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Gene: Hsd3b5 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5) Mus musculus
Symbol: Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Description: Predicted to have 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid binding activity. Involved in response to stilbenoid. Localizes to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Is expressed in several structures, including adrenal gland; gut; liver and biliary system; metanephros; and skeletal muscle. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2); PARTICIPATES IN isoprenoid metabolic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-dexrazoxane; (2,4,5-trichlorophenoxy)acetic acid; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3 beta-hydroxysteroid dehydrogenase type 5; 3 beta-hydroxysteroid dehydrogenase type V; 3(beta)HSDV; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; dihydrotestosterone 3-ketoreductase; hydroxysteroid dehydrogenase-5, delta<5>-3-beta; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; NADPH-dependent 3-keto-steroid reductase Hsd3b5; progesterone reductase
No known orthologs. homologs ...
Related Pseudogenes: Gm12400   Gm19210   Gm19211   Gm9678  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl398,618,634 - 98,630,252 (-)Ensembl
GRCm38398,618,636 - 98,645,534 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37398,422,559 - 98,449,457 (-)NCBIGRCm37mm9NCBIm37
MGSCv36398,747,697 - 98,774,558 (-)NCBImm8
Celera399,955,329 - 99,981,710 (-)NCBICelera
Cytogenetic Map3 F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hsd3b5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553473
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.