PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) - Rat Genome Database

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Gene: PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) Homo sapiens
Analyze
Symbol: PRKAA2
Name: protein kinase AMP-activated catalytic subunit alpha 2
RGD ID: 730888
HGNC Page HGNC:9377
Description: Enables AMP-activated protein kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; negative regulation of hepatocyte apoptotic process; and protein localization to lipid droplet. Acts upstream of with a positive effect on lipid droplet disassembly. Located in Golgi apparatus; nuclear speck; and nucleotide-activated protein kinase complex. Implicated in type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMPK; AMPK alpha 2; AMPK subunit alpha-2; AMPK-alpha-2 chain; AMPK2; AMPKa2; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; PRKAA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,645,314 - 56,715,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl156,645,314 - 56,715,335 (+)EnsemblGRCh38hg38GRCh38
GRCh37157,110,987 - 57,181,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,883,578 - 56,953,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34156,823,040 - 56,886,142NCBI
Celera155,395,857 - 55,465,885 (+)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,223,513 - 55,293,426 (+)NCBIHuRef
CHM1_1157,226,353 - 57,296,384 (+)NCBICHM1_1
T2T-CHM13v2.0156,524,182 - 56,594,202 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(-)-Arctigenin  (EXP)
(-)-matairesinol  (EXP)
(R)-lipoic acid  (ISO)
(R,R)-tramadol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,7,9-tetramethyluric acid  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxy-TEMPO  (EXP)
4-nonylphenol  (ISO)
acadesine  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (EXP)
AICA ribonucleotide  (EXP,ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
Arctiin  (EXP)
aristolochic acid A  (EXP)
ATP  (ISO)
atrazine  (ISO)
bafilomycin A1  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
butanal  (EXP)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
carnitine  (ISO)
cisplatin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
cyproconazole  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
Deoxyschizandrin  (EXP)
dibutyl phthalate  (EXP,ISO)
dihydroxyacetone  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
econazole  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formononetin  (ISO)
formoterol fumarate  (ISO)
geldanamycin  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glyphosate  (EXP)
gramine  (EXP)
hexaconazole  (ISO)
hexadecanoic acid  (EXP)
histamine  (EXP)
isoprenaline  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
mercury dichloride  (ISO)
Mesaconitine  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methotrexate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (EXP)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
nitrites  (ISO)
nitrofen  (ISO)
nordihydroguaiaretic acid  (ISO)
oleic acid  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
Pseudolaric acid B  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Salidroside  (ISO)
Sanggenon C  (ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sucrose  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
syringin  (EXP)
tebuconazole  (ISO)
telmisartan  (EXP)
temozolomide  (EXP)
testosterone enanthate  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tramadol  (ISO)
triadimefon  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
xanthone  (ISO)
xylazine  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cellular response to calcium ion  (IEA,ISS)
cellular response to glucose starvation  (IBA,IDA,IEA)
cellular response to glucose stimulus  (IEA,ISS)
cellular response to nutrient levels  (IDA,IEA,ISS,NAS)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (IEA,ISS)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
cholesterol biosynthetic process  (IEA)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
energy homeostasis  (ISS)
fatty acid biosynthetic process  (IEA)
fatty acid homeostasis  (ISS)
glucose homeostasis  (IEA,ISS)
intracellular signal transduction  (IEA)
lipid biosynthetic process  (IEA,ISS)
lipid droplet disassembly  (IDA)
negative regulation of apoptotic process  (IEA,ISS)
negative regulation of gene expression  (IEA,ISS)
negative regulation of hepatocyte apoptotic process  (IDA)
negative regulation of TOR signaling  (IBA,IEA,ISS)
negative regulation of TORC1 signaling  (IDA,IEA)
negative regulation of tubulin deacetylation  (IEA,ISS)
positive regulation of autophagy  (IEA,ISS)
positive regulation of glycolytic process  (ISS)
positive regulation of macroautophagy  (TAS)
positive regulation of peptidyl-lysine acetylation  (IEA,ISS)
positive regulation of protein localization  (IEA,ISS)
protein localization to lipid droplet  (IDA,IEA)
protein phosphorylation  (ISO)
regulation of circadian rhythm  (IEA,ISS)
regulation of gene expression  (IEA,ISO)
regulation of lipid metabolic process  (ISO)
regulation of macroautophagy  (IEA,ISS)
regulation of microtubule cytoskeleton organization  (IEA,ISS)
regulation of stress granule assembly  (IEA)
response to activity  (ISO)
response to caffeine  (ISO)
response to muscle activity  (IEA,ISO)
rhythmic process  (IEA)
signal transduction  (TAS)
Wnt signaling pathway  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
High myopia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. AMP-activated protein kinase (AMPK) is decreased in the mouse brain during experimental cerebral malaria. Apoorv TS, etal., Neurosci Lett. 2018 Jan 1;662:290-294. doi: 10.1016/j.neulet.2017.10.054. Epub 2017 Oct 28.
