Ripk2 (receptor (TNFRSF)-interacting serine-threonine kinase 2) - Rat Genome Database

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Gene: Ripk2 (receptor (TNFRSF)-interacting serine-threonine kinase 2) Mus musculus
Analyze
Symbol: Ripk2
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
RGD ID: 1319358
MGI Page MGI
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to muramyl dipeptide; immune response-activating signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and response to bacterium. Predicted to be located in cytoskeleton; cytosol; and vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2210420D18Rik; CAR; CARD3; CARDIAK; CCK; D4Bwg0615e; R; receptor-interacting protein 2; receptor-interacting serine/threonine-protein kinase 2; RI; RICK; RIP2; tyrosine-protein kinase RIPK2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39416,122,740 - 16,163,674 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl416,122,733 - 16,163,647 (-)EnsemblGRCm39 Ensembl
GRCm38416,122,732 - 16,163,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl416,122,733 - 16,163,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37416,050,522 - 16,090,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36416,050,522 - 16,090,647 (-)NCBIMGSCv36mm8
Celera415,919,468 - 15,959,561 (-)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6alpha-methylprednisolone  (ISO)
aconitine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
furan  (ISO)
gentamycin  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
metam  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Mitotane  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
PF-3758309  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (ISO)
sulfasalazine  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zidovudine  (ISO)
zinc oxide  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
adaptive immune response  (IMP)
apoptotic process  (IEA,ISO)
canonical NF-kappaB signal transduction  (IMP)
CD4-positive, alpha-beta T cell proliferation  (IMP)
cellular response to lipopolysaccharide  (IMP)
cellular response to lipoteichoic acid  (IMP)
cellular response to muramyl dipeptide  (IDA,ISO,ISS)
cellular response to peptidoglycan  (IMP)
chromatin remodeling  (IEA)
cytokine-mediated signaling pathway  (IMP)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (IMP)
ERK1 and ERK2 cascade  (IBA,IDA,IMP)
immature T cell proliferation in thymus  (IMP)
innate immune response  (IBA,IMP,ISO)
JNK cascade  (IBA,IMP)
lipopolysaccharide-mediated signaling pathway  (IMP)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IMP,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA,IMP,ISO,ISS)
positive regulation of apoptotic process  (IDA)
positive regulation of canonical NF-kappaB signal transduction  (IBA,IDA,IMP,ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IMP)
positive regulation of chemokine production  (IMP)
positive regulation of cytokine-mediated signaling pathway  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP)
positive regulation of immature T cell proliferation in thymus  (IMP)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-2 production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of JNK cascade  (IMP)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (ISO,ISS)
positive regulation of peptidyl-threonine phosphorylation  (ISO,ISS)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO,ISS)
positive regulation of protein K63-linked ubiquitination  (ISO,ISS)
positive regulation of protein ubiquitination  (ISO)
positive regulation of stress-activated MAPK cascade  (IMP)
positive regulation of T-helper 1 cell differentiation  (IMP)
positive regulation of T-helper 1 type immune response  (IMP)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of type II interferon production  (IMP)
positive regulation of xenophagy  (IMP)
protein homooligomerization  (IEA,ISO)
regulation of cysteine-type endopeptidase activity  (IMP)
response to exogenous dsRNA  (IMP)
response to interleukin-1  (IMP)
response to interleukin-12  (IMP)
response to interleukin-18  (IMP)
stress-activated MAPK cascade  (IMP)
T cell proliferation  (IMP)
T cell receptor signaling pathway  (IMP)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (IMP)
xenophagy  (IMP)

