Acaa1b (acetyl-Coenzyme A acyltransferase 1B) - Rat Genome Database
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Gene: Acaa1b (acetyl-Coenzyme A acyltransferase 1B) Mus musculus
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Symbol: Acaa1b
Name: acetyl-Coenzyme A acyltransferase 1B
RGD ID: 1621308
MGI Page MGI
Description: Predicted to have acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Localizes to mitochondrion. Is expressed in alimentary system; chondrocranium; ganglia; genitourinary system; and metencephalon basal plate. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN valine, leucine and isoleucine degradation pathway; INTERACTS WITH 1,1-dichloroethene; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; MGC29978; peroxisomal 3-oxoacyl-CoA thiolase B; thiolase B
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,977,111 - 118,986,161 (-)NCBIGRCm39mm39
GRCm389119,148,043 - 119,157,093 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,148,023 - 119,157,093 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,057,161 - 119,066,211 (-)NCBIGRCm37mm9NCBIm37
MGSCv369118,996,741 - 119,005,791 (-)NCBImm8
Celera9119,615,929 - 119,624,979 (-)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
aspartame  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
capecitabine  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
folpet  (EXP)
GW 7647  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (EXP)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
pyrazinecarboxamide  (ISO)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
tacrolimus hydrate  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15043762   PMID:15489334   PMID:15589695   PMID:16141072   PMID:16141073  
PMID:18287559   PMID:18614015   PMID:19334288   PMID:19772884   PMID:21267068   PMID:21352884   PMID:21386911   PMID:21491542   PMID:21873635   PMID:31666509  


Genomics

Comparative Map Data
Acaa1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,977,111 - 118,986,161 (-)NCBIGRCm39mm39
GRCm389119,148,043 - 119,157,093 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,148,023 - 119,157,093 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,057,161 - 119,066,211 (-)NCBIGRCm37mm9NCBIm37
MGSCv369118,996,741 - 119,005,791 (-)NCBImm8
Celera9119,615,929 - 119,624,979 (-)NCBICelera
Cytogenetic Map9F3NCBI
ACAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,103,129 - 38,137,242 (-)EnsemblGRCh38hg38GRCh38
GRCh38338,122,710 - 38,137,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,164,201 - 38,178,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,139,211 - 38,153,619 (-)NCBINCBI36hg18NCBI36
Build 34338,139,210 - 38,153,619NCBI
Celera338,100,002 - 38,114,534 (-)NCBI
Cytogenetic Map3p22.2ENTREZGENE
HuRef338,205,163 - 38,219,695 (-)NCBIHuRef
CHM1_1338,116,181 - 38,130,713 (-)NCBICHM1_1
Acaa1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08127,836,235 - 127,845,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,032,830 - 127,052,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,110,413 - 124,118,950 (-)NCBIRGSC3.4rn4RGSC3.4
Celera8118,033,536 - 118,055,577 (-)NCBICelera
Cytogenetic Map8q32NCBI
ACAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,302,976 - 38,317,009 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0338,020,439 - 38,035,341 (-)NCBIMhudiblu_PPA_v0panPan3
ACAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl237,889,500 - 7,901,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1237,889,481 - 7,901,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ACAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,964,875 - 23,020,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,964,844 - 23,020,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,168,888 - 25,179,542 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,282,556 - 1,297,154 (+)NCBI
ChlSab1.1 Ensembl151,282,650 - 1,297,832 (+)Ensembl
Acaa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,665,228 - 2,677,248 (-)NCBI

Position Markers
Acaa1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map971.33UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:258
Interacting mature miRNAs:275
Transcripts:ENSMUST00000010795, ENSMUST00000127952
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000010795   ⟹   ENSMUSP00000010795
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,148,023 - 119,157,093 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127952
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,149,335 - 119,150,063 (-)Ensembl
RefSeq Acc Id: NM_146230   ⟹   NP_666342
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,977,111 - 118,986,161 (-)NCBI
GRCm389119,148,043 - 119,157,093 (-)ENTREZGENE
MGSCv379119,057,161 - 119,066,211 (-)RGD
Celera9119,615,929 - 119,624,979 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512114   ⟹   XP_006512177
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,977,111 - 118,986,045 (-)NCBI
GRCm389119,148,043 - 119,156,977 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006512116   ⟹   XP_006512179
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,979,318 - 118,986,149 (-)NCBI
GRCm389119,149,797 - 119,157,081 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242970   ⟹   XP_011241272
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,977,111 - 118,985,550 (-)NCBI
GRCm389119,148,043 - 119,156,482 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666342   ⟸   NM_146230
- Peptide Label: precursor
- UniProtKB: Q8VCH0 (UniProtKB/Swiss-Prot),   Q3UKM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512177   ⟸   XM_006512114
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006512179   ⟸   XM_006512116
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011241272   ⟸   XM_011242970
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000010795   ⟸   ENSMUST00000010795
Protein Domains
Thiolase_C   Thiolase_N

Promoters
RGD ID:6844059
Promoter ID:MM_KWN:59117
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000084361
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,059,406 - 119,060,077 (-)MPROMDB
RGD ID:6844056
Promoter ID:MM_KWN:59118
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000084360
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,065,791 - 119,066,291 (-)MPROMDB
RGD ID:8671178
Promoter ID:EPDNEW_M13620
Type:initiation region
Name:Acaa1b_1
Description:Mus musculus acetyl-Coenzyme A acyltransferase 1B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,157,066 - 119,157,126EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3605455 AgrOrtholog
Ensembl Genes ENSMUSG00000010651 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000010795 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000010795 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:235674 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3605455 ENTREZGENE
NCBI Gene 235674 ENTREZGENE
Pfam Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acaa1b PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs AcCoA-C-Actrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.379402 ENTREZGENE
UniProt Q3TUU3_MOUSE UniProtKB/TrEMBL
  Q3UKM0 ENTREZGENE, UniProtKB/TrEMBL
  Q8VCH0 ENTREZGENE, UniProtKB/Swiss-Prot