ESRRA (estrogen related receptor alpha) - Rat Genome Database

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Gene: ESRRA (estrogen related receptor alpha) Homo sapiens
Analyze
Symbol: ESRRA
Name: estrogen related receptor alpha
RGD ID: 730826
HGNC Page HGNC
Description: Enables DNA-binding transcription factor activity; protein domain specific binding activity; and sequence-specific double-stranded DNA binding activity. Involved in regulation of transcription, DNA-templated. Located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nuclear lumen. Biomarker of congestive heart failure.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ERR-alpha; ERR1; ERRa; ERRalpha; ESRL1; estrogen receptor-like 1; estrogen related receptor, alpha; estrogen-related nuclear receptor alpha; estrogen-related receptor alpha; NR3B1; nuclear receptor subfamily 3 group B member 1; steroid hormone receptor ERR1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: ESRRAP1   ESRRAP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,305,524 - 64,316,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1164,305,497 - 64,316,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,072,996 - 64,084,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,829,620 - 63,840,786 (+)NCBINCBI36hg18NCBI36
Build 341163,829,619 - 63,840,786NCBI
Celera1161,399,143 - 61,410,294 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,400,773 - 60,411,951 (+)NCBIHuRef
CHM1_11163,956,034 - 63,967,223 (+)NCBICHM1_1
T2T-CHM13v2.01164,295,491 - 64,306,724 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,6-diaminoacridine  (EXP)
5-aza-2'-deoxycytidine  (EXP)
8-Br-cAMP  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (EXP)
aldehydo-D-glucose  (ISO)
alpha-naphthoflavone  (EXP)
aristolochic acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP)
beta-naphthoflavone  (EXP)
biochanin A  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carmustine  (EXP)
CHIR 99021  (ISO)
chlormidazole  (EXP)
clenbuterol  (ISO)
colforsin daropate hydrochloride  (EXP)
cyazofamid  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
daidzein  (EXP)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
endosulfan  (ISO)
ethanol  (ISO)
etoposide  (EXP)
fenpyroximate  (EXP)
ferroheme b  (ISO)
flavone  (EXP)
fluoxastrobin  (EXP)
fulvestrant  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
glucose  (ISO)
heme b  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (ISO)
isoflavones  (EXP)
kresoxim-methyl  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
metformin  (ISO)
methotrexate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
prostaglandin E2  (EXP)
pyridaben  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
thioacetamide  (ISO)
topotecan  (EXP)
toxaphene  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
trifloxystrobin  (EXP)
trifluridine  (EXP)
trilobatin  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISA)
cytoplasm  (IDA,IEA)
fibrillar center  (IDA)
intercellular bridge  (IDA)
microtubule cytoskeleton  (IDA)
nucleoplasm  (IDA,IEA,TAS)
nucleus  (IDA,IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:3267207   PMID:8224847   PMID:8621448   PMID:9058380   PMID:9271417   PMID:9286700   PMID:9344655   PMID:9395481   PMID:9824153   PMID:10598588   PMID:11165056   PMID:11437591  
PMID:11574675   PMID:11984006   PMID:11986328   PMID:12181319   PMID:12397057   PMID:12477932   PMID:12522104   PMID:12560563   PMID:12579315   PMID:14610283   PMID:14701856   PMID:14978033  
PMID:15231680   PMID:15231747   PMID:15302935   PMID:15318176   PMID:15337744   PMID:15598686   PMID:15604093   PMID:15821111   PMID:15883633   PMID:16024613   PMID:16150865   PMID:16439465  
PMID:16681769   PMID:17053040   PMID:17157980   PMID:17294452   PMID:17418098   PMID:17418099   PMID:17488637   PMID:17509876   PMID:17556356   PMID:17631492   PMID:18063693   PMID:18174157  
PMID:18328649   PMID:18331830   PMID:18418639   PMID:18441008   PMID:18509053   PMID:18660489   PMID:18673300   PMID:18697814   PMID:18778951   PMID:18974123   PMID:19061896   PMID:19064572  
PMID:19138740   PMID:19171140   PMID:19264843   PMID:19274049   PMID:19276159   PMID:19389810   PMID:19429439   PMID:19453261   PMID:19462000   PMID:19491275   PMID:19505873   PMID:19546226  
