Prkaa2 (protein kinase AMP-activated catalytic subunit alpha 2) - Rat Genome Database

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Gene: Prkaa2 (protein kinase AMP-activated catalytic subunit alpha 2) Heterocephalus glaber
Analyze
Symbol: Prkaa2
Name: protein kinase AMP-activated catalytic subunit alpha 2
RGD ID: 18917326
Description: ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); chromatin binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to glucose starvation (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Cardiomegaly (ortholog); cardiomyopathy (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); cytoplasmic stress granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5'-AMP-activated protein kinase catalytic subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,450,078 - 3,496,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,443,720 - 3,496,078 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cellular response to calcium ion  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cholesterol biosynthetic process  (IEA)
energy homeostasis  (ISO)
fatty acid homeostasis  (ISO)
glucose homeostasis  (ISO)
intracellular signal transduction  (IEA)
lipid biosynthetic process  (ISO)
lipid droplet disassembly  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of TORC1 signaling  (ISO)
negative regulation of tubulin deacetylation  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of peptidyl-lysine acetylation  (ISO)
positive regulation of protein localization  (ISO)
protein localization to lipid droplet  (ISO)
protein phosphorylation  (ISO)
regulation of circadian rhythm  (ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of macroautophagy  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of stress granule assembly  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to muscle activity  (ISO)
rhythmic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkaa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,450,078 - 3,496,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,443,720 - 3,496,078 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PRKAA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,645,314 - 56,715,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl156,645,314 - 56,715,335 (+)EnsemblGRCh38hg38GRCh38
GRCh37157,110,987 - 57,181,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,883,578 - 56,953,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34156,823,040 - 56,886,142NCBI
Celera155,395,857 - 55,465,885 (+)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,223,513 - 55,293,426 (+)NCBIHuRef
CHM1_1157,226,353 - 57,296,384 (+)NCBICHM1_1
T2T-CHM13v2.0156,524,182 - 56,594,202 (+)NCBIT2T-CHM13v2.0
Prkaa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394104,886,846 - 104,967,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4104,887,071 - 104,967,087 (-)EnsemblGRCm39 Ensembl
GRCm384105,029,649 - 105,109,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4105,029,874 - 105,109,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv374104,702,255 - 104,782,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364104,532,922 - 104,607,801 (-)NCBIMGSCv36mm8
Celera4103,380,658 - 103,460,821 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map449.05NCBI
Prkaa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,036,945 - 125,109,010 (-)NCBIGRCr8
mRatBN7.25119,807,992 - 119,879,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,813,226 - 119,879,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,434,721 - 122,501,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,157,776 - 124,224,205 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,209,020 - 124,275,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,568,845 - 124,642,569 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,574,079 - 124,642,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,436,023 - 128,503,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,007,672 - 126,074,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,012,897 - 126,079,238 (-)NCBI
Celera5118,363,351 - 118,429,630 (-)NCBICelera
RH 3.4 Map5688.6RGD
Cytogenetic Map5q34NCBI
Prkaa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554643,003,837 - 3,062,197 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554642,996,608 - 3,062,197 (-)NCBIChiLan1.0ChiLan1.0
PRKAA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21170,111,715 - 170,181,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,264,046 - 169,334,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0155,928,577 - 55,998,628 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1157,639,731 - 57,702,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,664,237 - 57,702,227 (+)Ensemblpanpan1.1panPan2
PRKAA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1552,809,792 - 52,855,072 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,815,609 - 52,876,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,877,206 - 52,944,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0552,996,830 - 53,064,324 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl552,999,820 - 53,064,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1552,940,854 - 53,008,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0552,886,688 - 52,954,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0553,172,006 - 53,239,515 (-)NCBIUU_Cfam_GSD_1.0
Prkaa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505870,476,415 - 70,543,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365224,875,046 - 4,939,879 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365224,872,360 - 4,939,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,681,784 - 155,754,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,683,392 - 155,754,283 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,547,653 - 143,572,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12076,258,063 - 76,319,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,259,763 - 76,319,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,974,342 - 41,041,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005289   ⟹   ENSHGLP00000005220
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248623,450,078 - 3,496,142 (-)Ensembl
RefSeq Acc Id: XM_004869629   ⟹   XP_004869686
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248623,443,720 - 3,496,078 (-)NCBI
RefSeq Acc Id: XM_021248227   ⟹   XP_021103886
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248623,451,045 - 3,496,078 (-)NCBI
RefSeq Acc Id: XM_021248228   ⟹   XP_021103887
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248623,443,720 - 3,482,778 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004869686 (Get FASTA)   NCBI Sequence Viewer  
  XP_021103886 (Get FASTA)   NCBI Sequence Viewer  
  XP_021103887 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005220
Reference Protein Sequences
RefSeq Acc Id: XP_004869686   ⟸   XM_004869629
- Peptide Label: isoform X1
- UniProtKB: G5APP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103887   ⟸   XM_021248228
- Peptide Label: isoform X3
- UniProtKB: G5APP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103886   ⟸   XM_021248227
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000005220   ⟸   ENSHGLT00000005289


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003818 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000005289 ENTREZGENE
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AMPK_C UniProtKB/TrEMBL
  AMPKA2_C UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PRKAA1/2_AID UniProtKB/TrEMBL
  PRKAA2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Prkaa2 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam AdenylateSensor UniProtKB/TrEMBL
  AMPK_alpha_AID UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP KA1-like UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt G5APP8 ENTREZGENE, UniProtKB/TrEMBL