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Gene: PFKM (phosphofructokinase, muscle) Homo sapiens
Symbol: PFKM
Name: phosphofructokinase, muscle
Description: Exhibits several functions, including 6-phosphofructokinase activity; ATP binding activity; and fructose binding activity. Involved in several processes, including fructose 6-phosphate metabolic process; glycolytic process through fructose-6-phosphate; and muscle cell cellular homeostasis. Localizes to 6-phosphofructokinase complex; apical plasma membrane; and nucleus. Implicated in glycogen storage disease VII.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 6-phosphofructo-1-kinase; 6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; ATP-PFK; GSD7; MGC8699; PFK-1; PFK-A; PFK-M; PFK1; PFKA; PFKX; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase muscle; phosphofructokinase, polypeptide X; phosphofructokinase-M; phosphohexokinase; PPP1R122
Mus musculus (house mouse) : Pfkm (phosphofructokinase, muscle)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pfkm (phosphofructokinase, muscle)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pfkm (phosphofructokinase, muscle)
Pan paniscus (bonobo/pygmy chimpanzee) : PFKM (phosphofructokinase, muscle)
Canis lupus familiaris (dog) : PFKM (phosphofructokinase, muscle)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pfkm (phosphofructokinase, muscle)
Sus scrofa (pig) : PFKM (phosphofructokinase, muscle)
Chlorocebus sabaeus (African green monkey) : PFKM (phosphofructokinase, muscle)
Heterocephalus glaber (naked mole-rat) : Pfkm (phosphofructokinase, muscle)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1248,105,139 - 48,146,404 (+)EnsemblGRCh38hg38GRCh38
GRCh381248,105,253 - 48,146,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371248,499,656 - 48,540,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,802,817 - 46,826,154 (+)NCBINCBI36hg18NCBI36
Build 341246,802,814 - 46,826,154NCBI
Celera1247,297,160 - 47,337,691 (+)NCBI
Cytogenetic Map12q13.11NCBI
HuRef1245,531,136 - 45,571,668 (+)NCBIHuRef
CHM1_11248,465,088 - 48,505,624 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PFKM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68621
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.