CTSL (cathepsin L) - Rat Genome Database

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Gene: CTSL (cathepsin L) Homo sapiens
Analyze
Symbol: CTSL
Name: cathepsin L
RGD ID: 736036
HGNC Page HGNC
Description: Enables several functions, including collagen binding activity; fibronectin binding activity; and serpin family protein binding activity. Involved in several processes, including collagen catabolic process; proteolysis; and viral entry into host cell. Located in several cellular components, including Golgi apparatus; lysosome; and multivesicular body. Part of collagen-containing extracellular matrix. Implicated in hypertrophic cardiomyopathy. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin L1; CATL; CTSL1; FLJ31037; major excreted protein; MEP; procathepsin L
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CTSLP1   CTSLP2   CTSLP3   CTSLP4   CTSLP6   CTSLP8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,724,051 - 87,731,469 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,726,119 - 87,731,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,341,034 - 90,346,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,530,794 - 89,536,204 (+)NCBINCBI36hg18NCBI36
Build 34987,570,533 - 87,575,862NCBI
Celera960,911,195 - 60,916,605 (+)NCBI
Cytogenetic Map9q21.33NCBI
HuRef960,165,416 - 60,170,826 (+)NCBIHuRef
CHM1_1990,488,740 - 90,494,151 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-diaminobutyric acid  (EXP)
2-methoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methyladenine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (EXP)
aflatoxin B1  (ISO)
albendazole  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
aloxistatin  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
amphetamine  (ISO)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (EXP)
asperphenamate  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buspirone  (ISO)
butan-1-ol  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CCCP  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
choline  (EXP)
chondroitin sulfate  (EXP)
cimetidine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cytarabine  (EXP)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
fenamidone  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
glucose  (EXP)
glyphosate  (EXP)
imiquimod  (ISO)
indoles  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
ranitidine  (ISO)
rotenone  (ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
teicoplanin  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
tioguanine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (ISO)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEP)
antigen processing and presentation  (TAS)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (TAS)
antigen processing and presentation of peptide antigen  (ISS)
autophagic cell death  (ISO)
CD4-positive, alpha-beta T cell lineage commitment  (ISS)
cell communication  (ISO)
cellular response to starvation  (ISO)
cellular response to thyroid hormone stimulus  (IEP)
collagen catabolic process  (IDA)
decidualization  (ISO)
elastin catabolic process  (ISS)
enkephalin processing  (ISS)
epithelial tube branching involved in lung morphogenesis  (ISO)
fusion of virus membrane with host endosome membrane  (IDA)
fusion of virus membrane with host plasma membrane  (IDA)
hair follicle morphogenesis  (ISO)
immune response  (IBA)
macrophage apoptotic process  (NAS)
male gonad development  (ISO)
multicellular organism aging  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
nerve development  (ISO)
protein autoprocessing  (IDA,ISO)
protein processing  (ISO)
proteolysis  (IDA,IEA,ISO)
proteolysis involved in cellular protein catabolic process  (IBA,IDA)
receptor-mediated endocytosis of virus by host cell  (IDA)
regulation of actin cytoskeleton reorganization  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to gonadotropin  (ISO)
response to odorant  (ISO)
response to organic cyclic compound  (ISO)
Sertoli cell differentiation  (ISO)
spermatogenesis  (ISO)
thyroid hormone generation  (ISO)
viral entry into host cell  (IDA)
zymogen activation  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aricha R, etal., FASEB J. 2006 Feb;20(2):374-6. Epub 2005 Dec 19.
2. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
3. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
4. Durmaz R, etal., Neurochem Res. 2008 Sep;33(9):1683-91. Epub 2008 Apr 11.
5. GOA_HUMAN data from the GO Consortium
6. Hilliard LM, etal., Am J Nephrol. 2009;29(5):454-64. Epub 2008 Nov 21.
7. Hsing LC, etal., J Autoimmun. 2009 Aug 5.
8. Huang X, etal., Diabetes. 2003 Sep;52(9):2411-8.
9. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
10. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
11. Judge AR, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C372-82. Epub 2006 Aug 23.
12. Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51.
13. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
14. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
15. Mareninova OA, etal., J Clin Invest. 2009 Nov;119(11):3340-55. doi: 10.1172/JCI38674. Epub 2009 Oct 1.
16. Meng W, etal., J Musculoskelet Neuronal Interact. 2001 Dec;2(2):171-6.
17. O'Neal P, etal., J Cell Biochem. 2009 Nov 1;108(4):963-73.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Provenzano PP, etal., Matrix Biol. 2005 Jan;23(8):543-55. Epub 2004 Dec 1.
20. Qi L and Zhang XD, Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):83-91. doi: 10.1093/abbs/gmt133. Epub 2013 Dec 8.
21. Reiser J, etal., J Biol Chem 2004 Aug 13;279(33):34827-32. Epub 2004 Jun 14.
22. RGD automated import pipeline for gene-chemical interactions
23. Sebzda T, etal., World J Gastroenterol. 2005 Jan 28;11(4):587-92.
24. Sodha NR, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H428-34. Epub 2008 Dec 12.
25. Tang Q, etal., J Mol Med. 2009 Mar;87(3):249-60. Epub 2008 Dec 19.
26. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:116880   PMID:1551416   PMID:1837142   PMID:1939080   PMID:2275556   PMID:2835398   PMID:3342889   PMID:3421948   PMID:3490478   PMID:3545185   PMID:3550705   PMID:7340337  
PMID:8419312   PMID:8666891   PMID:8811434   PMID:8889548   PMID:8896443   PMID:9076588   PMID:9141479   PMID:9468501   PMID:9548757   PMID:9585570   PMID:9632704   PMID:9733783  
PMID:9837884   PMID:9918848   PMID:10022822   PMID:10218831   PMID:10395917   PMID:10428479   PMID:10716919   PMID:10849756   PMID:11278902   PMID:11327826   PMID:11435427   PMID:11514663  
PMID:11517935   PMID:11767948   PMID:11771045   PMID:11777924   PMID:11801256   PMID:11978977   PMID:12137950   PMID:12437117   PMID:12437119   PMID:12477932   PMID:12492488   PMID:12504904  
PMID:12748383   PMID:12754519   PMID:12809493   PMID:12818188   PMID:12921779   PMID:12926111   PMID:12949073   PMID:14511383   PMID:14702039   PMID:14718574   PMID:15099520   PMID:15100281  
PMID:15174051   PMID:15196205   PMID:15255544   PMID:15318816   PMID:15454886   PMID:15489334   PMID:15498563   PMID:15512772   PMID:15665831   PMID:15816632   PMID:15832773   PMID:15982660  
PMID:16081529   PMID:16303743   PMID:16335952   PMID:16339146   PMID:16354158   PMID:16433682   PMID:16565075   PMID:16740135   PMID:16913838   PMID:16918298   PMID:17192395   PMID:17227755  
PMID:17519890   PMID:17561110   PMID:17574778   PMID:17643114   PMID:17889653   PMID:17928356   PMID:18163891   PMID:18221013   PMID:18366346   PMID:18450756   PMID:18495127   PMID:18562523  
PMID:18616803   PMID:18619973   PMID:18624398   PMID:18658137   PMID:18971274   PMID:19005484   PMID:19270352   PMID:19291794   PMID:19550400   PMID:19663777   PMID:19915865   PMID:19924101  
PMID:19939935   PMID:19958782   PMID:19959474   PMID:20075068   PMID:20302512   PMID:20347002   PMID:20497254   PMID:20524145   PMID:20567828   PMID:20837372   PMID:20881085   PMID:20926012  
PMID:21029616   PMID:21134415   PMID:21217776   PMID:21226994   PMID:21308479   PMID:21326229   PMID:21382349   PMID:21383048   PMID:21395501   PMID:21484410   PMID:21496199   PMID:21501115  
PMID:21555518   PMID:21562164   PMID:21585286   PMID:21700710   PMID:21715684   PMID:21742978   PMID:21750527   PMID:21756348   PMID:21769426   PMID:21775114   PMID:21873635   PMID:21880013  
PMID:21896479   PMID:21898833   PMID:21900206   PMID:21925292   PMID:21965756   PMID:21967108   PMID:21988832   PMID:22031933   PMID:22222211   PMID:22281037   PMID:22365146   PMID:22451661  
PMID:22571763   PMID:22658674   PMID:22674323   PMID:22695494   PMID:22871890   PMID:22952693   PMID:22963824   PMID:23009386   PMID:23063511   PMID:23229094   PMID:23337117   PMID:23376485  
PMID:23533145   PMID:23536651   PMID:23603447   PMID:23677785   PMID:23900981   PMID:23915070   PMID:23958260   PMID:24108784   PMID:24319737   PMID:24402045   PMID:24583396   PMID:25037231  
PMID:25333746   PMID:25384089   PMID:25416956   PMID:25516668   PMID:25558848   PMID:25626674   PMID:25632968   PMID:25633482   PMID:25957406   PMID:25991043   PMID:26081835   PMID:26186194  
