Irs2 (insulin receptor substrate 2) - Rat Genome Database
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Gene: Irs2 (insulin receptor substrate 2) Mus musculus
Analyze
Symbol: Irs2
Name: insulin receptor substrate 2
RGD ID: 736205
MGI Page MGI
Description: Exhibits phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of insulin secretion. Localizes to cytosol; plasma membrane; and protein-containing complex. Is expressed in several structures, including brain ventricular layer; hindlimb digit skin; jaw; metanephros; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2); PARTICIPATES IN leptin system pathway; erythropoietin signaling pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4PS; Ir; Irs-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,034,681 - 11,058,929 (-)NCBIGRCm39mm39
GRCm38810,984,681 - 11,008,929 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37810,986,961 - 11,008,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv36810,986,933 - 11,008,402 (-)NCBImm8
Celera811,160,160 - 11,181,560 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
avobenzone  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
candesartan  (EXP)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (ISO)
genistein  (ISO)
gingerol  (EXP)
glucose  (EXP,ISO)
hexadecanoic acid  (EXP)
indole-3-methanol  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
maneb  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
myrtenal  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phoxim  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rottlerin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
XL147  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,TAS)
plasma membrane  (IBA,IDA)
protein-containing complex  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue amount  (IAGP)
abnormal b wave implicit time  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal energy homeostasis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal mating frequency  (IAGP)
abnormal oogenesis  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovulation  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal prolactin level  (IAGP)
abnormal retinal layer morphology  (IAGP)
abnormal retinal progenitor cell morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal triglyceride level  (IAGP)
abnormal vascular wound healing  (IAGP)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent pancreatic beta cells  (IAGP)
anovulation  (IAGP)
decreased a wave amplitude  (IAGP)
decreased b wave amplitude  (IAGP)
decreased basal metabolism  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating prolactin level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased gonadotroph cell number  (IAGP)
decreased liver glycogen level  (IAGP)
decreased oocyte number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased skeletal muscle glycogen level  (IAGP)
decreased total retina thickness  (IAGP)
decreased vasodilation  (IAGP)
decreased white adipose tissue amount  (IAGP)
enlarged pancreatic islets  (IAGP)
female infertility  (IAGP)
hepatic steatosis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased brown fat cell lipid droplet size  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased fasting circulating glucose level  (IAGP)
increased food intake  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
pancreatic islet hyperplasia  (IAGP)
polydipsia  (IAGP)
polyovular ovarian follicle  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
prolonged diestrus  (IAGP)
prolonged estrous cycle  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
retinal outer nuclear layer degeneration  (IAGP)
retinal photoreceptor degeneration  (IAGP)
short photoreceptor inner segment  (IAGP)
short photoreceptor outer segment  (IAGP)
small ovary  (IAGP)
small pancreatic islets  (IAGP)
small pituitary gland  (IAGP)
small pituitary intermediate lobe  (IAGP)
weight loss  (IAGP)
References

