NGF (nerve growth factor) - Rat Genome Database

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Gene: NGF (nerve growth factor) Homo sapiens
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Symbol: NGF
Name: nerve growth factor
RGD ID: 1352304
HGNC Page HGNC:7808
Description: Enables peptidase regulator activity and signaling receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors; neuron apoptotic process; and positive regulation of macromolecule metabolic process. Acts upstream of or within neuron projection morphogenesis. Predicted to be located in Golgi lumen; cytosol; and extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Biomarker of several diseases, including artery disease (multiple); interstitial cystitis; lung disease (multiple); neurogenic bladder; and obstructive sleep apnea.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: beta-nerve growth factor; Beta-NGF; HSAN5; MGC161426; MGC161428; nerve growth factor (beta polypeptide); nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGFB; pro-nerve growth factor long
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,285,917 - 115,338,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1115,285,904 - 115,338,770 (-)EnsemblGRCh38hg38GRCh38
GRCh371115,828,538 - 115,880,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,630,060 - 115,682,380 (-)NCBINCBI36Build 36hg18NCBI36
Build 341115,540,580 - 115,592,899NCBI
Celera1114,057,456 - 114,109,776 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,686,915 - 113,739,240 (-)NCBIHuRef
CHM1_11115,943,440 - 115,995,752 (-)NCBICHM1_1
T2T-CHM13v2.01115,297,082 - 115,349,408 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (EXP)
asthma  (IDA,IEP,ISO)
atherosclerosis  (IEP)
atopic dermatitis  (IEP)
bacterial meningitis  (ISO)
bladder disease  (ISO)
bladder neck obstruction  (ISO)
Bronchial Hyperreactivity  (EXP)
Burns  (ISO)
Charcot-Marie-Tooth disease  (IAGP)
chronic kidney disease  (EXP)
Chronic Pancreatitis  (ISO)
chronic ulcer of skin  (EXP)
Cocaine-Related Disorders  (EXP)
Congenital Pain Insensitivity  (IAGP)
corneal ulcer  (EXP)
coronary artery disease  (IEP)
cystitis  (EXP,ISO)
degenerative disc disease  (ISO)
diabetic encephalopathy  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (IEP)
end stage renal disease  (EXP,IDA)
epilepsy with generalized tonic-clonic seizures  (EXP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
glaucoma  (ISO)
glomerulonephritis  (EXP,IEP)
hereditary sensory and autonomic neuropathy type 5  (IAGP)
hereditary sensory neuropathy  (EXP)
heroin dependence  (EXP)
Hyperalgesia  (EXP,ISO)
hyperhomocysteinemia  (ISO)
Hyperkinesis  (EXP)
hypertension  (ISO)
hypothyroidism  (ISO)
IgA glomerulonephritis  (IAGP)
Inflammation  (EXP,ISO)
interstitial cystitis  (IDA,IEP,ISO)
interstitial lung disease  (IEP)
interstitial nephritis  (EXP)
Lewy body dementia  (EXP)
Lung Injury  (EXP,ISO)
malignant mesothelioma  (EXP)
mental depression  (ISO)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (EXP)
myofascial pain syndrome  (ISO)
Nerve Degeneration  (EXP)
nervous system disease  (EXP)
Neurobehavioral Manifestations  (EXP)
neurodegenerative disease  (EXP)
neurogenic bladder  (IEP,ISO)
Neurogenic Inflammation  (EXP)
obstructive sleep apnea  (IEP)
Overactive Urinary Bladder  (EXP,IDA,IEP,ISO)
Pain  (IDA,ISO)
Parkinson's disease  (EXP)
Parkinsonism  (EXP)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (EXP)
pulmonary fibrosis  (IEP)
pulmonary sarcoidosis  (IEP)
respiratory syncytial virus infectious disease  (ISO)
retinitis pigmentosa  (ISO)
rhinitis  (IEP)
Rib Fractures  (ISO)
sciatic neuropathy  (ISO)
sensorineural hearing loss  (IEP)
Spinal Cord Injuries  (ISO)
status epilepticus  (EXP)
Stroke  (ISO)
systemic scleroderma  (IEP)
visual epilepsy  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4-methylcatechol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
agathisflavone  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Asiaticoside  (ISO)
ATP  (ISO)
azamethiphos  (ISO)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP)
beta-D-glucosamine  (ISO)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
bucladesine  (EXP)
C60 fullerene  (ISO)
cabergoline  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calmidazolium  (ISO)
capsaicin  (EXP,ISO)
carbon monoxide  (ISO)
carmustine  (ISO)
carrageenan  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dihydrolipoic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopaminechrome (enol form)  (ISO)
doxorubicin  (EXP)
ebselen  (ISO)
echinacoside  (ISO)
edaravone  (EXP)
endosulfan  (ISO)
epalrestat  (ISO)
epinastine  (ISO)
epothilone B  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
everolimus  (ISO)
excitatory amino acid agonist  (ISO)
fenthion  (ISO)
fluphenazine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
Fusarenone X  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (ISO)
gentamycin  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycidol  (ISO)
Goe 6976  (ISO)
heptachlor  (ISO)
heroin  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
ketamine  (ISO)
ketotifen  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
masoprocol  (ISO)
mepyramine  (ISO)
mercury atom  (EXP,ISO)
mercury(0)  (EXP,ISO)
methamphetamine  (ISO)
Methanandamide  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
mithramycin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naproxen  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nitrates  (ISO)
nitric oxide  (ISO)
nocodazole  (ISO)
O-acetyl-L-carnitine  (ISO)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
parathion-methyl  (ISO)
PD-166866  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pergolide  (ISO)
permethrin  (ISO)
peroxynitrous acid  (ISO)
phenethyl caffeate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
procymidone  (ISO)
progesterone  (ISO)
promethazine  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
ranitidine  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
salubrinal  (ISO)
SB 203580  (ISO)
scopolamine  (ISO)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sorbinil  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sumatriptan  (ISO)
tacrolimus hydrate  (ISO)
taurine  (ISO)
temozolomide  (EXP)
terbutaline  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (EXP)
thiopental  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triprolidine  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
udenafil  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vindesine  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IGI)
adult locomotory behavior  (ISO)
aging  (ISO)
axon extension  (ISO)
circadian rhythm  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IDA)
inflammatory response  (ISO)
memory  (IBA,ISO)
modulation of chemical synaptic transmission  (IBA)
negative regulation of cell population proliferation  (TAS)
negative regulation of endopeptidase activity  (IEA)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of peptidase activity  (IEA)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
nerve development  (IBA)
nerve growth factor signaling pathway  (IBA,ISO)
neuron apoptotic process  (IGI,ISO)
neuron projection development  (ISO)
neuron projection morphogenesis  (IBA,IDA)
peripheral nervous system development  (IBA,ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collateral sprouting  (IBA,ISO)
positive regulation of DNA binding  (ISS)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IMP,ISO,ISS)
positive regulation of neuron differentiation  (ISO,TAS)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotrophin TRK receptor signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IBA)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of Ras protein signal transduction  (ISS)
positive regulation of stem cell proliferation  (ISO)
protein phosphorylation  (ISO)
regulation of neuron differentiation  (IBA,ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to ozone  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)
signal transduction  (IEA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
2. Nerve growth factor and its monocyte receptors are affected in kidney disease. Antonucci MT, etal., Nephron Clin Pract. 2009;111(1):c21-8. doi: 10.1159/000178819. Epub 2008 Dec 9.
3. Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae. Barichello T, etal., Brain Res Bull. 2013 Mar;92:56-9. doi: 10.1016/j.brainresbull.2012.05.014. Epub 2012 Jun 7.
4. Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor. Bjorling DE, etal., BJU Int. 2001 May;87(7):697-702.
5. Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice. Boudes M, etal., Neurourol Urodyn. 2011 Nov;30(8):1659-65. doi: 10.1002/nau.21180. Epub 2011 Jun 29.
6. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Chaldakov GN, etal., Arch Physiol Biochem. 2001 Oct;109(4):357-60.
7. Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis. Chaldakov GN, etal., Atherosclerosis. 2001 Nov;159(1):57-66.
8. Combination therapy with intranasal NGF and electroacupuncture enhanced cell proliferation and survival in rats after stroke. Cheng S, etal., Neurol Res. 2008 Dec 5.
9. Effect of angiotensin II receptor antagonist telmisartan on detrusor overactivity in rats with bladder outlet obstruction. Cho ST, etal., Urology. 2012 Nov;80(5):1163.e1-7. doi: 10.1016/j.urology.2012.05.002. Epub 2012 Jul 13.
10. Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. Chung CW, etal., J Biol Chem. 2010 Feb 5;285(6):4206-12. doi: 10.1074/jbc.M109.040444. Epub 2009 Dec 7.
11. Increased neurotrophin production in a Penicillium chrysogenum-induced allergic asthma model in mice. Chung YJ, etal., J Toxicol Environ Health A. 2007 Jun;70(12):1020-6.
12. Stretch-activated signaling of nerve growth factor secretion in bladder and vascular smooth muscle cells from hypertensive and hyperactive rats. Clemow DB, etal., J Cell Physiol. 2000 Jun;183(3):289-300.
13. Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. Coffey CS, etal., Am J Rhinol Allergy. 2009 Nov-Dec;23(6):571-4.
14. Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression. Dagnell C, etal., Respir Res. 2010 Nov 8;11:156.
15. mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. De Simone R, etal., Neuropathol Appl Neurobiol. 1996 Feb;22(1):54-9.
16. Role of nerve growth factor in allergic and inflammatory lung diseases. El-Banna SM, etal., J Microbiol Immunol Infect. 2006 Dec;39(6):444-51.
17. Melatonin treatment protects against spinal cord injury induced functional and biochemical changes in rat urinary bladder. Ersahin M, etal., J Pineal Res. 2012 Apr;52(3):340-8. doi: 10.1111/j.1600-079X.2011.00948.x. Epub 2012 Jan 6.
18. Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. Fukuoka T, etal., J Neurosci. 2001 Jul 1;21(13):4891-900.
19. Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease. Gelfo F, etal., J Alzheimers Dis. 2011 Jan 1;25(2):213-7.
20. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
21. Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Goldbart AD, etal., Pediatr Res. 2007 Oct;62(4):489-94.
22. Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone. Grills BL and Schuijers JA, Acta Orthop Scand. 1998 Aug;69(4):415-9.
23. Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats. Guerios SD, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R111-22. doi: 10.1152/ajpregu.00728.2007. Epub 2008 Apr 30.
24. Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice. Guerios SD, etal., Neurosci Lett. 2006 Jan 16;392(3):193-7. Epub 2005 Oct 3.
25. Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat. Gwak YS, etal., Neurosci Lett. 2003 Jan 16;336(2):117-20.
26. Linkage and association study of neurotrophins and their receptors as novel susceptibility genes for childhood IgA nephropathy. Hahn WH, etal., Pediatr Res. 2011 Apr;69(4):299-305. doi: 10.1203/PDR.0b013e31820b9365.
27. Effect of hyaluronic acid on urine nerve growth factor in cyclophosphamide-induced cystitis. Ho DR, etal., Int J Urol. 2011 Jul;18(7):525-31. doi: 10.1111/j.1442-2042.2011.02779.x. Epub 2011 May 23.
28. A study of the cough reflex in idiopathic pulmonary fibrosis. Hope-Gill BD, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):995-1002. Epub 2003 Aug 13.
29. Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury. Kasahara K, etal., Spine (Phila Pa 1976). 2006 Aug 15;31(18):2059-66.
30. Urinary nerve growth factor level in children with neurogenic bladder due to myelomeningocele. Korzeniecka-Kozerska A, etal., Scand J Urol. 2013 Jan 10.
31. Neuronal modulation of lung injury induced by polymeric hexamethylene diisocyanate in mice. Lee CT, etal., Toxicol Appl Pharmacol. 2007 Oct 1;224(1):19-28. Epub 2007 Jun 27.
32. Serum nerve grow factor and brain-derived neurotrophic factor profiles in Sjogren's syndrome concomitant with interstitial lung disease. Li YJ, etal., Clin Rheumatol. 2014 Apr 2.
33. Serum neurotrophin profile in systemic sclerosis. Lise MC, etal., PLoS One. 2010 Nov 9;5(11):e13918.
34. Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease. Liu HT and Kuo HC, PLoS One. 2012;7(9):e44687. doi: 10.1371/journal.pone.0044687. Epub 2012 Sep 17.
35. Intravesical botulinum toxin A injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis. Liu HT and Kuo HC, Urology. 2007 Sep;70(3):463-8.
36. Increased serum nerve growth factor levels in patients with overactive bladder syndrome refractory to antimuscarinic therapy. Liu HT, etal., Neurourol Urodyn. 2011 Nov;30(8):1525-9. doi: 10.1002/nau.21118. Epub 2011 Aug 8.
37. RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model. Liu W, etal., J Autoimmun. 2008 Jun;30(4):257-65. Epub 2007 Dec 26.
38. Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy. Murakawa Y, etal., Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):473-83.
39. Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa. Muzi S, etal., Cornea. 2010 Oct;29(10):1163-8.
40. The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics. Noga O, etal., Clin Exp Allergy. 2001 Dec;31(12):1906-12.
41. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Noga O, etal., Clin Exp Allergy. 2003 May;33(5):649-54.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs. Orita S, etal., J Orthop Res. 2010 Dec;28(12):1614-20.
44. Serum and tear levels of nerve growth factor in diabetic retinopathy patients. Park KS, etal., Am J Ophthalmol. 2008 Mar;145(3):432-7. doi: 10.1016/j.ajo.2007.11.011.
45. Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome/interstitial cystitis. Pinto R, etal., Eur Urol. 2010 Sep;58(3):360-5. doi: 10.1016/j.eururo.2010.02.031. Epub 2010 Mar 6.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats. Pirchl M, etal., Eur J Neurosci. 2010 Nov;32(9):1516-27.
48. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Qu L, etal., Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(21):2539-44.
49. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Raap U, etal., Allergy. 2006 Dec;61(12):1416-8.
50. Differential up-regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects. Raap U, etal., Clin Exp Allergy. 2008 Sep;38(9):1493-8. Epub 2008 Jul 17.
