PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) - Rat Genome Database

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Gene: PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) Chlorocebus sabaeus
Analyze
Symbol: PRKAA2
Name: protein kinase AMP-activated catalytic subunit alpha 2
RGD ID: 18507683
Description: ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN cellular response to organonitrogen compound (ortholog); cellular response to prostaglandin E stimulus (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Cardiomegaly (ortholog); cardiomyopathy (ortholog); FOUND IN apical plasma membrane (ortholog); nucleotide-activated protein kinase complex (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5'-AMP-activated protein kinase catalytic subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12076,258,063 - 76,319,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,259,763 - 76,319,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,974,342 - 41,041,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cellular response to calcium ion  (IEA)
cellular response to glucose starvation  (IEA)
cellular response to glucose stimulus  (IEA)
cellular response to nutrient levels  (IEA)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
cholesterol biosynthetic process  (IEA)
chromatin remodeling  (IEA)
energy homeostasis  (ISO)
fatty acid homeostasis  (ISO)
glucose homeostasis  (IEA)
intracellular signal transduction  (IEA)
lipid biosynthetic process  (IEA)
lipid droplet disassembly  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of hepatocyte apoptotic process  (IEA)
negative regulation of TOR signaling  (IEA)
negative regulation of TORC1 signaling  (IEA)
negative regulation of tubulin deacetylation  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of glycolytic process  (ISO)
positive regulation of peptidyl-lysine acetylation  (IEA)
positive regulation of protein localization  (IEA)
protein localization to lipid droplet  (IEA)
protein phosphorylation  (ISO)
regulation of circadian rhythm  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of lipid metabolic process  (ISO)
regulation of macroautophagy  (IEA)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of stress granule assembly  (IEA)
response to activity  (ISO)
response to caffeine  (ISO)
response to muscle activity  (IEA,ISO)
rhythmic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKAA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12076,258,063 - 76,319,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,259,763 - 76,319,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,974,342 - 41,041,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PRKAA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,645,314 - 56,715,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl156,645,314 - 56,715,335 (+)EnsemblGRCh38hg38GRCh38
GRCh37157,110,987 - 57,181,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,883,578 - 56,953,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34156,823,040 - 56,886,142NCBI
Celera155,395,857 - 55,465,885 (+)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,223,513 - 55,293,426 (+)NCBIHuRef
CHM1_1157,226,353 - 57,296,384 (+)NCBICHM1_1
T2T-CHM13v2.0156,524,182 - 56,594,202 (+)NCBIT2T-CHM13v2.0
Prkaa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394104,886,846 - 104,967,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4104,887,071 - 104,967,087 (-)EnsemblGRCm39 Ensembl
GRCm384105,029,649 - 105,109,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4105,029,874 - 105,109,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv374104,702,255 - 104,782,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364104,532,922 - 104,607,801 (-)NCBIMGSCv36mm8
Celera4103,380,658 - 103,460,821 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map449.05NCBI
Prkaa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,036,945 - 125,109,010 (-)NCBIGRCr8
mRatBN7.25119,807,992 - 119,879,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,813,226 - 119,879,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,434,721 - 122,501,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,157,776 - 124,224,205 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,209,020 - 124,275,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,568,845 - 124,642,569 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,574,079 - 124,642,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,436,023 - 128,503,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,007,672 - 126,074,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,012,897 - 126,079,238 (-)NCBI
Celera5118,363,351 - 118,429,630 (-)NCBICelera
RH 3.4 Map5688.6RGD
Cytogenetic Map5q34NCBI
Prkaa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554643,003,837 - 3,062,197 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554642,996,608 - 3,062,197 (-)NCBIChiLan1.0ChiLan1.0
PRKAA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21170,111,715 - 170,181,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,264,046 - 169,334,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0155,928,577 - 55,998,628 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1157,639,731 - 57,702,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,664,237 - 57,702,227 (+)Ensemblpanpan1.1panPan2
PRKAA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1552,809,792 - 52,855,072 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,815,609 - 52,876,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,877,206 - 52,944,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0552,996,830 - 53,064,324 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl552,999,820 - 53,064,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1552,940,854 - 53,008,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0552,886,688 - 52,954,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0553,172,006 - 53,239,515 (-)NCBIUU_Cfam_GSD_1.0
Prkaa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505870,476,415 - 70,543,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365224,875,046 - 4,939,879 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365224,872,360 - 4,939,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,681,784 - 155,754,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,683,392 - 155,754,283 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,547,653 - 143,572,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Prkaa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,450,078 - 3,496,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,443,720 - 3,496,078 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 17
Low 34 13 43
Below cutoff 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000017214   ⟹   ENSCSAP00000016698
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2076,259,763 - 76,319,430 (-)Ensembl
RefSeq Acc Id: XM_007978593   ⟹   XP_007976784
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12076,258,063 - 76,319,512 (-)NCBI
Vero_WHO_p1.0NW_02366603340,974,346 - 41,041,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038000520   ⟹   XP_037856448
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603340,974,342 - 41,034,076 (+)NCBI
RefSeq Acc Id: XM_038000521   ⟹   XP_037856449
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603340,974,400 - 41,041,274 (+)NCBI
RefSeq Acc Id: XM_038000522   ⟹   XP_037856450
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603340,974,400 - 41,041,274 (+)NCBI
RefSeq Acc Id: XM_038000528   ⟹   XP_037856456
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603340,974,435 - 41,041,274 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007976784   ⟸   XM_007978593
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S759 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000016698   ⟸   ENSCSAT00000017214
RefSeq Acc Id: XP_037856448   ⟸   XM_038000520
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037856449   ⟸   XM_038000521
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037856450   ⟸   XM_038000522
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037856456   ⟸   XM_038000528
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001319 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017214.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AMPK_C UniProtKB/TrEMBL
  AMPKA2_C UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PRKAA1/2_AID UniProtKB/TrEMBL
  PRKAA2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103224740 UniProtKB/TrEMBL
NCBI Gene PRKAA2 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam AdenylateSensor UniProtKB/TrEMBL
  AMPK_alpha_AID UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9S759 ENTREZGENE, UniProtKB/TrEMBL