2. New targets of urocortin-mediated cardioprotection. Barry SP, etal., J Mol Endocrinol. 2010 Aug;45(2):69-85. doi: 10.1677/JME-09-0148. Epub 2010 May 25.
3. Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis. Chen M, etal., Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
6. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
7. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
8. A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population. Horikoshi M, etal., Diabetes. 2006 Apr;55(4):919-23.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues. Sayed-Ahmed MM, etal., Cardiovasc Toxicol. 2019 Aug;19(4):344-356. doi: 10.1007/s12012-018-9500-0.
15. Metformin protects against infection-induced myocardial dysfunction. Tzanavari T, etal., Metabolism. 2016 Oct;65(10):1447-58. doi: 10.1016/j.metabol.2016.06.012. Epub 2016 Jul 9.
16. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. Viollet B, etal., J Clin Invest 2003 Jan;111(1):91-8.
17. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:1322130   PMID:1365882   PMID:1536860   PMID:2900138   PMID:7959015   PMID:7988703   PMID:8889548   PMID:9148944   PMID:9224708   PMID:9693118   PMID:10642499   PMID:10698692  
PMID:10760274   PMID:11052978   PMID:11171059   PMID:11257506   PMID:11389854   PMID:11500364   PMID:11797013   PMID:12067722   PMID:12091379   PMID:12391032   PMID:12413941   PMID:12427743  
PMID:12444247   PMID:12456889   PMID:12477932   PMID:12519745   PMID:12663462   PMID:12740371   PMID:12788940   PMID:12847291   PMID:12853467   PMID:12941758   PMID:14532170   PMID:14613924  
PMID:14651849   PMID:14709557   PMID:14729328   PMID:14742438   PMID:14985344   PMID:14985505   PMID:15024086   PMID:15058305   PMID:15060529   PMID:15231718   PMID:15297373   PMID:15371448  
PMID:15489334   PMID:15572372   PMID:16054041   PMID:16054095   PMID:16054096   PMID:16275868   PMID:16344560   PMID:16483872   PMID:16505254   PMID:16518831   PMID:16598851   PMID:16624523  
PMID:16670154   PMID:16710414   PMID:16801347   PMID:16984726   PMID:17012231   PMID:17179156   PMID:17950019   PMID:18029386   PMID:18195011   PMID:18439900   PMID:18614941   PMID:18674809  
PMID:18801964   PMID:18836454   PMID:18974883   PMID:18996102   PMID:19170765   PMID:19171932   PMID:19274086   PMID:19434633   PMID:19440859   PMID:19470831   PMID:19502591   PMID:19528236  
PMID:19574280   PMID:19616115   PMID:19720090   PMID:19720831   PMID:19723084   PMID:19728147   PMID:19836452   PMID:19913121   PMID:19948975   PMID:20124121   PMID:20167927   PMID:20217115  
PMID:20392842   PMID:20558612   PMID:20562859   PMID:20602615   PMID:20628086   PMID:20647423   PMID:20682687   PMID:20801214   PMID:20821366   PMID:20876741   PMID:21072212   PMID:21209024  
PMID:21344388   PMID:21432774   PMID:21516116   PMID:21543851   PMID:21651489   PMID:21673972   PMID:21768291   PMID:21825219   PMID:21873635   PMID:22137581   PMID:22212710   PMID:22286170  
PMID:22305490   PMID:22561688   PMID:22728651   PMID:22797923   PMID:22810586   PMID:22897928   PMID:22939624   PMID:23000302   PMID:23293026   PMID:23396962   PMID:23476055   PMID:23723070  
PMID:24414799   PMID:24563466   PMID:24722188   PMID:24981860   PMID:25126726   PMID:25184681   PMID:25241761   PMID:25412657   PMID:25416956   PMID:25590814   PMID:25687571   PMID:25799226  
PMID:25840010   PMID:25846811   PMID:25858560   PMID:26108355   PMID:26186194   PMID:26337566   PMID:26344197   PMID:26351140   PMID:26374855   PMID:26427488   PMID:26496610   PMID:26831516  
PMID:26843621   PMID:26876938   PMID:27638620   PMID:27687210   PMID:27732087   PMID:27758765   PMID:27779715   PMID:27797909   PMID:28085543   PMID:28143904   PMID:28162974   PMID:28183804  
PMID:28322508   PMID:28380382   PMID:28514442   PMID:28552616   PMID:28561066   PMID:28611215   PMID:28675297   PMID:28973039   PMID:29053956   PMID:29339542   PMID:29657085   PMID:29892012  
