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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfasalazine
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Accession:CHEBI:9334 term browser browse the term
Definition:An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Synonyms:exact_synonym: 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
 related_synonym: 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid;   2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid;   4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene;   5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid;   5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid;   5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid;   Azulfidine;   Formula=C18H14N4O5S;   InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+;   InChIKey=NCEXYHBECQHGNR-QZQOTICOSA-N;   SMILES=OC(=O)c1cc(ccc1O)\\N=N\\c1ccc(cc1)S(=O)(=O)Nc1ccccn1;   Salazosulfapiridina;   Salazosulfapyridine;   Salazosulfapyridinum;   Salicylazosulfapyridine;   Sulfasalazina;   Sulfasalazinum
 alt_id: CHEBI:101223
 xref: Beilstein:356241;   Beilstein:8132868;   CAS:599-79-1;   DrugBank:DB00795;   Gmelin:2666050;   KEGG:C07316;   KEGG:D00448
 xref_mesh: MESH:D012460
 xref: PDBeChem:SAS;   PMID:11362329;   PMID:11485124;   PMID:11587223;   PMID:14981898;   PMID:15248210;   PMID:16322111;   PMID:17386570;   PMID:2434548;   PMID:7720170;   Patent:US2396145;   Reaxys:8132868



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sulfasalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase increases expression EXP Sulfasalazine results in increased expression of AADAT mRNA CTD PMID:22016648 NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions ISO [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium CTD PMID:19853032 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases transport
multiple interactions
decreases methylation
affects transport
increases activity
ISO ABCG2 protein results in increased transport of Sulfasalazine
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]; yu ping feng san inhibits the reaction [Sulfasalazine results in increased activity of ABCG2 protein]
ABCG2 gene polymorphism affects the transport of Sulfasalazine
CTD PMID:18167504 PMID:18408567 PMID:20019844 PMID:27475308 PMID:30083819 More... NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression EXP Sulfasalazine results in increased expression of ACAA1B mRNA CTD PMID:31830553 NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Sulfasalazine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression EXP Sulfasalazine results in increased expression of ACOT1 mRNA CTD PMID:31830553 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression EXP Sulfasalazine results in increased expression of ACOT3 mRNA CTD PMID:31830553 NCBI chr12:84,098,918...84,107,174
Ensembl chr12:84,098,918...84,107,176
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases expression EXP Sulfasalazine results in increased expression of ACOX1 mRNA CTD PMID:31830553 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:15633128 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions
affects localization
ISO BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein] CTD PMID:12381674 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 decreases expression EXP Sulfasalazine results in decreased expression of ALDH1A1 mRNA CTD PMID:31830553 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases expression EXP Sulfasalazine results in increased expression of ALDH1A7 mRNA CTD PMID:31830553 NCBI chr19:20,670,318...20,704,920
Ensembl chr19:20,670,317...20,704,926
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein] CTD PMID:15867298 NCBI chr 1:87,025,724...87,029,328
Ensembl chr 1:87,025,724...87,029,328
JBrowse link
G Anxa2 annexin A2 increases expression EXP Sulfasalazine results in increased expression of ANXA2 mRNA CTD PMID:22016648 NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077
JBrowse link
G Apoa4 apolipoprotein A-IV decreases expression EXP Sulfasalazine results in decreased expression of APOA4 mRNA CTD PMID:31830553 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
JBrowse link
G Azin1 antizyme inhibitor 1 increases expression EXP Sulfasalazine results in increased expression of AZIN1 mRNA CTD PMID:22016648 NCBI chr15:38,487,674...38,523,506
Ensembl chr15:38,487,671...38,519,510
JBrowse link
G Bax BCL2-associated X protein affects localization
multiple interactions
ISO Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]
CTD PMID:12381674 PMID:31428839 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon
CTD
RGD
PMID:12381674 PMID:31428839 PMID:29572553 RGD:152995414 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G C6 complement component 6 decreases expression EXP Sulfasalazine results in decreased expression of C6 mRNA CTD PMID:31830553 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Acetic Acid results in increased cleavage of CASP1 protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein] CTD PMID:30408459 PMID:35595039 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]
CTD PMID:12381674 PMID:16322111 PMID:17051331 PMID:19473188 PMID:19859796 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein
CTD PMID:16322111 PMID:19859796 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity
ISO
EXP
Sulfasalazine results in increased activity of CAT protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]
Sulfasalazine results in decreased activity of CAT protein
CTD PMID:19028562 PMID:19071188 PMID:28421826 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA CTD PMID:19015640 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA] CTD PMID:17449585 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA
CTD PMID:17202759 PMID:19015640 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Sulfasalazine results in increased expression of CCNG1 mRNA CTD PMID:22016648 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
