CLIC1 (chloride intracellular channel 1) - Rat Genome Database

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Gene: CLIC1 (chloride intracellular channel 1) Homo sapiens
Analyze
Symbol: CLIC1
Name: chloride intracellular channel 1
RGD ID: 1353337
HGNC Page HGNC:2062
Description: Enables chloride channel activity. Involved in platelet aggregation. Acts upstream of or within chloride transport. Located in extracellular exosome; nuclear envelope; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: chloride channel ABP; chloride intracellular channel protein 1; CL1C1; CLCNL1; G6; hRNCC; NCC27; nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; regulatory nuclear chloride ion channel protein; RNCC protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CLIC1P1   LOC100420638   LOC401864  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,730,581 - 31,737,318 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,730,581 - 31,739,763 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,698,358 - 31,705,095 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,806,337 - 31,812,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,806,338 - 31,812,320NCBI
Celera633,296,583 - 33,302,566 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,484,582 - 31,490,568 (-)NCBIHuRef
CHM1_1631,700,475 - 31,706,458 (-)NCBICHM1_1
T2T-CHM13v2.0631,583,614 - 31,590,355 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP)
amphetamine  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
buspirone  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
cannabidiol  (EXP)
carmustine  (EXP)
CGP 52608  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (EXP)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dihydroartemisinin  (EXP)
diuron  (EXP)
dopamine  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
fenamidone  (ISO)
fenoldopam  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fonofos  (EXP)
FR900359  (EXP)
fulvestrant  (EXP)
furan  (ISO)
glafenine  (ISO)
iron dichloride  (EXP)
ivermectin  (EXP)
leflunomide  (EXP)
lovastatin  (ISO)
methimazole  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nicotine  (EXP)
paracetamol  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
Salinomycin  (EXP)
SB 431542  (EXP)
sodium dichromate  (ISO)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
terbufos  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (EXP)
warfarin  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1345164   PMID:7711732   PMID:7938007   PMID:8125298   PMID:9139710   PMID:9339381   PMID:9841507   PMID:10191309   PMID:10384126   PMID:10793131   PMID:10834939   PMID:11195932  
PMID:11551966   PMID:11978800   PMID:12163479   PMID:12477932   PMID:12681486   PMID:14574404   PMID:14613939   PMID:14656967   PMID:14667819   PMID:15190104   PMID:15326289   PMID:15489334  
PMID:15827065   PMID:16009940   PMID:16130169   PMID:16236267   PMID:16289162   PMID:16712791   PMID:16791210   PMID:17326840   PMID:17347778   PMID:17620599   PMID:18028448   PMID:18710659  
PMID:18850721   PMID:19056867   PMID:19143814   PMID:19143821   PMID:19190083   PMID:19299076   PMID:19659809   PMID:19703605   PMID:19738201   PMID:19845400   PMID:19851445   PMID:19913121  
PMID:19946888   PMID:20458337   PMID:20461716   PMID:20507120   PMID:20587610   PMID:20628086   PMID:21319273   PMID:21858536   PMID:21873635   PMID:21988832   PMID:22082111   PMID:22173998  
PMID:22242893   PMID:22268729   PMID:22304920   PMID:22426742   PMID:22516433   PMID:22578365   PMID:22623428   PMID:22664934   PMID:22791942   PMID:22952844   PMID:23166591   PMID:23376485  
PMID:23382103   PMID:23457643   PMID:23533145   PMID:23593969   PMID:23792823   PMID:23874603   PMID:24058583   PMID:24089665   PMID:24115360   PMID:24328417   PMID:24338975   PMID:24587680  
PMID:24661138   PMID:24711643   PMID:24989236   PMID:24999758   PMID:25205595   PMID:25209805   PMID:25227665   PMID:25279971   PMID:25468996   PMID:25546839   PMID:25582317   PMID:25920608  
PMID:25921289   PMID:26344197   PMID:26429879   PMID:26496610   PMID:26618866   PMID:26641092   PMID:26760575   PMID:26831064   PMID:27371349   PMID:27461670   PMID:27576135   PMID:27684187  