PMID:26299995   PMID:26343556   PMID:26344197   PMID:26374357   PMID:26474873   PMID:26661692   PMID:26706414   PMID:26757339   PMID:26757413   PMID:26797274   PMID:26953343   PMID:26960148  
PMID:26975192   PMID:26992470   PMID:27055649   PMID:27351223   PMID:27373979   PMID:27609421   PMID:27718373   PMID:27729455   PMID:27764212   PMID:27902765   PMID:27956696   PMID:27989700  
PMID:28074340   PMID:28478025   PMID:28514442   PMID:28614652   PMID:28698143   PMID:28743268   PMID:28787468   PMID:29149174   PMID:29150431   PMID:29154036   PMID:29246726   PMID:29278883  
PMID:29331585   PMID:29345177   PMID:30679571   PMID:30999160   PMID:31269957   PMID:32221306   PMID:32394467   PMID:32468052   PMID:32512386   PMID:32513696   PMID:32842606   PMID:32855215  
PMID:33293479   PMID:33315943   PMID:33364201   PMID:33774649  


Genomics

Comparative Map Data
CTSL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,724,051 - 87,731,469 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,726,119 - 87,731,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,341,034 - 90,346,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,530,794 - 89,536,204 (+)NCBINCBI36hg18NCBI36
Build 34987,570,533 - 87,575,862NCBI
Celera960,911,195 - 60,916,605 (+)NCBI
Cytogenetic Map9q21.33NCBI
HuRef960,165,416 - 60,170,826 (+)NCBIHuRef
CHM1_1990,488,740 - 90,494,151 (+)NCBICHM1_1
Ctsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,509,704 - 64,518,586 (-)NCBIGRCm39mm39
GRCm39 Ensembl1364,507,151 - 64,518,704 (-)Ensembl
GRCm381364,361,890 - 64,370,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,359,337 - 64,370,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,464,522 - 64,471,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv361364,377,945 - 64,385,037 (-)NCBImm8
Celera1366,025,830 - 66,032,878 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
Ctsl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.217764,370 - 770,533 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
RH 3.4 Map1716.0RGD
Cytogenetic Map17p14NCBI
CTSL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1986,903,001 - 86,908,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,903,006 - 86,908,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0958,851,899 - 58,857,170 (+)NCBIMhudiblu_PPA_v0panPan3
CTSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,215,774 - 72,219,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,978,019 - 72,981,188 (-)NCBI
ROS_Cfam_1.0172,520,707 - 72,523,876 (-)NCBI
UMICH_Zoey_3.1172,331,483 - 72,334,652 (-)NCBI
UNSW_CanFamBas_1.0172,097,122 - 72,100,291 (-)NCBI
UU_Cfam_GSD_1.0172,802,852 - 72,806,021 (-)NCBI
Ctsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947118,687,401 - 118,693,831 (-)NCBI
SpeTri2.0NW_0049366803,047,355 - 3,050,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,668,264 - 27,674,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,668,523 - 27,674,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,907,421 - 31,913,554 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,347,770 - 98,353,426 (+)NCBI
ChlSab1.1 Ensembl1298,347,800 - 98,353,467 (+)Ensembl
Vero_WHO_p1.0NW_02366603886,669,582 - 86,675,194 (+)NCBI

Position Markers
GDB:451830  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,342,558 - 90,343,050UniSTSGRCh37
Build 36989,532,378 - 89,532,870RGDNCBI36
Celera960,912,779 - 60,913,271RGD
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map10q11.22UniSTS
HuRef960,167,000 - 60,167,492UniSTS
GDB:594510  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,344,544 - 90,346,000UniSTSGRCh37
Build 36989,534,364 - 89,535,820RGDNCBI36
Celera960,914,765 - 60,916,221RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,168,986 - 60,170,442UniSTS
PMC171390P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,342,606 - 90,343,024UniSTSGRCh37
Build 36989,532,426 - 89,532,844RGDNCBI36
