Tdo2 (tryptophan 2,3-dioxygenase) - Rat Genome Database

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Gene: Tdo2 (tryptophan 2,3-dioxygenase) Mus musculus
Analyze
Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
RGD ID: 68532
MGI Page MGI
Description: Predicted to enable several functions, including heme binding activity; identical protein binding activity; and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Is expressed in cerebellum; liver; male reproductive gland or organ; and small intestine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; INTERACTS WITH (5-hydroxyindol-3-yl)acetic acid; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AA407491; chky; T; TD; TDO; tdo variant1; tdo variant2; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-2,3-dioxygenase; tryptophanase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,865,719 - 81,883,035 (-)NCBIGRCm39mm39
GRCm39 Ensembl381,864,397 - 81,883,509 (-)Ensembl
GRCm38381,958,412 - 81,975,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,957,090 - 81,976,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,762,334 - 81,779,650 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,044,339 - 82,061,655 (-)NCBImm8
Celera381,983,687 - 82,001,014 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(5-hydroxyindol-3-yl)acetic acid  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
680C91  (EXP)
acetamide  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP,ISO)
allopurinol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
andrographolide  (EXP)
anthranilic acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
buspirone  (ISO)
buta-1,3-diene  (EXP)
caffeine  (ISO)
carbaryl  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
corticosterone  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dimethoate  (EXP)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
ferroheme b  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fumonisin B1  (EXP)
genistein  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
heme b  (ISO)
Heptachlor epoxide  (EXP)
kynurenine  (EXP)
L-tryptophan  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (ISO)
nitroglycerin  (ISO)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
pyridine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP)
tolmetin  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
XL147  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7679723   PMID:10205167   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12147685   PMID:12466851   PMID:12477932   PMID:14681479   PMID:14714090  
PMID:15581617   PMID:16141072   PMID:16141073   PMID:16707424   PMID:16934000   PMID:19185577   PMID:19323847   PMID:19428689   PMID:20815922   PMID:20959529   PMID:21267068   PMID:21873635  
PMID:22308364   PMID:23786539   PMID:24190896   PMID:24194600   PMID:24844751   PMID:25035993   PMID:25917818   PMID:27316339   PMID:27392942   PMID:27592202   PMID:28117398   PMID:28223212  
PMID:28285122   PMID:28465467   PMID:30106261   PMID:30733279   PMID:31726186   PMID:33363543  


