INSL3 (insulin like 3) - Rat Genome Database
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Gene: INSL3 (insulin like 3) Homo sapiens
Analyze
Symbol: INSL3
Name: insulin like 3
RGD ID: 736797
Description: Exhibits protease binding activity. Involved in positive regulation of epithelial cell migration and positive regulation of wound healing. Predicted to localize to extracellular space. Implicated in cryptorchidism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: insulin-like 3; insulin-like 3 (Leydig cell); ley-I-L; leydig insulin -like hormone; leydig insulin -like peptide; leydig insulin-like peptide; MGC119818; MGC119819; prepro-INSL3; relaxin-like factor b; RLF; RLNL
Orthologs:
Mus musculus (house mouse) : Insl3 (insulin-like 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Insl3 (insulin-like 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Insl3 (insulin like 3)
Canis lupus familiaris (dog) : INSL3 (insulin like 3)
Sus scrofa (pig) : INSL3 (insulin like 3)
Chlorocebus sabaeus (African green monkey) : INSL3 (insulin like 3)
Heterocephalus glaber (naked mole-rat) : Insl3 (insulin like 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,816,512 - 17,821,574 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,816,512 - 17,821,519 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,927,322 - 17,932,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,788,322 - 17,793,320 (-)NCBINCBI36hg18NCBI36
Build 341917,788,321 - 17,793,320NCBI
Celera1917,829,042 - 17,834,041 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,492,756 - 17,497,784 (-)NCBIHuRef
CHM1_11917,926,865 - 17,931,926 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
cryptorchidism  (EXP,IAGP)
genetic disease  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:7559633   PMID:7659163   PMID:7852540   PMID:8020942   PMID:8022486   PMID:8022790   PMID:8034302   PMID:8253799   PMID:8662778   PMID:9354668   PMID:9753072   PMID:10391220  
PMID:10451226   PMID:10729310   PMID:10759163   PMID:10899310   PMID:10982185   PMID:11095425   PMID:11147585   PMID:11182749   PMID:11380919   PMID:11383919   PMID:11746019   PMID:12036966  
PMID:12114498   PMID:12200137   PMID:12477932   PMID:12506116   PMID:12684664   PMID:12970298   PMID:14615376   PMID:15057824   PMID:15340161   PMID:15489334   PMID:15579743   PMID:15579790  
PMID:15592455   PMID:15649866   PMID:15708846   PMID:15755855   PMID:15956746   PMID:15956751   PMID:16010410   PMID:16394084   PMID:16467267   PMID:16687567   PMID:16867980   PMID:17014531  
PMID:17028442   PMID:17314233   PMID:17356050   PMID:17437853   PMID:17473281   PMID:17549672   PMID:17559848   PMID:17666478   PMID:18063691   PMID:18310050   PMID:18433302   PMID:18611973  
PMID:18772597   PMID:19017913   PMID:19067106   PMID:19086273   PMID:19110449   PMID:19226271   PMID:19329805   PMID:19416166   PMID:19416188   PMID:19416190   PMID:19416220   PMID:19423540  
PMID:19755411   PMID:19773279   PMID:19950223   PMID:20082125   PMID:20200332   PMID:20406964   PMID:20438785   PMID:20550598   PMID:20560146   PMID:20570702   PMID:20713036   PMID:21586896  
PMID:21873635   PMID:22216350   PMID:22574850   PMID:23028900   PMID:23150680   PMID:23539510   PMID:23898208   PMID:23928669   PMID:24243640   PMID:24640568   PMID:24659579   PMID:24908673  
PMID:25516081   PMID:25728210   PMID:26077926   PMID:26186194   PMID:26579638   PMID:26625974   PMID:26840636   PMID:26874000   PMID:28514442   PMID:29084059   PMID:29254383   PMID:29785651  
PMID:29987050   PMID:31286756   PMID:31444964   PMID:32296183  


Genomics

Comparative Map Data
INSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,816,512 - 17,821,574 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,816,512 - 17,821,519 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,927,322 - 17,932,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,788,322 - 17,793,320 (-)NCBINCBI36hg18NCBI36
Build 341917,788,321 - 17,793,320NCBI
Celera1917,829,042 - 17,834,041 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,492,756 - 17,497,784 (-)NCBIHuRef
CHM1_11917,926,865 - 17,931,926 (-)NCBICHM1_1