PMID:19608650   PMID:19622763   PMID:19822186   PMID:19913121   PMID:20067526   PMID:20211987   PMID:20351196   PMID:20484414   PMID:20497091   PMID:20561910   PMID:20628086   PMID:20668045  
PMID:20838448   PMID:20851810   PMID:20870744   PMID:20961995   PMID:21102463   PMID:21177257   PMID:21190936   PMID:21447778   PMID:21449913   PMID:21486805   PMID:21506092   PMID:21513704  
PMID:21546870   PMID:21596133   PMID:21732060   PMID:21734015   PMID:21873635   PMID:21949640   PMID:21988832   PMID:22014575   PMID:22082156   PMID:22096509   PMID:22242598   PMID:22266318  
PMID:22333182   PMID:22939629   PMID:23123734   PMID:23275563   PMID:23403054   PMID:23403292   PMID:23516535   PMID:23525223   PMID:23680656   PMID:23700042   PMID:23720198   PMID:23788330  
PMID:23836899   PMID:23836911   PMID:23975195   PMID:24216484   PMID:24419103   PMID:24425001   PMID:24457025   PMID:24504521   PMID:24559156   PMID:24967384   PMID:24979764   PMID:25288732  
PMID:25480584   PMID:25643697   PMID:25865501   PMID:25903400   PMID:25912138   PMID:26160845   PMID:26312764   PMID:26496610   PMID:26542058   PMID:26586335   PMID:26639757   PMID:26744532  
PMID:26760575   PMID:27041564   PMID:27153547   PMID:27227989   PMID:27231954   PMID:27402251   PMID:27456360   PMID:27501743   PMID:27532429   PMID:27639646   PMID:28348226   PMID:28473536  
PMID:28514442   PMID:28596418   PMID:28627585   PMID:28993941   PMID:29117863   PMID:29214989   PMID:29599373   PMID:29844126   PMID:29862528   PMID:29940916   PMID:29968728   PMID:30042415  
PMID:30185207   PMID:30322948   PMID:30478447   PMID:30609256   PMID:30920960   PMID:30954508   PMID:30977157   PMID:31040369   PMID:31427441   PMID:31594836   PMID:31617661   PMID:31753913  
PMID:31811028   PMID:31907393   PMID:32030850   PMID:32176739   PMID:32226548   PMID:32296183   PMID:32366476   PMID:32572171   PMID:32641987   PMID:32855526   PMID:33184978   PMID:33197888  
PMID:33242950   PMID:33446092   PMID:33450359   PMID:33525981   PMID:33591949   PMID:33753865   PMID:33961781   PMID:34131782   PMID:34184087   PMID:34229541   PMID:35048632   PMID:35264626  


Genomics

Comparative Map Data
ESRRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,305,524 - 64,316,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1164,305,497 - 64,316,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,072,996 - 64,084,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,829,620 - 63,840,786 (+)NCBINCBI36hg18NCBI36
Build 341163,829,619 - 63,840,786NCBI
Celera1161,399,143 - 61,410,294 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,400,773 - 60,411,951 (+)NCBIHuRef
CHM1_11163,956,034 - 63,967,223 (+)NCBICHM1_1
T2T-CHM13v2.01164,295,491 - 64,306,724 (+)NCBI
Esrra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,888,345 - 6,899,416 (-)NCBIGRCm39mm39
GRCm39 Ensembl196,888,345 - 6,899,208 (-)Ensembl
GRCm38196,910,977 - 6,922,048 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,910,977 - 6,921,840 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl196,910,977 - 6,921,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv37196,985,467 - 6,996,298 (-)NCBIGRCm37mm9NCBIm37
MGSCv36196,978,021 - 6,988,814 (-)NCBImm8
Celera196,687,756 - 6,698,743 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.08NCBI
Esrra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21204,104,100 - 204,114,182 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1204,104,101 - 204,114,268 (-)Ensembl
Rnor_6.01222,168,729 - 222,178,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,168,730 - 222,178,725 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,159,583 - 229,169,692 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,587,681 - 209,597,677 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1201,638,048 - 201,648,043 (-)NCBICelera
Cytogenetic Map1q43NCBI
Esrra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,768,450 - 20,787,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,768,450 - 20,775,205 (-)NCBIChiLan1.0ChiLan1.0
ESRRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11163,009,295 - 63,018,744 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,009,295 - 63,018,744 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01159,662,565 - 59,673,789 (+)NCBIMhudiblu_PPA_v0panPan3
ESRRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,755,547 - 52,762,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,756,344 - 52,763,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,363,416 - 51,368,398 (-)NCBI