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
54. Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. Ricci A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):186-94.
55. Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation. Saab CY, etal., J Neuroimmunol. 2009 Feb 4.
56. Nicorandil ameliorates hypertension-related bladder dysfunction in the rat. Saito M, etal., Neurourol Urodyn. 2012 Jun;31(5):695-701. doi: 10.1002/nau.21213. Epub 2012 Mar 30.
57. [Nerve growth factor and brain-derived neurotrophic factor: a possible etiopathogenic role in sensorineural hearing loss. Preliminary data]. Salvinelli F, etal., Ann Ist Super Sanita. 2003;39(2):189-94.
58. Neural hyperresponsiveness and nerve growth factor in allergic rhinitis. Sanico AM, etal., Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):154-8.
59. Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats. Santos FM, etal., Mol Pain. 2012 Jul 29;8:57. doi: 10.1186/1744-8069-8-57.
60. Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. Sasaki K, etal., Diabetes. 2004 Oct;53(10):2723-30.
61. Nerve growth factor enhances Clara cell proliferation after lung injury. Sonar SS, etal., Eur Respir J. 2010 Jul;36(1):105-15. Epub 2010 Jan 14.
62. Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment. Song C, etal., J Neurosci. 2009 Jan 7;29(1):14-22.
63. Glaucoma alters the expression of NGF and NGF receptors in visual cortex and geniculate nucleus of rats: effect of eye NGF application. Sposato V, etal., Vision Res. 2009 Jan;49(1):54-63. Epub 2008 Nov 11.
64. Vascular and Neuronal Protection Induced by the Ocular Administration of Nerve Growth Factor in Diabetic-Induced Rat Encephalopathy. Tirassa P, etal., CNS Neurosci Ther. 2013 Mar 26. doi: 10.1111/cns.12085.
65. Nerve growth factor induces systemic hyperalgesia after thoracic burn injury in the rat. Ueda M, etal., Neurosci Lett. 2002 Aug 9;328(2):97-100.
66. Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Urrego F, etal., Pediatr Pulmonol. 2009 Nov;44(11):1075-84.
67. Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice. Vera PL, etal., Neurourol Urodyn. 2010 Nov;29(8):1451-7. doi: 10.1002/nau.20878.
68. Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain. Winston JH, etal., Pain. 2005 Sep;117(1-2):214-22.
69. The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation. Xanthos DN, etal., Neuropharmacology. 2009 Mar;56(3):684-91. Epub 2008 Dec 11.
70. Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration. Yan Q, etal., Biomed Eng Online. 2012 Jul 9;11:36. doi: 10.1186/1475-925X-11-36.
71. Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats. Yoshimura N, etal., J Neurosci. 2006 Oct 18;26(42):10847-55.
72. Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat. Zhang L, etal., Neurobiol Dis. 2009 Feb 19.
Additional References at PubMed
PMID:1383421   PMID:1692298   PMID:2025430   PMID:2374737   PMID:2906326   PMID:3871525   PMID:6327169   PMID:6330750   PMID:6648531   PMID:6688123   PMID:7537086   PMID:7789166  
PMID:7806500   PMID:8178451   PMID:8615794   PMID:8808283   PMID:8895847   PMID:9069267   PMID:9182757   PMID:9252186   PMID:9351801   PMID:9575168   PMID:9915784   PMID:10022904  
PMID:10322959   PMID:10362258   PMID:10391209   PMID:10490030   PMID:10629055   PMID:10681572   PMID:10712923   PMID:10764727   PMID:10806167   PMID:11157096   PMID:11244088   PMID:11278287  
PMID:11487608   PMID:11520933   PMID:11729324   PMID:11738045   PMID:11830582   PMID:11877300   PMID:12205295   PMID:12371150   PMID:12376548   PMID:12397373   PMID:12453472   PMID:12477932  
PMID:12531456   PMID:12676754   PMID:12676795   PMID:12787561   PMID:12787574   PMID:12900521   PMID:12918708   PMID:12925217   PMID:14708938   PMID:14960584   PMID:14970904   PMID:14976160  
PMID:14985763   PMID:15128850   PMID:15131306   PMID:15258592   PMID:15361847   PMID:15489334   PMID:15523689   PMID:15544837   PMID:15681836   PMID:15710408   PMID:15721744   PMID:15829579  
PMID:16079148   PMID:16153003   PMID:16215275   PMID:16284401   PMID:16313302   PMID:16319926   PMID:16546643   PMID:16630834   PMID:16710414   PMID:16741963   PMID:16786155   PMID:16832412  
PMID:16839849   PMID:16919030   PMID:16939974   PMID:16997282   PMID:17081983   PMID:17192954   PMID:17335080   PMID:17487982   PMID:17638883   PMID:17673289   PMID:17703412   PMID:17724343  
PMID:17850422   PMID:17854142   PMID:17881264   PMID:17893397   PMID:17992191   PMID:18068123   PMID:18179783   PMID:18191449   PMID:18199526   PMID:18203754   PMID:18221326   PMID:18230652  
PMID:18280641   PMID:18300262   PMID:18305571   PMID:18349121   PMID:18420729   PMID:18438945   PMID:18596692   PMID:18635195   PMID:18727839   PMID:18763222   PMID:18780967   PMID:18810245  
PMID:18830907   PMID:18922682   PMID:18922683   PMID:19023688   PMID:19038326   PMID:19038341   PMID:19054925   PMID:19063739   PMID:19076929   PMID:19086053   PMID:19120874   PMID:19122660  
PMID:19177265   PMID:19183217   PMID:19221293   PMID:19258923   PMID:19264868   PMID:19399531   PMID:19403065   PMID:19475530   PMID:19490633   PMID:19560628   PMID:19598235   PMID:19626992  
PMID:19639490   PMID:19649262   PMID:19651702   PMID:19668232   PMID:19695094   PMID:19758188   PMID:19844736   PMID:19874574   PMID:19934806   PMID:19945432   PMID:19950533   PMID:19957796  
PMID:20119692   PMID:20159974   PMID:20164177   PMID:20219210   PMID:20233324   PMID:20360245   PMID:20375017   PMID:20398908   PMID:20503287   PMID:20518854   PMID:20542022   PMID:20680101  
PMID:20854189   PMID:20863878   PMID:20881126   PMID:20889312   PMID:20923384   PMID:20978020   PMID:21047631   PMID:21153361   PMID:21217078   PMID:21294249   PMID:21321391   PMID:21358750  
PMID:21378097   PMID:21387003   PMID:21397006   PMID:21429417   PMID:21596795   PMID:21621608   PMID:21673280   PMID:21693611   PMID:21768088   PMID:21873635   PMID:21893340   PMID:22036954  
PMID:22040304   PMID:22105621   PMID:22192858   PMID:22251933   PMID:22272270   PMID:22301435   PMID:22330829   PMID:22411587   PMID:22454143   PMID:22517242   PMID:22537619   PMID:22625872  
PMID:22703891   PMID:22731611   PMID:22789557   PMID:22804708   PMID:22932111   PMID:22948388   PMID:22948508   PMID:22954667   PMID:23034254   PMID:23086522   PMID:23091165   PMID:23095849  
PMID:23128606   PMID:23234779   PMID:23398122   PMID:23535911   PMID:23542336   PMID:23561736   PMID:23570892   PMID:23574818   PMID:23608378   PMID:23637956   PMID:23769609   PMID:23771673  
PMID:23778138   PMID:23869086   PMID:23883529   PMID:23885099   PMID:23912036   PMID:23959444   PMID:23973519   PMID:23989259   PMID:24112788   PMID:24146927   PMID:24180625   PMID:24212932  
PMID:24458144   PMID:24557415   PMID:24585880   PMID:24614892   PMID:24706316   PMID:24733087   PMID:24793757   PMID:24794250   PMID:24825909   PMID:24899094   PMID:24939299   PMID:25001650  
PMID:25019486   PMID:25033919   PMID:25064020   PMID:25069717   PMID:25162994   PMID:25181532   PMID:25275256   PMID:25285721   PMID:25286822   PMID:25383879   PMID:25491371   PMID:25496838  
PMID:25510766   PMID:25519715   PMID:25595986   PMID:25611484   PMID:25613138   PMID:25619719   PMID:25650935   PMID:25816145   PMID:25840418   PMID:25853140   PMID:25854576   PMID:25876154  
PMID:25916157   PMID:26021968   PMID:26066770   PMID:26118751   PMID:26337663   PMID:26408608   PMID:26457789   PMID:26547754   PMID:26569118   PMID:26572749   PMID:26616164   PMID:26825093  
PMID:26962689   PMID:26966186   PMID:27008247   PMID:27020638   PMID:27146986   PMID:27264679   PMID:27367919   PMID:27424144   PMID:27439311   PMID:27454463   PMID:27513943   PMID:27561780  
PMID:27577679   PMID:27654574   PMID:27683235   PMID:27792755   PMID:27802234   PMID:27835587   PMID:27862119   PMID:27908212   PMID:27936243   PMID:27978558   PMID:28068360   PMID:28237042  
PMID:28249734   PMID:28253191   PMID:28260038   PMID:28364186   PMID:28465581   PMID:28494216   PMID:28677145   PMID:28679437   PMID:28798232   PMID:29174194   PMID:29328070   PMID:29419974  
