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Gene: MDK (midkine) Homo sapiens
Symbol: MDK
Name: midkine
RGD ID: 69142
Description: Exhibits heparan sulfate binding activity and heparin binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell differentiation; and positive regulation of response to external stimulus. Colocalizes with collagen-containing extracellular matrix. Implicated in brain ischemia. Biomarker of endometriosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: amphiregulin-associated protein; ARAP; FLJ27379; midgestation and kidney protein; midkine (neurite growth-promoting factor 2); MK; NEGF2; neurite growth-promoting factor 2; neurite outgrowth-promoting factor 2; neurite outgrowth-promoting protein; retinoic acid inducible factor
Mus musculus (house mouse) : Mdk (midkine)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mdk (midkine)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdk (midkine)
Pan paniscus (bonobo/pygmy chimpanzee) : MDK (midkine)
Canis lupus familiaris (dog) : MDK (midkine)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdk (midkine)
Sus scrofa (pig) : MDK (midkine)
Chlorocebus sabaeus (African green monkey) : MDK (midkine)
Heterocephalus glaber (naked mole-rat) : Mdk (midkine)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1146,380,756 - 46,383,837 (+)EnsemblGRCh38hg38GRCh38
GRCh381146,380,784 - 46,383,837 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371146,402,334 - 46,405,387 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,359,194 - 46,361,951 (+)NCBINCBI36hg18NCBI36
Build 341146,359,794 - 46,361,950NCBI
Celera1146,550,196 - 46,552,952 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,109,292 - 46,112,345 (+)NCBIHuRef
CHM1_11146,400,770 - 46,403,840 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MDK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69142
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.