References - curated
1. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Bueno MP, etal., Fetal Diagn Ther. 2010;28(3):145-52. doi: 10.1159/000316932. Epub 2010 Aug 19.
3. Duan C, etal., J Biol Chem. 2004 Oct 15;279(42):43684-91. Epub 2004 Aug 16.
4. Freude S, etal., FASEB J. 2009 Oct;23(10):3315-24. doi: 10.1096/fj.09-132043. Epub 2009 Jun 1.
5. Hennige AM, etal., J Clin Invest. 2003 Nov;112(10):1521-32.
6. Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
7. Hookham MB, etal., FEBS J. 2013 Jul;280(14):3232-43. doi: 10.1111/febs.12305. Epub 2013 May 29.
8. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
9. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
10. Kumar M, etal., Protein Cell. 2012 Oct;3(10):726-38. doi: 10.1007/s13238-012-2055-0. Epub 2012 Oct 11.
11. Li B, etal., Endocrine. 2013 Feb;43(1):136-46. doi: 10.1007/s12020-012-9757-1. Epub 2012 Jul 22.
12. Mammarella S, etal., Hum Mol Genet. 2000 Oct 12;9(17):2517-21.
13. Matsunami T, etal., Metabolism. 2011 Jun;60(6):805-14. Epub 2010 Sep 16.
14. MGD and Homologene mouse data transfer
15. MGD data from the GO Consortium
16. MGD IEA
17. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
18. Okazawa K, etal., Diabetes Res Clin Pract. 2005 Apr;68(1):39-48.
19. OMIM Disease Annotation Pipeline
20. Pedros I, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1556-66. doi: 10.1016/j.bbadis.2014.05.025. Epub 2014 Jun 2.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Pipeline to import SMPDB annotations from SMPDB into RGD
24. RGD automated import pipeline
25. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7675087   PMID:8995447   PMID:9013772   PMID:9399964   PMID:9495343   PMID:9624169   PMID:9729467   PMID:9813005   PMID:10349636   PMID:10417963   PMID:10471495   PMID:10642598  
PMID:10801879   PMID:10829031   PMID:10949029   PMID:11014193   PMID:11018022   PMID:11042159   PMID:11076861   PMID:11078455   PMID:11147812   PMID:11217851   PMID:11259600   PMID:11375348  
PMID:11546755   PMID:11812758   PMID:11897712   PMID:11994408   PMID:12055235   PMID:12219087   PMID:12466851   PMID:12477932   PMID:12488434   PMID:12493745   PMID:12554758   PMID:12595588  
PMID:12746333   PMID:12783867   PMID:12810606   PMID:12810823   PMID:12842910   PMID:12869553   PMID:12904469   PMID:12941762   PMID:14693698   PMID:14733908   PMID:14736890   PMID:14755338  
PMID:14966273   PMID:15028732   PMID:15069074   PMID:15123681   PMID:15135063   PMID:15166310   PMID:15169905   PMID:15297443   PMID:15380067   PMID:15467829   PMID:15467830   PMID:15509777  
PMID:15550388   PMID:15565601   PMID:15572028   PMID:15581362   PMID:15587270   PMID:15611085   PMID:15685168   PMID:15689562   PMID:15705592   PMID:15764603   PMID:15821749   PMID:15841180  
PMID:15975995   PMID:16127164   PMID:16141072   PMID:16141073   PMID:16154098   PMID:16170201   PMID:16180138   PMID:16272563   PMID:16327801   PMID:16374520   PMID:16404553   PMID:16565260  
PMID:16625210   PMID:16750510   PMID:16774126   PMID:16916938   PMID:17068339   PMID:17127239   PMID:17200721   PMID:17222824   PMID:17299086   PMID:17316975   PMID:17325037   PMID:17329594  
PMID:17393136   PMID:17460360   PMID:17636024   PMID:17641201   PMID:17641282   PMID:17662267   PMID:17901049   PMID:17928362   PMID:17965023   PMID:18029441   PMID:18057093   PMID:18202124  
PMID:18256806   PMID:18278056   PMID:18288891   PMID:18566543   PMID:18590687   PMID:18590692   PMID:18590693   PMID:18618219   PMID:18633164   PMID:18717815   PMID:18802016   PMID:19001411  
PMID:19007875   PMID:19056742   PMID:19095950   PMID:19122000   PMID:19273608   PMID:19523444   PMID:19542202   PMID:19574401   PMID:19596788   PMID:19620044   PMID:19738441   PMID:19838201  
PMID:19920186   PMID:19933838   PMID:20028942   PMID:20074531   PMID:20111592   PMID:20360640   PMID:20545557   PMID:20547979   PMID:20604929   PMID:20947509   PMID:20959116   PMID:21081708  
PMID:21135130   PMID:21238928   PMID:21267068   PMID:21293061   PMID:21301804   PMID:21356519   PMID:21532614   PMID:21597043   PMID:21620379   PMID:21628386   PMID:21700708   PMID:21754917  
PMID:21873635   PMID:21926467   PMID:21940781   PMID:21955917   PMID:22074825   PMID:22160220   PMID:22210743   PMID:22288475   PMID:22315446   PMID:22383997   PMID:22456697   PMID:22560222  
PMID:22688336   PMID:22912850   PMID:23049845   PMID:23478411   PMID:23560040   PMID:23579070   PMID:23615913   PMID:23702782   PMID:23741292   PMID:23775122   PMID:23801577   PMID:23840624  
PMID:23907538   PMID:23940800   PMID:24037094   PMID:24159000   PMID:24177427   PMID:24253047   PMID:24517226   PMID:24567904   PMID:24677713   PMID:24712877   PMID:24760140   PMID:24788416  
PMID:24792588   PMID:24811175   PMID:24874427   PMID:24977713   PMID:25002528   PMID:25277391   PMID:25361392   PMID:25569103   PMID:26022372   PMID:26116826   PMID:26384875   PMID:26628674  
PMID:26657864   PMID:26740601   PMID:26888756   PMID:27013528   PMID:27217487   PMID:27330190   PMID:27457910   PMID:27525648   PMID:27708333   PMID:28003360   PMID:28190325   PMID:28424159  
PMID:28608285   PMID:28630133   PMID:28710407   PMID:28798046   PMID:28833887   PMID:29028997   PMID:29400692   PMID:29610318   PMID:29628894   PMID:29685905   PMID:29728617   PMID:29867232  
PMID:29998910   PMID:30116740   PMID:30367392   PMID:30451856   PMID:30474117   PMID:30532187   PMID:30553769   PMID:30770439   PMID:30858352   PMID:30952933   PMID:31262748   PMID:31306739  
PMID:32015092   PMID:32290105  