PMID:29476769   PMID:29499660   PMID:29527653   PMID:29539621   PMID:29584618   PMID:29799860   PMID:29802376   PMID:30039889   PMID:30070410   PMID:30092220   PMID:30296891   PMID:30393197  
PMID:30418350   PMID:30575339   PMID:30663865   PMID:30680928   PMID:30771434   PMID:30981636   PMID:31002151   PMID:31077183   PMID:31301255   PMID:31541132   PMID:31685654   PMID:31732726  
PMID:31775361   PMID:31775768   PMID:31838083   PMID:31901598   PMID:31925656   PMID:31996124   PMID:32001246   PMID:32151405   PMID:32240297   PMID:32294802   PMID:32440884   PMID:32488129  
PMID:32569620   PMID:32693191   PMID:32767928   PMID:32813897   PMID:32814053   PMID:32827836   PMID:32892409   PMID:33026185   PMID:33398073   PMID:33649819   PMID:34000361   PMID:34074169  
PMID:34214954   PMID:34556815   PMID:34589551   PMID:34639085   PMID:34763683   PMID:34991456   PMID:35008797   PMID:35095908   PMID:35216240   PMID:35219096   PMID:35309353   PMID:35351958  
PMID:35579787  


Genomics

Comparative Map Data
NGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,285,917 - 115,338,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1115,285,904 - 115,338,770 (-)EnsemblGRCh38hg38GRCh38
GRCh371115,828,538 - 115,880,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,630,060 - 115,682,380 (-)NCBINCBI36Build 36hg18NCBI36
Build 341115,540,580 - 115,592,899NCBI
Celera1114,057,456 - 114,109,776 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,686,915 - 113,739,240 (-)NCBIHuRef
CHM1_11115,943,440 - 115,995,752 (-)NCBICHM1_1
T2T-CHM13v2.01115,297,082 - 115,349,408 (-)NCBIT2T-CHM13v2.0
Ngf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,377,235 - 102,428,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,377,235 - 102,428,329 (+)EnsemblGRCm39 Ensembl
GRCm383102,469,919 - 102,521,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,469,919 - 102,521,013 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,273,851 - 102,324,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,598,989 - 102,650,066 (+)NCBIMGSCv36mm8
Celera3104,674,123 - 104,724,621 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Ngf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22189,901,058 - 189,954,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,519,156 - 197,572,237 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02195,377,191 - 195,431,562 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02190,206,371 - 190,261,316 (+)NCBIRnor_WKY
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
RH 3.4 Map21294.4RGD
Cytogenetic Map2q34NCBI
Ngf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBIChiLan1.0ChiLan1.0
NGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,272,750 - 122,325,909 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0187,223,597 - 87,276,759 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,900,647 - 52,901,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,900,647 - 52,901,607 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,550,068 - 52,550,845 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01753,781,750 - 53,834,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,781,750 - 53,782,527 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,820,833 - 52,821,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,855,816 - 52,856,593 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,428,944 - 53,429,721 (-)NCBIUU_Cfam_GSD_1.0
Ngf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,803,009 - 13,853,189 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,256,749 - 105,307,837 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,256,691 - 105,307,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,436,784 - 115,446,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,361,795 - 18,413,987 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,413,108 - 18,413,833 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603821,083,578 - 21,157,325 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ngf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477211,010,845 - 11,070,017 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477211,009,765 - 11,070,050 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D1S3540  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,828,728 - 115,828,821UniSTSGRCh37
Build 361115,630,251 - 115,630,344RGDNCBI36
Celera1114,057,647 - 114,057,740RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,687,106 - 113,687,199UniSTS
TNG Radiation Hybrid Map163038.0UniSTS
Stanford-G3 RH Map15429.0UniSTS
GeneMap99-GB4 RH Map1386.97UniSTS
NCBI RH Map1843.9UniSTS
GeneMap99-G3 RH Map15385.0UniSTS
D1S2148  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,874,897 - 115,875,382UniSTSGRCh37
Build 361115,676,420 - 115,676,905RGDNCBI36
Celera1114,103,825 - 114,104,310RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,733,282 - 113,733,767UniSTS
D1S2206  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,854,221 - 115,854,356UniSTSGRCh37
Build 361115,655,744 - 115,655,879RGDNCBI36
Celera1114,083,154 - 114,083,289RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,712,613 - 113,712,748UniSTS
D1S2209  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,829,837 - 115,829,984UniSTSGRCh37
Build 361115,631,360 - 115,631,507RGDNCBI36
Celera1114,058,756 - 114,058,903RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,688,215 - 113,688,362UniSTS
D1S2220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,874,408 - 115,874,669UniSTSGRCh37
Build 361115,675,931 - 115,676,192RGDNCBI36
Celera1114,103,336 - 114,103,597RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,732,793 - 113,733,054UniSTS
GDB:181532  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,836,184 - 115,836,700UniSTSGRCh37
Build 361115,637,707 - 115,638,223RGDNCBI36
Celera1114,065,101 - 114,065,617RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,694,561 - 113,695,077UniSTS
SHGC-75366  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,828,593 - 115,828,670UniSTSGRCh37
Build 361115,630,116 - 115,630,193RGDNCBI36
Celera1114,057,512 - 114,057,589RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,686,971 - 113,687,048UniSTS
TNG Radiation Hybrid Map163046.0UniSTS
GeneMap99-GB4 RH Map1374.01UniSTS
GeneMap99-GB4 RH Map1387.02UniSTS
Whitehead-RH Map1440.7UniSTS
hsbngfac  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,828,825 - 115,829,053UniSTSGRCh37
Build 361115,630,348 - 115,630,576RGDNCBI36
Celera1114,057,744 - 114,057,972RGD
Cytogenetic Map1p13.1UniSTS
HuRef1113,687,203 - 113,687,431UniSTS
GeneMap99-GB4 RH Map1387.02UniSTS
NGFB  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371115,828,625 - 115,829,386UniSTSGRCh37
Celera1114,057,544 - 114,058,305UniSTS
HuRef1113,687,003 - 113,687,764UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:265
Interacting mature miRNAs:268
Transcripts:ENST00000369512
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 249 1660 145 11 33 12 1307 158 606 91 492 178 5 567 1165
Low 1909 586 1503 553 460 404 2477 1652 2234 296 884 1330 159 1 637 1197 2
Below cutoff 176 289 68 53 406 41 523 360 827 17 49 65 10 417 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006710663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB037517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF150960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL512638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY315821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE045524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH358394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000369512   ⟹   ENSP00000358525
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,285,917 - 115,338,249 (-)Ensembl
RefSeq Acc Id: ENST00000675637   ⟹   ENSP00000502831
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,285,917 - 115,338,253 (-)Ensembl
RefSeq Acc Id: ENST00000676038   ⟹   ENSP00000502380
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,285,904 - 115,338,256 (-)Ensembl
RefSeq Acc Id: ENST00000679806   ⟹   ENSP00000506492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,285,917 - 115,338,770 (-)Ensembl