PMID:29950484   PMID:29987050   PMID:30057310   PMID:30270274   PMID:30886144   PMID:30948266   PMID:31358971   PMID:31515488   PMID:31900314   PMID:31983282   PMID:32029622   PMID:32196931  
PMID:32296183   PMID:32707033   PMID:32814053   PMID:32958832   PMID:33190588   PMID:33961781   PMID:34031501   PMID:34077757   PMID:34079125   PMID:34347929   PMID:34432599   PMID:34461288  
PMID:34821530   PMID:35172150   PMID:35256949   PMID:35390516   PMID:35438362   PMID:36114006   PMID:36215168   PMID:36563529   PMID:36658117   PMID:36732624   PMID:36736316   PMID:36931259  
PMID:37014579   PMID:37079666   PMID:37541260   PMID:37827155   PMID:37874507   PMID:37962491   PMID:38301894   PMID:38424484  


Genomics

Comparative Map Data
PRKAA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,645,314 - 56,715,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl156,645,314 - 56,715,335 (+)EnsemblGRCh38hg38GRCh38
GRCh37157,110,987 - 57,181,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,883,578 - 56,953,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34156,823,040 - 56,886,142NCBI
Celera155,395,857 - 55,465,885 (+)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,223,513 - 55,293,426 (+)NCBIHuRef
CHM1_1157,226,353 - 57,296,384 (+)NCBICHM1_1
T2T-CHM13v2.0156,524,182 - 56,594,202 (+)NCBIT2T-CHM13v2.0
Prkaa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394104,886,846 - 104,967,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4104,887,071 - 104,967,087 (-)EnsemblGRCm39 Ensembl
GRCm384105,029,649 - 105,109,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4105,029,874 - 105,109,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv374104,702,255 - 104,782,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364104,532,922 - 104,607,801 (-)NCBIMGSCv36mm8
Celera4103,380,658 - 103,460,821 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map449.05NCBI
Prkaa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,036,945 - 125,109,010 (-)NCBIGRCr8
mRatBN7.25119,807,992 - 119,879,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,813,226 - 119,879,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,434,721 - 122,501,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,157,776 - 124,224,205 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,209,020 - 124,275,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,568,845 - 124,642,569 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,574,079 - 124,642,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,436,023 - 128,503,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,007,672 - 126,074,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,012,897 - 126,079,238 (-)NCBI
Celera5118,363,351 - 118,429,630 (-)NCBICelera
RH 3.4 Map5688.6RGD
Cytogenetic Map5q34NCBI
Prkaa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554643,003,837 - 3,062,197 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554642,996,608 - 3,062,197 (-)NCBIChiLan1.0ChiLan1.0
PRKAA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21170,111,715 - 170,181,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,264,046 - 169,334,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0155,928,577 - 55,998,628 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1157,639,731 - 57,702,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,664,237 - 57,702,227 (+)Ensemblpanpan1.1panPan2
PRKAA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1552,809,792 - 52,855,072 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,815,609 - 52,876,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,877,206 - 52,944,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0552,996,830 - 53,064,324 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl552,999,820 - 53,064,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1552,940,854 - 53,008,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0552,886,688 - 52,954,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0553,172,006 - 53,239,515 (-)NCBIUU_Cfam_GSD_1.0
