MGST2 (microsomal glutathione S-transferase 2) - Rat Genome Database

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Gene: MGST2 (microsomal glutathione S-transferase 2) Homo sapiens
Analyze
Symbol: MGST2
Name: microsomal glutathione S-transferase 2
RGD ID: 1322562
HGNC Page HGNC:7063
Description: Enables several functions, including glutathione binding activity; glutathione peroxidase activity; and glutathione transferase activity. Involved in glutathione biosynthetic process; leukotriene biosynthetic process; and membrane lipid catabolic process. Located in intracellular membrane-bounded organelle and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ27438; glutathione peroxidase MGST2; GST2; leukotriene C4 synthase MGST2; MGC14097; MGST-II; microsomal glutathione S-transferase II; microsomal GST-2; microsomal GST-II; truncated microsomal glutathione S-transferase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,665,819 - 139,754,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4139,665,768 - 139,740,745 (+)EnsemblGRCh38hg38GRCh38
GRCh374140,586,973 - 140,661,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,806,372 - 140,844,857 (+)NCBINCBI36Build 36hg18NCBI36
Build 344140,944,526 - 140,983,009NCBI
Celera4137,919,740 - 137,958,224 (+)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,315,768 - 136,391,008 (+)NCBIHuRef
CHM1_14140,564,114 - 140,639,227 (+)NCBICHM1_1
T2T-CHM13v2.04142,985,421 - 143,074,258 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methylcholine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
amphetamine  (ISO)
atrazine  (ISO)
Azaspiracid  (EXP)
benzo[a]pyrene  (EXP,ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
busulfan  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
chenodeoxycholic acid  (EXP)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corn oil  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (EXP)
entinostat  (EXP)
ethylparaben  (EXP)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
indirubin  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
ivermectin  (EXP)
ketamine  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
melphalan  (EXP)
methyl methanesulfonate  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
PhIP  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
quercetin  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulindac  (ISO)
sunitinib  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
theophylline  (EXP)
thiram  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. The role of glutathione-S-transferase in anti-cancer drug resistance. Townsend DM and Tew KD, Oncogene 2003 Oct 20;22(47):7369-75.
Additional References at PubMed
PMID:8703034   PMID:8889549   PMID:9092565   PMID:9278457   PMID:9302651   PMID:10673221   PMID:11322876   PMID:12477932   PMID:15489334   PMID:16169070   PMID:16344560   PMID:16498398  
PMID:16773312   PMID:19343046   PMID:20379614   PMID:21873635   PMID:23409838   PMID:25544563   PMID:25910212   PMID:26066610   PMID:26320552   PMID:28514442   PMID:32296183   PMID:32393512  
PMID:32807901   PMID:33741927   PMID:33961781   PMID:35253629   PMID:35509820   PMID:36244648   PMID:36470425  


Genomics

Comparative Map Data
MGST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,665,819 - 139,754,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4139,665,768 - 139,740,745 (+)EnsemblGRCh38hg38GRCh38
GRCh374140,586,973 - 140,661,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,806,372 - 140,844,857 (+)NCBINCBI36Build 36hg18NCBI36
Build 344140,944,526 - 140,983,009NCBI
Celera4137,919,740 - 137,958,224 (+)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,315,768 - 136,391,008 (+)NCBIHuRef
CHM1_14140,564,114 - 140,639,227 (+)NCBICHM1_1
T2T-CHM13v2.04142,985,421 - 143,074,258 (+)NCBIT2T-CHM13v2.0
Mgst2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39351,544,179 - 51,590,096 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl351,567,781 - 51,590,098 (+)EnsemblGRCm39 Ensembl