JBrowse link
G Cd14 CD14 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd19 CD19 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061
JBrowse link
G Cd27 CD27 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973
JBrowse link
G Cd38 CD38 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717
JBrowse link
G Cd3d CD3 antigen, delta polypeptide multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637
JBrowse link
G Cd46 CD46 antigen, complement regulatory protein decreases expression ISO Sulfasalazine results in decreased expression of CD46 mRNA CTD PMID:15625186 NCBI chr 1:194,721,279...194,781,149
Ensembl chr 1:194,719,134...194,774,557
JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement decreases expression ISO Sulfasalazine results in decreased expression of CD55 mRNA CTD PMID:15625186 PMID:17166698 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481
JBrowse link
G Cd59b CD59b antigen decreases expression ISO Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein CTD PMID:15625186 PMID:17166698 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA CTD PMID:19015640 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
ISO protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cldn2 claudin 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein] CTD PMID:35290143 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135
JBrowse link
G Clu clusterin increases expression EXP Sulfasalazine results in increased expression of CLU mRNA CTD PMID:22016648 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] CTD PMID:15633128 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP
ISO
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]
CTD PMID:19015640 PMID:26165751 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
affects secretion
ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein] CTD PMID:12231210 PMID:28863153 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
affects secretion
decreases expression
ISO
EXP
[Sulfasalazine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine results in decreased expression of and results in decreased activity of CXCL8 protein
Sulfasalazine results in decreased expression of CXCL8 mRNA
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of CXCL8 protein]
CTD PMID:12133438 PMID:12135912 PMID:12231210 PMID:15269287 PMID:15528384 More... NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects secretion
multiple interactions
ISO Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]
CTD PMID:12231210 PMID:28863153 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Sulfasalazine results in increased expression of CYP1A1 mRNA CTD PMID:17202759 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases expression ISO Sulfasalazine results in decreased expression of CYP27B1 mRNA CTD PMID:15243130 NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875
JBrowse link
G Cyp2a21-ps cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene increases expression EXP Sulfasalazine results in increased expression of CYP2A21-PS mRNA CTD PMID:31830553 NCBI chr 7:26,645,383...26,651,977
Ensembl chr 7:26,616,806...26,651,771
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression EXP Sulfasalazine results in increased expression of CYP2A5 mRNA CTD PMID:31830553 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression EXP Sulfasalazine results in increased expression of CYP2B10 mRNA CTD PMID:31830553 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases expression EXP Sulfasalazine results in increased expression of CYP2C29 mRNA CTD PMID:31830553 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases expression EXP Sulfasalazine results in increased expression of CYP2C38 mRNA CTD PMID:31830553 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 increases expression EXP Sulfasalazine results in increased expression of CYP2C39 mRNA CTD PMID:31830553 NCBI chr19:39,335,790...39,558,012
Ensembl chr19:39,499,306...39,556,973
JBrowse link
G Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 increases expression EXP Sulfasalazine results in increased expression of CYP2C50 mRNA CTD PMID:31830553 NCBI chr19:40,078,123...40,102,399
Ensembl chr19:40,078,132...40,102,394
JBrowse link
G Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 increases expression EXP Sulfasalazine results in increased expression of CYP2C54 mRNA CTD PMID:31830553 NCBI chr19:40,026,383...40,062,289
Ensembl chr19:40,026,384...40,062,271
JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 increases expression EXP Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein CTD PMID:31830553 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Sulfasalazine results in increased expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Dio1 deiodinase, iodothyronine, type I multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366
JBrowse link
G Dio2 deiodinase, iodothyronine, type II multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]
CTD PMID:16728495 PMID:21068073 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression EXP Sulfasalazine results in increased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr 8:86,264,262...86,281,990
Ensembl chr 8:86,264,262...86,281,973
JBrowse link
G Egf epidermal growth factor increases expression EXP Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
[Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein
CTD PMID:20007406 PMID:31830553 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Sulfasalazine results in decreased expression of EGR1 mRNA CTD PMID:31830553 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression EXP Sulfasalazine results in increased expression of EPHX1 mRNA CTD PMID:22016648 PMID:31830553 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
JBrowse link
