| 1310455 | Tox | thymocyte selection-associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell lineage commitment (ortholog); CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (ortholog); CD8-positive, alpha-beta T cell lineage commitment (ortholog); FOUND I N nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 5 | 24672487 | 24968754 | Rat | 136 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321364 | Tox | thymocyte selection-associated high mobility group box | Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; cerebral cortex neuron differentiation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differ entiation; and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 6686353 | 6991557 | Mouse | 156 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605410 | TOX | thymocyte selection associated high mobility group box | The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009] | 8 | 58805412 | 59119147 | Human | 138 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8875362 | Tox | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell lineage commitment (ortholog); CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (ortholog); CD8-positive, alpha-beta T cell lineage commitment (ortholog); FOUND I N nucleus (ortholog) | NW_004955444 | 19453789 | 19796419 | Chinchilla | 18 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11857055 | TOX | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN lymph node development (ortholog); lymphocyte differentiation (ortholog); Peyer's patch development (ortholog); FOUND IN nucleus (inferred) | 8 | 55246933 | 55553839 | Bonobo | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12310262 | TOX | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN lymph node development (ortholog); lymphocyte differentiation (ortholog); Peyer's patch development (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH masitinib | 29 | 9542471 | 9841759 | Dog | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12587467 | Tox | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN lymph node development (ortholog); lymphocyte differentiation (ortholog); Peyer's patch development (ortholog); FOUND IN nucleus (inferred) | NW_004936496 | 13847210 | 14146110 | Squirrel | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14043408 | TOX | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN lymph node development (ortholog); lymphocyte differentiation (ortholog); Peyer's patch development (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18582030 | TOX | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN lymph node development (ortholog); lymphocyte differentiation (ortholog); Peyer's patch development (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18920297 | Tox | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN CD4-positive, alpha-beta T cell lineage commitment (ortholog); CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (ortholog); CD8-positive, alpha-beta T cell lineage commit ment (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155255684 | tox | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625960103 | Tox | thymocyte selection associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell lineage commitment (ortholog); CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (ortholog); CD8-positive, alpha-beta T cell lineage commitment (ortholog); FOUND I N nucleus (ortholog) | | | | Black Rat | 18 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155245313 | tox.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856362 | tox.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861727 | tox.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863857 | tox.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865193 | tox.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469261 | tox.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16550807 | TOX-DT | TOX divergent transcript | | 8 | 59119210 | 59123478 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1619629 | Rhox8 | reproductive homeobox 8 | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | X | 36963657 | 36979643 | Mouse | 29 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1550105 | Duox1 | dual oxidase 1 | Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within reactive oxygen species metabolic process. Located in plasma membrane. Is expressed in brain; placenta; and thyroid gland. Orthologous to human DUOX1 (dual oxidase 1). [provided by Alliance of Genome Resou rces, Apr 2025] | 2 | 122143525 | 122178454 | Mouse | 174 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332300 | Duox2 | dual oxidase 2 | Predicted to enable NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including bone mineralization; endocrine system development; and thyroid hormone metabolic process. Predicted to be located in several cellular components, including cell leading edge; cell surface; and endoplasmic reticulum. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in placenta and thyroid gland. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 122109727 | 122129221 | Mouse | 212 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1353863 | DUOX2 | dual oxidase 2 | The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide gen erating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008] | 15 | 45092650 | 45114172 | Human | 378 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735184 | Tox2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity (ortholog); INVOLVED IN female gonad development; positive regulation of transcription by RNA polymerase II; response to gonadotropin; FOUND IN nucleoplasm (ortholo g); INTERACTS WITH 4,4'-sulfonyldiphenol; alpha-Zearalanol; atrazine | 3 | 172272718 | 172400235 | Rat | 91 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1350992 | TOX2 | TOX high mobility group box family member 2 | Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 43914852 | 44069616 | Human | 91 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1625908 | Tox2 | TOX high mobility group box family member 2 | Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Pre dicted to be active in nucleus. Is expressed in several structures, including genitourinary system; lens epithelium; notochord; retina; and spleen. Orthologous to human TOX2 (TOX high mobility group box family member 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 163045047 | 163166092 | Mouse | 100 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8949032 | Tox2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotrop in (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955445 | 13210606 | 13343344 | Chinchilla | 8 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11779807 | TOX2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotropin (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 20 | 40242893 | 40400054 | Bonobo | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12394764 | TOX2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotropin (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 24 | 31523323 | 31656361 | Dog | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12461344 | Tox2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotropin (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | NW_004936530 | 2646783 | 2774162 | Squirrel | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14196737 | TOX2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotropin (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18693898 | TOX2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotropin (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18912865 | Tox2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotrop in (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626108112 | Tox2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN female gonad development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to gonadotrop in (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 8 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1311529 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling; positive regulation of DNA-templated transcription; negative regulation of neuron apoptotic process (ortholog); ASSOC IATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 19 | 32820957 | 32929776 | Rat | 137 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1323035 | TOX3 | TOX high mobility group box family member 3 | The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been impl icated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] | 16 | 52436416 | 52547802 | Human | 128 