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Gene: Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1) Mus musculus
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Symbol: Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
RGD ID: 736283
Description: Exhibits calcidiol 1-monooxygenase activity. Involved in calcium ion transport; response to vitamin D; and vitamin D metabolic process. Localizes to mitochondrion. Is expressed in several structures, including lower jaw molar; metanephros; and testis. Used to study rickets. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; and type 1 diabetes mellitus. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1); PARTICIPATES IN tuberculosis pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1alpha(OH)ase; 25(OH)D 1alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha); 25-hydroxyvitamin D3 1alpha-hydroxylase; 25-OHD-1 alpha-hydroxylase; calcidiol 1-monooxygenase; Cp2; Cp2b; Cyp; Cyp1; Cyp27; Cyp27b; Cyp4; Cyp40; cytochrome p450 27B1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 27b1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450C1 alpha; cytochrome P450VD1-alpha; MGC91184; P450c; P450c1; P450VD1alpha; Pd; Pddr; Vd; VD3 1A hydroxylase; Vdd; Vdd1; Vddr; VddrI; Vdr
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)EnsemblGRCm38mm10GRCm38
GRCm3810127,048,246 - 127,054,884 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,485,302 - 126,490,062 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,451,200 - 126,455,955 (+)NCBImm8
Celera10129,440,145 - 129,444,905 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cyp27b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736283
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.