ROS_Cfam_1.01853,800,958 - 53,808,348 (-)NCBI
ROS_Cfam_1.0 Ensembl1853,800,961 - 53,810,470 (-)Ensembl
UMICH_Zoey_3.11852,893,602 - 52,898,808 (-)NCBI
UNSW_CanFamBas_1.01852,480,190 - 52,485,175 (-)NCBI
UU_Cfam_GSD_1.01853,264,070 - 53,269,055 (-)NCBI
Esrra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,456,185 - 8,463,755 (-)NCBI
SpeTri2.0NW_0049365994,898,534 - 4,922,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESRRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,803,510 - 7,813,836 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,803,504 - 7,812,868 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,869,329 - 6,878,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ESRRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,918,741 - 9,929,481 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl19,917,436 - 9,929,450 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038107,259,172 - 107,269,573 (-)NCBIVero_WHO_p1.0
Esrra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,999,932 - 22,009,485 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476721,999,932 - 22,007,582 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
WI-8671  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,084,166 - 64,084,290UniSTSGRCh37
Build 361163,840,742 - 63,840,866RGDNCBI36
Celera1161,410,250 - 61,410,374RGD
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q13.1UniSTS
HuRef1160,411,907 - 60,412,031UniSTS
GeneMap99-GB4 RH Map11249.53UniSTS
Whitehead-RH Map11339.2UniSTS
NCBI RH Map11573.2UniSTS
RH92300  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,072,053 - 64,072,215UniSTSGRCh37
Build 361163,828,629 - 63,828,791RGDNCBI36
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map11q13UniSTS
HuRef1160,399,782 - 60,399,944UniSTS
GeneMap99-GB4 RH Map11247.67UniSTS
PMC137182P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,078,652 - 64,078,839UniSTSGRCh37
Build 361163,835,228 - 63,835,415RGDNCBI36
Celera1161,404,725 - 61,404,912RGD
Cytogenetic Map11q13UniSTS
HuRef1160,406,382 - 60,406,569UniSTS
PMC137182P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,078,680 - 64,078,839UniSTSGRCh37
Build 361163,835,256 - 63,835,415RGDNCBI36
Celera1161,404,753 - 61,404,912RGD
Cytogenetic Map11q13UniSTS
HuRef1160,406,410 - 60,406,569UniSTS
BARC0081  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371321,834,809 - 21,835,088UniSTSGRCh37
GRCh371164,081,432 - 64,082,279UniSTSGRCh37
Build 361320,732,809 - 20,733,088RGDNCBI36
Celera1161,407,516 - 61,408,363UniSTS
Celera132,896,497 - 2,896,776RGD
HuRef1160,409,173 - 60,410,020UniSTS
HuRef132,635,616 - 2,635,895UniSTS
SGC30525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,084,105 - 64,084,207UniSTSGRCh37
Build 361163,840,681 - 63,840,783RGDNCBI36
Celera1161,410,189 - 61,410,291RGD
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q13.1UniSTS
HuRef1160,411,846 - 60,411,948UniSTS
GeneMap99-GB4 RH Map11247.89UniSTS
Whitehead-RH Map11327.5UniSTS
NCBI RH Map11573.2UniSTS
G33076  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,084,495 - 64,084,671UniSTSGRCh37
Build 361163,841,071 - 63,841,247RGDNCBI36
Celera1161,410,579 - 61,410,755RGD
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q13.1UniSTS
HuRef1160,412,236 - 60,412,412UniSTS
SHGC-11941  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13UniSTS
Esrra  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371321,835,452 - 21,836,452UniSTSGRCh37
GRCh371320,133,424 - 20,134,423UniSTSGRCh37
Celera131,195,266 - 1,196,262UniSTS
Celera132,897,140 - 2,898,140UniSTS
HuRef13938,261 - 939,257UniSTS
HuRef132,636,259 - 2,637,259UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR137hsa-miR-137Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22723937
MIR137hsa-miR-137OncomiRDBexternal_infoNANA22723937

Predicted Target Of
Summary Value
Count of predictions:2985
Count of miRNA genes:848
Interacting mature miRNAs:1032
Transcripts:ENST00000000442, ENST00000405666, ENST00000406310, ENST00000467987, ENST00000468670, ENST00000539594, ENST00000545035
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2431 2790 1715 616 1777 458 4349 2157 3301 411 1347 1605 172 1204 2784 4
Low 8 201 11 8 169 7 7 40 433 8 113 8 3 1 4 2 2