RefSeq Acc Id: ENST00000680116   ⟹   ENSP00000505694
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,285,917 - 115,338,249 (-)Ensembl
RefSeq Acc Id: ENST00000680540   ⟹   ENSP00000506569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,286,025 - 115,289,021 (-)Ensembl
RefSeq Acc Id: ENST00000680752   ⟹   ENSP00000505558
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,286,025 - 115,338,459 (-)Ensembl
RefSeq Acc Id: ENST00000681124   ⟹   ENSP00000506364
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1115,285,917 - 115,338,249 (-)Ensembl
RefSeq Acc Id: NM_002506   ⟹   NP_002497
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381115,285,917 - 115,338,249 (-)NCBI
GRCh371115,828,537 - 115,880,857 (-)ENTREZGENE
Build 361115,630,060 - 115,682,380 (-)NCBI Archive
HuRef1113,686,915 - 113,739,240 (-)ENTREZGENE
CHM1_11115,943,440 - 115,995,752 (-)NCBI
T2T-CHM13v2.01115,297,082 - 115,349,408 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006710663   ⟹   XP_006710726
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381115,285,917 - 115,338,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541518   ⟹   XP_011539820
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381115,285,917 - 115,303,458 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002497   ⟸   NM_002506
- Peptide Label: precursor
- UniProtKB: Q9UKL8 (UniProtKB/Swiss-Prot),   P01138 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006710726   ⟸   XM_006710663
- Peptide Label: isoform X2
- UniProtKB: Q9UKL8 (UniProtKB/Swiss-Prot),   P01138 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011539820   ⟸   XM_011541518
- Peptide Label: isoform X1
- UniProtKB: A0A346FYQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000358525   ⟸   ENST00000369512
RefSeq Acc Id: ENSP00000502831   ⟸   ENST00000675637
RefSeq Acc Id: ENSP00000502380   ⟸   ENST00000676038
RefSeq Acc Id: ENSP00000505558   ⟸   ENST00000680752
RefSeq Acc Id: ENSP00000506364   ⟸   ENST00000681124
RefSeq Acc Id: ENSP00000505694   ⟸   ENST00000680116
RefSeq Acc Id: ENSP00000506492   ⟸   ENST00000679806
RefSeq Acc Id: ENSP00000506569   ⟸   ENST00000680540
Protein Domains
NGF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01138-F1-model_v2 AlphaFold P01138 1-241 view protein structure

Promoters
RGD ID:6856726
Promoter ID:EPDNEW_H1528
Type:initiation region
Name:NGF_1
Description:nerve growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381115,338,236 - 115,338,296EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002506.3(NGF):c.170C>T (p.Ala57Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000547214] Chr1:115286626 [GRCh38]
Chr1:115829247 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.680_682delinsA (p.Thr227fs) indel Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000022672] Chr1:115286114..115286116 [GRCh38]
Chr1:115828735..115828737 [GRCh37]
Chr1:1p13.2
pathogenic
NM_002506.3(NGF):c.661C>T (p.Arg221Trp) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000015089] Chr1:115286135 [GRCh38]
Chr1:115828756 [GRCh37]
Chr1:1p13.2
pathogenic
NM_002506.3(NGF):c.561C>T (p.Ser187=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000526575] Chr1:115286235 [GRCh38]
Chr1:115828856 [GRCh37]
Chr1:1p13.2
likely benign
GRCh38/hg38 1p13.3-12(chr1:109756630-118650204)x3 copy number gain See cases [RCV000051827] Chr1:109756630..118650204 [GRCh38]
Chr1:110299252..119192827 [GRCh37]
Chr1:110100775..118994350 [NCBI36]
Chr1:1p13.3-12
pathogenic
NM_002506.2(NGF):c.251C>T (p.Ser84Leu) single nucleotide variant Malignant melanoma [RCV000064037] Chr1:115286545 [GRCh38]
Chr1:115829166 [GRCh37]
Chr1:115630689 [NCBI36]
Chr1:1p13.2
not provided
NM_002506.2(NGF):c.106C>T (p.His36Tyr) single nucleotide variant Malignant melanoma [RCV000064038] Chr1:115286690 [GRCh38]
Chr1:115829311 [GRCh37]
Chr1:115630834 [NCBI36]
Chr1:1p13.2
not provided
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12
pathogenic
NM_002506.3(NGF):c.687T>C (p.Cys229=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000399968] Chr1:115286109 [GRCh38]
Chr1:115828730 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.335C>G (p.Pro112Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000265567]|not provided [RCV000494698] Chr1:115286461 [GRCh38]
Chr1:115829082 [GRCh37]
Chr1:1p13.2
likely pathogenic|uncertain significance
NM_002506.3(NGF):c.104C>T (p.Ala35Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000268865]|not provided [RCV001618498]|not specified [RCV001699424] Chr1:115286692 [GRCh38]
Chr1:115829313 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.-13+14G>A single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000383246]|not specified [RCV000430743] Chr1:115293613 [GRCh38]
Chr1:115836234 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002506.3(NGF):c.214G>A (p.Val72Met) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000546440]|not specified [RCV000603122] Chr1:115286582 [GRCh38]
Chr1:115829203 [GRCh37]
Chr1:1p13.2
benign
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
NM_002506.3(NGF):c.421G>C (p.Val141Leu) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000357900] Chr1:115286375 [GRCh38]
Chr1:115828996 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.196C>A (p.Gln66Lys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000361135] Chr1:115286600 [GRCh38]
Chr1:115829221 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.54G>A (p.Ala18=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000326286]|not provided [RCV001618499] Chr1:115286742 [GRCh38]
Chr1:115829363 [GRCh37]
Chr1:1p13.2
benign|likely benign|conflicting interpretations of pathogenicity
NM_002506.3(NGF):c.247C>T (p.Arg83Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631359]|not provided [RCV000235572] Chr1:115286549 [GRCh38]
Chr1:115829170 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.284G>A (p.Arg95His) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000545363]|not provided [RCV001722274] Chr1:115286512 [GRCh38]
Chr1:115829133 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002506.3(NGF):c.562G>A (p.Gly188Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000700443]|not provided [RCV000236895] Chr1:115286234 [GRCh38]
Chr1:115828855 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.239G>A (p.Arg80Gln) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000322937]|not provided [RCV001706427]|not specified [RCV001699337] Chr1:115286557 [GRCh38]
Chr1:115829178 [GRCh37]
Chr1:1p13.2
benign|likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_002506.3(NGF):c.173C>T (p.Ala58Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000553133] Chr1:115286623 [GRCh38]
Chr1:115829244 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.106C>A (p.His36Asn) single nucleotide variant not provided [RCV000262770] Chr1:115286690 [GRCh38]
Chr1:115829311 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.133G>A (p.Asp45Asn) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000532480] Chr1:115286663 [GRCh38]
Chr1:115829284 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.*120T>G single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000354557] Chr1:115285950 [GRCh38]
Chr1:115828571 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.477G>A (p.Val159=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000300728] Chr1:115286319 [GRCh38]
Chr1:115828940 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.372C>G (p.Ser124=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000549147] Chr1:115286424 [GRCh38]
Chr1:115829045 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.191C>T (p.Ala64Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000531393]|not provided [RCV000597730] Chr1:115286605 [GRCh38]
Chr1:115829226 [GRCh37]
Chr1:1p13.2
conflicting interpretations of pathogenicity|uncertain significance
NM_002506.3(NGF):c.706A>C (p.Lys236Gln) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000541314] Chr1:115286090 [GRCh38]
Chr1:115828711 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.483A>G (p.Gly161=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000537837] Chr1:115286313 [GRCh38]