Celera960,912,827 - 60,913,245RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,167,048 - 60,167,466UniSTS
D9S1706  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,346,038 - 90,346,267UniSTSGRCh37
Build 36989,535,858 - 89,536,087RGDNCBI36
Celera960,916,259 - 60,916,488RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,170,480 - 60,170,709UniSTS
Stanford-G3 RH Map92935.0UniSTS
GeneMap99-GB4 RH Map9284.53UniSTS
Whitehead-RH Map9328.7UniSTS
Whitehead-YAC Contig Map9 UniSTS
NCBI RH Map9751.3UniSTS
GeneMap99-G3 RH Map92833.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1031
Count of miRNA genes:589
Interacting mature miRNAs:659
Transcripts:ENST00000340342, ENST00000342020, ENST00000343150, ENST00000375894, ENST00000482054, ENST00000495822
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 1 1 2 1 9 1 19 8 9 1
Medium 2400 2590 1717 621 991 462 4337 2154 3623 415 1435 1566 175 1 1195 2784 5 2
Low 24 394 7 2 429 2 11 39 110 3 5 21 4
Below cutoff 11 3 1 240 4 1 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001257971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF217997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF467444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL160279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW270438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC142983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI824449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI829385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM680778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB963086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN993009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN344049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN344051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y18462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000340342   ⟹   ENSP00000365061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,109 - 87,731,386 (+)Ensembl
RefSeq Acc Id: ENST00000342020   ⟹   ENSP00000340470
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,140 - 87,728,997 (+)Ensembl
RefSeq Acc Id: ENST00000343150   ⟹   ENSP00000345344
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,119 - 87,731,469 (+)Ensembl
RefSeq Acc Id: ENST00000375894
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,114 - 87,731,073 (+)Ensembl
RefSeq Acc Id: ENST00000482054
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,140 - 87,729,680 (+)Ensembl
RefSeq Acc Id: ENST00000495822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,134 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000676466
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,223 - 87,731,127 (+)Ensembl
RefSeq Acc Id: ENST00000676480   ⟹   ENSP00000504279
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,461 - 87,731,354 (+)Ensembl
RefSeq Acc Id: ENST00000676531   ⟹   ENSP00000503439
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,725,735 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000676576
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,182 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000676769   ⟹   ENSP00000504405
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,166 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000676881   ⟹   ENSP00000502901
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,122 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000676909
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,839 - 87,731,298 (+)Ensembl
RefSeq Acc Id: ENST00000676946   ⟹   ENSP00000503470
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,725,712 - 87,731,389 (+)Ensembl
RefSeq Acc Id: ENST00000676961
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,176 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000677019   ⟹   ENSP00000504473
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,105 - 87,731,189 (+)Ensembl
RefSeq Acc Id: ENST00000677262   ⟹   ENSP00000503851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,119 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000677345
