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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:9334
Term: sulfasalazine
Definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Chemical ID: MESH:D012460
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases activityISOHIF1A (Homo sapiens)6480464CTDSulfasalazine results in increased activity of HIF1A proteinPMID:19502547
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDSulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]PMID:12808024
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