Prkaa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505870,476,415 - 70,543,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365224,875,046 - 4,939,879 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365224,872,360 - 4,939,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,681,784 - 155,754,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,683,392 - 155,754,283 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,547,653 - 143,572,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12076,258,063 - 76,319,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,259,763 - 76,319,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,974,342 - 41,041,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkaa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,450,078 - 3,496,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,443,720 - 3,496,078 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKAA2
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p32.3-31.3(chr1:50222546-61618373)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|See cases [RCV000051819] Chr1:50222546..61618373 [GRCh38]
Chr1:50688218..62084045 [GRCh37]
Chr1:50460805..61856633 [NCBI36]
Chr1:1p32.3-31.3
pathogenic
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1
pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:53738212-61439648)x1 copy number loss See cases [RCV000053839] Chr1:53738212..61439648 [GRCh38]
Chr1:54203885..61905320 [GRCh37]
Chr1:53976473..61677908 [NCBI36]
Chr1:1p32.3-31.3
pathogenic
NM_006252.3(PRKAA2):c.772A>G (p.Thr258Ala) single nucleotide variant Malignant melanoma [RCV000064834] Chr1:56696143 [GRCh38]
Chr1:57161816 [GRCh37]
Chr1:56934404 [NCBI36]
Chr1:1p32.2
not provided
NM_006252.3(PRKAA2):c.715C>T (p.Arg239Cys) single nucleotide variant Malignant melanoma [RCV000060221] Chr1:56696086 [GRCh38]
Chr1:57161759 [GRCh37]
Chr1:56934347 [NCBI36]
Chr1:1p32.2
not provided
GRCh38/hg38 1p32.2(chr1:56429283-57190889)x3 copy number gain See cases [RCV000138097] Chr1:56429283..57190889 [GRCh38]
Chr1:56894955..57656562 [GRCh37]
Chr1:56667543..57429150 [NCBI36]
Chr1:1p32.2
uncertain significance
GRCh38/hg38 1p32.3-31.3(chr1:53627272-64248854)x1 copy number loss See cases [RCV000139470] Chr1:53627272..64248854 [GRCh38]
Chr1:54092945..64714537 [GRCh37]
Chr1:53865533..64487125 [NCBI36]
Chr1:1p32.3-31.3
pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:52787503-67339873)x3 copy number gain See cases [RCV000141758] Chr1:52787503..67339873 [GRCh38]
Chr1:53253175..67805556 [GRCh37]
Chr1:53025763..67578144 [NCBI36]
Chr1:1p32.3-31.3
likely pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p32.3-31.3(chr1:55791287-63405767)x1 copy number loss See cases [RCV000447265] Chr1:55791287..63405767 [GRCh37]
Chr1:1p32.3-31.3
pathogenic
GRCh37/hg19 1p32.3-31.3(chr1:55831175-62285511)x3 copy number gain See cases [RCV000447469] Chr1:55831175..62285511 [GRCh37]
Chr1:1p32.3-31.3
uncertain significance
GRCh37/hg19 1p32.2(chr1:56897995-57698341)x3 copy number gain See cases [RCV000446240] Chr1:56897995..57698341 [GRCh37]
Chr1:1p32.2
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p32.2(chr1:57109660-57189793)x3 copy number gain not provided [RCV000749004] Chr1:57109660..57189793 [GRCh37]
Chr1:1p32.2
benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_006252.4(PRKAA2):c.1399T>C (p.Leu467=) single nucleotide variant not provided [RCV000964231] Chr1:56706197 [GRCh38]
Chr1:57171870 [GRCh37]
Chr1:1p32.2
benign
NM_006252.4(PRKAA2):c.939T>C (p.Ser313=) single nucleotide variant PRKAA2-related condition [RCV003916017]|not provided [RCV000960221] Chr1:56704121 [GRCh38]
Chr1:57169794 [GRCh37]
Chr1:1p32.2
benign
NM_006252.4(PRKAA2):c.1236G>A (p.Pro412=) single nucleotide variant not provided [RCV000940392] Chr1:56704418 [GRCh38]
