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Gene: ICAM5 (intercellular adhesion molecule 5) Homo sapiens
Symbol: ICAM5
Name: intercellular adhesion molecule 5
Description: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ICAM-5; intercellular adhesion molecule 5, telencephalin; telencephalin; TLCN; TLN
Mus musculus (house mouse) : Icam5 (intercellular adhesion molecule 5, telencephalin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Icam5 (intercellular adhesion molecule 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Icam5 (intercellular adhesion molecule 5)
Pan paniscus (bonobo/pygmy chimpanzee) : ICAM5 (intercellular adhesion molecule 5)
Canis lupus familiaris (dog) : ICAM5 (intercellular adhesion molecule 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Icam5 (intercellular adhesion molecule 5)
Sus scrofa (pig) : LOC100511183 (intercellular adhesion molecule 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,289,351 - 10,296,778 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,400,655 - 10,407,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,261,655 - 10,268,453 (+)NCBINCBI36hg18NCBI36
Build 341910,261,654 - 10,268,453NCBI
Celera1910,296,051 - 10,302,851 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,980,634 - 9,987,434 (+)NCBIHuRef
CHM1_11910,400,920 - 10,407,719 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ICAM5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312830
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.