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1551816 | Tox3 | TOX high mobility group box family member 3 | Predicted to enable chromatin DNA binding activity; phosphoprotein binding activity; and protein homodimerization activity. Predicted to be involved in calcium-mediated signaling; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicte d to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and sensory organ. Orthologous to human TOX3 (TOX high mobility group box family member 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 90973665 | 91075746 | Mouse | 141 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8919179 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); negative regulation of neuron apoptotic process (ortholog); positive regulation of DNA-templated transcrip tion (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | NW_004955433 | 10328886 | 10426540 | Chinchilla | 19 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11840435 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wit hout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 16 | 32690290 | 32800974 | Bonobo | 26 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12278448 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); phosphoprotein binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wi thout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 2 | 62981706 | 63087519 | Dog | 26 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12579737 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wit hout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936475 | 5283615 | 5388104 | Squirrel | 26 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14259469 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); phosphoprotein binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wi thout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 26 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18397076 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wit hout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 26 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18908580 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); negative regulation of neuron apoptotic process (ortholog); positive regulation of DNA-templated transcrip tion (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 26 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 708449 | Tox4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcription elongation by RNA polymerase II (ortholog); RNA polymerase II promoter clearance (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); PTW/PP1 phosphatase complex (ortholog); INTERACTS WITH (+)-schisandrin B; ammonium chloride; bisphenol A | 15 | 27462735 | 27476320 | Rat | 87 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1350277 | TOX4 | TOX high mobility group box family member 4 | Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin and chromosome, telomeric region. Part of PTW/PP1 phosphatase complex. [provided by Alliance of Genome Resources, Apr 2025] | 14 | 21477195 | 21499170 | Human | 82 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1553718 | Tox4 | TOX high mobility group box family member 4 | Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, tel omeric region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 52516603 | 52532966 | Mouse | 92 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8916132 | Tox4 | TOX high mobility group box family member 4 | INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcription elongation by RNA polymerase II (ortholog); RNA polymerase II promoter clearance (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); PTW/PP1 phosph atase complex (ortholog) | NW_004955550 | 2195710 | 2209729 | Chinchilla | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11690053 | TOX4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN regulation of transcription elongation by RNA polymerase II (ortholog); FOUND IN chromatin (ortholog) | 14 | 2294892 | 2316901 | Bonobo | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12184978 | TOX4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcription elongation by RNA polymerase II (ortholog); RNA polymerase II promoter clearance (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); PTW/PP1 phosphatase complex (ortholog) | 15 | 18512270 | 18528293 | Dog | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12723269 | Tox4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); regulation of transcription elongation by RNA polymerase II (inferred); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | NW_004936880 | 628316 | 646006 | Squirrel | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14086244 | TOX4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcription elongation by RNA polymerase II (ortholog); RNA polymerase II promoter clearance (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); PTW/PP1 phosphatase complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 22 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18406824 | TOX4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); regulation of transcription elongation by RNA polymerase II (inferred); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | | | | Green Monkey | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18916616 | Tox4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); regulation of transcription elongation by RNA polymerase II (inferred); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | | | | Naked Mole-Rat | 21 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626103209 | Tox4 | TOX high mobility group box family member 4 | INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcription elongation by RNA polymerase II (ortholog); RNA polymerase II promoter clearance (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); PTW/PP1 phosph atase complex (ortholog) | | | | Black Rat | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12234199 | LOC100684441 | TOX high mobility group box family member 4-like | | 4 | 43476630 | 43478869 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12235208 | LOC100688303 | TOX high mobility group box family member 4-like | | 38 | 6082923 | 6085059 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11906044 | LOC100979454 | TOX high mobility group box family member 4-like | | 4 | 104945274 | 104949947 | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 12598755 | LOC101969313 | TOX high mobility group box family member 4-like | | NW_004936585 | 1021774 | 1023580 | Squirrel | | name | gene, pseudo, MODEL [RefSeq] |
| 18398505 | LOC103236134 | TOX high mobility group box family member 4-like | | | | | Green Monkey | | name | gene, protein-coding, MODEL [RefSeq] |
| 626022065 | LOC116889873 | TOX high mobility group box family member 4-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1585613 | Tox3l1 | TOX high mobility group box family member 3 like 1 | | 2 | 155710403 | 155742735 | Rat | | symbol , PhenoGen , name | gene, ncrna, VALIDATED [RefSeq] |
| 13922572 | LOC106508025 | TOX high mobility group box family member 4 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 6484053 | TOX4P1 | TOX high mobility group box family member 4 pseudogene 1 | | 4 | 112455857 | 112457986 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 41057908 | Tox4-ps1 | TOX high mobility group box family member 4, pseudogene 1 | | 7 | 102517681 | 102592288 | Rat | | symbol , old_gene_name , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 14268729 | DUOX2 | dual oxidase 2 | ENCODES a protein that exhibits calcium ion binding (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN adenohypophysis morphogenesis (ortholog); bone mineralization (ortholog); cuticle development (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATE D WITH cholera (ortholog); congenital hypothyroidism (ortholog); Crohn's disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); cell leading edge (ortholog); INTERACTS WITH 3',5'-cyclic AMP; ammonia; copper(II) sulfate | | | | Pig | 69 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155240187 | tox2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155251021 | tox3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155237240 | tox4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155240186 | tox2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245941 | tox2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251022 | tox3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235039 | tox3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237241 | tox4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254471 | tox4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1316162 | ANTXR1 | ANTXR cell adhesion molecule 1 | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative age nt of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] | 2 | 69013144 | 69249327 | Human | 310 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 736060 | GSTM1 | glutathione S-transferase mu 1 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encod es a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] | 1 | 109687817 | 109693745 | Human | 979 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1349768 | GSTM3 | glutathione S-transferase mu 3 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encod es a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] | 1 | 109733937 | 109741038 | Human | 446 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737133 | GSTA2 | glutathione S-transferase alpha 2 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental tox ght:700;'>toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008] | 6 | 52750087 | 52763475 | Human | 337 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735264 | GSTM2 | glutathione S-transferase mu 2 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encod es a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008] | 1 | 109668057 | 109683997 | Human | 496 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606334 | GSTM4 | glutathione S-transferase mu 4 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encod es a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008] | 1 | 109656099 | 109667727 | Human | 213 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1343128 | GSTM5 | glutathione S-transferase mu 5 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encod es a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008] | 1 | 109711751 | 109718268 | Human | 105 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 2771 | Gucy2c | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity; toxic substance binding; INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); PARTICIPATES IN purine metaboli c pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate | 4 | 171299715 | 171380296 | Rat | 117 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9004229 | Gucy2c | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog) | NW_004955413 | 11410586 | 11489201 | Chinchilla | 18 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12041700 | GUCY2C | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred) | 12 | 14608794 | 14687190 | Bonobo | 37 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12253149 | GUCY2C | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred) | 27 | 31915552 | 31989748 | Dog | 34 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12647578 | Gucy2c | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred) | NW_004936587 | 2742911 | 2811139 | Squirrel | 37 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 18376672 | GUCY2C | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 37 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 18917398 | Gucy2c | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 37 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 625844338 | Gucy2c | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATE D WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog) | | | | Black Rat | 18 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 69489 | UGT2A1 | UDP glucuronosyltransferase family 2 member A1 complex locus | The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022] | 4 | 69588417 | 69653247 | Human | 84 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1601678 | UGT2A2 | UDP glucuronosyltransferase family 2 member A2 | The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A1 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022] | 4 | 69588417 | 69639642 | Human | 27 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316163 | Antxr1 | anthrax toxin receptor 1 | Predicted to enable actin filament binding activity; collagen binding activity; and transmembrane signaling receptor activity. Acts upstream of or within blood vessel development; negative regulation of extracellular matrix assembly; and positive regulation of metallopeptidase activity. Predicted to be located in external side of plasma membrane; filopodium membrane; and lamellipodium membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; chondrocranium; costal cartilage; immune system; and liver. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to human ANTXR1 (ANTXR cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 87110835 | 87312757 | Mouse | 229 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1620775 | Antxr2 | anthrax toxin receptor 2 | Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within collagen fibril organization; single fertilization; and uterus development. Located in external side of plasma membrane. Is expressed in cerebral cortex and retina. Human ortholog(s) of this gene implicated in fibroma and hyaline fibromatosis syndrome. Orthologous to human ANTXR2 (ANTXR cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 98032547 | 98178876 | Mouse | 181 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1558486 | Antxrl | anthrax toxin receptor-like | Predicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in testis. Orthologous to human ANTXRL (ANTXR like). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 33774625 | 33798280 | Mouse | 19 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 12001049 | LOC100969124 | anthrax toxin receptor-like | | 10 | 43269844 | 44029825 | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 8874890 | LOC102018009 | anthrax toxin receptor-like | | NW_004955510 | 6344262 | 6376039 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 12294892 | LOC102154920 | anthrax toxin receptor-like | | 4 | 34928988 | 34954358 | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 18350205 | LOC103215817 | anthrax toxin receptor-like | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); FOUND IN cell surface (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 8 | name | gene, protein-coding, MODEL [RefSeq] |
| 18348778 | LOC103215853 | anthrax toxin receptor-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 625881771 | LOC116914936 | anthrax toxin receptor-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 124923054 | LOC120885656 | anthrax toxin receptor-like | | | | | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 125073373 | LOC120885724 | anthrax toxin receptor-like | | | | | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 124996868 | LOC120885726 | anthrax toxin receptor-like | | | | | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 12552622 | LOC101967932 | multidrug and toxin extrusion protein 1 | ENCODES a protein that exhibits antiporter activity (inferred); L-amino acid transmembrane transporter activity (inferred); L-arginine transmembrane transporter activity (inferred); INVOLVED IN amino acid import across plasma membrane (inferred); L-alpha-amino acid transmembrane transport (inferred) ; L-arginine import across plasma membrane (inferred); FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); membrane (inferred) | NW_004936881 | 222722 | 260719 | Squirrel | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 9040720 | LOC102027057 | multidrug and toxin extrusion protein 1 | | NW_004955467 | 238300 | 282495 | Chinchilla | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14079623 | LOC102157639 | multidrug and toxin extrusion protein 2 | ENCODES a protein that exhibits antiporter activity (inferred); polyspecific organic cation:proton antiporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN organic cation transport (inferred); proton transmembrane transport (inferred); transmembrane transport (infer red); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Pig | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 11730902 | LOC100989777 | ras-related C3 botulinum toxin substrate 1 | | 6 | 141918410 | 141919483 | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 40918639 | LOC119881459 | ras-related C3 botulinum toxin substrate 1 | ENCODES a protein that exhibits GTP binding (ortholog); Rho GDP-dissociation inhibitor binding (ortholog); INVOLVED IN actin filament organization (ortholog); cell motility (ortholog); neuron migration (ortholog); FOUND IN cytosol (ortholog); lamellipodium (ortholog); membrane (ortholog) | | | | Dog | 52 | name | gene, protein-coding, MODEL [RefSeq] |