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytoskeleton  (ISO,ISS)
cytosol  (ISO,TAS)
endoplasmic reticulum  (IEA)
plasma membrane  (ISO,ISS)
protein-containing complex  (ISO,ISS)
vesicle  (ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8812455   PMID:9575181   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11894097   PMID:11894098   PMID:12091384   PMID:12466851   PMID:12477932   PMID:14610273  
PMID:14638696   PMID:14663141   PMID:15190255   PMID:15203566   PMID:15289440   PMID:15489334   PMID:15620648   PMID:15661922   PMID:15691841   PMID:15691843   PMID:15761153   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16413926   PMID:16418290   PMID:17277144   PMID:17403772   PMID:17433728   PMID:17452523   PMID:17562858   PMID:17579072   PMID:17635956   PMID:17947236  
PMID:17961803   PMID:18079694   PMID:18085666   PMID:18261938   PMID:18301258   PMID:18310079   PMID:18403232   PMID:18511561   PMID:18522545   PMID:18566542   PMID:19188356   PMID:19213760  
PMID:19360122   PMID:19464198   PMID:19473975   PMID:19805227   PMID:19853061   PMID:19933833   PMID:20351139   PMID:20668698   PMID:20685341   PMID:20921147   PMID:20949042   PMID:21123652  
PMID:21135058   PMID:21205640   PMID:21236705   PMID:21469090   PMID:21552281   PMID:21606507   PMID:21683629   PMID:21731762   PMID:21844230   PMID:21873635   PMID:21887730   PMID:21895414  
PMID:21959219   PMID:22033934   PMID:22314416   PMID:22491249   PMID:22509021   PMID:22520462   PMID:22607974   PMID:22747758   PMID:22807671   PMID:22905357   PMID:22914170   PMID:23148704  
PMID:23321697   PMID:23356698   PMID:23525089   PMID:23684310   PMID:23892723   PMID:23918989   PMID:23952047   PMID:23954160   PMID:24062413   PMID:24319055   PMID:24477914   PMID:24670424  
PMID:24722226   PMID:24733360   PMID:24766550   PMID:24927559   PMID:25036629   PMID:25084278   PMID:25146926   PMID:25254654   PMID:25778803   PMID:26018251   PMID:26130752   PMID:26160380  
PMID:26216961   PMID:26391398   PMID:26463597   PMID:26582949   PMID:26834734   PMID:27064448   PMID:27363341   PMID:27482714   PMID:27670111   PMID:27830463   PMID:28330897   PMID:28400473  
PMID:28410990   PMID:28658623   PMID:28671696   PMID:28698147   PMID:29056340   PMID:29058172   PMID:29425505   PMID:30012848   PMID:30026309   PMID:30044969   PMID:30052281   PMID:30366765  
PMID:30394320   PMID:30405132   PMID:30794604   PMID:31113864   PMID:31903123   PMID:32101030   PMID:32101731   PMID:32150572   PMID:32295905   PMID:32349637   PMID:32473019   PMID:32487756  
PMID:32610078   PMID:32954645   PMID:33070627   PMID:33091794   PMID:33238586   PMID:33261639   PMID:33413510   PMID:33443037   PMID:33580557   PMID:34759307   PMID:36103821   PMID:36858599  
PMID:37121674   PMID:37777791   PMID:38064597   PMID:38729551  


Genomics

Comparative Map Data
Ripk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39416,122,740 - 16,163,674 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl416,122,733 - 16,163,647 (-)EnsemblGRCm39 Ensembl
GRCm38416,122,732 - 16,163,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl416,122,733 - 16,163,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37416,050,522 - 16,090,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36416,050,522 - 16,090,647 (-)NCBIMGSCv36mm8
Celera415,919,468 - 15,959,561 (-)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.7NCBI
RIPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38889,757,816 - 89,791,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl889,757,806 - 89,791,064 (+)EnsemblGRCh38hg38GRCh38
GRCh37890,770,044 - 90,803,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36890,839,110 - 90,872,433 (+)NCBINCBI36Build 36hg18NCBI36
Build 34890,839,172 - 90,872,432NCBI
Celera886,964,831 - 86,998,139 (+)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef885,980,380 - 86,013,697 (+)NCBIHuRef
CHM1_1890,811,006 - 90,844,310 (+)NCBICHM1_1
T2T-CHM13v2.0890,880,976 - 90,914,226 (+)NCBIT2T-CHM13v2.0
Ripk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8534,428,573 - 34,459,808 (-)NCBIGRCr8
mRatBN7.2529,630,806 - 29,662,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl529,631,570 - 29,662,657 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx531,792,628 - 31,823,715 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0533,385,294 - 33,416,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0533,345,474 - 33,376,561 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0529,838,713 - 29,870,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl529,838,747 - 29,870,735 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0534,512,111 - 34,543,807 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4530,714,817 - 30,745,941 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1530,715,463 - 30,738,284 (-)NCBI
Celera528,836,598 - 28,867,674 (-)NCBICelera
Cytogenetic Map5q13NCBI
Ripk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554176,669,675 - 6,702,228 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554176,669,675 - 6,698,142 (+)NCBIChiLan1.0ChiLan1.0
RIPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27107,156,375 - 107,189,911 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1882,693,378 - 82,735,495 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0886,447,216 - 86,480,511 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1888,397,768 - 88,431,690 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl888,398,468 - 88,456,268 (+)Ensemblpanpan1.1panPan2
RIPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12935,283,209 - 35,311,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,282,072 - 35,311,333 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2935,435,813 - 35,464,812 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02935,480,726 - 35,509,728 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2935,479,776 - 35,509,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12935,472,061 - 35,501,046 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02935,492,803 - 35,521,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02935,926,135 - 35,955,236 (+)NCBIUU_Cfam_GSD_1.0
Ripk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530344,137,166 - 44,185,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365443,606,879 - 3,655,532 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365443,606,925 - 3,653,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl447,027,098 - 47,074,704 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1447,026,558 - 47,075,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2451,491,234 - 51,539,306 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1884,843,391 - 84,881,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl884,843,471 - 84,881,303 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603955,998,663 - 56,036,344 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247442,201,319 - 2,226,890 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247442,194,339 - 2,227,498 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ripk2
1140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:578
Count of miRNA genes:324
Interacting mature miRNAs:358
Transcripts:ENSMUST00000037035, ENSMUST00000183871
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse

Markers in Region
D4Bwg0615e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38416,122,858 - 16,122,956UniSTSGRCm38
MGSCv37416,050,005 - 16,050,103UniSTSGRCm37
Celera415,918,951 - 15,919,049UniSTS
Cytogenetic Map4A2UniSTS
cM Map45.4UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001329751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_138102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF461040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF487539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL807379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000037035   ⟹   ENSMUSP00000038833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl416,122,733 - 16,163,647 (-)Ensembl
GRCm38.p6 Ensembl416,122,733 - 16,163,647 (-)Ensembl
Ensembl Acc Id: ENSMUST00000183871   ⟹   ENSMUSP00000139381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl416,122,741 - 16,163,643 (-)Ensembl
GRCm38.p6 Ensembl416,122,741 - 16,163,643 (-)Ensembl
RefSeq Acc Id: NM_001329751   ⟹   NP_001316680
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39416,122,741 - 16,163,643 (-)NCBI
GRCm38416,122,741 - 16,163,643 (-)NCBI
Sequence:
RefSeq Acc Id: NM_138952   ⟹   NP_620402
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39416,122,741 - 16,163,643 (-)NCBI
GRCm38416,122,741 - 16,163,643 (-)NCBI
MGSCv37416,050,522 - 16,090,645 (-)RGD
Celera415,919,468 - 15,959,561 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_138102
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39416,122,741 - 16,163,643 (-)NCBI
GRCm38416,122,741 - 16,163,643 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006537677   ⟹   XP_006537740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39416,122,740 - 16,163,673 (-)NCBI
GRCm38416,122,732 - 16,163,677 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006537678   ⟹   XP_006537741
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39416,122,740 - 16,163,674 (-)NCBI
GRCm38416,122,732 - 16,163,678 (-)NCBI
Sequence:
RefSeq Acc Id: NP_620402   ⟸   NM_138952
- Peptide Label: isoform 1
- UniProtKB: P58801 (UniProtKB/Swiss-Prot),   Q547H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006537740   ⟸   XM_006537677
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006537741   ⟸   XM_006537678
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001316680   ⟸   NM_001329751
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000139381   ⟸   ENSMUST00000183871
Ensembl Acc Id: ENSMUSP00000038833   ⟸   ENSMUST00000037035
Protein Domains
CARD   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58801-F1-model_v2 AlphaFold P58801 1-539 view protein structure

Promoters
RGD ID:6834778
Promoter ID:MM_KWN:36770
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK040773_A730041O05RIK,   OTTMUST00000010515,   OTTMUST00000010516,   UC008SBS.1,   UC008SBT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36416,090,536 - 16,091,387 (+)MPROMDB
RGD ID:6882882
Promoter ID:EPDNEW_M4892
Type:initiation region
Name:Ripk2_1
Description:Mus musculus receptor -interacting serine-threonine kinase 2, transcript variant 3, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38416,163,521 - 16,163,581EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891456 AgrOrtholog
Ensembl Genes ENSMUSG00000041135 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037035 ENTREZGENE
  ENSMUST00000037035.12 UniProtKB/Swiss-Prot
  ENSMUST00000183871 ENTREZGENE
  ENSMUST00000183871.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD_RIP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt-int_Ser/Thr_kinase-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr_protein_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:192656 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891456 ENTREZGENE
NCBI Gene 192656 ENTREZGENE
PANTHER RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ripk2 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
  STPK_RIP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P58801 ENTREZGENE
  Q547H1 ENTREZGENE, UniProtKB/TrEMBL
  RIPK2_MOUSE UniProtKB/Swiss-Prot
  V9GXY4_MOUSE UniProtKB/TrEMBL