Genomics

Comparative Map Data
Tdo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,865,719 - 81,883,035 (-)NCBIGRCm39mm39
GRCm39 Ensembl381,864,397 - 81,883,509 (-)Ensembl
GRCm38381,958,412 - 81,975,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,957,090 - 81,976,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,762,334 - 81,779,650 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,044,339 - 82,061,655 (-)NCBImm8
Celera381,983,687 - 82,001,014 (-)NCBICelera
Cytogenetic Map3E3NCBI
TDO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4155,854,738 - 155,920,406 (+)EnsemblGRCh38hg38GRCh38
GRCh384155,903,696 - 155,920,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374156,824,848 - 156,841,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,044,297 - 157,061,000 (+)NCBINCBI36hg18NCBI36
Build 344157,182,451 - 157,199,155NCBI
Celera4154,156,425 - 154,173,133 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,563,673 - 152,580,472 (+)NCBIHuRef
CHM1_14156,802,468 - 156,819,210 (+)NCBICHM1_1
Tdo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22167,269,581 - 167,287,511 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2167,269,579 - 167,287,511 (-)Ensembl
Rnor_6.02180,897,059 - 180,914,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,897,011 - 180,914,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,305,349 - 200,323,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,594,020 - 173,611,833 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,544,125 - 173,561,939 (-)NCBI
Celera2161,299,362 - 161,317,278 (-)NCBICelera
RH 3.4 Map21078.8RGD
Cytogenetic Map2q34NCBI
Tdo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,229,273 - 11,245,375 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,229,795 - 11,245,255 (-)NCBIChiLan1.0ChiLan1.0
TDO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14160,085,840 - 160,102,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,085,645 - 160,102,266 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,269,097 - 148,285,533 (+)NCBIMhudiblu_PPA_v0panPan3
TDO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,406,110 - 53,424,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,405,957 - 53,423,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,741,684 - 53,760,577 (+)NCBI
ROS_Cfam_1.01554,113,213 - 54,132,114 (+)NCBI
UMICH_Zoey_3.11553,366,630 - 53,385,412 (+)NCBI
UNSW_CanFamBas_1.01553,475,754 - 53,494,647 (+)NCBI
UU_Cfam_GSD_1.01553,790,005 - 53,808,893 (+)NCBI
Tdo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530136,991,004 - 37,015,635 (-)NCBI
SpeTri2.0NW_0049365762,537,702 - 2,555,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,708,746 - 44,740,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,708,722 - 44,725,954 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,704,213 - 46,721,456 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TDO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,467,075 - 102,485,434 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl7102,467,640 - 102,485,394 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603782,125,379 - 82,143,064 (+)NCBIVero_WHO_p1.0
Tdo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248482,380,827 - 2,395,807 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AI194855  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,961,095 - 81,961,214UniSTSGRCm38
MGSCv37381,765,017 - 81,765,136UniSTSGRCm37
Celera381,986,373 - 81,986,492UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3792.22UniSTS
RH124606  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,958,511 - 81,958,627UniSTSGRCm38
MGSCv37381,762,433 - 81,762,549UniSTSGRCm37
Celera381,983,786 - 81,983,902UniSTS
Cytogenetic Map3E3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4945016083450160Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34958758483587697Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34958758483587697Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35271817686718412Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35271817686718412Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35271817686718412Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35301585087015850Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:641
Count of miRNA genes:410
Interacting mature miRNAs:482
Transcripts:ENSMUST00000029645, ENSMUST00000137974, ENSMUST00000151089
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029645   ⟹   ENSMUSP00000029645
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl381,864,397 - 81,883,509 (-)Ensembl
GRCm38.p6 Ensembl381,957,090 - 81,976,202 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137974
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl381,868,340 - 81,871,342 (-)Ensembl
GRCm38.p6 Ensembl381,961,033 - 81,964,035 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151089
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl381,866,031 - 81,871,390 (-)Ensembl
GRCm38.p6 Ensembl381,958,724 - 81,964,083 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193879   ⟹   ENSMUSP00000141237
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl381,866,098 - 81,883,509 (-)Ensembl
GRCm38.p6 Ensembl381,958,791 - 81,976,202 (-)Ensembl
RefSeq Acc Id: NM_019911   ⟹   NP_064295
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39381,865,719 - 81,883,035 (-)NCBI
GRCm38381,958,412 - 81,975,728 (-)ENTREZGENE
MGSCv37381,762,334 - 81,779,650 (-)RGD
Celera381,983,687 - 82,001,014 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064295   ⟸   NM_019911
- UniProtKB: P48776 (UniProtKB/Swiss-Prot),   Q8VCW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000029645   ⟸   ENSMUST00000029645
RefSeq Acc Id: ENSMUSP00000141237   ⟸   ENSMUST00000193879

Promoters
RGD ID:6834535
Promoter ID:MM_KWN:34667
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000055915,   OTTMUST00000055916
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36381,767,591 - 81,768,842 (-)MPROMDB
RGD ID:6834532
Promoter ID:MM_KWN:34668
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000055914
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36381,779,391 - 81,779,891 (-)MPROMDB
RGD ID:6880954
Promoter ID:EPDNEW_M3928
Type:multiple initiation site
Name:Tdo2_1
Description:Mus musculus tryptophan 2,3-dioxygenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38381,975,751 - 81,975,811EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928486 AgrOrtholog
Ensembl Genes ENSMUSG00000028011 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029645 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141237 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029645 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000193879 UniProtKB/TrEMBL
InterPro Trp/Indoleamine_2_3_dOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp_2_3_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1928486 ENTREZGENE
NCBI Gene 56720 ENTREZGENE
PANTHER PTHR10138 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trp_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tdo2 PhenoGen
Superfamily-SCOP SSF140959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C5NSA7_MOUSE UniProtKB/TrEMBL
  P48776 ENTREZGENE
  Q8VCW3 ENTREZGENE, UniProtKB/TrEMBL
  T23O_MOUSE UniProtKB/Swiss-Prot