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Gene: IRS1 (insulin receptor substrate 1) Homo sapiens
Symbol: IRS1
Name: insulin receptor substrate 1
Description: Exhibits several functions, including phosphotyrosine residue binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of small molecule metabolic process; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to caveola; cytosol; and nucleoplasm. Implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HIRS-1; IRS-1
Mus musculus (house mouse) : Irs1 (insulin receptor substrate 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irs1 (insulin receptor substrate 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs1 (insulin receptor substrate 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS1 (insulin receptor substrate 1)
Canis lupus familiaris (dog) : IRS1 (insulin receptor substrate 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs1 (insulin receptor substrate 1)
Sus scrofa (pig) : IRS1 (insulin receptor substrate 1)
Chlorocebus sabaeus (African green monkey) : IRS1 (insulin receptor substrate 1)
Heterocephalus glaber (naked mole-rat) : Irs1 (insulin receptor substrate 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW376_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2226,731,317 - 226,799,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382226,731,317 - 226,798,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372227,596,033 - 227,664,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,308,182 - 227,372,719 (-)NCBINCBI36hg18NCBI36
Build 342227,425,442 - 227,489,980NCBI
Celera2221,365,560 - 221,433,036 (-)NCBI
Cytogenetic Map2q36.3NCBI
HuRef2219,439,592 - 219,507,082 (-)NCBIHuRef
CHM1_12227,601,926 - 227,669,382 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733473
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.