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Gene: CCNE1 (cyclin E1) Homo sapiens
Symbol: CCNE1
Name: cyclin E1
Description: Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of mesenchymal stem cell proliferation; and protein phosphorylation. Localizes to cyclin E1-CDK2 complex and nucleoplasm. Implicated in breast adenocarcinoma. Biomarker of breast cancer; cervix uteri carcinoma in situ; lung non-small cell carcinoma; renal cell carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCNE; cyclin e; cyclin E variant ex5del; cyclin E variant ex7del; cyclin Es; cyclin Et; G1/S-specific cyclin-E1; pCCNE1; pluripotent specific cyclin E1
Mus musculus (house mouse) : Ccne1 (cyclin E1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccne1 (cyclin E1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccne1 (cyclin E1)
Pan paniscus (bonobo/pygmy chimpanzee) : CCNE1 (cyclin E1)
Canis lupus familiaris (dog) : CCNE1 (cyclin E1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccne1 (cyclin E1)
Sus scrofa (pig) : CCNE1 (cyclin E1)
Chlorocebus sabaeus (African green monkey) : CCNE1 (cyclin E1)
Heterocephalus glaber (naked mole-rat) : Ccne1 (cyclin E1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1929,811,991 - 29,824,312 (+)EnsemblGRCh38hg38GRCh38
GRCh381929,811,991 - 29,824,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371930,302,805 - 30,315,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361934,994,741 - 35,007,059 (+)NCBINCBI36hg18NCBI36
Build 341934,995,400 - 35,007,058NCBI
Celera1927,001,121 - 27,013,439 (+)NCBI
Cytogenetic Map19q12NCBI
HuRef1926,814,506 - 26,826,846 (+)NCBIHuRef
CHM1_11930,304,072 - 30,316,389 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CCNE1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736488
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.