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Gene: PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) Homo sapiens
Symbol: PRKAA2
Name: protein kinase AMP-activated catalytic subunit alpha 2
Description: Exhibits AMP-activated protein kinase activity and protein serine/threonine/tyrosine kinase activity. Predicted to be involved in several processes, including energy homeostasis; regulation of cellular catabolic process; and regulation of protein modification process. Localizes to Golgi apparatus and nuclear speck. Implicated in type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMPK; AMPK alpha 2; AMPK subunit alpha-2; AMPK-alpha-2 chain; AMPK2; AMPKa2; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; PRKAA
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl156,645,314 - 56,715,335 (+)EnsemblGRCh38hg38GRCh38
GRCh38156,645,314 - 56,715,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37157,110,990 - 57,181,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,883,578 - 56,953,596 (+)NCBINCBI36hg18NCBI36
Build 34156,823,040 - 56,886,142NCBI
Celera155,395,857 - 55,465,885 (+)NCBI
Cytogenetic Map1p32.2NCBI
HuRef155,223,513 - 55,293,426 (+)NCBIHuRef
CHM1_1157,226,353 - 57,296,384 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKAA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730888
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.