Chr1:57170091 [GRCh37]
Chr1:1p32.2
likely benign
NM_006252.4(PRKAA2):c.789-4C>T single nucleotide variant PRKAA2-related condition [RCV003923053]|not provided [RCV000905064] Chr1:56703967 [GRCh38]
Chr1:57169640 [GRCh37]
Chr1:1p32.2
benign|likely benign
NM_006252.4(PRKAA2):c.352C>T (p.Arg118Trp) single nucleotide variant High myopia [RCV000785689] Chr1:56692379 [GRCh38]
Chr1:57158052 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.1462C>T (p.Arg488Cys) single nucleotide variant Inborn genetic diseases [RCV003271944] Chr1:56707516 [GRCh38]
Chr1:57173189 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.95-7T>C single nucleotide variant not provided [RCV000954066] Chr1:56674374 [GRCh38]
Chr1:57140047 [GRCh37]
Chr1:1p32.2
benign
GRCh37/hg19 1p32.2(chr1:56844621-58438748)x1 copy number loss not provided [RCV001005096] Chr1:56844621..58438748 [GRCh37]
Chr1:1p32.2
uncertain significance
GRCh37/hg19 1p32.3-31.3(chr1:53675707-66644963)x1 copy number loss Chromosome 1p32-p31 deletion syndrome [RCV001263218] Chr1:53675707..66644963 [GRCh37]
Chr1:1p32.3-31.3
pathogenic
GRCh37/hg19 1p32.2(chr1:56897995-57698341) copy number gain not specified [RCV002053336] Chr1:56897995..57698341 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.19C>A (p.His7Asn) single nucleotide variant Inborn genetic diseases [RCV003277419] Chr1:56645406 [GRCh38]
Chr1:57111079 [GRCh37]
Chr1:1p32.2
uncertain significance
GRCh37/hg19 1p32.2-32.1(chr1:57137390-59037566)x3 copy number gain not provided [RCV002474846] Chr1:57137390..59037566 [GRCh37]
Chr1:1p32.2-32.1
uncertain significance
NM_006252.4(PRKAA2):c.1250C>T (p.Ala417Val) single nucleotide variant Inborn genetic diseases [RCV002817793] Chr1:56704432 [GRCh38]
Chr1:57170105 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.656T>C (p.Val219Ala) single nucleotide variant Inborn genetic diseases [RCV002757034] Chr1:56696027 [GRCh38]
Chr1:57161700 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.1556C>T (p.Ser519Phe) single nucleotide variant Inborn genetic diseases [RCV002976745] Chr1:56707610 [GRCh38]
Chr1:57173283 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.1595T>G (p.Leu532Arg) single nucleotide variant Inborn genetic diseases [RCV002830602] Chr1:56707649 [GRCh38]
Chr1:57173322 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.859G>A (p.Val287Ile) single nucleotide variant Inborn genetic diseases [RCV002674820] Chr1:56704041 [GRCh38]
Chr1:57169714 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.587A>G (p.Asp196Gly) single nucleotide variant Inborn genetic diseases [RCV003202025] Chr1:56695958 [GRCh38]
Chr1:57161631 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.1045G>A (p.Gly349Ser) single nucleotide variant Inborn genetic diseases [RCV003189625] Chr1:56704227 [GRCh38]
Chr1:57169900 [GRCh37]
Chr1:1p32.2
uncertain significance
NM_006252.4(PRKAA2):c.1645A>G (p.Thr549Ala) single nucleotide variant Inborn genetic diseases [RCV003381911] Chr1:56707699 [GRCh38]
Chr1:57173372 [GRCh37]
Chr1:1p32.2
uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3
likely pathogenic
NM_006252.4(PRKAA2):c.111A>G (p.Leu37=) single nucleotide variant PRKAA2-related condition [RCV003979028] Chr1:56674397 [GRCh38]
Chr1:57140070 [GRCh37]
Chr1:1p32.2
benign
NM_006252.4(PRKAA2):c.1563C>T (p.Thr521=) single nucleotide variant PRKAA2-related condition [RCV003964094] Chr1:56707617 [GRCh38]
Chr1:57173290 [GRCh37]
Chr1:1p32.2
likely benign
NM_006252.4(PRKAA2):c.728C>T (p.Thr243Ile) single nucleotide variant PRKAA2-related condition [RCV003934132] Chr1:56696099 [GRCh38]
Chr1:57161772 [GRCh37]
Chr1:1p32.2
likely benign
NM_006252.4(PRKAA2):c.749A>G (p.Gln250Arg) single nucleotide variant PRKAA2-related condition [RCV003914561] Chr1:56696120 [GRCh38]
Chr1:57161793 [GRCh37]
Chr1:1p32.2
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2539
Count of miRNA genes:1061
Interacting mature miRNAs:1301
Transcripts:ENST00000371244