GRCm38351,636,912 - 51,682,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl351,660,360 - 51,682,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37351,465,115 - 51,486,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36351,749,166 - 51,770,603 (+)NCBIMGSCv36mm8
Celera351,392,546 - 51,414,043 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map322.52NCBI
Mgst2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,821,787 - 137,866,664 (+)NCBIGRCr8
mRatBN7.22135,679,524 - 135,715,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,269,446 - 142,291,715 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,381,704 - 140,403,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02135,013,740 - 135,035,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,708,396 - 140,727,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,180,714 - 160,202,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,546,939 - 140,568,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12140,497,066 - 140,518,579 (+)NCBI
Celera2130,188,760 - 130,210,429 (+)NCBICelera
Cytogenetic Map2q26NCBI
Mgst2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554284,014,810 - 4,037,901 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554284,006,054 - 4,049,497 (-)NCBIChiLan1.0ChiLan1.0
MGST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23137,540,753 - 137,605,499 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14137,933,175 - 137,997,878 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04132,031,087 - 132,106,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14143,338,016 - 143,412,966 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4143,338,016 - 143,412,966 (+)Ensemblpanpan1.1panPan2
MGST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,067,062 - 3,070,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,314,243 - 3,335,238 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0193,136,172 - 3,157,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,122,591 - 3,157,324 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,069,101 - 3,090,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,429,861 - 3,450,892 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,793,259 - 3,814,268 (-)NCBIUU_Cfam_GSD_1.0
Mgst2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530150,548,928 - 50,578,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365357,995,248 - 8,015,463 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365357,995,185 - 8,015,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl887,327,425 - 87,390,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1887,318,180 - 87,394,563 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MGST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1786,629,691 - 86,666,912 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl786,629,642 - 86,666,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603766,152,315 - 66,189,340 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477719,901,862 - 19,927,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477719,902,013 - 19,924,272 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MGST2
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q28.2-31.21(chr4:128119872-142431375)x1 copy number loss See cases [RCV000051056] Chr4:128119872..142431375 [GRCh38]
Chr4:129041027..143352528 [GRCh37]
Chr4:129260477..143571978 [NCBI36]
Chr4:4q28.2-31.21		 pathogenic
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2		 pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2		 pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3		 pathogenic
GRCh38/hg38 4q26-31.21(chr4:116630862-145429900)x1 copy number loss See cases [RCV000053321] Chr4:116630862..145429900 [GRCh38]
Chr4:117552018..146351052 [GRCh37]
Chr4:117771466..146570502 [NCBI36]
Chr4:4q26-31.21		 pathogenic
GRCh38/hg38 4q28.3-31.1(chr4:138370686-139672312)x1 copy number loss See cases [RCV000054074] Chr4:138370686..139672312 [GRCh38]
Chr4:139291840..140593466 [GRCh37]
Chr4:139511290..140812916 [NCBI36]
Chr4:4q28.3-31.1		 uncertain significance
GRCh38/hg38 4q31.1-35.2(chr4:138510532-189963195)x3 copy number gain See cases [RCV000136810] Chr4:138510532..189963195 [GRCh38]
Chr4:139431686..190828225 [GRCh37]