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,076 - 87,731,353 (+)Ensembl
RefSeq Acc Id: ENST00000677349
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,236 - 87,731,261 (+)Ensembl
RefSeq Acc Id: ENST00000677523   ⟹   ENSP00000502922
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,727,594 - 87,731,320 (+)Ensembl
RefSeq Acc Id: ENST00000677615
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,213 - 87,731,322 (+)Ensembl
RefSeq Acc Id: ENST00000677638   ⟹   ENSP00000504275
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,193 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000677761   ⟹   ENSP00000503938
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,252 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000677821   ⟹   ENSP00000503298
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,086 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000677864   ⟹   ENSP00000503881
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,119 - 87,731,469 (+)Ensembl
RefSeq Acc Id: ENST00000677935
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,072 - 87,731,354 (+)Ensembl
RefSeq Acc Id: ENST00000677955   ⟹   ENSP00000504560
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,166 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000678259   ⟹   ENSP00000504702
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,727,594 - 87,731,469 (+)Ensembl
RefSeq Acc Id: ENST00000678367   ⟹   ENSP00000504639
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,119 - 87,731,469 (+)Ensembl
RefSeq Acc Id: ENST00000678442   ⟹   ENSP00000503897
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,724,051 - 87,731,295 (+)Ensembl
RefSeq Acc Id: ENST00000678596   ⟹   ENSP00000503146
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,170 - 87,731,320 (+)Ensembl
RefSeq Acc Id: ENST00000678599   ⟹   ENSP00000504676
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,186 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000678649   ⟹   ENSP00000504772
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,119 - 87,731,348 (+)Ensembl
RefSeq Acc Id: ENST00000678654
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,253 - 87,729,179 (+)Ensembl
RefSeq Acc Id: ENST00000678752
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,092 - 87,731,364 (+)Ensembl
RefSeq Acc Id: ENST00000678965
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,793 - 87,731,327 (+)Ensembl
RefSeq Acc Id: ENST00000679025   ⟹   ENSP00000503252
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,727,594 - 87,731,469 (+)Ensembl
RefSeq Acc Id: ENST00000679028   ⟹   ENSP00000503119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,857 - 87,731,326 (+)Ensembl
RefSeq Acc Id: ENST00000679030   ⟹   ENSP00000503891
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,170 - 87,731,393 (+)Ensembl
RefSeq Acc Id: ENST00000679141
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,119 - 87,731,327 (+)Ensembl
RefSeq Acc Id: ENST00000679149   ⟹   ENSP00000504313
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,725,551 - 87,731,466 (+)Ensembl
RefSeq Acc Id: ENST00000679157   ⟹   ENSP00000502968
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,725,644 - 87,731,466 (+)Ensembl
RefSeq Acc Id: ENST00000679252
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,726,213 - 87,731,308 (+)Ensembl
RefSeq Acc Id: NM_001257971   ⟹   NP_001244900
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
GRCh37990,340,974 - 90,346,384 (+)NCBI
HuRef960,165,416 - 60,170,826 (+)NCBI
CHM1_1990,488,740 - 90,494,151 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001257972   ⟹   NP_001244901
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
GRCh37990,340,974 - 90,346,384 (+)NCBI
HuRef960,165,416 - 60,170,826 (+)NCBI
CHM1_1990,488,740 - 90,494,151 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001257973   ⟹   NP_001244902
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
GRCh37990,340,974 - 90,346,384 (+)NCBI