Chr1:115828934 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.257G>A (p.Arg86His) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000535152] Chr1:115286539 [GRCh38]
Chr1:115829160 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p13.2-12(chr1:114507501-120494232)x3 copy number gain See cases [RCV000449311] Chr1:114507501..120494232 [GRCh37]
Chr1:1p13.2-12
pathogenic
NM_002506.3(NGF):c.393C>T (p.Gly131=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000527399]|not specified [RCV000434201] Chr1:115286403 [GRCh38]
Chr1:115829024 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002506.3(NGF):c.665T>G (p.Phe222Cys) single nucleotide variant not provided [RCV000427457] Chr1:115286131 [GRCh38]
Chr1:115828752 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.-120C>T single nucleotide variant not specified [RCV000442787] Chr1:115293734 [GRCh38]
Chr1:115836355 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.78C>T (p.Val26=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000871232]|not specified [RCV000429051] Chr1:115286718 [GRCh38]
Chr1:115829339 [GRCh37]
Chr1:1p13.2
benign|likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_002506.3(NGF):c.371C>T (p.Ser124Phe) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000534061] Chr1:115286425 [GRCh38]
Chr1:115829046 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.4T>C (p.Ser2Pro) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631357] Chr1:115286792 [GRCh38]
Chr1:115829413 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.670C>T (p.Arg224Trp) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631362] Chr1:115286126 [GRCh38]
Chr1:115828747 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.174G>A (p.Ala58=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631364] Chr1:115286622 [GRCh38]
Chr1:115829243 [GRCh37]
Chr1:1p13.2
likely benign|conflicting interpretations of pathogenicity
NM_002506.3(NGF):c.53C>T (p.Ala18Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631358] Chr1:115286743 [GRCh38]
Chr1:115829364 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.645C>T (p.Gly215=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631361] Chr1:115286151 [GRCh38]
Chr1:115828772 [GRCh37]
Chr1:1p13.2
likely benign|uncertain significance
NM_002506.3(NGF):c.-137+13G>T single nucleotide variant not specified [RCV000601755] Chr1:115338191 [GRCh38]
Chr1:115880812 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.672G>A (p.Arg224=) single nucleotide variant not specified [RCV000615854] Chr1:115286124 [GRCh38]
Chr1:115828745 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.35T>G (p.Phe12Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000560325] Chr1:115286761 [GRCh38]
Chr1:115829382 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
Chr1:1p22.1-11.2
pathogenic
NM_002506.3(NGF):c.83C>A (p.Ala28Glu) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631360] Chr1:115286713 [GRCh38]
Chr1:115829334 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.202C>T (p.Arg68Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631363] Chr1:115286594 [GRCh38]
Chr1:115829215 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.93C>G (p.Thr31=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631365] Chr1:115286703 [GRCh38]
Chr1:115829324 [GRCh37]
Chr1:1p13.2
likely benign|conflicting interpretations of pathogenicity
NM_002506.3(NGF):c.165G>A (p.Pro55=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000631366] Chr1:115286631 [GRCh38]
Chr1:115829252 [GRCh37]
Chr1:1p13.2
likely benign|conflicting interpretations of pathogenicity
NM_002506.3(NGF):c.515A>G (p.Gln172Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000700395] Chr1:115286281 [GRCh38]
Chr1:115828902 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.638T>C (p.Met213Thr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000690491] Chr1:115286158 [GRCh38]
Chr1:115828779 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.539G>A (p.Arg180Gln) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000699487] Chr1:115286257 [GRCh38]
Chr1:115828878 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.399C>A (p.Phe133Leu) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000687757] Chr1:115286397 [GRCh38]
Chr1:115829018 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_002506.3(NGF):c.315C>T (p.Phe105=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000977465] Chr1:115286481 [GRCh38]
Chr1:115829102 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.537C>T (p.Cys179=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001455180]|not provided [RCV000928189] Chr1:115286259 [GRCh38]
Chr1:115828880 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.600T>C (p.Tyr200=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001459957]|not provided [RCV000756441] Chr1:115286196 [GRCh38]
Chr1:115828817 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.335C>A (p.Pro112His) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001052306] Chr1:115286461 [GRCh38]
Chr1:115829082 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.184C>T (p.Arg62Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001052027] Chr1:115286612 [GRCh38]
Chr1:115829233 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.318G>C (p.Glu106Asp) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001036400] Chr1:115286478 [GRCh38]
Chr1:115829099 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p13.2-13.1(chr1:114024461-116189135)x1 copy number loss not provided [RCV001005130] Chr1:114024461..116189135 [GRCh37]
Chr1:1p13.2-13.1
likely pathogenic
NM_002506.3(NGF):c.160G>A (p.Ala54Thr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000793092] Chr1:115286636 [GRCh38]
Chr1:115829257 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.417C>T (p.Val139=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001462283]|not provided [RCV000981880] Chr1:115286379 [GRCh38]
Chr1:115829000 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.186C>T (p.Arg62=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000797235] Chr1:115286610 [GRCh38]
Chr1:115829231 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.185G>A (p.Arg62His) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000820016]|not provided [RCV002067402] Chr1:115286611 [GRCh38]
Chr1:115829232 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.508T>C (p.Phe170Leu) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000795207] Chr1:115286288 [GRCh38]
Chr1:115828909 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.-12-118G>C single nucleotide variant not provided [RCV000835099] Chr1:115286925 [GRCh38]
Chr1:115829546 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.2(NGF):c.-367C>T single nucleotide variant not provided [RCV000826444] Chr1:115338434 [GRCh38]
Chr1:115881055 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.560G>A (p.Ser187Asn) single nucleotide variant Charcot-Marie-Tooth disease [RCV000789501] Chr1:115286236 [GRCh38]
Chr1:115828857 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.145C>T (p.Arg49Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000819975] Chr1:115286651 [GRCh38]
Chr1:115829272 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.680C>A (p.Thr227Lys) single nucleotide variant Charcot-Marie-Tooth disease [RCV000789667]|Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001055668] Chr1:115286116 [GRCh38]
Chr1:115828737 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.31G>A (p.Ala11Thr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000804429] Chr1:115286765 [GRCh38]
Chr1:115829386 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.184C>A (p.Arg62Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000794538] Chr1:115286612 [GRCh38]
Chr1:115829233 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.146G>A (p.Arg49His) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000798441]|NGF-Related Disorder [RCV001824886] Chr1:115286650 [GRCh38]
Chr1:115829271 [GRCh37]
Chr1:1p13.2