Chr4:139651136..191121344 [NCBI36]
Chr4:4q31.1-35.2		 pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:131985253-190095391)x3 copy number gain See cases [RCV000137721] Chr4:131985253..190095391 [GRCh38]
Chr4:132906408..190828225 [GRCh37]
Chr4:133125858..191250527 [NCBI36]
Chr4:4q28.3-35.2		 pathogenic|likely benign
GRCh38/hg38 4q28.1-35.1(chr4:125432943-185761887)x3 copy number gain See cases [RCV000138578] Chr4:125432943..185761887 [GRCh38]
Chr4:126354098..186683041 [GRCh37]
Chr4:126573548..186920035 [NCBI36]
Chr4:4q28.1-35.1		 pathogenic|likely benign
GRCh38/hg38 4q28.3-35.2(chr4:134935616-190036318)x3 copy number gain See cases [RCV000143559] Chr4:134935616..190036318 [GRCh38]
Chr4:135856771..190957473 [GRCh37]
Chr4:136076221..191194467 [NCBI36]
Chr4:4q28.3-35.2		 pathogenic
GRCh37/hg19 4q28.3-35.1(chr4:136912336-184253252)x3 copy number gain See cases [RCV000240245] Chr4:136912336..184253252 [GRCh37]
Chr4:4q28.3-35.1		 pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2		 pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
Single allele deletion not provided [RCV000678021] Chr4:126549693..141313049 [GRCh37]
Chr4:4q28.1-31.1		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_002413.5(MGST2):c.225C>T (p.Asn75=) single nucleotide variant not provided [RCV000881874] Chr4:139695263 [GRCh38]
Chr4:140616417 [GRCh37]
Chr4:4q31.1		 benign
NM_002413.5(MGST2):c.277T>C (p.Tyr93His) single nucleotide variant not provided [RCV000973239] Chr4:139703502 [GRCh38]
Chr4:140624656 [GRCh37]
Chr4:4q31.1		 benign
GRCh37/hg19 4q31.1-31.21(chr4:139531815-146095109)x1 copy number loss not provided [RCV001005600] Chr4:139531815..146095109 [GRCh37]
Chr4:4q31.1-31.21		 pathogenic
GRCh37/hg19 4q28.3-31.21(chr4:134054911-142601496)x1 copy number loss not provided [RCV000847693] Chr4:134054911..142601496 [GRCh37]
Chr4:4q28.3-31.21		 uncertain significance
GRCh37/hg19 4q28.1-35.1(chr4:124873497-185278662)x3 copy number gain not provided [RCV000849686] Chr4:124873497..185278662 [GRCh37]
Chr4:4q28.1-35.1		 pathogenic
GRCh37/hg19 4q31.1-31.21(chr4:140522019-146347867)x1 copy number loss not provided [RCV000848032] Chr4:140522019..146347867 [GRCh37]
Chr4:4q31.1-31.21		 uncertain significance
GRCh37/hg19 4q28.3-31.21(chr4:137901978-141527647)x1 copy number loss not provided [RCV001005599] Chr4:137901978..141527647 [GRCh37]
Chr4:4q28.3-31.21		 pathogenic
GRCh37/hg19 4q28.3-32.3(chr4:131303317-168722402)x3 copy number gain not provided [RCV001537926] Chr4:131303317..168722402 [GRCh37]
Chr4:4q28.3-32.3		 pathogenic
GRCh37/hg19 4q28.3-31.21(chr4:138289049-145923298)x1 copy number loss not provided [RCV001834392] Chr4:138289049..145923298 [GRCh37]
Chr4:4q28.3-31.21		 pathogenic
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595) copy number gain not specified [RCV002053446] Chr4:104715235..145252595 [GRCh37]
Chr4:4q24-31.21		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q28.3-31.21(chr4:136035308-144718930) copy number gain not specified [RCV002053457] Chr4:136035308..144718930 [GRCh37]
Chr4:4q28.3-31.21		 uncertain significance
GRCh37/hg19 4q28.3-31.21(chr4:136529470-141564812)x1 copy number loss not provided [RCV001833074] Chr4:136529470..141564812 [GRCh37]
Chr4:4q28.3-31.21		 pathogenic
NM_018717.5(MAML3):c.3234C>G (p.Ser1078Arg) single nucleotide variant not specified [RCV004130129] Chr4:139719506 [GRCh38]
Chr4:140640660 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.326G>A (p.Arg109Gln) single nucleotide variant not specified [RCV004232901] Chr4:139704030 [GRCh38]
Chr4:140625184 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.280T>A (p.Phe94Ile) single nucleotide variant not specified [RCV004102030] Chr4:139703505 [GRCh38]
Chr4:140624659 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.208G>T (p.Ala70Ser) single nucleotide variant not specified [RCV004253254] Chr4:139695246 [GRCh38]
Chr4:140616400 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.351G>T (p.Leu117Phe) single nucleotide variant not specified [RCV004249761] Chr4:139704055 [GRCh38]
Chr4:140625209 [GRCh37]
Chr4:4q31.1		 uncertain significance