HuRef960,165,416 - 60,170,826 (+)NCBI
CHM1_1990,488,740 - 90,494,151 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382757   ⟹   NP_001369686
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
RefSeq Acc Id: NM_001382758   ⟹   NP_001369687
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
RefSeq Acc Id: NM_001382766   ⟹   NP_001369695
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
RefSeq Acc Id: NM_001382767   ⟹   NP_001369696
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
RefSeq Acc Id: NM_001382768   ⟹   NP_001369697
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
RefSeq Acc Id: NM_001912   ⟹   NP_001903
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
GRCh37990,340,974 - 90,346,384 (+)NCBI
Build 36989,530,794 - 89,536,204 (+)NCBI Archive
HuRef960,165,416 - 60,170,826 (+)ENTREZGENE
CHM1_1990,488,740 - 90,494,151 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145918   ⟹   NP_666023
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,731,469 (+)NCBI
GRCh37990,340,974 - 90,346,384 (+)ENTREZGENE
Build 36989,530,794 - 89,536,204 (+)NCBI Archive
HuRef960,165,416 - 60,170,826 (+)ENTREZGENE
CHM1_1990,488,740 - 90,494,151 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001244900 (Get FASTA)   NCBI Sequence Viewer  
  NP_001244901 (Get FASTA)   NCBI Sequence Viewer  
  NP_001244902 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369686 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369687 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369695 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369696 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369697 (Get FASTA)   NCBI Sequence Viewer  
  NP_001903 (Get FASTA)   NCBI Sequence Viewer  
  NP_666023 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA66974 (Get FASTA)   NCBI Sequence Viewer  
  AAG17239 (Get FASTA)   NCBI Sequence Viewer  
  AAH12612 (Get FASTA)   NCBI Sequence Viewer  
  AAI42984 (Get FASTA)   NCBI Sequence Viewer  
  AAM89516 (Get FASTA)   NCBI Sequence Viewer  
  AAN87068 (Get FASTA)   NCBI Sequence Viewer  
  AAQ05021 (Get FASTA)   NCBI Sequence Viewer  
  BAG52066 (Get FASTA)   NCBI Sequence Viewer  
  CAA28877 (Get FASTA)   NCBI Sequence Viewer  
  CAA30981 (Get FASTA)   NCBI Sequence Viewer  
  CAA77180 (Get FASTA)   NCBI Sequence Viewer  
  CAD97637 (Get FASTA)   NCBI Sequence Viewer  
  CAG33334 (Get FASTA)   NCBI Sequence Viewer  
  CAY55960 (Get FASTA)   NCBI Sequence Viewer  
  CAY55961 (Get FASTA)   NCBI Sequence Viewer  
  EAW62731 (Get FASTA)   NCBI Sequence Viewer  
  EAW62732 (Get FASTA)   NCBI Sequence Viewer  
  EAW62733 (Get FASTA)   NCBI Sequence Viewer  
  EAW62734 (Get FASTA)   NCBI Sequence Viewer  
  EAW62735 (Get FASTA)   NCBI Sequence Viewer  
  EAW62736 (Get FASTA)   NCBI Sequence Viewer  
  P07711 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001903   ⟸   NM_001912
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P07711 (UniProtKB/Swiss-Prot),   A0A024R276 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_666023   ⟸   NM_145918
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P07711 (UniProtKB/Swiss-Prot),   A0A024R276 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244900   ⟸   NM_001257971
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P07711 (UniProtKB/Swiss-Prot),   A0A024R276 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244902   ⟸   NM_001257973
- Peptide Label: isoform 2
- UniProtKB: Q9HBQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244901   ⟸   NM_001257972
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P07711 (UniProtKB/Swiss-Prot),   A0A024R276 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001369686   ⟸   NM_001382757
- Peptide Label: isoform 1 preproprotein
RefSeq Acc Id: NP_001369696   ⟸   NM_001382767
- Peptide Label: isoform 4 precursor
RefSeq Acc Id: NP_001369697   ⟸   NM_001382768
- Peptide Label: isoform 4 precursor
RefSeq Acc Id: NP_001369695   ⟸   NM_001382766
- Peptide Label: isoform 4 precursor