Genomics

Comparative Map Data
Irs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,034,681 - 11,058,929 (-)NCBIGRCm39mm39
GRCm38810,984,681 - 11,008,929 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37810,986,961 - 11,008,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv36810,986,933 - 11,008,402 (-)NCBImm8
Celera811,160,160 - 11,181,560 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.35NCBI
IRS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl13109,752,695 - 109,786,583 (-)EnsemblGRCh38hg38GRCh38
GRCh3813109,752,695 - 109,786,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713110,406,184 - 110,438,914 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613109,204,185 - 109,236,915 (-)NCBINCBI36hg18NCBI36
Build 3413109,204,186 - 109,236,915NCBI
Celera1391,250,464 - 91,283,200 (-)NCBI
Cytogenetic Map13q34NCBI
HuRef1391,005,522 - 91,037,072 (-)NCBIHuRef
CHM1_113110,375,378 - 110,407,600 (-)NCBICHM1_1
Irs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Irs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554042,531,484 - 2,555,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,531,484 - 2,555,383 (+)NCBIChiLan1.0ChiLan1.0
IRS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113110,013,214 - 110,044,465 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01390,886,095 - 90,917,724 (-)NCBIMhudiblu_PPA_v0panPan3
IRS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2258,223,387 - 58,227,535 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12258,197,016 - 58,229,026 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Irs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364722,772,187 - 2,796,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1176,626,179 - 76,653,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11176,626,158 - 76,654,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1388,045,439 - 88,076,468 (-)NCBI
Irs2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247932,615,092 - 2,636,835 (+)NCBI

Position Markers
Irs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38811,007,511 - 11,007,906UniSTSGRCm38
MGSCv37811,007,511 - 11,007,906UniSTSGRCm37
Celera811,180,711 - 11,181,106UniSTS
Cytogenetic Map8A1.1UniSTS
cM Map85.0UniSTS
39.MMHAP75FLE6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38810,996,903 - 10,997,066UniSTSGRCm38
MGSCv37810,996,903 - 10,997,066UniSTSGRCm37
Celera811,170,102 - 11,170,265UniSTS
Cytogenetic Map8A1.1UniSTS
Whitehead_YAC8 UniSTS
PMC86565P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38811,005,179 - 11,005,530UniSTSGRCm38
MGSCv37811,005,179 - 11,005,530UniSTSGRCm37
Celera811,178,379 - 11,178,730UniSTS
Cytogenetic Map8A1.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124701082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130397432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131723288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8490000034600000Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8716249923263799Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8716249934642953Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8749417341494326Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8761318541613356Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8761318541613356Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8761318541613356Mouse
14700791Mencq6_mmeniscus calcification QTL 6 (mouse)81097200012150000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:118
Interacting mature miRNAs:121
Transcripts:ENSMUST00000040514
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000040514   ⟹   ENSMUSP00000038514
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)Ensembl
RefSeq Acc Id: NM_001081212   ⟹   NP_001074681
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39811,034,681 - 11,058,929 (-)NCBI
GRCm38810,984,681 - 11,008,929 (-)NCBI
MGSCv37810,986,961 - 11,008,430 (-)RGD
Celera811,160,160 - 11,181,560 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC61743 (Get FASTA)   NCBI Sequence Viewer  
  AAI47581 (Get FASTA)   NCBI Sequence Viewer  
  BAE33160 (Get FASTA)   NCBI Sequence Viewer  
  P81122 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074681   ⟸   NM_001081212
- UniProtKB: P81122 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000038514   ⟸   ENSMUST00000040514
Protein Domains
IRS-type PTB   PH

Promoters
RGD ID:6843337
Promoter ID:MM_KWN:53605
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000040514,   NM_001081212
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36811,004,481 - 11,009,322 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109334 AgrOrtholog
Ensembl Genes ENSMUSG00000038894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000038514 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040514 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRS_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:384783 UniProtKB/Swiss-Prot
MGD MGI:109334 ENTREZGENE
NCBI Gene 384783 ENTREZGENE
PANTHER PTHR10614 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot
PhenoGen Irs2 PhenoGen
PRINTS INSULINRSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot
UniGene Mm.407207 ENTREZGENE
UniProt IRS2_MOUSE UniProtKB/Swiss-Prot
  O88970_MOUSE UniProtKB/TrEMBL
  P81122 ENTREZGENE
  Q3U2I0_MOUSE UniProtKB/TrEMBL
UniProt Secondary B9EJW3 UniProtKB/Swiss-Prot