G F3 coagulation factor III multiple interactions ISO Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte increases expression EXP Sulfasalazine results in increased expression of FABP4 mRNA CTD PMID:22016648 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Sulfasalazine results in increased expression of FGA mRNA CTD PMID:22016648 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression EXP Sulfasalazine results in decreased expression of FMC1 mRNA CTD PMID:31830553 NCBI chr 6:38,511,796...38,516,384
Ensembl chr 6:38,510,437...38,516,384
JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] CTD PMID:28421826 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression EXP Sulfasalazine results in increased expression of FTL1 mRNA CTD PMID:22016648 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G G0s2 G0/G1 switch gene 2 increases expression EXP Sulfasalazine results in increased expression of G0S2 mRNA CTD PMID:31830553 NCBI chr 1:192,954,468...192,955,496
Ensembl chr 1:192,954,469...192,955,525
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta decreases expression ISO Sulfasalazine results in decreased expression of GADD45B mRNA CTD PMID:15633128 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
JBrowse link
G Gdnf glial cell line derived neurotrophic factor multiple interactions ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein] CTD PMID:14687604 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP Sulfasalazine results in increased expression of GPT protein CTD PMID:31830553 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression EXP Sulfasalazine results in decreased expression of GPX3 mRNA CTD PMID:31830553 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein] CTD PMID:26165751 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase decreases activity ISO Sulfasalazine results in decreased activity of GSR protein CTD PMID:19028562 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO Sulfasalazine results in increased expression of GSTA5 mRNA CTD PMID:17202759 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases expression EXP Sulfasalazine results in increased expression of GSTA1 mRNA CTD PMID:31830553 NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Sulfasalazine results in increased expression of GSTA2 mRNA CTD PMID:31830553 NCBI chr 9:78,197,210...78,212,807
Ensembl chr 9:78,197,205...78,212,807
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression EXP Sulfasalazine results in increased expression of GSTM2 mRNA CTD PMID:31830553 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP Sulfasalazine results in increased expression of GSTM3 mRNA CTD PMID:31830553 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO Sulfasalazine results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 affects expression ISO Sulfasalazine affects the expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
increases activity
ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein
CTD PMID:12808024 PMID:19502547 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression EXP Sulfasalazine results in increased expression of HINT1 mRNA CTD PMID:22016648 NCBI chr11:54,757,209...54,761,332
Ensembl chr11:54,757,209...54,761,327
JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions
ISO Sulfasalazine results in increased expression of HMGB1 mRNA
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon
CTD
RGD
PMID:16141653 PMID:29572553 RGD:152995414 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
multiple interactions
increases expression
ISO HMOX1 protein results in increased susceptibility to Sulfasalazine
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein
CTD PMID:19234301 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression ISO Sulfasalazine results in decreased expression of HSD17B3 mRNA CTD PMID:29197623 NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP Sulfasalazine results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Sulfasalazine results in decreased expression of HSD3B1 mRNA CTD PMID:29197623 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
JBrowse link
G Hsd3b4 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 increases expression EXP Sulfasalazine results in increased expression of HSD3B4 mRNA CTD PMID:22016648 NCBI chr 3:98,406,387...98,417,895
Ensembl chr 3:98,406,387...98,417,830
JBrowse link
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 decreases expression EXP Sulfasalazine results in decreased expression of HSD3B5 mRNA CTD PMID:31830553 NCBI chr 3:98,525,952...98,552,850
Ensembl chr 3:98,525,950...98,537,568
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 increases expression EXP Sulfasalazine results in increased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Hspa1a heat shock protein 1A increases expression EXP Sulfasalazine results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa1b heat shock protein 1B decreases expression ISO Sulfasalazine results in decreased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
Sulfasalazine results in increased expression of ICAM1 protein
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon
CTD
RGD
PMID:11264155 PMID:15553846 PMID:17259377 PMID:20823682 PMID:26165751 More... RGD:152995414 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Idh3b isocitrate dehydrogenase 3 (NAD+) beta increases expression EXP Sulfasalazine results in increased expression of IDH3B mRNA CTD PMID:22016648 NCBI chr 2:130,121,229...130,126,371
Ensembl chr 2:130,121,229...130,126,467
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA] CTD PMID:20884048 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
[Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:11529938 PMID:15269287 PMID:17051331 PMID:25231984 PMID:29594315 More... NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Sulfasalazine affects the expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta decreases expression ISO Sulfasalazine results in decreased expression of IKBKB protein CTD PMID:15564333 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon
CTD
RGD