GRCh37/hg19 4q26-32.3(chr4:117518683-168174703)x3 copy number gain not provided [RCV003484198] Chr4:117518683..168174703 [GRCh37]
Chr4:4q26-32.3		 pathogenic
GRCh37/hg19 4q27-35.2(chr4:123399154-190957473)x3 copy number gain not specified [RCV003986533] Chr4:123399154..190957473 [GRCh37]
Chr4:4q27-35.2		 pathogenic
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3 copy number gain not specified [RCV003986496] Chr4:101203509..190957473 [GRCh37]
Chr4:4q24-35.2		 pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_002413.5(MGST2):c.107C>T (p.Thr36Met) single nucleotide variant not specified [RCV004417313] Chr4:139678591 [GRCh38]
Chr4:140599745 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.433C>T (p.Arg145Trp) single nucleotide variant not specified [RCV004417315] Chr4:139704137 [GRCh38]
Chr4:140625291 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.208G>A (p.Ala70Thr) single nucleotide variant not specified [RCV004417314] Chr4:139695246 [GRCh38]
Chr4:140616400 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.415A>G (p.Ile139Val) single nucleotide variant not provided [RCV004585537] Chr4:139704119 [GRCh38]
Chr4:140625273 [GRCh37]
Chr4:4q31.1		 uncertain significance
NM_002413.5(MGST2):c.268C>T (p.Arg90Cys) single nucleotide variant not specified [RCV004645582] Chr4:139703493 [GRCh38]
Chr4:140624647 [GRCh37]
Chr4:4q31.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1398
Count of miRNA genes:777
Interacting mature miRNAs:916
Transcripts:ENST00000265498, ENST00000502587, ENST00000503816, ENST00000506797, ENST00000515067, ENST00000515137
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406993219GWAS642195_Hintelligence QTL GWAS642195 (human)0.000009intelligence4139666260139666261Human
407197191GWAS846167_Hgamma-glutamylglutamine measurement QTL GWAS846167 (human)0.000005gamma-glutamylglutamine measurement4139718024139718025Human
407253986GWAS902962_Hfacial height measurement QTL GWAS902962 (human)0.00001facial height measurement4139688171139688172Human
407171009GWAS819985_Hself reported educational attainment QTL GWAS819985 (human)7e-10self reported educational attainment4139719129139719130Human
407195308GWAS844284_Hgamma-glutamylmethionine measurement QTL GWAS844284 (human)0.000003gamma-glutamylmethionine measurement4139718024139718025Human
406911179GWAS560155_Hself reported educational attainment QTL GWAS560155 (human)5e-08self reported educational attainment4139716661139716662Human
407249706GWAS898682_Hvesicoureteral reflux QTL GWAS898682 (human)0.0000008vesicoureteral reflux4139710205139710206Human
407268008GWAS916984_Hbody height QTL GWAS916984 (human)0.000005body height (VT:0001253)body height (CMO:0000106)4139688171139688172Human
407413734GWAS1062710_Hresponse to calcium channel blocker QTL GWAS1062710 (human)0.000006response to calcium channel blocker4139691697139691698Human
407096780GWAS745756_Heducational attainment QTL GWAS745756 (human)5e-08educational attainment4139733877139733878Human
407197429GWAS846405_Heducational attainment QTL GWAS846405 (human)1e-09educational attainment4139751052139751053Human
407096594GWAS745570_Heducational attainment QTL GWAS745570 (human)0.000001educational attainment4139700324139700325Human
407125815GWAS774791_Hcolor vision disorder QTL GWAS774791 (human)0.000002color vision disorder4139684374139684375Human
407411676GWAS1060652_Hresponse to calcium channel blocker QTL GWAS1060652 (human)0.000003response to calcium channel blocker4139691697139691698Human
407146107GWAS795083_Hfructose-1-phosphate measurement, glucose-6-phosphate measurement, fructose-6-phosphate measurement, glucose-1-phosphate measurement QTL GWAS795083 (human)0.000002blood carbohydrate or carbohydrate derivative amount (VT:0010903)4139729576139729577Human

Markers in Region
SHGC-144854  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374140,587,506 - 140,587,827UniSTSGRCh37
Build 364140,806,956 - 140,807,277RGDNCBI36
Celera4137,920,324 - 137,920,645RGD
Cytogenetic Map4q28.3UniSTS
HuRef4136,316,352 - 136,316,673UniSTS
TNG Radiation Hybrid Map484936.0UniSTS
RH71258  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374140,625,213 - 140,625,350UniSTSGRCh37
