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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10975
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Acc ID: CHEBI:9334
Term: sulfasalazine
Definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Chemical ID: MESH:D012460
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiadecreases expressionEXP 6480464CTDSulfasalazine results in decreased expression of NFKBIA proteinPMID:20823682
Nfkbiamultiple interactionsEXP 6480464CTDSulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]PMID:16934226 PMID:32272095
Nfkbiadecreases expressionISONFKBIA (Homo sapiens)6480464CTDSulfasalazine results in decreased expression of NFKBIA proteinPMID:11786414
Nfkbiadecreases phosphorylationISONfkbia (Rattus norvegicus)6480464CTDSulfasalazine results in decreased phosphorylation of NFKBIA proteinPMID:19365232
Nfkbiadecreases phosphorylationISONFKBIA (Homo sapiens)6480464CTDSulfasalazine results in decreased phosphorylation of NFKBIA proteinPMID:17051331
Nfkbiaincreases degradationISONFKBIA (Homo sapiens)6480464CTDSulfasalazine results in increased degradation of NFKBIA proteinPMID:15494508
Nfkbiamultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDSulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]PMID:15793857 PMID:22245600
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTDSulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]PMID:9486988
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