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Gene: PRC1 (protein regulator of cytokinesis 1) Homo sapiens
Symbol: PRC1
Name: protein regulator of cytokinesis 1
Description: This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: anaphase spindle elongation 1 homolog; ASE1; MGC1671; MGC3669; protein regulating cytokinesis 1
Mus musculus (house mouse) : Prc1 (protein regulator of cytokinesis 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prc1 (protein regulator of cytokinesis 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prc1 (protein regulator of cytokinesis 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRC1 (protein regulator of cytokinesis 1)
Canis lupus familiaris (dog) : PRC1 (protein regulator of cytokinesis 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prc1 (protein regulator of cytokinesis 1)
Sus scrofa (pig) : PRC1 (protein regulator of cytokinesis 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381590,966,038 - 90,994,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,509,268 - 91,537,881 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,310,272 - 89,338,808 (-)NCBINCBI36hg18NCBI36
Build 341589,310,272 - 89,338,808NCBI
Celera1567,918,486 - 67,947,023 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,620,243 - 67,648,754 (-)NCBIHuRef
CHM1_11591,350,870 - 91,379,451 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PRC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323372
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.