Build 364140,844,663 - 140,844,800RGDNCBI36
Celera4137,958,030 - 137,958,167RGD
Cytogenetic Map4q28.3UniSTS
HuRef4136,354,062 - 136,354,199UniSTS
GeneMap99-GB4 RH Map4613.19UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2437 2788 2252 4969 1726 2345 5 624 1936 465 2267 7289 6456 45 3727 1 851 1742 1611 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001204366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011531972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001741221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA122237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC112236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY341028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE312976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB257575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN344085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000265498   ⟹   ENSP00000265498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,665,819 - 139,704,243 (+)Ensembl
Ensembl Acc Id: ENST00000502587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,665,997 - 139,679,124 (+)Ensembl
Ensembl Acc Id: ENST00000503816   ⟹   ENSP00000423008
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,666,016 - 139,731,435 (+)Ensembl
Ensembl Acc Id: ENST00000506797   ⟹   ENSP00000424278
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,665,835 - 139,704,224 (+)Ensembl
Ensembl Acc Id: ENST00000515067
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,666,028 - 139,704,068 (+)Ensembl
Ensembl Acc Id: ENST00000515137
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,665,933 - 139,740,745 (+)Ensembl
Ensembl Acc Id: ENST00000616265   ⟹   ENSP00000482639
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4139,665,768 - 139,740,745 (+)Ensembl
RefSeq Acc Id: NM_001204366   ⟹   NP_001191295
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,740,745 (+)NCBI
GRCh374140,586,922 - 140,661,899 (+)ENTREZGENE
HuRef4136,315,768 - 136,391,008 (+)ENTREZGENE
CHM1_14140,564,114 - 140,639,227 (+)NCBI
T2T-CHM13v2.04142,985,421 - 143,060,389 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001204367   ⟹   NP_001191296
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,740,745 (+)NCBI
GRCh374140,586,922 - 140,661,899 (+)ENTREZGENE
HuRef4136,315,768 - 136,391,008 (+)ENTREZGENE
CHM1_14140,564,114 - 140,639,227 (+)NCBI
T2T-CHM13v2.04142,985,421 - 143,060,389 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001204368   ⟹   NP_001191297
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,704,243 (+)NCBI
GRCh374140,586,922 - 140,661,899 (+)ENTREZGENE
HuRef4136,315,768 - 136,391,008 (+)ENTREZGENE
CHM1_14140,564,114 - 140,602,590 (+)NCBI
T2T-CHM13v2.04142,985,421 - 143,023,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002413   ⟹   NP_002404
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,704,243 (+)NCBI
GRCh374140,586,922 - 140,661,899 (+)ENTREZGENE
Build 364140,806,372 - 140,844,857 (+)NCBI Archive
HuRef4136,315,768 - 136,391,008 (+)ENTREZGENE
CHM1_14140,564,114 - 140,602,590 (+)NCBI
T2T-CHM13v2.04142,985,421 - 143,023,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008211   ⟹   XP_016863700
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,754,618 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008212   ⟹   XP_016863701
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,733,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008213   ⟹   XP_016863702
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,716,765 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047415701   ⟹   XP_047271657
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,819 - 139,741,884 (+)NCBI
RefSeq Acc Id: XM_054350049   ⟹   XP_054206024
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04142,985,421 - 143,074,258 (+)NCBI
RefSeq Acc Id: XM_054350050   ⟹   XP_054206025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04142,985,421 - 143,055,675 (+)NCBI
RefSeq Acc Id: XM_054350051   ⟹   XP_054206026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04142,985,421 - 143,036,641 (+)NCBI