| 18920941 | LOC101710685 | multidrug and toxin extrusion protein 2-like | ENCODES a protein that exhibits antiporter activity (inferred); xenobiotic transmembrane transporter activity (inferred); INVOLVED IN transmembrane transport (inferred); xenobiotic detoxification by transmembrane export across the plasma membrane (inferred); FOU ND IN membrane (inferred) | | | | Naked Mole-Rat | 8 | name , description | gene, protein-coding, MODEL [RefSeq] |
| 12470337 | LOC101970809 | multidrug and toxin extrusion protein 2-like | ENCODES a protein that exhibits antiporter activity (inferred); polyspecific organic cation:proton antiporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN organic cation transport (inferred); proton transmembrane transport (inferred); transmembrane transport (infer red); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936881 | 168930 | 221399 | Squirrel | 13 | name | gene, protein-coding, MODEL [RefSeq] |
| 8733954 | LOC102028395 | multidrug and toxin extrusion protein 2-like | | NW_004955467 | 177210 | 239747 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 12345326 | LOC100684677 | ras-related C3 botulinum toxin substrate 1-like | | 12 | 52995491 | 52997808 | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 11700628 | LOC100972350 | ras-related C3 botulinum toxin substrate 1-like | | 4 | 99709299 | 99709937 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11787637 | LOC100985182 | ras-related C3 botulinum toxin substrate 1-like | | X | 126569979 | 126570487 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11838581 | LOC100986696 | ras-related C3 botulinum toxin substrate 1-like | | 6 | 83757671 | 83759345 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11671162 | LOC100994316 | ras-related C3 botulinum toxin substrate 1-like | | 13 | 22497209 | 22501268 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12628210 | LOC101967586 | ras-related C3 botulinum toxin substrate 1-like | | NW_004936580 | 840194 | 840823 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 8841865 | LOC102028043 | ras-related C3 botulinum toxin substrate 1-like | | NW_004955402 | 34576757 | 34577472 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 18913651 | LOC110348115 | ras-related C3 botulinum toxin substrate 1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 14007439 | LOC100155636 | ras-related C3 botulinum toxin substrate 1 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 18908787 | LOC101697356 | ras-related C3 botulinum toxin substrate 1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18931244 | LOC101715473 | ras-related C3 botulinum toxin substrate 1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18742241 | LOC103214527 | ras-related C3 botulinum toxin substrate 1 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18415227 | LOC103236704 | ras-related C3 botulinum toxin substrate 1 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 598133321 | LOC140710737 | ras-related C3 botulinum toxin substrate 1 pseudogene | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 1620238 | Rpl15-ps2 | ribosomal protein L15, pseudogene 2 | INTERACTS WITH perfluorohexanesulfonic acid; T-2 toxin | 9 | 71967843 | 71968902 | Mouse | 2 | description | gene, pseudo, INFERRED [RefSeq] |
| 10217 | Atp7b | ATPase, copper transporting, beta polypeptide | Enables P-type divalent copper transporter activity. Acts upstream of or within several processes, including copper ion transport; intracellular monoatomic cation homeostasis; and lactation. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 22482799 | 22550347 | Mouse | 447 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8968861 | Tmem181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (ortholog) | NW_004955439 | 3843823 | 3914702 | Chinchilla | 1 | description | gene, protein-coding, MODEL [RefSeq] |
| 625900030 | Tmem181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (ortholog) | | | | Black Rat | 1 | description | gene, protein-coding, MODEL [RefSeq] |
| 16554465 | AL590762.1 | pseudogene similar to part of ras-related C3 botulinum toxin substrate | | | | | Human | | name | gene, processed_pseudogene |
| 1307144 | Antxr1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (ortholog); collagen binding (ortholog); signaling receptor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); ASSOCI ATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); filopodium membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 4 | 121148102 | 121335549 | Rat | 196 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8863341 | Antxr1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (ortholog); collagen binding (ortholog); signaling receptor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); ASSOCI ATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); filopodium membrane (ortholog) | NW_004955424 | 15820734 | 16034278 | Chinchilla | 33 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11823702 | ANTXR1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (inferred); collagen binding (inferred); metal ion binding (inferred); INVOLVED IN blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); positive regulation of metallopeptidase activity (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); filopodium membrane (inferred) | 2A | 69054253 | 69290554 | Bonobo | 43 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12130638 | ANTXR1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (inferred); collagen binding (inferred); metal ion binding (inferred); INVOLVED IN blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); positive regulation of metallopeptidase activity (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); filopodium membrane (inferred) | 10 | 67829573 | 68021368 | Dog | 41 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12735765 | Antxr1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (inferred); collagen binding (inferred); metal ion binding (inferred); INVOLVED IN blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); positive regulation of metallopeptidase activity (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); filopodium membrane (inferred) | NW_004936491 | 13288986 | 13516878 | Squirrel | 43 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14171072 | ANTXR1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (inferred); collagen binding (inferred); metal ion binding (inferred); INVOLVED IN blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); positive regulation of metallopeptidase activity (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); filopodium membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18355693 | ANTXR1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (inferred); collagen binding (inferred); metal ion binding (inferred); INVOLVED IN blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); positive regulation of metallopeptidase activity (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); filopodium membrane (inferred) | | | | Green Monkey | 43 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18909029 | Antxr1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (ortholog); collagen binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-c loacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN external side of plasma membrane (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626091785 | Antxr1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (ortholog); collagen binding (ortholog); signaling receptor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); ASSOCI ATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); filopodium membrane (ortholog) | | | | Black Rat | 33 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1346318 | ANTXR2 | ANTXR cell adhesion molecule 2 | This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multi ple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] | 4 | 79901146 | 80073472 | Human | 291 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1561294 | Antxr2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH anthrax disease; ankylosing spondylitis (ortholog); congenital my opathy 1A (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 14 | 11845774 | 11986166 | Rat | 162 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8962295 | Antxr2 | ANTXR cell adhesion molecule 2 | INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); congenital myopathy 1A (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (o rtholog); membrane (ortholog) | NW_004955433 | 4212729 | 4345611 | Chinchilla | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11773787 | ANTXR2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); congenital myopathy 