Acc Id: ENSP00000363667   ⟸   ENST00000374541
RefSeq Acc Id: ENSP00000395384   ⟸   ENST00000446349
RefSeq Acc Id: ENSP00000262539   ⟸   ENST00000262539
Promoters
RGD ID:7215797
Promoter ID:EPDNEW_H13645
Type:initiation region
Name:PTPN3_1
Description:protein tyrosine phosphatase, non-receptor type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389109,498,307 - 109,498,367EPDNEW
RGD ID:6808009
Promoter ID:HG_KWN:64475
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat,   Lymphoblastoid
Transcripts:NR_026918,   UC010MTV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369111,219,171 - 111,219,671 (-)MPROMDB
RGD ID:6813685
Promoter ID:HG_ACW:81855
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:PTPN3.NAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 369111,224,846 - 111,225,346 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000050315] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99349916-115767475)x1 copy number loss See cases [RCV000052921] Chr9:99349916..115767475 [GRCh38]
Chr9:102112198..118529754 [GRCh37]
Chr9:101152019..117569575 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.1-32(chr9:88522292-113687796)x3 copy number gain See cases [RCV000053752] Chr9:88522292..113687796 [GRCh38]
Chr9:91137207..116450076 [GRCh37]
Chr9:90327027..115489897 [NCBI36]
Chr9:9q22.1-32
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
NM_002829.4(PTPN3):c.632C>T (p.Ala211Val) single nucleotide variant Malignant tumor of prostate [RCV000149070] Chr9:109436926 [GRCh38]
Chr9:112199206 [GRCh37]
Chr9:9q31.3
uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q31.1-32(chr9:103767420-112984794)x1 copy number loss See cases [RCV000134976] Chr9:103767420..112984794 [GRCh38]
Chr9:106529701..115747074 [GRCh37]
Chr9:105569522..114786895 [NCBI36]
Chr9:9q31.1-32
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-31.3(chr9:99024205-109947890)x1 copy number loss See cases [RCV000138281] Chr9:99024205..109947890 [GRCh38]
Chr9:101786487..112710170 [GRCh37]
Chr9:100826308..111749991 [NCBI36]
Chr9:9q22.33-31.3
pathogenic|likely pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3
pathogenic
GRCh38/hg38 9q31.2-33.1(chr9:107530314-117965944)x1 copy number loss See cases [RCV000140794] Chr9:107530314..117965944 [GRCh38]
Chr9:110292595..120728222 [GRCh37]
Chr9:109332416..119768043 [NCBI36]
Chr9:9q31.2-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000148264] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.3(chr9:111529810-113539990)x3 copy number gain See cases [RCV000449057] Chr9:111529810..113539990 [GRCh37]
Chr9:9q31.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.3-33.1(chr9:111348809-118687200)x1 copy number loss See cases [RCV000449308] Chr9:111348809..118687200 [GRCh37]
Chr9:9q31.3-33.1
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089)x1 copy number loss See cases [RCV000447763] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3
pathogenic
GRCh37/hg19 9q31.1-31.3(chr9:103271401-113948226)x1 copy number loss See cases [RCV000447957] Chr9:103271401..113948226 [GRCh37]
Chr9:9q31.1-31.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.2-32(chr9:108664157-115356416)x3 copy number gain not provided [RCV000683161] Chr9:108664157..115356416 [GRCh37]
Chr9:9q31.2-32
likely pathogenic
GRCh37/hg19 9q31.1-31.3(chr9:106487247-114541579)x1 copy number loss not provided [RCV000683163] Chr9:106487247..114541579 [GRCh37]
Chr9:9q31.1-31.3
pathogenic
GRCh37/hg19 9q31.3(chr9:111885869-112218403)x3 copy number gain not provided [RCV000748601] Chr9:111885869..112218403 [GRCh37]
Chr9:9q31.3
benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_002829.4(PTPN3):c.2145C>T (p.Ile715=) single nucleotide variant not provided [RCV000879131] Chr9:109389341 [GRCh38]
Chr9:112151621 [GRCh37]
Chr9:9q31.3
benign
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9655 AgrOrtholog
COSMIC PTPN3 COSMIC
Ensembl Genes ENSG00000070159 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000262539 UniProtKB/TrEMBL
  ENSP00000363667 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000395384 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000416654 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000262539 UniProtKB/TrEMBL
  ENST00000374541 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000412145 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000446349 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000070159 GTEx
HGNC ID HGNC:9655 ENTREZGENE
Human Proteome Map PTPN3 Human Proteome Map
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ez/rad/moesin_like UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPN3/4_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-3/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5774 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5774 ENTREZGENE
OMIM 176877 OMIM
Pfam FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33999 PharmGKB
PIRSF Tyr-Ptase_nr3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7Z3V3 ENTREZGENE, UniProtKB/TrEMBL
  B7Z9V1 ENTREZGENE, UniProtKB/TrEMBL
  B7ZA03 ENTREZGENE, UniProtKB/TrEMBL
  J3KN34_HUMAN UniProtKB/TrEMBL
  P26045 ENTREZGENE, UniProtKB/Swiss-Prot
  Q8N4S3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0AUW9 UniProtKB/Swiss-Prot
  E7EN99 UniProtKB/Swiss-Prot
  E9PGU7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN3  protein tyrosine phosphatase non-receptor type 3    protein tyrosine phosphatase, non-receptor type 3  Symbol and/or name change 5135510 APPROVED
2011-08-17 PTPN3  protein tyrosine phosphatase, non-receptor type 3  PTPN3  protein tyrosine phosphatase, non-receptor type 3  Symbol and/or name change 5135510 APPROVED