PMID:27751915   PMID:27825122   PMID:27983917   PMID:28302793   PMID:28378944   PMID:28514442   PMID:28515276   PMID:28944858   PMID:28977470   PMID:29061300   PMID:29368798   PMID:29395067  
PMID:29462791   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29669336   PMID:29791485   PMID:29924966   PMID:30135216   PMID:30196744   PMID:30282979   PMID:30442762   PMID:30575818  
PMID:30614302   PMID:30833792   PMID:30948266   PMID:31046837   PMID:31075359   PMID:31106658   PMID:31180492   PMID:31316050   PMID:31324722   PMID:31364737   PMID:31473882   PMID:31483794  
PMID:31527615   PMID:31536960   PMID:31586073   PMID:31871319   PMID:31879279   PMID:31980649   PMID:32097463   PMID:32098256   PMID:32152539   PMID:32296183   PMID:32416067   PMID:32513696  
PMID:32586242   PMID:32604772   PMID:32656583   PMID:32687490   PMID:32707033   PMID:32780723   PMID:32841520   PMID:33079727   PMID:33194618   PMID:33288678   PMID:33432550   PMID:33469837  
PMID:33517284   PMID:33916271   PMID:33961781   PMID:34148879   PMID:34240838   PMID:34316702   PMID:34428256   PMID:34597346   PMID:34709727   PMID:34732716   PMID:34766585   PMID:34969734  
PMID:35156780   PMID:35256949   PMID:35271311   PMID:35384245   PMID:35446349   PMID:35509820   PMID:35562734   PMID:35676659   PMID:35696571   PMID:35722791   PMID:35831314   PMID:35833506  
PMID:35944360   PMID:35987950   PMID:36012204   PMID:36181109   PMID:36215168   PMID:36225252   PMID:36244648   PMID:36424410   PMID:36517590   PMID:36526897   PMID:37104099   PMID:37506885  
PMID:37827155   PMID:38113892   PMID:38257829  


Genomics

Comparative Map Data
CLIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,730,581 - 31,737,318 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,730,581 - 31,739,763 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,698,358 - 31,705,095 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,806,337 - 31,812,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,806,338 - 31,812,320NCBI
Celera633,296,583 - 33,302,566 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,484,582 - 31,490,568 (-)NCBIHuRef
CHM1_1631,700,475 - 31,706,458 (-)NCBICHM1_1
T2T-CHM13v2.0631,583,614 - 31,590,355 (-)NCBIT2T-CHM13v2.0
Clic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,269,219 - 35,277,695 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,268,942 - 35,277,725 (+)EnsemblGRCm39 Ensembl
GRCm381735,050,243 - 35,058,719 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,049,966 - 35,058,749 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,187,188 - 35,195,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,658,299 - 34,666,775 (+)NCBIMGSCv36mm8
Celera1738,146,956 - 38,155,404 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.58NCBI
Clic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,769,522 - 3,778,367 (-)NCBIGRCr8
mRatBN7.2203,764,867 - 3,773,711 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,761,461 - 3,773,712 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,464,357 - 4,473,242 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,826,411 - 3,835,295 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,364,302 - 4,373,178 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,040,314 - 5,049,166 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,040,337 - 5,049,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,113,249 - 7,122,096 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,498,935 - 3,842,500 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,499,166 - 3,842,700 (-)NCBI
Celera204,252,631 - 4,261,199 (+)NCBICelera
Cytogenetic Map20p12NCBI
Clic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437269,276 - 275,949 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437269,276 - 275,949 (-)NCBIChiLan1.0ChiLan1.0
CLIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,207,812 - 46,213,829 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,169,313 - 42,175,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,391,958 - 31,397,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,280,645 - 32,286,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,280,645 - 32,286,621 (-)Ensemblpanpan1.1panPan2
CLIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,209,777 - 1,215,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,209,780 - 1,215,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,346,316 - 1,351,766 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,355,142 - 1,360,592 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,355,144 - 1,360,616 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,214,391 - 1,219,842 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,281,637 - 1,287,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,349,279 - 1,354,941 (-)NCBIUU_Cfam_GSD_1.0
Clic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,757,960 - 35,763,366 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,797,966 - 1,803,401 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,797,966 - 1,803,401 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1723,842,829 - 23,851,162 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CLIC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,286,051 - 40,292,377 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,286,491 - 40,292,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,643,590 - 31,649,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clic1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,476,213 - 24,482,529 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,476,262 - 24,482,529 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CLIC1
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p21.33(chr6:31384577-31902308)x3 copy number gain See cases [RCV000448679] Chr6:31384577..31902308 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31
likely pathogenic
NC_000006.11:g.(?_30695893)_(31937492_?)dup duplication not provided [RCV003107453] Chr6:30695893..31937492 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p21.33(chr6:31384577-31902308) copy number gain not specified [RCV002053564] Chr6:31384577..31902308 [GRCh37]
Chr6:6p21.33
uncertain significance
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2
uncertain significance
NM_001288.6(CLIC1):c.276G>T (p.Arg92Ser) single nucleotide variant Inborn genetic diseases [RCV002968950] Chr6:31733672 [GRCh38]
Chr6:31701449 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_001288.6(CLIC1):c.62T>C (p.Ile21Thr) single nucleotide variant Inborn genetic diseases [RCV002793812] Chr6:31734241 [GRCh38]
Chr6:31702018 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_001288.6(CLIC1):c.611G>C (p.Arg204Pro) single nucleotide variant Inborn genetic diseases [RCV002822798] Chr6:31730957 [GRCh38]
Chr6:31698734 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_001288.6(CLIC1):c.34G>A (p.Val12Met) single nucleotide variant Inborn genetic diseases [RCV002830616] Chr6:31736267 [GRCh38]
Chr6:31704044 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_001288.6(CLIC1):c.508G>A (p.Gly170Ser) single nucleotide variant Inborn genetic diseases [RCV002793116] Chr6:31732273 [GRCh38]
Chr6:31700050 [GRCh37]
Chr6:6p21.33
likely benign
NM_001288.6(CLIC1):c.184G>T (p.Gly62Trp) single nucleotide variant Inborn genetic diseases [RCV003217763] Chr6:31733927 [GRCh38]
Chr6:31701704 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_001288.6(CLIC1):c.414G>C (p.Lys138Asn) single nucleotide variant Inborn genetic diseases [RCV003184330] Chr6:31732367 [GRCh38]
Chr6:31700144 [GRCh37]
Chr6:6p21.33
uncertain significance
NM_001288.6(CLIC1):c.410T>C (p.Leu137Pro) single nucleotide variant Inborn genetic diseases [RCV003374881] Chr6:31732371 [GRCh38]
Chr6:31700148 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_001288.6(CLIC1):c.620A>G (p.His207Arg) single nucleotide variant Inborn genetic diseases [RCV003371482] Chr6:31730948 [GRCh38]
Chr6:31698725 [GRCh37]
Chr6:6p21.33
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR183hsa-miR-183-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIR192hsa-miR-192-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16822819