RefSeq Acc Id: NP_001369687   ⟸   NM_001382758
- Peptide Label: isoform 3
RefSeq Acc Id: ENSP00000365061   ⟸   ENST00000340342
RefSeq Acc Id: ENSP00000340470   ⟸   ENST00000342020
RefSeq Acc Id: ENSP00000345344   ⟸   ENST00000343150
RefSeq Acc Id: ENSP00000503470   ⟸   ENST00000676946
RefSeq Acc Id: ENSP00000502901   ⟸   ENST00000676881
RefSeq Acc Id: ENSP00000504405   ⟸   ENST00000676769
RefSeq Acc Id: ENSP00000503439   ⟸   ENST00000676531
RefSeq Acc Id: ENSP00000504279   ⟸   ENST00000676480
RefSeq Acc Id: ENSP00000504473   ⟸   ENST00000677019
RefSeq Acc Id: ENSP00000502922   ⟸   ENST00000677523
RefSeq Acc Id: ENSP00000503851   ⟸   ENST00000677262
RefSeq Acc Id: ENSP00000504560   ⟸   ENST00000677955
RefSeq Acc Id: ENSP00000503881   ⟸   ENST00000677864
RefSeq Acc Id: ENSP00000503298   ⟸   ENST00000677821
RefSeq Acc Id: ENSP00000503938   ⟸   ENST00000677761
RefSeq Acc Id: ENSP00000504275   ⟸   ENST00000677638
RefSeq Acc Id: ENSP00000503897   ⟸   ENST00000678442
RefSeq Acc Id: ENSP00000504639   ⟸   ENST00000678367
RefSeq Acc Id: ENSP00000504702   ⟸   ENST00000678259
RefSeq Acc Id: ENSP00000504772   ⟸   ENST00000678649
RefSeq Acc Id: ENSP00000503146   ⟸   ENST00000678596
RefSeq Acc Id: ENSP00000504676   ⟸   ENST00000678599
RefSeq Acc Id: ENSP00000502968   ⟸   ENST00000679157
RefSeq Acc Id: ENSP00000504313   ⟸   ENST00000679149
RefSeq Acc Id: ENSP00000503252   ⟸   ENST00000679025
RefSeq Acc Id: ENSP00000503119   ⟸   ENST00000679028
RefSeq Acc Id: ENSP00000503891   ⟸   ENST00000679030
Protein Domains
Inhibitor_I29   Pept_C1

Promoters
RGD ID:7215391
Promoter ID:EPDNEW_H13442
Type:initiation region
Name:CTSL_1
Description:cathepsin L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,726,119 - 87,726,179EPDNEW
RGD ID:6807425
Promoter ID:HG_KWN:63911
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   NB4
Transcripts:ENST00000342020,   ENST00000343150,   NM_145918,   OTTHUMT00000052941,   UC004APH.1,   UC004APJ.1,   UC004APK.1,   UC004APL.1,   UC010MQH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36989,530,691 - 89,531,191 (+)MPROMDB
RGD ID:6851516
Promoter ID:EP73559
Type:single initiation site
Name:HS_CTSL
Description:Cathepsin L , transcript variant 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36989,530,854 - 89,530,914EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q21.33-22.2(chr9:87418580-90406012)x1 copy number loss See cases [RCV000050968] Chr9:87418580..90406012 [GRCh38]
Chr9:90033495..93168294 [GRCh37]
Chr9:89223315..92208114 [NCBI36]
Chr9:9q21.33-22.2
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q21.11-31.2(chr9:68420430-106579493)x3 copy number gain See cases [RCV000136788] Chr9:68420430..106579493 [GRCh38]
Chr9:71130848..109341774 [GRCh37]
Chr9:70225166..108381595 [NCBI36]
Chr9:9q21.11-31.2
pathogenic
GRCh38/hg38 9q21.33-22.31(chr9:86079851-91827221)x1 copy number loss See cases [RCV000137602] Chr9:86079851..91827221 [GRCh38]
Chr9:88694766..94589503 [GRCh37]
Chr9:87884586..93629324 [NCBI36]
Chr9:9q21.33-22.31
pathogenic
GRCh38/hg38 9q21.33-22.1(chr9:87209403-87977877)x3 copy number gain See cases [RCV000138224] Chr9:87209403..87977877 [GRCh38]
Chr9:89824318..90592792 [GRCh37]
Chr9:89014138..89782612 [NCBI36]
Chr9:9q21.33-22.1
uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3
pathogenic
GRCh38/hg38 9p24.3-q22.1(chr9:203861-88130444)x4 copy number gain See cases [RCV000141904] Chr9:203861..88130444 [GRCh38]
Chr9:203861..90745359 [GRCh37]
Chr9:193861..89935179 [NCBI36]
Chr9:9p24.3-q22.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9q21.11-22.1(chr9:70966262-90761254)x4 copy number gain See cases [RCV000512280] Chr9:70966262..90761254 [GRCh37]
Chr9:9q21.11-22.1
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.2-22.32(chr9:79520825-97201274) copy number gain not provided [RCV000767645] Chr9:79520825..97201274 [GRCh37]
Chr9:9q21.2-22.32
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
GRCh37/hg19 9q21.33-22.31(chr9:90002910-94567835)x3 copy number gain not provided [RCV001006243] Chr9:90002910..94567835 [GRCh37]