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S2690  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,155,539 - 57,155,738UniSTSGRCh37
Build 36156,928,127 - 56,928,326RGDNCBI36
Celera155,440,399 - 55,440,596RGD
Cytogenetic Map1p31UniSTS
HuRef155,268,071 - 55,268,266UniSTS
Marshfield Genetic Map183.07UniSTS
Marshfield Genetic Map183.07RGD
Genethon Genetic Map185.0UniSTS
deCODE Assembly Map179.63UniSTS
Whitehead-YAC Contig Map1 UniSTS
SHGC-68634  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,162,452 - 57,162,676UniSTSGRCh37
Build 36156,935,040 - 56,935,264RGDNCBI36
Celera155,447,310 - 55,447,534RGD
Cytogenetic Map1p31UniSTS
HuRef155,274,980 - 55,275,204UniSTS
TNG Radiation Hybrid Map131657.0UniSTS
GDB:573976  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,173,230 - 57,173,418UniSTSGRCh37
Build 36156,945,818 - 56,946,006RGDNCBI36
Celera155,458,107 - 55,458,295RGD
Cytogenetic Map1p31UniSTS
HuRef155,285,649 - 55,285,837UniSTS
SHGC-141488  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,181,033 - 57,181,328UniSTSGRCh37
Build 36156,953,621 - 56,953,916RGDNCBI36
Celera155,465,910 - 55,466,205RGD
Cytogenetic Map1p31UniSTS
HuRef155,293,451 - 55,293,746UniSTS
TNG Radiation Hybrid Map131657.0UniSTS
PRKAA2_1075  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,173,361 - 57,174,032UniSTSGRCh37
Build 36156,945,949 - 56,946,620RGDNCBI36
Celera155,458,238 - 55,458,909RGD
HuRef155,285,780 - 55,286,451UniSTS
D1S2056E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,179,294 - 57,179,390UniSTSGRCh37
Build 36156,951,882 - 56,951,978RGDNCBI36
Celera155,464,171 - 55,464,267RGD
Cytogenetic Map1p31UniSTS
HuRef155,291,713 - 55,291,809UniSTS
GeneMap99-GB4 RH Map1156.99UniSTS
GeneMap99-GB4 RH Map1153.53UniSTS
PRKAA2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,173,468 - 57,173,549UniSTSGRCh37
Build 36156,946,056 - 56,946,137RGDNCBI36
Celera155,458,345 - 55,458,426RGD
HuRef155,285,887 - 55,285,968UniSTS
SHGC-74882  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,180,597 - 57,180,731UniSTSGRCh37
Build 36156,953,185 - 56,953,319RGDNCBI36
Celera155,465,474 - 55,465,608RGD
Cytogenetic Map1p31UniSTS
HuRef155,293,015 - 55,293,149UniSTS
TNG Radiation Hybrid Map131657.0UniSTS
GeneMap99-GB4 RH Map1156.48UniSTS
NCBI RH Map1370.7UniSTS
D1S2084  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,112,237 - 57,112,421UniSTSGRCh37
Build 36156,884,825 - 56,885,009RGDNCBI36
Celera155,397,104 - 55,397,288RGD
Cytogenetic Map1p31UniSTS
HuRef155,224,760 - 55,224,944UniSTS
Whitehead-RH Map1177.8UniSTS
Whitehead-YAC Contig Map1 UniSTS
SHGC-74886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,180,263 - 57,180,488UniSTSGRCh37
Build 36156,952,851 - 56,953,076RGDNCBI36
Celera155,465,140 - 55,465,365RGD
Cytogenetic Map1p31UniSTS
HuRef155,292,681 - 55,292,906UniSTS
TNG Radiation Hybrid Map131657.0UniSTS
GeneMap99-GB4 RH Map1156.99UniSTS
SHGC-35382  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37157,173,404 - 57,173,608UniSTSGRCh37
Build 36156,945,992 - 56,946,196RGDNCBI36
Celera155,458,281 - 55,458,485RGD
Cytogenetic Map1p31UniSTS
HuRef155,285,823 - 55,286,027UniSTS
Stanford-G3 RH Map12761.0UniSTS
GeneMap99-GB4 RH Map1156.58UniSTS
GeneMap99-GB4 RH Map1156.99UniSTS
Whitehead-RH Map1177.7UniSTS
NCBI RH Map1373.3UniSTS
GeneMap99-G3 RH Map12767.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 790 779 54 39 18 35 1029 1553 180 189 132 120 9 1 11 899 1 2
Low 1455 1439 1463 409 393 255 3020 611 3465 211 1310 1461 159 1125 1818 4
Below cutoff 114 620 201 172 826 171 284 21 85 15 11 19 3 68 71