Predicted Target Of
Summary Value
Count of predictions:1104
Count of miRNA genes:249
Interacting mature miRNAs:268
Transcripts:ENST00000375779, ENST00000375780, ENST00000375784, ENST00000395892
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH65001  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371763,639,941 - 63,640,075UniSTSGRCh37
GRCh37631,701,359 - 31,701,656UniSTSGRCh37
Build 36631,809,338 - 31,809,635RGDNCBI36
Celera1760,210,251 - 60,210,385UniSTS
Celera633,299,584 - 33,299,881RGD
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map17q24.1UniSTS
HuRef1759,032,150 - 59,032,284UniSTS
HuRef631,487,583 - 31,487,880UniSTS
G43219  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,698,459 - 31,698,725UniSTSGRCh37
Build 36631,806,438 - 31,806,704RGDNCBI36
Celera633,296,684 - 33,296,950RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,484,683 - 31,484,949UniSTS
D6S2782  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,703,524 - 31,703,887UniSTSGRCh37
GRCh37631,703,526 - 31,703,676UniSTSGRCh37
Build 36631,811,503 - 31,811,866RGDNCBI36
Celera633,301,751 - 33,301,901UniSTS
Celera633,301,749 - 33,302,112RGD
HuRef631,489,743 - 31,490,114UniSTS
HuRef631,489,745 - 31,489,903UniSTS
9N-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,703,556 - 31,703,650UniSTSGRCh37
Build 36631,811,535 - 31,811,629RGDNCBI36
Celera633,301,781 - 33,301,875RGD
HuRef631,489,775 - 31,489,877UniSTS
STS-W60956  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,698,631 - 31,698,756UniSTSGRCh37
Build 36631,806,610 - 31,806,735RGDNCBI36
Celera633,296,856 - 33,296,981RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,484,855 - 31,484,980UniSTS
GeneMap99-GB4 RH Map6119.82UniSTS
N3_2_2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,703,524 - 31,703,887UniSTSGRCh37
Build 36631,811,503 - 31,811,866RGDNCBI36
Celera633,301,749 - 33,302,112RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,489,743 - 31,490,114UniSTS
CLIC1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,701,402 - 31,701,676UniSTSGRCh37
GRCh3712121,352,415 - 121,352,526UniSTSGRCh37
Celera633,299,627 - 33,299,901UniSTS
Celera12120,986,310 - 120,986,421UniSTS
HuRef12118,361,723 - 118,361,834UniSTS
HuRef631,487,626 - 31,487,900UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 58 208 16 15 281 15 14 4 11 15 87 40 2
Medium 2374 2775 1706 606 1667 448 4249 2093 2808 403 1361 1568 169 1204 2696 4
Low 1 1 1 1 92 96 889 92
Below cutoff 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001287593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF034607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF129756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI192421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL670886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM562536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB124154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR354443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX783058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY057217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U93205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000375779   ⟹   ENSP00000364934
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,730,581 - 31,736,572 (-)Ensembl
RefSeq Acc Id: ENST00000375780   ⟹   ENSP00000364935
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,730,581 - 31,737,318 (-)Ensembl
RefSeq Acc Id: ENST00000375784   ⟹   ENSP00000364940
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,730,599 - 31,736,530 (-)Ensembl
RefSeq Acc Id: ENST00000395892   ⟹   ENSP00000379229
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,730,581 - 31,739,763 (-)Ensembl
RefSeq Acc Id: ENST00000616760   ⟹   ENSP00000479808
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,730,583 - 31,736,545 (-)Ensembl
RefSeq Acc Id: NM_001287593   ⟹   NP_001274522
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,730,581 - 31,737,318 (-)NCBI
HuRef631,484,582 - 31,491,322 (-)NCBI
CHM1_1631,700,475 - 31,707,209 (-)NCBI