Chr9:9q21.33-22.31
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_001912.5(CTSL):c.852A>C (p.Gly284=) single nucleotide variant not provided [RCV000930945] Chr9:87730448 [GRCh38]
Chr9:90345363 [GRCh37]
Chr9:9q21.33
likely benign
NM_001912.5(CTSL):c.350C>A (p.Ser117Tyr) single nucleotide variant not provided [RCV000909270] Chr9:87728350 [GRCh38]
Chr9:90343265 [GRCh37]
Chr9:9q21.33
benign
GRCh37/hg19 9q21.33-22.2(chr9:90031614-93173691)x1 copy number loss not provided [RCV001258443] Chr9:90031614..93173691 [GRCh37]
Chr9:9q21.33-22.2
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2537 AgrOrtholog
COSMIC CTSL COSMIC
Ensembl Genes ENSG00000135047 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000340470 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000345344 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000365061 UniProtKB/Swiss-Prot
  ENSP00000502901 UniProtKB/Swiss-Prot
  ENSP00000502922 UniProtKB/TrEMBL
  ENSP00000502968 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000503119 UniProtKB/TrEMBL
  ENSP00000503146 UniProtKB/TrEMBL
  ENSP00000503252 UniProtKB/TrEMBL
  ENSP00000503298 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000503439 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000503470 UniProtKB/Swiss-Prot
  ENSP00000503851 UniProtKB/Swiss-Prot
  ENSP00000503881 UniProtKB/Swiss-Prot
  ENSP00000503891 UniProtKB/TrEMBL
  ENSP00000503897 UniProtKB/Swiss-Prot
  ENSP00000503938 UniProtKB/Swiss-Prot
  ENSP00000504275 UniProtKB/TrEMBL
  ENSP00000504279 UniProtKB/Swiss-Prot
  ENSP00000504313 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000504405 UniProtKB/Swiss-Prot
  ENSP00000504473 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000504560 UniProtKB/TrEMBL
  ENSP00000504639 UniProtKB/TrEMBL
  ENSP00000504676 UniProtKB/TrEMBL
  ENSP00000504702 UniProtKB/TrEMBL
  ENSP00000504772 UniProtKB/TrEMBL
Ensembl Transcript ENST00000340342 UniProtKB/Swiss-Prot
  ENST00000342020 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000343150 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000676480 UniProtKB/Swiss-Prot
  ENST00000676531 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000676769 UniProtKB/Swiss-Prot
  ENST00000676881 UniProtKB/Swiss-Prot
  ENST00000676946 UniProtKB/Swiss-Prot
  ENST00000677019 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000677262 UniProtKB/Swiss-Prot
  ENST00000677523 UniProtKB/TrEMBL
  ENST00000677638 UniProtKB/TrEMBL
  ENST00000677761 UniProtKB/Swiss-Prot
  ENST00000677821 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000677864 UniProtKB/Swiss-Prot
  ENST00000677955 UniProtKB/TrEMBL
  ENST00000678259 UniProtKB/TrEMBL
  ENST00000678367 UniProtKB/TrEMBL
  ENST00000678442 UniProtKB/Swiss-Prot
  ENST00000678596 UniProtKB/TrEMBL
  ENST00000678599 UniProtKB/TrEMBL
  ENST00000678649 UniProtKB/TrEMBL
  ENST00000679025 UniProtKB/TrEMBL
  ENST00000679028 UniProtKB/TrEMBL
  ENST00000679030 UniProtKB/TrEMBL
  ENST00000679149 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000679157 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000135047 GTEx
HGNC ID HGNC:2537 ENTREZGENE
Human Proteome Map CTSL Human Proteome Map
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1514 ENTREZGENE
OMIM 116880 OMIM
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CTSL1 RGD, PharmGKB
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R276 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V2H7_HUMAN UniProtKB/TrEMBL
  A0A7I2V484_HUMAN UniProtKB/TrEMBL
  A0A7I2V5F7_HUMAN UniProtKB/TrEMBL
  A0A7I2V5M3_HUMAN UniProtKB/TrEMBL
  A0A7I2V601_HUMAN UniProtKB/TrEMBL
  A0A7I2YQA2_HUMAN UniProtKB/TrEMBL
  A0A7I2YQB5_HUMAN UniProtKB/TrEMBL
  CATL1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5T8F0_HUMAN UniProtKB/TrEMBL
  Q9HBQ7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6IAV1 UniProtKB/Swiss-Prot
  Q96QJ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-02 CTSL  cathepsin L  CTSL1  cathepsin L1  Symbol and/or name change 5135510 APPROVED