Insl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,141,896 - 72,143,221 (+)NCBI
GRCm38871,689,252 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,689,214 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,213,151 - 74,214,474 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,618,241 - 74,619,564 (+)NCBImm8
Celera874,203,798 - 74,205,121 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Insl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,120,753 - 20,122,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,121,352 - 20,122,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,981,216 - 19,983,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,890,131 - 18,891,475 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,890,128 - 18,891,473 (+)NCBI
Celera1618,601,812 - 18,603,156 (+)NCBICelera
Cytogenetic Map16p14NCBI
Insl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,413,764 - 3,415,691 (+)NCBIChiLan1.0ChiLan1.0
INSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,071,128 - 45,072,446 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
INSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,929,581 - 59,931,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,929,591 - 59,931,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,499,023 - 59,500,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q12-q13NCBI
INSL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,291,220 - 16,296,705 (-)NCBI
Insl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,368,660 - 1,369,740 (-)NCBI

Position Markers
RH70894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371917,927,330 - 17,927,559UniSTSGRCh37
Build 361917,788,330 - 17,788,559RGDNCBI36
Celera1917,829,050 - 17,829,279RGD
Cytogenetic Map19p13.2-p12UniSTS
HuRef1917,492,764 - 17,492,993UniSTS
GeneMap99-GB4 RH Map1997.17UniSTS
D19S992  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371917,927,427 - 17,927,590UniSTSGRCh37
Build 361917,788,427 - 17,788,590RGDNCBI36
Celera1917,829,147 - 17,829,310RGD
Cytogenetic Map19p13.2-p12UniSTS
HuRef1917,492,861 - 17,493,024UniSTS
Stanford-G3 RH Map19604.0UniSTS
GeneMap99-G3 RH Map19604.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:786
Count of miRNA genes:307
Interacting mature miRNAs:318
Transcripts:ENST00000317306, ENST00000379695, ENST00000598577
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 56
Medium 3 318 1 358 3 1 1 367 7 2 2
Low 943 705 452 180 1404 59 1011 114 1860 184 600 883 126 567 439 1
Below cutoff 1209 1423 1084 365 133 329 2539 1377 1651 168 359 573 42 606 1671 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001265587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY082014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX334591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC007042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X73637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000317306   ⟹   ENSP00000321724
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1917,816,512 - 17,821,519 (-)Ensembl
RefSeq Acc Id: ENST00000379695   ⟹   ENSP00000369017
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1917,816,514 - 17,821,574 (-)Ensembl
RefSeq Acc Id: ENST00000598577   ⟹   ENSP00000469309
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1917,816,513 - 17,821,505 (-)Ensembl
RefSeq Acc Id: NM_001265587   ⟹   NP_001252516
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381917,816,512 - 17,821,519 (-)NCBI
GRCh371917,927,322 - 17,932,383 (-)NCBI
HuRef1917,492,756 - 17,497,784 (-)NCBI
CHM1_11917,926,865 - 17,931,926 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005543   ⟹   NP_005534
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381917,816,512 - 17,821,519 (-)NCBI
GRCh371917,927,322 - 17,932,383 (-)NCBI
Build 361917,788,322 - 17,793,320 (-)NCBI Archive
HuRef1917,492,756 - 17,497,784 (-)NCBI
CHM1_11917,926,865 - 17,931,926 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005534   ⟸   NM_005543
- Peptide Label: isoform 2 precursor
- UniProtKB: P51460 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001252516   ⟸   NM_001265587
- Peptide Label: isoform 1 precursor