PMID:15604057 PMID:17051331 PMID:25231984 PMID:25727887 PMID:29731490 More... RGD:152995414 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il10ra interleukin 10 receptor, alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447
JBrowse link
G Il12a interleukin 12a multiple interactions EXP Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]] CTD PMID:11529938 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
JBrowse link
G Il12b interleukin 12b multiple interactions EXP Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL18 protein] CTD PMID:35595039 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of IL1B mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
CTD PMID:12133438 PMID:12231210 PMID:15604057 PMID:15793857 PMID:15867298 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1r1 interleukin 1 receptor, type I multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA] CTD PMID:17449585 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:15867298 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il2 interleukin 2 multiple interactions ISO
EXP
[Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]
CTD PMID:17051331 PMID:29594315 PMID:32272095 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein] CTD PMID:7815356 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
CTD PMID:12135912 PMID:17051331 PMID:19956958 PMID:20884048 PMID:21070844 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Insr insulin receptor increases expression ISO Sulfasalazine results in increased expression of INSR protein CTD PMID:15564333 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP Sulfasalazine results in decreased expression of IRS2 mRNA CTD PMID:31830553 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
JBrowse link
G Itgam integrin alpha M multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein] CTD PMID:8094364 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein] CTD PMID:8094364 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Itk IL2 inducible T cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein] CTD PMID:32272095 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Jchain immunoglobulin joining chain multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr 5:88,667,663...88,675,667
Ensembl chr 5:88,667,668...88,675,750
JBrowse link
G Lck lymphocyte protein tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434
JBrowse link
G Ldhc lactate dehydrogenase C increases activity
multiple interactions
EXP Sulfasalazine results in increased activity of LDHC protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein]
CTD PMID:28421826 NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566
JBrowse link
G Lhb luteinizing hormone beta multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] CTD PMID:28421826 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lsm10 U7 snRNP-specific Sm-like protein LSM10 decreases expression EXP Sulfasalazine results in decreased expression of LSM10 mRNA CTD PMID:31830553 NCBI chr 4:125,990,350...125,992,375
Ensembl chr 4:125,990,416...125,992,377
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Sulfasalazine results in increased phosphorylation of MAPK9 protein CTD PMID:15633128 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mir223 microRNA 223 multiple interactions ISO Sulfasalazine inhibits the reaction [Acetic Acid results in decreased expression of MIR223 mRNA] CTD PMID:35595039 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] CTD PMID:15633128 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]
CTD PMID:12745093 PMID:22119283 PMID:30972795 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
ISO
EXP
Sulfasalazine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
Sulfasalazine results in decreased activity of MPO protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon
CTD
RGD
PMID:17373747 PMID:20380826 PMID:22119283 PMID:23665423 PMID:25231984 More... RGD:152995414 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Sulfasalazine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr 1:155,003,620...155,022,560
Ensembl chr 1:155,003,023...155,022,560
JBrowse link
G Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr19:11,227,043...11,243,513
Ensembl chr19:11,227,039...11,243,605
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine CTD PMID:19578646 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
JBrowse link
G Muc17 mucin 17, cell surface associated multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC3 mRNA] CTD PMID:17449585 NCBI chr 5:137,163,772...137,202,809
Ensembl chr 5:137,163,770...137,202,830
JBrowse link
G Muc2 mucin 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA] CTD PMID:17449585 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430
JBrowse link
G Muc4 mucin 4 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA] CTD PMID:17449585 NCBI chr16:32,555,089...32,602,786
Ensembl chr16:32,555,015...32,602,754
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein] CTD PMID:35290143 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) affects metabolic processing
affects response to substance
increases metabolic processing
increases acetylation
ISO NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine
CTD PMID:12465141 PMID:15032315 PMID:17377643 PMID:17502830 PMID:19560446 NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
CTD PMID:19234301 PMID:31428839 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
decreases expression
decreases localization
ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine results in decreased expression of NFKB1 protein
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]
CTD PMID:9486988 PMID:12135912 PMID:15269287 PMID:17259377 PMID:26165751 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
decreases expression
decreases phosphorylation
increases degradation
ISO
EXP
Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine results in increased degradation of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]