T2T-CHM13v2.0631,583,614 - 31,590,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001287594   ⟹   NP_001274523
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,730,581 - 31,736,530 (-)NCBI
HuRef631,484,582 - 31,491,322 (-)NCBI
CHM1_1631,700,475 - 31,706,439 (-)NCBI
T2T-CHM13v2.0631,583,614 - 31,589,567 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001288   ⟹   NP_001279
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,730,599 - 31,736,530 (-)NCBI
GRCh37631,698,358 - 31,705,095 (-)NCBI
Build 36631,806,337 - 31,812,320 (-)NCBI Archive
HuRef631,484,582 - 31,491,322 (-)NCBI
CHM1_1631,700,475 - 31,706,458 (-)NCBI
T2T-CHM13v2.0631,583,632 - 31,589,567 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001274522 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274523 (Get FASTA)   NCBI Sequence Viewer  
  NP_001279 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC25675 (Get FASTA)   NCBI Sequence Viewer  
  AAD18073 (Get FASTA)   NCBI Sequence Viewer  
  AAD20437 (Get FASTA)   NCBI Sequence Viewer  
  AAD26137 (Get FASTA)   NCBI Sequence Viewer  
  AAH64527 (Get FASTA)   NCBI Sequence Viewer  
  AAH95469 (Get FASTA)   NCBI Sequence Viewer  
  AQY77258 (Get FASTA)   NCBI Sequence Viewer  
  AQY77259 (Get FASTA)   NCBI Sequence Viewer  
  BAB63376 (Get FASTA)   NCBI Sequence Viewer  
  BAD97099 (Get FASTA)   NCBI Sequence Viewer  
  BAG36725 (Get FASTA)   NCBI Sequence Viewer  
  CAA61020 (Get FASTA)   NCBI Sequence Viewer  
  CAB46078 (Get FASTA)   NCBI Sequence Viewer  
  CAG46868 (Get FASTA)   NCBI Sequence Viewer  
  EAX03503 (Get FASTA)   NCBI Sequence Viewer  
  EAX03504 (Get FASTA)   NCBI Sequence Viewer  
  EAX03505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000364934.2
  ENSP00000364935
  ENSP00000364935.2
  ENSP00000364940
  ENSP00000364940.3
  ENSP00000372896.2
  ENSP00000372897.2
  ENSP00000379229.1
  ENSP00000382926.3
  ENSP00000382931.1
  ENSP00000391395.1
  ENSP00000398056.2
  ENSP00000400280.1
  ENSP00000400532.1
  ENSP00000401292.2
  ENSP00000404037.1
  ENSP00000404589.1
  ENSP00000406088.1
  ENSP00000406335.2
  ENSP00000406968.1
  ENSP00000407429.2
  ENSP00000407791.2
  ENSP00000408094.1
  ENSP00000408357.1
  ENSP00000409247.1
  ENSP00000409979.1
  ENSP00000410965.1
  ENSP00000412217.1
  ENSP00000413330.1
  ENSP00000416211.1
  ENSP00000477623.1
  ENSP00000478930.1
  ENSP00000479501.1
  ENSP00000479808
  ENSP00000479808.1
  ENSP00000480256.1
  ENSP00000482255.1
  ENSP00000484581.1
GenBank Protein O00299 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001279   ⟸   NM_001288
- UniProtKB: Q15089 (UniProtKB/Swiss-Prot),   Q502X1 (UniProtKB/Swiss-Prot),   O00299 (UniProtKB/Swiss-Prot),   Q5SRT3 (UniProtKB/TrEMBL),   Q53FB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274522   ⟸   NM_001287593
- UniProtKB: Q15089 (UniProtKB/Swiss-Prot),   Q502X1 (UniProtKB/Swiss-Prot),   O00299 (UniProtKB/Swiss-Prot),   Q5SRT3 (UniProtKB/TrEMBL),   Q53FB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274523   ⟸   NM_001287594
- UniProtKB: Q15089 (UniProtKB/Swiss-Prot),   Q502X1 (UniProtKB/Swiss-Prot),   O00299 (UniProtKB/Swiss-Prot),   Q53FB0 (UniProtKB/TrEMBL),   Q5SRT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000364934   ⟸   ENST00000375779
RefSeq Acc Id: ENSP00000364935   ⟸   ENST00000375780
RefSeq Acc Id: ENSP00000364940   ⟸   ENST00000375784
RefSeq Acc Id: ENSP00000479808   ⟸   ENST00000616760
RefSeq Acc Id: ENSP00000379229   ⟸   ENST00000395892
Protein Domains
GST C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00299-F1-model_v2 AlphaFold O00299 1-241 view protein structure

Promoters
RGD ID:6872674
Promoter ID:EPDNEW_H9468
Type:initiation region
Name:CLIC1_2
Description:chloride intracellular channel 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9469  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,736,313 - 31,736,373EPDNEW
RGD ID:6872608
Promoter ID:EPDNEW_H9469
Type:initiation region
Name:CLIC1_1
Description:chloride intracellular channel 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9468  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,736,513 - 31,736,573EPDNEW