- UniProtKB: P51460 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000469309   ⟸   ENST00000598577
RefSeq Acc Id: ENSP00000369017   ⟸   ENST00000379695
RefSeq Acc Id: ENSP00000321724   ⟸   ENST00000317306

Promoters
RGD ID:7239067
Promoter ID:EPDNEW_H25278
Type:multiple initiation site
Name:INSL3_1
Description:insulin like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381917,821,519 - 17,821,579EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005543.4(INSL3):c.330C>G (p.Asn110Lys) single nucleotide variant Cryptorchidism [RCV000015954] Chr19:17816920 [GRCh38]
Chr19:17927729 [GRCh37]
Chr19:19p13.11
pathogenic
NM_005543.4(INSL3):c.278C>T (p.Pro93Leu) single nucleotide variant Cryptorchidism [RCV000015955] Chr19:17816972 [GRCh38]
Chr19:17927781 [GRCh37]
Chr19:19p13.11
pathogenic
NM_005543.4(INSL3):c.304C>T (p.Arg102Cys) single nucleotide variant Cryptorchidism [RCV000015956] Chr19:17816946 [GRCh38]
Chr19:17927755 [GRCh37]
Chr19:19p13.11
pathogenic
NM_005543.4(INSL3):c.305G>A (p.Arg102His) single nucleotide variant Cryptorchidism [RCV000015957] Chr19:17816945 [GRCh38]
Chr19:17927754 [GRCh37]
Chr19:19p13.11
pathogenic
NM_005543.4(INSL3):c.217C>T (p.Arg73Ter) single nucleotide variant Cryptorchidism [RCV000030739] Chr19:17817033 [GRCh38]
Chr19:17927842 [GRCh37]
Chr19:19p13.11
pathogenic
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3 copy number gain See cases [RCV000050635] Chr19:17176767..34924150 [GRCh38]
Chr19:17287576..35415054 [GRCh37]
Chr19:17148576..40106894 [NCBI36]
Chr19:19p13.11-q13.11
pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11
pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3 copy number gain See cases [RCV000136696] Chr19:15133594..24193591 [GRCh38]
Chr19:15244405..24376393 [GRCh37]
Chr19:15105405..24168233 [NCBI36]
Chr19:19p13.12-12
pathogenic|likely pathogenic
NM_005543.4(INSL3):c.148dup (p.Arg50fs) duplication Inborn genetic diseases [RCV000623139] Chr19:17821358..17821359 [GRCh38]
Chr19:17932167..17932168 [GRCh37]
Chr19:19p13.11
uncertain significance
GRCh37/hg19 19p13.11-11(chr19:16526787-24631604)x3 copy number gain not provided [RCV000752593] Chr19:16526787..24631604 [GRCh37]
Chr19:19p13.11-11
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.11(chr19:17921282-18025754)x3 copy number gain not provided [RCV000847969] Chr19:17921282..18025754 [GRCh37]
Chr19:19p13.11
uncertain significance
GRCh37/hg19 19p13.12-12(chr19:14286624-20956753)x3 copy number gain not provided [RCV001259370] Chr19:14286624..20956753 [GRCh37]
Chr19:19p13.12-12
pathogenic
GRCh37/hg19 19p13.11(chr19:17639605-17992841)x3 copy number gain not provided [RCV001259369] Chr19:17639605..17992841 [GRCh37]
Chr19:19p13.11
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6086 AgrOrtholog
COSMIC INSL3 COSMIC
Ensembl Genes ENSG00000248099 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000321724 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000369017 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000469309 UniProtKB/TrEMBL
Ensembl Transcript ENST00000317306 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000379695 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000598577 UniProtKB/TrEMBL
GTEx ENSG00000248099 GTEx
HGNC ID HGNC:6086 ENTREZGENE
Human Proteome Map INSL3 Human Proteome Map
InterPro INSL3 UniProtKB/Swiss-Prot
  INSL3/INSL4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot
KEGG Report hsa:3640 UniProtKB/Swiss-Prot
NCBI Gene 3640 ENTREZGENE
OMIM 146738 OMIM
  219050 OMIM
PANTHER PTHR10423 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10423:SF4 UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PharmGKB PA29893 PharmGKB
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.37062 ENTREZGENE
UniProt INSL3_HUMAN UniProtKB/Swiss-Prot
  M0QXQ3_HUMAN UniProtKB/TrEMBL
  P51460 ENTREZGENE
UniProt Secondary B4DZ72 UniProtKB/Swiss-Prot
  G3XAG0 UniProtKB/Swiss-Prot
  Q3KPI5 UniProtKB/Swiss-Prot
  Q3KPI6 UniProtKB/Swiss-Prot
  Q6YNB5 UniProtKB/Swiss-Prot
  Q9UEA2 UniProtKB/Swiss-Prot
  Q9UPH6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 INSL3  insulin like 3    insulin-like 3 (Leydig cell)  Symbol and/or name change 5135510 APPROVED