RefSeq Acc Id: NP_001191295   ⟸   NM_001204366
- Peptide Label: isoform 1
- UniProtKB: D6RBB5 (UniProtKB/Swiss-Prot),   Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001191296   ⟸   NM_001204367
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_002404   ⟸   NM_002413
- Peptide Label: isoform 1
- UniProtKB: D6RBB5 (UniProtKB/Swiss-Prot),   Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001191297   ⟸   NM_001204368
- Peptide Label: isoform 3 precursor
- UniProtKB: Q99735 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016863700   ⟸   XM_017008211
- Peptide Label: isoform X1
- UniProtKB: D6RBB5 (UniProtKB/Swiss-Prot),   Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016863701   ⟸   XM_017008212
- Peptide Label: isoform X1
- UniProtKB: D6RBB5 (UniProtKB/Swiss-Prot),   Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016863702   ⟸   XM_017008213
- Peptide Label: isoform X1
- UniProtKB: D6RBB5 (UniProtKB/Swiss-Prot),   Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000423008   ⟸   ENST00000503816
Ensembl Acc Id: ENSP00000424278   ⟸   ENST00000506797
Ensembl Acc Id: ENSP00000482639   ⟸   ENST00000616265
Ensembl Acc Id: ENSP00000265498   ⟸   ENST00000265498
RefSeq Acc Id: XP_047271657   ⟸   XM_047415701
- Peptide Label: isoform X1
- UniProtKB: Q99735 (UniProtKB/Swiss-Prot),   D6RBB5 (UniProtKB/Swiss-Prot),   Q7Z5B8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054206024   ⟸   XM_054350049
- Peptide Label: isoform X1
- UniProtKB: Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot),   D6RBB5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054206025   ⟸   XM_054350050
- Peptide Label: isoform X1
- UniProtKB: Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot),   D6RBB5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054206026   ⟸   XM_054350051
- Peptide Label: isoform X1
- UniProtKB: Q7Z5B8 (UniProtKB/Swiss-Prot),   Q99735 (UniProtKB/Swiss-Prot),   D6RBB5 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99735-F1-model_v2 AlphaFold Q99735 1-147 view protein structure

Promoters
RGD ID:6868526
Promoter ID:EPDNEW_H7427
Type:initiation region
Name:MGST2_1
Description:microsomal glutathione S-transferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7428  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,850 - 139,665,910EPDNEW
RGD ID:6868528
Promoter ID:EPDNEW_H7428
Type:initiation region
Name:MGST2_2
Description:microsomal glutathione S-transferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7427  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384139,665,961 - 139,666,021EPDNEW
RGD ID:6802458
Promoter ID:HG_KWN:49162
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000265498,   UC010IOI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364140,806,336 - 140,806,872 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7063 AgrOrtholog
COSMIC MGST2 COSMIC
Ensembl Genes ENSG00000085871 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000265498 ENTREZGENE
  ENST00000265498.6 UniProtKB/Swiss-Prot
  ENST00000503816 ENTREZGENE
  ENST00000503816.1 UniProtKB/Swiss-Prot
  ENST00000506797 ENTREZGENE
  ENST00000506797.5 UniProtKB/Swiss-Prot
  ENST00000515137 ENTREZGENE
  ENST00000616265 ENTREZGENE
  ENST00000616265.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot
GTEx ENSG00000085871 GTEx
HGNC ID HGNC:7063 ENTREZGENE
Human Proteome Map MGST2 Human Proteome Map
InterPro 5_LipOase_AP UniProtKB/Swiss-Prot
  FLAP/GST2/LTC4S_CS UniProtKB/Swiss-Prot
  MAPEG UniProtKB/Swiss-Prot
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot
KEGG Report hsa:4258 UniProtKB/Swiss-Prot
NCBI Gene 4258 ENTREZGENE
OMIM 601733 OMIM
PANTHER MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  MICROSOMAL GLUTATHIONE S-TRANSFERASE 2 UniProtKB/Swiss-Prot
Pfam MAPEG UniProtKB/Swiss-Prot
PharmGKB MGST2 RGD, PharmGKB
PRINTS 5LPOXGNASEAP UniProtKB/Swiss-Prot
PROSITE FLAP_GST2_LTC4S UniProtKB/Swiss-Prot
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot
UniProt D6RBB5 ENTREZGENE
  MGST2_HUMAN UniProtKB/Swiss-Prot
  Q7Z5B8 ENTREZGENE
  Q99735 ENTREZGENE
UniProt Secondary D6RBB5 UniProtKB/Swiss-Prot
  Q7Z5B8 UniProtKB/Swiss-Prot