CTD PMID:9486988 PMID:11786414 PMID:15494508 PMID:15793857 PMID:16934226 More... NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein] CTD PMID:30408459 PMID:35595039 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases expression
EXP
ISO
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA
CTD PMID:11529938 PMID:15867298 PMID:16925772 PMID:16934226 PMID:17259377 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO
EXP
Sulfasalazine results in increased expression of NQO1 mRNA CTD PMID:19234301 PMID:22016648 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein CTD PMID:17267514 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G Oat ornithine aminotransferase increases expression EXP Sulfasalazine results in increased expression of OAT mRNA CTD PMID:22016648 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
JBrowse link
G Ocln occludin multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein] CTD PMID:35290143 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 increases expression EXP Sulfasalazine results in increased expression of ODC1 mRNA CTD PMID:22016648 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA] CTD PMID:11901219 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Sulfasalazine results in increased expression of PCNA mRNA CTD PMID:22016648 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression EXP Sulfasalazine results in increased expression of PGAM2 mRNA CTD PMID:22016648 NCBI chr11:5,751,637...5,753,796
Ensembl chr11:5,751,640...5,753,733
JBrowse link
G Pla2g1b phospholipase A2, group IB, pancreas multiple interactions ISO Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein] CTD PMID:15528384 NCBI chr 5:115,604,201...115,612,781
Ensembl chr 5:115,604,321...115,612,781
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO
EXP
Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
CTD PMID:19365232 PMID:26165751 PMID:31830553 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO
EXP
Sulfasalazine results in increased expression of PRDX1 mRNA CTD PMID:16141653 PMID:22016648 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression EXP Sulfasalazine results in increased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) decreases expression ISO Sulfasalazine results in decreased expression of PSMB9 mRNA CTD PMID:17202759 NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO
EXP
Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
CTD PMID:17259377 PMID:19956958 PMID:25576893 PMID:29187079 PMID:30408459 More... NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression EXP Sulfasalazine results in increased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 2:90,741,057...90,748,395
Ensembl chr 2:90,739,060...90,748,389
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
JBrowse link
G Rbp4 retinol binding protein 4, plasma affects expression EXP Sulfasalazine affects the expression of RBP4 mRNA CTD PMID:22016648 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases activity
increases localization
affects localization
decreases localization
ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
Sulfasalazine results in decreased activity of RELA protein
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in decreased localization of RELA protein
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon
CTD
RGD
PMID:9486988 PMID:12135912 PMID:14687604 PMID:15269287 PMID:15564333 More... RGD:152995414 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression EXP Sulfasalazine results in increased expression of RGS16 mRNA CTD PMID:31830553 NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214
JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA] CTD PMID:19693652 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647
JBrowse link
G Rnf186 ring finger protein 186 decreases expression EXP Sulfasalazine results in decreased expression of RNF186 mRNA CTD PMID:31830553 NCBI chr 4:138,694,430...138,695,676
Ensembl chr 4:138,694,423...138,695,676
JBrowse link
G Saa3 serum amyloid A 3 increases expression EXP Sulfasalazine results in increased expression of SAA3 mRNA CTD PMID:22016648 NCBI chr 7:46,361,422...46,365,100
Ensembl chr 7:46,361,422...46,365,124
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715
JBrowse link
G Sele selectin, endothelial cell increases expression ISO Sulfasalazine results in increased expression of SELE protein CTD PMID:11264155 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Serpina4-ps1 serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1 decreases expression EXP Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA CTD PMID:31830553 NCBI chr12:104,044,218...104,053,179
Ensembl chr12:104,046,908...104,052,983
JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 increases expression EXP Sulfasalazine results in increased expression of SERPINC1 mRNA CTD PMID:22016648 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433
JBrowse link
G Sik1 salt inducible kinase 1 decreases expression EXP Sulfasalazine results in decreased expression of SIK1 mRNA CTD PMID:31830553 NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778
JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr 1:171,458,506...171,480,522
Ensembl chr 1:171,459,971...171,480,603
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 decreases expression EXP Sulfasalazine results in decreased expression of SLC22A7 mRNA CTD PMID:31830553 NCBI chr17:46,743,111...46,749,403
Ensembl chr17:46,743,109...46,749,383
JBrowse link
G Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 decreases expression EXP Sulfasalazine results in decreased expression of SLC25A24 mRNA CTD PMID:31830553 NCBI chr 3:109,030,465...109,075,725
Ensembl chr 3:109,030,465...109,075,773
JBrowse link
G Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 increases expression EXP Sulfasalazine results in increased expression of SLC25A6 mRNA CTD PMID:22016648 NCBI chr  X:36,059,250...36,062,461
Ensembl chr  X:36,059,304...36,062,460
JBrowse link