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001282450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB362579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB478332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ514553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ692867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X51416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000000442   ⟹   ENSP00000000442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,305,524 - 64,316,743 (+)Ensembl
RefSeq Acc Id: ENST00000405666   ⟹   ENSP00000384851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,306,227 - 64,316,743 (+)Ensembl
RefSeq Acc Id: ENST00000406310   ⟹   ENSP00000385971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,305,497 - 64,316,738 (+)Ensembl
RefSeq Acc Id: ENST00000467987
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,313,771 - 64,315,890 (+)Ensembl
RefSeq Acc Id: ENST00000468670   ⟹   ENSP00000441970
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,306,446 - 64,307,504 (+)Ensembl
RefSeq Acc Id: ENST00000539594   ⟹   ENSP00000439896
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,305,580 - 64,315,173 (+)Ensembl
RefSeq Acc Id: ENST00000545035   ⟹   ENSP00000444710
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,314,284 - 64,316,029 (+)Ensembl
RefSeq Acc Id: ENST00000677967   ⟹   ENSP00000503245
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,305,524 - 64,316,738 (+)Ensembl
RefSeq Acc Id: NM_001282450   ⟹   NP_001269379
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,878 - 64,316,743 (+)NCBI
HuRef1160,400,729 - 60,411,956 (+)NCBI
CHM1_11163,956,689 - 63,967,228 (+)NCBI
T2T-CHM13v2.01164,295,845 - 64,306,724 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282451   ⟹   NP_001269380
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,524 - 64,316,743 (+)NCBI
HuRef1160,400,729 - 60,411,956 (+)NCBI
CHM1_11163,955,990 - 63,967,228 (+)NCBI
T2T-CHM13v2.01164,295,491 - 64,306,724 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004451   ⟹   NP_004442
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,524 - 64,316,743 (+)NCBI
GRCh371164,072,990 - 64,084,215 (+)NCBI
Build 361163,829,620 - 63,840,786 (+)NCBI Archive
HuRef1160,400,729 - 60,411,956 (+)NCBI
CHM1_11163,955,990 - 63,967,228 (+)NCBI
T2T-CHM13v2.01164,295,491 - 64,306,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017017313   ⟹   XP_016872802
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,878 - 64,316,743 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047426523   ⟹   XP_047282479
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,878 - 64,316,743 (+)NCBI
RefSeq Acc Id: XM_047426524   ⟹   XP_047282480
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,878 - 64,316,743 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_004442   ⟸   NM_004451
- Peptide Label: isoform 1
- UniProtKB: P11474 (UniProtKB/Swiss-Prot),   Q569H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269380   ⟸   NM_001282451
- Peptide Label: isoform 2
- UniProtKB: P11474 (UniProtKB/Swiss-Prot),   Q569H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269379   ⟸   NM_001282450
- Peptide Label: isoform 1
- UniProtKB: P11474 (UniProtKB/Swiss-Prot),   Q569H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016872802   ⟸   XM_017017313
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000444710   ⟸   ENST00000545035
RefSeq Acc Id: ENSP00000441970   ⟸   ENST00000468670
RefSeq Acc Id: ENSP00000384851   ⟸   ENST00000405666
RefSeq Acc Id: ENSP00000385971   ⟸   ENST00000406310
RefSeq Acc Id: ENSP00000439896   ⟸   ENST00000539594
RefSeq Acc Id: ENSP00000000442   ⟸   ENST00000000442
RefSeq Acc Id: ENSP00000503245   ⟸   ENST00000677967
RefSeq Acc Id: XP_047282480   ⟸   XM_047426524
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047282479   ⟸   XM_047426523
- Peptide Label: isoform X2
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11474-F1-model_v2 AlphaFold P11474 1-423 view protein structure

Promoters
RGD ID:6788899
Promoter ID:HG_KWN:13213
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000377688,   ENST00000405666,   ENST00000406310,   NM_004451,   OTTHUMT00000319305
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,828,781 - 63,830,647 (+)MPROMDB
RGD ID:6788898
Promoter ID:HG_KWN:13214
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000319306,   UC009YPN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,836,911 - 63,838,387 (+)MPROMDB