uncertain significance|not provided
NM_002506.3(NGF):c.38T>G (p.Leu13Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000802705] Chr1:115286758 [GRCh38]
Chr1:115829379 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.238C>T (p.Arg80Trp) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001043510] Chr1:115286558 [GRCh38]
Chr1:115829179 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.439A>T (p.Thr147Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000794521] Chr1:115286357 [GRCh38]
Chr1:115828978 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.681_682del (p.Ala228fs) deletion Charcot-Marie-Tooth disease [RCV000789668] Chr1:115286114..115286115 [GRCh38]
Chr1:115828735..115828736 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.154C>T (p.Arg52Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000799142] Chr1:115286642 [GRCh38]
Chr1:115829263 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.109T>C (p.Trp37Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000811327] Chr1:115286687 [GRCh38]
Chr1:115829308 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.318G>A (p.Glu106=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000941485] Chr1:115286478 [GRCh38]
Chr1:115829099 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.491A>T (p.Asn164Ile) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001067793] Chr1:115286305 [GRCh38]
Chr1:115828926 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.208A>G (p.Ile70Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001238906] Chr1:115286588 [GRCh38]
Chr1:115829209 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.216G>A (p.Val72=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001209786] Chr1:115286580 [GRCh38]
Chr1:115829201 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.372C>T (p.Ser124=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000928444] Chr1:115286424 [GRCh38]
Chr1:115829045 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.402G>A (p.Ser134=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000876379] Chr1:115286394 [GRCh38]
Chr1:115829015 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.468G>A (p.Glu156=) single nucleotide variant not provided [RCV000910930] Chr1:115286328 [GRCh38]
Chr1:115828949 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.193G>A (p.Gly65Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001244650] Chr1:115286603 [GRCh38]
Chr1:115829224 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.283C>A (p.Arg95Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001099158] Chr1:115286513 [GRCh38]
Chr1:115829134 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.145C>A (p.Arg49Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001236878] Chr1:115286651 [GRCh38]
Chr1:115829272 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.486G>A (p.Glu162=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV000934825] Chr1:115286310 [GRCh38]
Chr1:115828931 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.159C>T (p.Ser53=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001468856]|not provided [RCV000912567] Chr1:115286637 [GRCh38]
Chr1:115829258 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.-13+145C>A single nucleotide variant not provided [RCV001719268] Chr1:115293482 [GRCh38]
Chr1:115836103 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.562G>C (p.Gly188Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001034965] Chr1:115286234 [GRCh38]
Chr1:115828855 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.-13+228G>A single nucleotide variant not provided [RCV001616784] Chr1:115293399 [GRCh38]
Chr1:115836020 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.-137+150T>G single nucleotide variant not provided [RCV001641433] Chr1:115338054 [GRCh38]
Chr1:115880675 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.552C>T (p.Pro184=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001099075] Chr1:115286244 [GRCh38]
Chr1:115828865 [GRCh37]
Chr1:1p13.2
conflicting interpretations of pathogenicity|uncertain significance
NM_002506.3(NGF):c.632T>C (p.Leu211Pro) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001038641] Chr1:115286164 [GRCh38]
Chr1:115828785 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.52G>T (p.Ala18Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001205524] Chr1:115286744 [GRCh38]
Chr1:115829365 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.466G>A (p.Glu156Lys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001220422] Chr1:115286330 [GRCh38]
Chr1:115828951 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.662G>T (p.Arg221Leu) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001202277] Chr1:115286134 [GRCh38]
Chr1:115828755 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.316G>A (p.Glu106Lys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001054534] Chr1:115286480 [GRCh38]
Chr1:115829101 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.43G>A (p.Gly15Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001101152] Chr1:115286753 [GRCh38]
Chr1:115829374 [GRCh37]
Chr1:1p13.2
likely benign|conflicting interpretations of pathogenicity
NM_002506.3(NGF):c.224G>A (p.Arg75Lys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001328962] Chr1:115286572 [GRCh38]
Chr1:115829193 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.187G>A (p.Val63Met) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001324816] Chr1:115286609 [GRCh38]
Chr1:115829230 [GRCh37]
Chr1:1p13.2
uncertain significance
NC_000001.10:g.(?_115828681)_(115829426_?)dup duplication Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001319453] Chr1:115828681..115829426 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.572G>T (p.Gly191Val) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001373059] Chr1:115286224 [GRCh38]
Chr1:115828845 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p21.2-12(chr1:102021465-119737478) copy number loss Seizure [RCV001352640] Chr1:102021465..119737478 [GRCh37]
Chr1:1p21.2-12
pathogenic
NM_002506.3(NGF):c.388A>G (p.Arg130Gly) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001296799] Chr1:115286408 [GRCh38]
Chr1:115829029 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.69G>A (p.Glu23=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001442191] Chr1:115286727 [GRCh38]
Chr1:115829348 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.18C>T (p.Tyr6=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001402000] Chr1:115286778 [GRCh38]
Chr1:115829399 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.381C>T (p.Ile127=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001505348] Chr1:115286415 [GRCh38]
Chr1:115829036 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.205A>C (p.Asn69His) single nucleotide variant not provided [RCV001507971] Chr1:115286591 [GRCh38]
Chr1:115829212 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.480G>A (p.Leu160=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001482933] Chr1:115286316 [GRCh38]
Chr1:115828937 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.201C>A (p.Thr67=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001473956] Chr1:115286595 [GRCh38]
Chr1:115829216 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.246C>T (p.Leu82=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001424346] Chr1:115286550 [GRCh38]
Chr1:115829171 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.-136-167C>T single nucleotide variant not provided [RCV001762798] Chr1:115293917 [GRCh38]
Chr1:115836538 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.504T>A (p.Ser168Arg) single nucleotide variant not provided [RCV001754119] Chr1:115286292 [GRCh38]
Chr1:115828913 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.-13+185T>C single nucleotide variant not provided [RCV001779840] Chr1:115293442 [GRCh38]
Chr1:115836063 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.613C>G (p.His205Asp) single nucleotide variant not provided [RCV001816059] Chr1:115286183 [GRCh38]
