Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1) Mus musculus
Symbol: Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
RGD ID: 736283
Description: Enables calcidiol 1-monooxygenase activity. Involved in calcitriol biosynthetic process from calciol; response to vitamin D; and vitamin D catabolic process. Acts upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in several structures, including lower jaw molar; metanephros; and testis. Used to study rickets. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1alpha(OH)ase; 25(OH)D 1alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha); 25-hydroxyvitamin D3 1alpha-hydroxylase; 25-OHD-1 alpha-hydroxylase; calcidiol 1-monooxygenase; Cp2; Cp2b; Cyp; Cyp1; Cyp27; Cyp27b; Cyp4; Cyp40; cytochrome p450 27B1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 27b1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450C1 alpha; cytochrome P450VD1-alpha; MGC91184; P450c; P450c1; P450VD1alpha; Pd; Pddr; Vd; VD3 1A hydroxylase; Vdd; Vdd1; Vddr; VddrI; Vdr
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910126,884,115 - 126,891,897 (+)NCBIGRCm39mm39
GRCm39 Ensembl10126,884,119 - 126,888,875 (+)Ensembl
GRCm3810127,048,246 - 127,054,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,485,302 - 126,490,062 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,451,200 - 126,455,955 (+)NCBImm8
Celera10129,440,145 - 129,444,905 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
acrylamide  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
caesium atom  (ISO)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
etoposide  (ISO)
flavonoids  (ISO)
genistein  (ISO)
gentamycin  (ISO)
ketoconazole  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
melphalan  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
oxybenzone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
PD 0325901  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloroethene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vitamin D  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
membrane  (IEA)
mitochondrion  (HDA,IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IEA)
abnormal clavicle morphology  (IEA)
abnormal cranium morphology  (IEA)
abnormal femur morphology  (IAGP)
abnormal fibula morphology  (IEA)
abnormal humerus morphology  (IEA)
abnormal joint morphology  (IEA)
abnormal keratinocyte differentiation  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pelvic girdle bone morphology  (IEA)
abnormal radius morphology  (IEA)
abnormal rib morphology  (IEA)
abnormal scapula morphology  (IEA)
abnormal tibia morphology  (IEA)
abnormal ulna morphology  (IEA)
abnormal vertebrae morphology  (IEA)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent mature ovarian follicles  (IAGP)
anovulation  (IAGP)
decreased body length  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased exploration in new environment  (IEA)
decreased grip strength  (IEA)
decreased leukocyte cell number  (IEA)
decreased locomotor activity  (IEA)
decreased lymphocyte cell number  (IEA)
decreased osteoclast cell number  (IAGP)
decreased T cell number  (IAGP)
decreased total body fat amount  (IEA)
decreased vertical activity  (IEA)
disorganized long bone epiphyseal plate  (IAGP)
endometrium hypoplasia  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged parathyroid gland  (IAGP)
female infertility  (IAGP)
impaired skin barrier function  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IEA)
increased circulating bilirubin level  (IEA)
increased circulating parathyroid hormone level  (IAGP)
increased hemoglobin content  (IEA)
increased long bone epiphyseal plate size  (IAGP)
increased urine phosphate level  (IAGP)
osteomalacia  (IAGP)
postnatal growth retardation  (IAGP)
rickets  (IAGP)
short tibia  (IEA)
slow postnatal weight gain  (IAGP)
small ovary  (IAGP)
small uterus  (IAGP)
thickened long bone epiphysis  (IAGP)

References - curated
# Reference Title Reference Citation
1. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Bailey R, etal., Diabetes. 2007 Oct;56(10):2616-21. Epub 2007 Jul 2.
2. Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice. Borges CC, etal., J Nutr Sci Vitaminol (Tokyo). 2018;64(2):106-115. doi: 10.3177/jnsv.64.106.
3. Metabolism of 25-hydroxyvitamin D in copper-laden rat: a model of Wilson's disease. Carpenter TO, etal., Am J Physiol. 1988 Feb;254(2 Pt 1):E150-4.
4. Role of insulin in the stimulation of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase by phosphorus deprivation in rats. Ikeda K, etal., Metabolism. 1987 Jun;36(6):555-7.
5. Metabolic acidosis suppresses 25-hydroxyvitamin in D3-1alpha-hydroxylase in the rat kidney. Distinct site and mechanism of action. Kawashima H, etal., J Clin Invest. 1982 Jul;70(1):135-40.
6. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. Kitanaka S, etal., N Engl J Med. 1998 Mar 5;338(10):653-61.
7. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. Lange CM, etal., J Hepatol. 2011 May;54(5):887-93. doi: 10.1016/j.jhep.2010.08.036. Epub 2011 Jan 20.