RGD ID:6814970
Promoter ID:HG_MRA:2790
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:BC011528
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,839,356 - 63,839,856 (+)MPROMDB
RGD ID:7220875
Promoter ID:EPDNEW_H16183
Type:initiation region
Name:ESRRA_1
Description:estrogen related receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16184  EPDNEW_H16185  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,524 - 64,305,584EPDNEW
RGD ID:7220877
Promoter ID:EPDNEW_H16184
Type:initiation region
Name:ESRRA_2
Description:estrogen related receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16183  EPDNEW_H16185  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,305,878 - 64,305,938EPDNEW
RGD ID:7220879
Promoter ID:EPDNEW_H16185
Type:initiation region
Name:ESRRA_3
Description:estrogen related receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16183  EPDNEW_H16184  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,306,174 - 64,306,234EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_012094.4(PRDX5):c.371C>T (p.Ala124Val) single nucleotide variant Malignant melanoma [RCV000069590] Chr11:64320725 [GRCh38]
Chr11:64088197 [GRCh37]
Chr11:63844773 [NCBI36]
Chr11:11q13.1
not provided
GRCh38/hg38 11q12.3-13.1(chr11:62893226-64335043)x1 copy number loss See cases [RCV000140879] Chr11:62893226..64335043 [GRCh38]
Chr11:62660698..64102515 [GRCh37]
Chr11:62417274..63859091 [NCBI36]
Chr11:11q12.3-13.1
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_004451.5(ESRRA):c.92C>T (p.Thr31Ile) single nucleotide variant not provided [RCV000971925] Chr11:64307271 [GRCh38]
Chr11:64074743 [GRCh37]
Chr11:11q13.1
benign
dup(11)(q13.1q13.1) duplication Ependymoma [RCV000785872] Chr11:63533279..65429676 [GRCh37]
Chr11:11q13.1
likely pathogenic
NM_004451.5(ESRRA):c.258C>T (p.Ala86=) single nucleotide variant not provided [RCV000977745] Chr11:64307437 [GRCh38]
Chr11:64074909 [GRCh37]
Chr11:11q13.1
likely benign
NM_004451.5(ESRRA):c.861T>C (p.Ala287=) single nucleotide variant not provided [RCV000918128] Chr11:64315119 [GRCh38]
Chr11:64082591 [GRCh37]
Chr11:11q13.1
benign
NM_004451.5(ESRRA):c.81G>A (p.Ser27=) single nucleotide variant not provided [RCV000923190] Chr11:64307260 [GRCh38]
Chr11:64074732 [GRCh37]
Chr11:11q13.1
likely benign
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3471 AgrOrtholog
COSMIC ESRRA COSMIC
Ensembl Genes ENSG00000173153 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000000442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000384851 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385971 UniProtKB/TrEMBL
  ENSP00000439896 UniProtKB/TrEMBL
  ENSP00000441970 UniProtKB/TrEMBL
  ENSP00000444710 UniProtKB/TrEMBL
  ENSP00000503245 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000000442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000405666 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000406310 UniProtKB/TrEMBL
  ENST00000468670 UniProtKB/TrEMBL
  ENST00000539594 UniProtKB/TrEMBL
  ENST00000545035 UniProtKB/TrEMBL
  ENST00000677967 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000173153 GTEx
HGNC ID HGNC:3471 ENTREZGENE
Human Proteome Map ESRRA Human Proteome Map
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oest-rel_rcp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oest_rcpt/oest-rel_rcp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2101 ENTREZGENE
OMIM 601998 OMIM
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ESRRA RGD, PharmGKB
PIRSF ER-like_NR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERR1-2-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6E1WCP9_HUMAN UniProtKB/TrEMBL
  A8CGI6_HUMAN UniProtKB/TrEMBL
  ERR1_HUMAN UniProtKB/Swiss-Prot
  F5GWT5_HUMAN UniProtKB/TrEMBL
  F5H0E9_HUMAN UniProtKB/TrEMBL
  H0YGT3_HUMAN UniProtKB/TrEMBL
  P11474 ENTREZGENE
  Q569H8 ENTREZGENE, UniProtKB/TrEMBL
  Q6GMQ8_HUMAN UniProtKB/TrEMBL
  Q96I02_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q14514 UniProtKB/Swiss-Prot
  Q6P3W9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 ESRRA  estrogen related receptor alpha    estrogen-related receptor alpha  Symbol and/or name change 5135510 APPROVED
2011-08-16 ESRRA  estrogen-related receptor alpha  ESRRA  estrogen-related receptor alpha  Symbol and/or name change 5135510 APPROVED