G Slc30a1 solute carrier family 30 (zinc transporter), member 1 decreases expression EXP Sulfasalazine results in decreased expression of SLC30A1 mRNA CTD PMID:31830553 NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 multiple interactions EXP Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] CTD PMID:19576933 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions
decreases activity
ISO Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfasalazine results in decreased activity of SLC46A1 protein
CTD PMID:17475902 PMID:18174275 PMID:19762432 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 decreases activity
multiple interactions
ISO
EXP
Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
CTD PMID:19015640 PMID:19576933 PMID:20007406 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression EXP Sulfasalazine results in decreased expression of SOCS2 mRNA CTD PMID:31830553 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression EXP Sulfasalazine results in increased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod3 superoxide dismutase 3, extracellular decreases expression EXP Sulfasalazine results in decreased expression of SOD3 mRNA CTD PMID:31830553 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Sulfasalazine results in increased expression of SPP1 mRNA CTD PMID:22016648 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression
ISO Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA
CTD PMID:29197623 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein] CTD PMID:32272095 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet multiple interactions
decreases activity
ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509
JBrowse link
G Tff3 trefoil factor 3, intestinal multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA] CTD PMID:17449585 NCBI chr17:31,344,280...31,348,585
Ensembl chr17:31,344,280...31,348,620
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
decreases expression
EXP [Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form
CTD PMID:17641275 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA] CTD PMID:16614379 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633128 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression EXP Sulfasalazine results in increased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 increases expression EXP Sulfasalazine results in increased expression of TIMP3 mRNA CTD PMID:22016648 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein] CTD PMID:35290143 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 PMID:32272095 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions ISO Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein] CTD PMID:35290143 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
decreases expression
decreases secretion
ISO
EXP
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in decreased expression of TNF mRNA
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon
CTD
RGD
PMID:8094364 PMID:8598465 PMID:9486988 PMID:11901219 PMID:12135912 More... RGD:152995414 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases secretion ISO Sulfasalazine results in increased secretion of TNFRSF11B protein CTD PMID:15593184 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr16:11,131,131...11,137,938
Ensembl chr16:11,131,676...11,137,938
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions ISO Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNFRSF1A protein] CTD PMID:35595039 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 decreases expression ISO Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein CTD PMID:15593184 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
G Tpm3 tropomyosin 3, gamma decreases expression ISO Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form CTD PMID:19369484 NCBI chr 3:89,979,958...90,008,209
Ensembl chr 3:89,979,956...90,008,209
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein] CTD PMID:32272095 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit increases secretion EXP Sulfasalazine results in increased secretion of TSHB protein CTD PMID:12587019 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP Sulfasalazine results in increased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
decreases expression
ISO Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA
CTD PMID:15269287 NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242
JBrowse link
G Ubc ubiquitin C increases expression EXP Sulfasalazine results in increased expression of UBC mRNA CTD PMID:22016648 NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
increases expression
ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein
Sulfasalazine results in increased expression of VCAM1 protein
CTD PMID:11264155 PMID:15553846 PMID:17259377 PMID:19693652 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vim vimentin increases expression EXP Sulfasalazine results in increased expression of VIM mRNA CTD PMID:22016648 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      biological role 22194
        biochemical role 21464
          ferroptosis inducer 16323
            sulfasalazine 219
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    main group molecular entity 22136
                      s-block molecular entity 21732
                        hydrogen molecular entity 21649
                          hydrides 20781
                            inorganic hydride 18692
                              pnictogen hydride 18672
                                nitrogen hydride 18539
                                  azane 18446
                                    ammonia 18445
                                      organic amino compound 18445
                                        aromatic amine 15737
                                          anilines 14578
                                            substituted aniline 14210
                                              sulfanilamide 2895
                                                sulfasalazine 219
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