RGD ID:6853246
Promoter ID:EP74444
Type:initiation region
Name:HS_CLIC1_2
Description:Chloride intracellular channel 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #2 of 2; 5' exon 1; site 2; major promoter.; see alsoEP74443  
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,812,065 - 31,812,125EPD
RGD ID:6803898
Promoter ID:HG_KWN:52979
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000375778,   ENST00000375779,   ENST00000375780,   OTTHUMT00000076166
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,812,091 - 31,813,957 (-)MPROMDB
RGD ID:6853244
Promoter ID:EP74443
Type:initiation region
Name:HS_CLIC1_1
Description:Chloride intracellular channel 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 2; 5' exon 1; site 1.; see alsoEP74444  
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,812,233 - 31,812,293EPD
RGD ID:6804153
Promoter ID:HG_KWN:52980
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000375696,   ENST00000375705,   ENST00000375740,   ENST00000383401,   ENST00000395892,   OTTHUMT00000076245,   OTTHUMT00000076248,   OTTHUMT00000268163,   OTTHUMT00000268164,   UC003NWT.1,   UC003NWU.1,   UC003NWV.1,   UC003NWW.1,   UC003NWX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,814,491 - 31,815,917 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2062 AgrOrtholog
COSMIC CLIC1 COSMIC
Ensembl Genes ENSG00000206394 UniProtKB/Swiss-Prot
  ENSG00000213719 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000223639 UniProtKB/Swiss-Prot
  ENSG00000226248 UniProtKB/Swiss-Prot
  ENSG00000226417 UniProtKB/Swiss-Prot
  ENSG00000226651 UniProtKB/Swiss-Prot
  ENSG00000230685 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000375779.6 UniProtKB/Swiss-Prot
  ENST00000375780 ENTREZGENE
  ENST00000375780.6 UniProtKB/Swiss-Prot
  ENST00000375784 ENTREZGENE
  ENST00000375784.8 UniProtKB/Swiss-Prot
  ENST00000383404.6 UniProtKB/Swiss-Prot
  ENST00000383405.6 UniProtKB/Swiss-Prot
  ENST00000395892.5 UniProtKB/Swiss-Prot
  ENST00000400052.7 UniProtKB/Swiss-Prot
  ENST00000400058.5 UniProtKB/Swiss-Prot
  ENST00000415179.5 UniProtKB/Swiss-Prot
  ENST00000418285.6 UniProtKB/Swiss-Prot
  ENST00000420458.5 UniProtKB/Swiss-Prot
  ENST00000422167.6 UniProtKB/Swiss-Prot
  ENST00000423055.5 UniProtKB/Swiss-Prot
  ENST00000423143.5 UniProtKB/Swiss-Prot
  ENST00000423804.5 UniProtKB/Swiss-Prot
  ENST00000425464.6 UniProtKB/Swiss-Prot
  ENST00000431921.5 UniProtKB/Swiss-Prot
  ENST00000433916.5 UniProtKB/Swiss-Prot
  ENST00000434202.5 UniProtKB/Swiss-Prot
  ENST00000435242.5 UniProtKB/Swiss-Prot
  ENST00000438708.5 UniProtKB/Swiss-Prot
  ENST00000438750.5 UniProtKB/Swiss-Prot
  ENST00000442045.5 UniProtKB/Swiss-Prot
  ENST00000447338.5 UniProtKB/Swiss-Prot
  ENST00000447369.5 UniProtKB/Swiss-Prot
  ENST00000451546.5 UniProtKB/Swiss-Prot
  ENST00000456863.6 UniProtKB/Swiss-Prot
  ENST00000457485.6 UniProtKB/Swiss-Prot
  ENST00000614673.1 UniProtKB/Swiss-Prot
  ENST00000614982.1 UniProtKB/Swiss-Prot
  ENST00000616760 ENTREZGENE
  ENST00000616760.1 UniProtKB/Swiss-Prot
  ENST00000618288.1 UniProtKB/Swiss-Prot
  ENST00000619727.1 UniProtKB/Swiss-Prot
  ENST00000621055.1 UniProtKB/Swiss-Prot
  ENST00000622613.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000206394 GTEx
  ENSG00000213719 GTEx
  ENSG00000223639 GTEx
  ENSG00000226248 GTEx
  ENSG00000226417 GTEx
  ENSG00000226651 GTEx
  ENSG00000230685 GTEx
HGNC ID HGNC:2062 ENTREZGENE
Human Proteome Map CLIC1 Human Proteome Map
InterPro CLIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLIC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1192 ENTREZGENE
OMIM 602872 OMIM
PANTHER CHLORIDE INTRACELLULAR CHANNEL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26588 PharmGKB
PRINTS INTCLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CLIC1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q15089 ENTREZGENE
  Q502X1 ENTREZGENE
  Q53FB0 ENTREZGENE, UniProtKB/TrEMBL
  Q5SRT3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q15089 UniProtKB/Swiss-Prot
  Q502X1 UniProtKB/Swiss-Prot