8. The deficiency and the supplementation of vitamin D and liver: Lessons of chronic fructose-rich diet in mice. Maia-Ceciliano TC, etal., J Steroid Biochem Mol Biol. 2019 Sep;192:105399. doi: 10.1016/j.jsbmb.2019.105399. Epub 2019 Jun 5.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
12. Possible mechanism of impaired calcium and vitamin D metabolism in nephrotic rats. Mizokuchi M, etal., Kidney Int. 1992 Aug;42(2):335-40.
13. Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions. Nishikawa M, etal., Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Panda DK, etal., Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7498-503.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms. Ramos-Lopez E, etal., Diabetes Obes Metab. 2008 Aug;10(8):683-5. Epub 2008 May 12.
18. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. Ramos-Lopez E, etal., J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):807-10. Epub 2007 Jan 16.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Effects of repeated administration of rifampicin and isoniazid on vitamin D metabolism in mice. Sheng L, etal., Steroids. 2015 Dec;104:203-7. doi: 10.1016/j.steroids.2015.10.004. Epub 2015 Oct 22.
23. Single-nucleotide polymorphism at CYP27B1-1260, but not VDR Taq I, is possibly associated with persistent hepatitis B virus infection. Zhu Q, etal., Genet Test Mol Biomarkers. 2012 Sep;16(9):1115-21. doi: 10.1089/gtmb.2012.0148.
Additional References at PubMed
PMID:9295274   PMID:9389537   PMID:9465024   PMID:10418998   PMID:10423037   PMID:10832023   PMID:10882104   PMID:11149489   PMID:11415990   PMID:11416036   PMID:11544199   PMID:12205031  
PMID:12477932   PMID:12520522   PMID:12674324   PMID:12674325   PMID:12689675   PMID:12745259   PMID:12865326   PMID:14651853   PMID:14656762   PMID:14657008   PMID:14681479   PMID:14717923  
PMID:14739296   PMID:15102089   PMID:15225794   PMID:15225799   PMID:15643054   PMID:15691891   PMID:15741244   PMID:15769857   PMID:15843402   PMID:15972816   PMID:16371465   PMID:16436465  
PMID:16584176   PMID:17148678   PMID:17254773   PMID:17267208   PMID:17290304   PMID:17400175   PMID:17699549   PMID:18029472   PMID:18313834   PMID:18385669   PMID:18509362   PMID:18535110  
PMID:18614015   PMID:18678710   PMID:18840526   PMID:18845643   PMID:19197242   PMID:19225558   PMID:19261615   PMID:19320717   PMID:19429446   PMID:19477943   PMID:19819968   PMID:19944755  
PMID:20150282   PMID:20193763   PMID:20236619   PMID:20458748   PMID:20651168   PMID:20807842   PMID:20965147   PMID:21191070   PMID:21343672   PMID:21482732   PMID:21791625   PMID:21873635  
PMID:21966280   PMID:22037453   PMID:22572998   PMID:22592802   PMID:22623742   PMID:22640808   PMID:22648952   PMID:23188491   PMID:23385000   PMID:23624390   PMID:23895994   PMID:24019880  
PMID:24140714   PMID:24412515   PMID:24470103   PMID:24509850   PMID:25268137   PMID:25370849   PMID:25576706   PMID:26202309   PMID:26323657   PMID:26441239   PMID:26639637   PMID:26790152  
PMID:26851346   PMID:27074284   PMID:27108944   PMID:27119753   PMID:27535551   PMID:27626380   PMID:28003380   PMID:28025137   PMID:28107527   PMID:28178628   PMID:28686309   PMID:28765041  
PMID:28808057   PMID:29107736   PMID:29109124   PMID:29441580   PMID:29500225   PMID:30578920   PMID:30641101   PMID:30723466   PMID:30809535   PMID:31053643   PMID:31292298   PMID:31636184  
PMID:31880094   PMID:31945466   PMID:32325033   PMID:32736700   PMID:33197428   PMID:33586492   PMID:33965570   PMID:34603779  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910126,884,115 - 126,891,897 (+)NCBIGRCm39mm39
GRCm39 Ensembl10126,884,119 - 126,888,875 (+)Ensembl
GRCm3810127,048,246 - 127,054,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,485,302 - 126,490,062 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,451,200 - 126,455,955 (+)NCBImm8
Celera10129,440,145 - 129,444,905 (+)NCBICelera
Cytogenetic Map10D3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381257,762,334 - 57,767,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,762,334 - 57,768,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,156,117 - 58,160,861 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,442,384 - 56,447,243 (-)NCBINCBI36hg18NCBI36
Build 341256,442,385 - 56,447,151NCBI
Celera1257,813,712 - 57,818,571 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,192,956 - 55,197,815 (-)NCBIHuRef
CHM1_11258,123,921 - 58,128,780 (-)NCBICHM1_1
T2T-CHM13v2.01257,730,683 - 57,735,427 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2762,869,340 - 62,876,242 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl762,871,297 - 62,876,241 (+)Ensembl
Rnor_6.0770,333,150 - 70,340,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,335,061 - 70,340,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,512,763 - 70,517,707 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera760,014,507 - 60,019,451 (+)NCBICelera