Chr1:115828804 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.321C>T (p.Val107=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001802624] Chr1:115286475 [GRCh38]
Chr1:115829096 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.389G>A (p.Arg130Lys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002001930] Chr1:115286407 [GRCh38]
Chr1:115829028 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.124C>G (p.His42Asp) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001971455] Chr1:115286672 [GRCh38]
Chr1:115829293 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.445G>T (p.Ala149Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001908435] Chr1:115286351 [GRCh38]
Chr1:115828972 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.412A>G (p.Ser138Gly) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002006037] Chr1:115286384 [GRCh38]
Chr1:115829005 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.575T>C (p.Ile192Thr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001947636] Chr1:115286221 [GRCh38]
Chr1:115828842 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.136A>G (p.Thr46Ala) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001969057] Chr1:115286660 [GRCh38]
Chr1:115829281 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.487G>A (p.Val163Met) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001908367] Chr1:115286309 [GRCh38]
Chr1:115828930 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.280C>A (p.Pro94Thr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001945918] Chr1:115286516 [GRCh38]
Chr1:115829137 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.253C>T (p.Pro85Ser) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002008038] Chr1:115286543 [GRCh38]
Chr1:115829164 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p13.3-11.2(chr1:111647582-121343783) copy number gain not specified [RCV002053602] Chr1:111647582..121343783 [GRCh37]
Chr1:1p13.3-11.2
pathogenic
NM_002506.3(NGF):c.394G>A (p.Glu132Lys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001963739] Chr1:115286402 [GRCh38]
Chr1:115829023 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.512A>G (p.Lys171Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001942353] Chr1:115286284 [GRCh38]
Chr1:115828905 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.573C>T (p.Gly191=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001943655] Chr1:115286223 [GRCh38]
Chr1:115828844 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.43G>C (p.Gly15Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001977277] Chr1:115286753 [GRCh38]
Chr1:115829374 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.222_223delinsAG (p.Arg75Gly) indel Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001977319] Chr1:115286573..115286574 [GRCh38]
Chr1:115829194..115829195 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.530C>T (p.Thr177Ile) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002027365] Chr1:115286266 [GRCh38]
Chr1:115828887 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.445G>A (p.Ala149Thr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001971952] Chr1:115286351 [GRCh38]
Chr1:115828972 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.124C>T (p.His42Tyr) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002051260] Chr1:115286672 [GRCh38]
Chr1:115829293 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.420C>T (p.Ser140=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001989599] Chr1:115286376 [GRCh38]
Chr1:115828997 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.361C>T (p.Arg121Trp) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001925260] Chr1:115286435 [GRCh38]
Chr1:115829056 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.188T>C (p.Val63Ala) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001936844] Chr1:115286608 [GRCh38]
Chr1:115829229 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.343A>G (p.Arg115Gly) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002018311] Chr1:115286453 [GRCh38]
Chr1:115829074 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.340A>C (p.Asn114His) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001998854] Chr1:115286456 [GRCh38]
Chr1:115829077 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.275A>G (p.Gln92Arg) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001878308] Chr1:115286521 [GRCh38]
Chr1:115829142 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.283C>T (p.Arg95Cys) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV001993690] Chr1:115286513 [GRCh38]
Chr1:115829134 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_002506.3(NGF):c.657C>T (p.Ala219=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002186396] Chr1:115286139 [GRCh38]
Chr1:115828760 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.219C>T (p.Asp73=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002196652] Chr1:115286577 [GRCh38]
Chr1:115829198 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.276G>A (p.Gln92=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002189038] Chr1:115286520 [GRCh38]
Chr1:115829141 [GRCh37]
Chr1:1p13.2
benign
NM_002506.3(NGF):c.553G>A (p.Val185Ile) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002193518] Chr1:115286243 [GRCh38]
Chr1:115828864 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.354G>A (p.Arg118=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002220456] Chr1:115286442 [GRCh38]
Chr1:115829063 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.609G>A (p.Thr203=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002084497] Chr1:115286187 [GRCh38]
Chr1:115828808 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.441C>T (p.Thr147=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002164261] Chr1:115286355 [GRCh38]
Chr1:115828976 [GRCh37]
Chr1:1p13.2
likely benign
NM_002506.3(NGF):c.165G>C (p.Pro55=) single nucleotide variant Congenital sensory neuropathy with selective loss of small myelinated fibers [RCV002201367] Chr1:115286631 [GRCh38]
Chr1:115829252 [GRCh37]
Chr1:1p13.2
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7808 AgrOrtholog
COSMIC NGF COSMIC
Ensembl Genes ENSG00000134259 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000358525 ENTREZGENE
  ENSP00000358525.2 UniProtKB/Swiss-Prot
  ENSP00000502380.1 UniProtKB/Swiss-Prot
  ENSP00000502831 ENTREZGENE
  ENSP00000502831.1 UniProtKB/Swiss-Prot
  ENSP00000505558.1 UniProtKB/Swiss-Prot
  ENSP00000505694.1 UniProtKB/Swiss-Prot
  ENSP00000506364.1 UniProtKB/TrEMBL
  ENSP00000506492.1 UniProtKB/Swiss-Prot
  ENSP00000506569.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000369512 ENTREZGENE
  ENST00000369512.3 UniProtKB/Swiss-Prot
  ENST00000675637 ENTREZGENE
  ENST00000675637.2 UniProtKB/Swiss-Prot
  ENST00000676038.2 UniProtKB/Swiss-Prot
  ENST00000679806.1 UniProtKB/Swiss-Prot
  ENST00000680116.1 UniProtKB/Swiss-Prot
  ENST00000680540.1 UniProtKB/Swiss-Prot
  ENST00000680752.1 UniProtKB/Swiss-Prot
  ENST00000681124.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000134259 GTEx
HGNC ID HGNC:7808 ENTREZGENE
Human Proteome Map NGF Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_bsu_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4803 UniProtKB/Swiss-Prot
NCBI Gene 4803 ENTREZGENE
OMIM 162030 OMIM
  608654 OMIM
PANTHER PTHR11589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NGF RGD, PharmGKB
PIRSF NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAMLNGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF_2 UniProtKB/Swiss-Prot
SMART NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A346FYQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A7P0TAZ6_HUMAN UniProtKB/TrEMBL
  NGF_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9UKL8 ENTREZGENE
UniProt Secondary A1A4E5 UniProtKB/Swiss-Prot
  Q6FHA0 UniProtKB/Swiss-Prot
  Q96P60 UniProtKB/Swiss-Prot
  Q9P2Q8 UniProtKB/Swiss-Prot
  Q9UKL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 NGF  nerve growth factor  NGF  nerve growth factor (beta polypeptide)  Symbol and/or name change 5135510 APPROVED