MLH1 (mutL homolog 1) - Rat Genome Database

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Gene: MLH1 (mutL homolog 1) Homo sapiens
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Symbol: MLH1
Name: mutL homolog 1
RGD ID: 733729
HGNC Page HGNC
Description: Enables chromatin binding activity and enzyme binding activity. Contributes to MutSalpha complex binding activity and single-stranded DNA binding activity. Acts upstream of or within mismatch repair. Located in nucleoplasm. Implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Biomarker of cervix uteri carcinoma in situ; colon cancer; respiratory system cancer (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: COCA2; DNA mismatch repair protein Mlh1; FCC2; hMLH1; HNPCC; HNPCC2; MGC5172; mismatch repair protein; MMRCS1; mutL homolog 1, colon cancer, nonpolyposis type 2; mutL protein homolog 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl336,993,350 - 37,050,846 (+)EnsemblGRCh38hg38GRCh38
GRCh38336,993,487 - 37,050,846 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37337,035,009 - 37,092,337 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,009,983 - 37,067,341 (+)NCBINCBI36hg18NCBI36
Build 34337,009,982 - 37,067,341NCBI
Celera336,977,606 - 37,035,102 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef336,975,521 - 37,033,106 (+)NCBIHuRef
CHM1_1336,986,471 - 37,043,967 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model