Cytogenetic Map7q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554585,472,404 - 5,477,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,472,404 - 5,477,001 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11231,419,773 - 31,424,822 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,419,773 - 31,424,822 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,158,814 - 31,164,462 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1101,825,224 - 1,830,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,826,046 - 1,829,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,888,246 - 1,893,920 (-)NCBI
ROS_Cfam_1.0101,834,457 - 1,840,136 (-)NCBI
ROS_Cfam_1.0 Ensembl101,834,464 - 1,839,154 (-)Ensembl
UMICH_Zoey_3.1101,812,161 - 1,817,832 (-)NCBI
UNSW_CanFamBas_1.0102,054,207 - 2,059,882 (-)NCBI
UU_Cfam_GSD_1.0102,179,134 - 2,184,808 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494556,964,979 - 56,970,660 (+)NCBI
SpeTri2.0NW_0049366461,899,686 - 1,904,104 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl523,050,114 - 23,058,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,053,129 - 23,058,865 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11153,675,704 - 53,681,372 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,675,226 - 53,680,443 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,280,050 - 192,285,176 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480210,176,919 - 10,181,657 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462480210,176,865 - 10,181,725 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,052,440 - 127,052,542UniSTSGRCm38
MGSCv3710126,489,496 - 126,489,598UniSTSGRCm37
Celera10129,444,339 - 129,444,441UniSTS
Cytogenetic Map10D3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,049,092 - 127,049,855UniSTSGRCm38
MGSCv3710126,486,148 - 126,486,911UniSTSGRCm37
Celera10129,440,991 - 129,441,754UniSTS
Cytogenetic Map10D3UniSTS
cM Map10 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,051,080 - 127,051,558UniSTSGRCm38
MGSCv3710126,488,136 - 126,488,614UniSTSGRCm37
Celera10129,442,979 - 129,443,457UniSTS
Cytogenetic Map10D3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,050,313 - 127,051,573UniSTSGRCm38
MGSCv3710126,487,369 - 126,488,629UniSTSGRCm37
Celera10129,442,212 - 129,443,472UniSTS
Cytogenetic Map10D3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D3UniSTS
Cytogenetic Map10B4UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:1403
Count of miRNA genes:579
Interacting mature miRNAs:693
Transcripts:ENSMUST00000165764, ENSMUST00000171868, ENSMUST00000172069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000165764   ⟹   ENSMUSP00000130005
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10126,884,119 - 126,888,838 (+)Ensembl
GRCm38.p6 Ensembl10127,048,250 - 127,052,969 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171868
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10126,884,540 - 126,885,735 (+)Ensembl
GRCm38.p6 Ensembl10127,048,671 - 127,049,866 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172069   ⟹   ENSMUSP00000127367
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10126,884,119 - 126,888,875 (+)Ensembl
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)Ensembl
RefSeq Acc Id: NM_010009   ⟹   NP_034139
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,884,115 - 126,888,875 (+)NCBI
GRCm3810127,048,246 - 127,053,006 (+)NCBI
MGSCv3710126,485,302 - 126,490,062 (+)RGD
Celera10129,440,145 - 129,444,905 (+)RGD
RefSeq Acc Id: XM_006513187   ⟹   XP_006513250
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,884,975 - 126,891,897 (+)NCBI
GRCm3810127,049,104 - 127,054,884 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034139   ⟸   NM_010009
- UniProtKB: O35084 (UniProtKB/Swiss-Prot),   Q66JY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513250   ⟸   XM_006513187
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000127367   ⟸   ENSMUST00000172069
RefSeq Acc Id: ENSMUSP00000130005   ⟸   ENSMUST00000165764

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35084-F1-model_v2 AlphaFold O35084 1-507 view protein structure

RGD ID:6819147
Promoter ID:MM_KWN:5861
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6
Transcripts:UC007HHS.1,   UC007HHT.1
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,485,086 - 126,485,757 (+)MPROMDB
RGD ID:8673454
Promoter ID:EPDNEW_M14758
Type:single initiation site
Description:Mus musculus cytochrome P450, family 27, subfamily b, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,048,239 - 127,048,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098274 AgrOrtholog
Ensembl Genes ENSMUSG00000006724 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000127367.2 UniProtKB/TrEMBL
  ENSMUSP00000130005 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000165764 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000172069.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13115 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp27b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CP27B_MOUSE UniProtKB/Swiss-Prot