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_006252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI732856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL710110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM979925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB985850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF552084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA710012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF056019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ200485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ200486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ628625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF495958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000371244   ⟹   ENSP00000360290
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl156,645,314 - 56,715,335 (+)Ensembl
RefSeq Acc Id: ENST00000610361   ⟹   ENSP00000481378
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl156,645,388 - 56,715,334 (+)Ensembl
RefSeq Acc Id: NM_006252   ⟹   NP_006243
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38156,645,314 - 56,715,335 (+)NCBI
GRCh37157,110,990 - 57,181,008 (+)ENTREZGENE
Build 36156,883,578 - 56,953,596 (+)NCBI Archive
HuRef155,223,513 - 55,293,426 (+)ENTREZGENE
CHM1_1157,226,353 - 57,296,384 (+)NCBI
T2T-CHM13v2.0156,524,182 - 56,594,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001693   ⟹   XP_016857182
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38156,645,753 - 56,715,335 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054337539   ⟹   XP_054193514
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0156,524,621 - 56,594,202 (+)NCBI
RefSeq Acc Id: NP_006243   ⟸   NM_006252
- UniProtKB: Q9H1E8 (UniProtKB/Swiss-Prot),   Q9UD43 (UniProtKB/Swiss-Prot),   P54646 (UniProtKB/Swiss-Prot),   A0MZF5 (UniProtKB/TrEMBL),   B2RA25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016857182   ⟸   XM_017001693
- Peptide Label: isoform X1
- UniProtKB: A0MZF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000360290   ⟸   ENST00000371244
RefSeq Acc Id: ENSP00000481378   ⟸   ENST00000610361
RefSeq Acc Id: XP_054193514   ⟸   XM_054337539
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54646-F1-model_v2 AlphaFold P54646 1-552 view protein structure

Promoters
RGD ID:6855676
Promoter ID:EPDNEW_H1003
Type:initiation region
Name:PRKAA2_1
Description:protein kinase AMP-activated catalytic subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38156,645,314 - 56,645,374EPDNEW
RGD ID:6786305
Promoter ID:HG_KWN:2899
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:NM_006252,   OTTHUMT00000095577,   OTTHUMT00000095578
Position:
Human AssemblyChrPosition (strand)Source
Build 36156,883,441 - 56,883,941 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9377 AgrOrtholog
COSMIC PRKAA2 COSMIC
Ensembl Genes ENSG00000162409 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000371244 ENTREZGENE
  ENST00000371244.9 UniProtKB/Swiss-Prot
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000162409 GTEx
HGNC ID HGNC:9377 ENTREZGENE
Human Proteome Map PRKAA2 Human Proteome Map
InterPro AMPK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPKA2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKAA1/2_AID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKAA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5563 UniProtKB/Swiss-Prot
NCBI Gene 5563 ENTREZGENE
OMIM 600497 OMIM
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AdenylateSensor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPK_alpha_AID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33745 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0MZF5 ENTREZGENE, UniProtKB/TrEMBL
  AAPK2_HUMAN UniProtKB/Swiss-Prot
  B2RA25 ENTREZGENE, UniProtKB/TrEMBL
  K9J960_HUMAN UniProtKB/TrEMBL
  K9J973_HUMAN UniProtKB/TrEMBL
  P54646 ENTREZGENE
  Q9H1E8 ENTREZGENE
  Q9UD43 ENTREZGENE
UniProt Secondary Q9H1E8 UniProtKB/Swiss-Prot
  Q9UD43 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 PRKAA2  protein kinase AMP-activated catalytic subunit alpha 2  PRKAA2  protein kinase, AMP-activated, alpha 2 catalytic subunit  Symbol and/or name change 5135510 APPROVED