1A (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred) | 4 | 44124282 | 44284949 | Bonobo | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12219630 | ANTXR2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); co ngenital myopathy 1A (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred); INTERACTS WITH bisphenol A | 32 | 4143407 | 4302194 | Dog | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12491606 | Antxr2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); congenital myopathy 1A (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred) | NW_004936749 | 1936307 | 2014452 | Squirrel | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13921097 | ANTXR2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); co ngenital myopathy 1A (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred) | | | | Pig | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18616759 | ANTXR2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); congenital myopathy 1A (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred) | | | | Green Monkey | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18926002 | Antxr2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); congenital myopathy 1A (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 33 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625909345 | Antxr2 | ANTXR cell adhesion molecule 2 | INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH ankylosing spondylitis (ortholog); anthrax disease (ortholog); congenital myopathy 1A (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (o rtholog); membrane (ortholog) | | | | Black Rat | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1344271 | TNFRSF19 | TNF receptor superfamily member 19 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducin g apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] | 13 | 23570412 | 23676093 | Human | 182 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1558479 | Tnfrsf19 | tumor necrosis factor receptor superfamily, member 19 | Predicted to enable signaling receptor activity. Acts upstream of or within hair follicle development and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, in cluding alimentary system; brain; embryo mesenchyme; integumental system; and respiratory system. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 61201283 | 61284304 | Mouse | 193 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2526 | Hbegf | heparin-binding EGF-like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity; heparin binding (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; negative regulation of glycoprotein biosynthetic process; positive regulation of cell growth; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; ASSOCIATED WITH acute kidney failure; Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol | 18 | 28380337 | 28390220 | Rat | 413 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552258 | Hbegf | heparin-binding EGF-like growth factor | Enables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, spreading of epidermal cells. Acts upstr eam of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; heart; submandibular gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 36637980 | 36648858 | Mouse | 486 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 13847461 | HBEGF | heparin binding EGF like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); negative regulation of glycoprotein biosynthetic process (ortholog); positive regulation of cell growth ( ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred); INTERACTS WITH bis(2-chloroethyl) sulfide; molybdenum atom; resveratrol | | | | Pig | 66 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1602061 | ANTXRL | ANTXR like | Predicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 46286092 | 46330129 | Human | 19 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8983348 | Antxrl | ANTXR like | | NW_004955510 | 6297209 | 6343033 | Chinchilla | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12009118 | ANTXRL | ANTXR like | | 10 | 43928771 | 43971522 | Bonobo | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12331496 | ANTXRL | ANTXR like | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred) | 4 | 34885718 | 34916651 | Dog | 8 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13844137 | ANTXRL | ANTXR like | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred) | | | | Pig | 8 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626137773 | Antxrl | ANTXR like | | | | | Black Rat | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1563190 | Antxrl1 | ANTXR like 1 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred); INTERACTS WITH atrazine; bisphenol A; 1,2-dimethylhydrazine (ortholog) | 16 | 9369046 | 9393569 | Rat | 19 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 6500283 | Antxrl2 | ANTXR like 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred) | 16 | 9306293 | 9338559 | Rat | 7 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1596785 | Antxrl3 | ANTXR like 3 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred) | 16 | 9337985 | 9364423 | Rat | 7 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 9644912 | Gm30083 | predicted gene, 30083 | Predicted to enable transmembrane signaling receptor activity. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 33710374 | 33738860 | Mouse | 7 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 13184668 | LOC110598553 | ANTXR like | | NW_004936554 | 7472740 | 7489155 | Squirrel | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1310963 | Nlrp1a | NLR family, pyrin domain containing 1A | ENCODES a protein that exhibits scaffold protein binding; ATP binding (ortholog); ATP hydrolysis activity (ortholog); INVOLVED IN negative regulation of cellular defense response; positive regulation of pyroptotic inflammatory response; antiviral innate immune response (ortholog); PARTICIPATES IN in terleukin-1 signaling pathway; NOD-like receptor signaling pathway; ASSOCIATED WITH Autoinflammation with Arthritis and Dyskeratosis (ortholog); genetic disease (ortholog); Multiple Self-healing Palmoplantar Carcinoma (ortholog); FOUND IN neuronal cell body; protein-containing complex; canonical inflammasome complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 56277134 | 56332229 | Rat | 176 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605371 | SLC47A1 | solute carrier family 47 member 1 | This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008] | 17 | 19533854 | 19579034 | Human | 282 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1603576 | SLC47A2 | solute carrier family 47 member 2 | This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and tox -weight:700;'>toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] | 17 | 19678317 | 19718979 | Human | 133 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 731977 | Cflar | CASP8 and FADD-like apoptosis regulator | Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; negative regulation of necroptotic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 58750353 | 58798043 | Mouse | 476 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1347509 | CFLAR | CASP8 and FADD like apoptosis regulator | The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011] | 2 | 201116164 | 201176687 | Human | 451 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 736529 | Gucy2c | guanylate cyclase 2c | Enables guanylate cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in alim entary system; liver; and spinal cord. Used to study abdominal obesity-metabolic syndrome and obesity. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 136674282 | 136758740 | Mouse | 136 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 708448 | Phax | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits toxic substance binding; mRNA cap binding complex binding (ortholog); INVOLVED IN RNA stabilization (ortholog); snRNA export from nucleus (ortholog); PARTICIPATES IN RNA transport pathway; ASSOCIATED WITH Hirschsprung's disease (o rtholog); FOUND IN neuronal cell body; cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ammonium chloride | 18 | 52251231 | 52267916 | Rat | 84 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736057 | PROK1 | prokineticin 1 | The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011] | 1 | 110451149 | 110457358 | Human | 74 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 731800 | Kif1c | kinesin family member 1C | Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; hindbrain meni nges; submandibular gland primordium; telencephalon; and vibrissa. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 70591170 | 70622796 | Mouse | 108 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1352320 | DPH1 | diphthamide biosynthesis 1 | The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotox style='font-weight:700;'>toxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016] | 17 | 2030112 | 2043898 | Human | 153 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1557600 | Dph1 | diphthamide biosynthesis 1 | Enables 2-(3-amino-3-carboxypropyl)histidine synthase activity. Involved in protein histidyl modification to diphthamide. Acts upstream of or within fibroblast proliferation. Part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Is expressed in several structures, including gonad; gut; hemo lymphoid system gland; liver; and lung. Used to study Miller-Dieker lissencephaly syndrome and diphthamide deficiency syndrome 1. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 1. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 75068469 | 75081309 | Mouse | 143 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1304634 | Dph2 | diphthamide biosynthesis 2 | ENCODES a protein that exhibits 2-(3-amino-3-carboxypropyl)histidine synthase activity (ortholog); 4 iron, 4 sulfur cluster binding (ortholog); INVOLVED IN protein histidyl modification to diphthamide (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); diphthamide deficiency syndrome (ortholog); diphthamide deficiency syndrome 2 (ortholog); FOUND IN 2-(3-amino-3-carboxypropyl)histidine synthase complex (ortholog); cytosol (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cobalt dichloride | 5 | 136713868 | 136716828 | Rat | 90 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312184 | DPH2 | diphthamide biosynthesis 2 | This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] | 1 | 43970010 | 43973369 | Human | 156 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1623210 | Dph2 | DPH2 homolog | Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Is expressed in l iver lobe. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 2. Orthologous to human DPH2 (diphthamide biosynthesis 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 117745838 | 117749220 | Mouse | 92 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 732106 | Fadd | Fas associated via death domain | Enables signaling adaptor activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; and regulation of apoptotic process. Acts upstream of or wit hin several processes, including extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and negative regulation of necroptotic process. Predicted to be located in cell body; cytosol; and plasma membrane. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in immunodeficiency 90 and leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 144132060 | 144136178 | Mouse | 504 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1345195 | FADD | Fas associated via death domain | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-rece ptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] | 11 | 70203296 | 70207390 | Human | 461 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 12218713 | ALDH3A2 | aldehyde dehydrogenase 3 family member A2 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); long-chain fatty aldehyde dehydrogenase (NAD+) activity (ortholog); long-chain-alcohol oxidase activity (ortholog); INVOLVED IN central nervous system development (ortholog); epidermis development (ortholog); f ormaldehyde metabolic process (ortholog); PARTICIPATES IN phytanic acid degradation pathway; Refsum disease pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); Sjogren-Larsson syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); peroxisome (ortholog) | 5 | 40515768 | 40641377 | Dog | 53 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1311123 | Slc47a1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity; polyspecific organic cation:proton antiporter activity; xenobiotic transmembrane transporter activity; INVOLVED IN monoatomic cation transmembrane transport; monoatomic cation transport; organic cation transport; PARTICIPATES IN cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN plasma membrane; vesicle; apical plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; alpha-Zearalanol | 10 | 46533580 | 46590128 | Rat | 310 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322414 | Slc47a1 | solute carrier family 47, member 1 | Enables polyspecific organic cation:proton antiporter activity. Involved in monoatomic cation transmembrane transport and xenobiotic transmembrane transport. Located in plasma membrane. Is expressed in several structures, including liver; lung; metanephros; nervous system; and spleen. Orthologous to several human genes including SLC47A1 (solute carrier family 47 member 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 61234226 | 61269668 | Mouse | 312 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 11890627 | SLC47A1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity (ortholog); xenobiotic transmembrane transporter activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (ortholog); monoatomic cation transport (ortholog); organic cation transport (ortholog); PARTICIPATES I N cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN vesicle (ortholog) | 17 | 31532821 | 31577523 | Bonobo | 42 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12305715 | SLC47A1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity (ortholog); xenobiotic transmembrane transporter activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (ortholog); monoatomic cation transport (ortholog); organic cation transport (ortholog); PARTICIPATES I N cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN vesicle (ortholog); INTERACTS WITH hexaconazole; penconazole; tebuconazole | 5 | 40643420 | 40679130 | Dog | 50 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18373041 | SLC47A1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity (ortholog); xenobiotic transmembrane transporter activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (ortholog); monoatomic cation transport (ortholog); organic cation transport (ortholog); PARTICIPATES I N cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN vesicle (ortholog) | | | | Green Monkey | 41 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18933280 | Slc47a1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity (ortholog); L-amino acid transmembrane transporter activity (ortholog); L-arginine transmembrane transporter activity (ortholog); INVOLVED IN amino acid import across plasma membrane (ortholog); L-alpha-amino acid transmembrane transport (ortholog); L-arginine import across plasma membrane (ortholog); PARTICIPATES IN cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 41 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1562382 | Slc47a2 | solute carrier family 47 member 2 | ENCODES a protein that exhibits antiporter activity (ortholog); polyspecific organic cation:proton antiporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic cation transport (ortholog); PARTICIPATES IN metformin pharmacokinetics pathway; FOUND IN plasma membr ane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon | 10 | 46490262 | 46532954 | Rat | 133 | old_gene_name | gene, protein-coding, INFERRED [RefSeq] |
| 1614799 | Slc47a2 | solute carrier family 47, member 2 | Enables organic cation transmembrane transporter activity and polyspecific organic cation:proton antiporter activity. Involved in organic cation transport. Located in plasma membrane. Is expressed in Harderian gland; esophagus; male reproductive gland or organ; and skin. Orthologous to human SLC47A1 (solute carrier family 47 member 1) and SLC47A2 (solute carrier family 47 member 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 61192453 | 61233686 | Mouse | 143 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11977069 | SLC47A2 | solute carrier family 47 member 2 | ENCODES a protein that exhibits antiporter activity (inferred); polyspecific organic cation:proton antiporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN organic cation transport (inferred); proton transmembrane transport (inferred); transmembrane transport (infer red); PARTICIPATES IN metformin pharmacokinetics pathway; FOUND IN membrane (inferred); plasma membrane (inferred) | 17 | 31412990 | 31454667 | Bonobo | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12342201 | SLC47A2 | solute carrier family 47 member 2 | ENCODES a protein that exhibits antiporter activity (inferred); polyspecific organic cation:proton antiporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN organic cation transport (inferred); proton transmembrane transport (inferred); transmembrane transport (infer red); PARTICIPATES IN metformin pharmacokinetics pathway; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH hexaconazole; penconazole; tebuconazole | 5 | 40491306 | 40515430 | Dog | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14081181 | SLC47A2 | solute carrier family 47 member 2 | ENCODES a protein that exhibits antiporter activity (inferred); polyspecific organic cation:proton antiporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN organic cation transport (inferred); proton transmembrane transport (inferred); transmembrane transport (infer red); PARTICIPATES IN metformin pharmacokinetics pathway; FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Pig | 16 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18525966 | SLC47A2 | solute carrier family 47 member 2 | ENCODES a protein that exhibits antiporter activity (inferred); polyspecific organic cation:proton antiporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN organic cation transport (inferred); proton transmembrane transport (inferred); transmembrane transport (infer red); PARTICIPATES IN metformin pharmacokinetics pathway; FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 7206882 | ANTXRLP1 | ANTXR like pseudogene 1 | INTERACTS WITH benzo[a]pyrene | 10 | 46219025 | 46269608 | Human | 1 | old_gene_name | gene, pseudo, VALIDATED [RefSeq] |
| 1614240 | Kti12 | KTI12 homolog, chromatin associated | Predicted to enable ATP binding activity. Predicted to be involved in tRNA wobble uridine modification. Is expressed in several structures, including adrenal gland; brain; genitourinary system; heart; and stomach. Orthologous to human KTI12 (KTI12 chromatin associated homolog). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 108705054 | 108706609 | Mouse | 51 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8937083 | Abtb2 | ankyrin repeat and BTB domain containing 2 | INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955422 | 11913334 | 12082421 | Chinchilla | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 626002334 | Abtb2 | ankyrin repeat and BTB domain containing 2 | INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 619755 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding; GTP binding; GTPase activity; INVOLVED IN actin cytoskeleton organization; actin filament organization; bone resorption; PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics path way; ASSOCIATED WITH congestive heart failure; Left Ventricular Hypertrophy; autosomal dominant intellectual developmental disorder 48 (ortholog); FOUND IN cytosol; GABA-ergic synapse; Golgi membrane; INTERACTS WITH 11-deoxycorticosterone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 16150411 | 16170864 | Rat | 639 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553531 | Rac1 | Rac family small GTPase 1 | Enables G protein activity; GTP binding activity; and GTP-dependent protein binding activity. Involved in several processes, including nervous system development; positive regulation of protein localization; and regulation of cell migration. Acts upstream of or within several processes, including ac tin filament polymerization; generation of neurons; and regulation of intracellular signal transduction. Located in several cellular components, including kinocilium; pericentriolar material; and ruffle membrane. Is active in glutamatergic synapse; synaptic membrane; and synaptic vesicle membrane. Is expressed in several structures, including early conceptus; eye; genitourinary system; nervous system; and organ of Corti. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 143491236 | 143513786 | Mouse | 839 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605432 | RAC1 | Rac family small GTPase 1 | The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases . Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] | 7 | 6374527 | 6403967 | Human | 794 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 8796556 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); G protein activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN actin filament (ortholog); cell cortex (ortholog); cell projection (ortholog) | NW_004955460 | 13270159 | 13295562 | Chinchilla | 315 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11945782 | RAC1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); G protein activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN actin filament (ortholog); cell cortex (ortholog); cell projection (ortholog) | 7 | 7039379 | 7068866 | Bonobo | 316 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12420176 | RAC1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathwa y; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN actin filament (ortholog); cell cortex (ortholog); cell projection (ortholog) | 6 | 11726259 | 11758532 | Dog | 251 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12587615 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathw ay; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog); GABA-ergic synapse (ortholog); Golgi membrane (ortholog) | NW_004936750 | 107689 | 122679 | Squirrel | 305 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13845955 | RAC1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathw ay; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog); GABA-ergic synapse (ortholog); Golgi membrane (ortholog); INTERACTS WITH cyclosporin A | | | | Pig | 322 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18498455 | RAC1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathw ay; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (ortholog); GABA-ergic synapse (ortholog); Golgi membrane (ortholog) | | | | Green Monkey | 305 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18911839 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); G protein activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN actin filament (ortholog); cell cortex (ortholog); cell projection (ortholog) | | | | Naked Mole-Rat | 316 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626157857 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); G protein activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN actin filament (ortholog); cell cortex (ortholog); cell projection (ortholog) | | | | Black Rat | 315 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1307568 | Rac2 | Rac family small GTPase 2 | ENCODES a protein that exhibits GTP binding (ortholog); GTPase activity (ortholog); protein kinase regulator activity (ortholog); INVOLVED IN actin cytoskeleton organization; bone resorption; actin filament organization (ortholog); PARTICIPATES IN B cell receptor signaling pathway; ceramide signalin g pathway; chemokine mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Periodontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 111981825 | 112009201 | Rat | 274 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316839 | RAC2 | Rac family small GTPase 2 | This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013] | 22 | 37225270 | 37244269 | Human | 332 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1316840 | Rac2 | Rac family small GTPase 2 | Enables GTPase activity and protein kinase regulator activity. Involved in several processes, including positive regulation of lamellipodium assembly; regulation of leukocyte chemotaxis; and regulation of mast cell degranulation. Acts upstream of or within several processes, including cell projectio n assembly; erythrocyte enucleation; and positive regulation of mast cell proliferation. Located in cytoplasm; membrane; and nuclear envelope. Is expressed in heart; maxilla; palatal shelf; and secondary palate. Used to study immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 78443369 | 78456983 | Mouse | 321 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8827041 | Rac2 | Rac family small GTPase 2 | ENCODES a protein that exhibits GTP binding (ortholog); GTPase activity (ortholog); protein kinase regulator activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); bone resorption (ortholog); ASSOCIATED WITH acute myeloid leukemia (orthol og); Chronic Periodontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955413 | 23697504 | 23710668 | Chinchilla | 58 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11819903 | RAC2 | Rac family small GTPase 2 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); bone resorption (ortholog); cell projection assembly (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Perio dontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (inferred); cytoplasm (inferred); cytosol (inferred) | 22 | 18138517 | 18159023 | Bonobo | 63 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12399152 | RAC2 | Rac family small GTPase 2 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); bone resorption (ortholog); cell projection assembly (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Perio dontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (inferred); cytoplasm (inferred); cytosol (inferred) | 10 | 27295597 | 27311864 | Dog | 78 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12527617 | Rac2 | Rac family small GTPase 2 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); bone resorption (ortholog); cell projection assembly (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Perio dontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936492 | 3726375 | 3737961 | Squirrel | 63 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13843581 | RAC2 | Rac family small GTPase 2 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); bone resorption (ortholog); cell projection assembly (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Perio dontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 79 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18503077 | RAC2 | Rac family small GTPase 2 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); bone resorption (ortholog); cell projection assembly (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Perio dontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 63 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18932031 | Rac2 | Rac family small GTPase 2 | ENCODES a protein that exhibits protein kinase regulator activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); bone resorption (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Periodontitis (ortholog); Disease Progr ession (ortholog); FOUND IN actin filament (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 63 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1344542 | RAC3 | Rac family small GTPase 3 | The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] | 17 | 82031678 | 82034204 | Human | 258 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1590052 | Rac3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); cerebral cortex GABAergic interneuron development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN growth cone; cell periphery (ortholog); endomembrane system (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol | 10 | 106501133 | 106503569 | Rat | 158 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1620652 | Rac3 | Rac family small GTPase 3 | Predicted to enable several functions, including GTP binding activity; GTPase activity; and calcium-dependent protein binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including GABAergic synaptic transmission; neuron development; and reg ulation of neuron maturation. Is active in glutamatergic synapse and postsynapse. Is expressed in brain and genitourinary system. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 120612294 | 120614795 | Mouse | 191 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8845126 | Rac3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); cerebral cortex GABAergic interneuron development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cell periphery (ortholog); endomembrane system (ortholog); filamentous actin (ortholog) | NW_004955506 | 1139098 | 1142443 | Chinchilla | 40 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11781046 | RAC3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); cerebral cortex GABAergic interneuron development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carci noma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cell periphery (ortholog); endomembrane system (ortholog); filamentous actin (ortholog) | 17 | 76436264 | 76439492 | Bonobo | 49 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12184933 | RAC3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (inferred); G protein activity (inferred); GTP binding (inferred); INVOLVED IN cerebral cortex GABAergic interneuron development (ortholog); homeostasis of number of cells within a tissue (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN growth cone (ortholog) | 9 | 293260 | 295990 | Dog | 61 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12506362 | Rac3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (inferred); G protein activity (inferred); GTP binding (inferred); INVOLVED IN cerebral cortex GABAergic interneuron development (ortholog); homeostasis of number of cells within a tissue (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN growth cone (ortholog) | NW_004936594 | 5527788 | 5530694 | Squirrel | 46 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14167989 | RAC3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (inferred); G protein activity (inferred); GTP binding (inferred); INVOLVED IN cerebral cortex GABAergic interneuron development (ortholog); homeostasis of number of cells within a tissue (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN growth cone (ortholog) | | | | Pig | 62 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18624700 | RAC3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (inferred); G protein activity (inferred); GTP binding (inferred); INVOLVED IN cerebral cortex GABAergic interneuron development (ortholog); homeostasis of number of cells within a tissue (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN growth cone (ortholog) | | | | Green Monkey | 46 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18918380 | Rac3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); cerebral cortex GABAergic interneuron development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carci noma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cell periphery (ortholog); endomembrane system (ortholog); filamentous actin (ortholog) | | | | Naked Mole-Rat | 46 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625959112 | Rac3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); cerebral cortex GABAergic interneuron development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cell periphery (ortholog); endomembrane system (ortholog); filamentous actin (ortholog) | | | | Black Rat | 40 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13848125 | SLC47A1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity (ortholog); xenobiotic transmembrane transporter activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (ortholog); monoatomic cation transport (ortholog); organic cation transport (ortholog); PARTICIPATES I N cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN vesicle (ortholog); INTERACTS WITH ammonia; deoxynivalenol | | | | Pig | 47 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1312119 | ART1 | ADP-ribosyltransferase 1 | ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile e nterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008] | 11 | 3645128 | 3664416 | Human | 53 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312120 | Art1 | ADP-ribosyltransferase 1 | Enables NAD+ poly-ADP-ribosyltransferase activity. Located in cell surface and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human ART1 (ADP-ribosyltransferase 1). [provided by Alliance of Genome Resour ces, Jul 2025] | 7 | 101750913 | 101771410 | Mouse | 60 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 11210 | Art2a | ADP-ribosyltransferase 2a | Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. Orthologous to human ART2P (ADP-ribosyltransferase 2, pseudogene). [provided by Alliance of Genome Resources , Apr 2025] | 7 | 101201657 | 101210072 | Mouse | 24 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 3521 | Art2b | ADP-ribosyltransferase 2b | ENCODES a protein that exhibits hydrolase activity, acting on glycosyl bonds (ortholog); NAD+-protein-arginine ADP-ribosyltransferase activity (ortholog); INVOLVED IN NAD+ catabolic process (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione | 1 | 165368623 | 165386280 | Rat | 32 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553246 | Art2b | ADP-ribosyltransferase 2b | Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. Orthologous to human ART2BP (ADP-ribosyltransferase 2B, pseudogene). [provided by Alliance of Genome Resourc es, Apr 2025] | 7 | 101224936 | 101234790 | Mouse | 60 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1320437 | ART3 | ADP-ribosyltransferase 3 (inactive) | This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] | 4 | 76011190 | 76112786 | Human | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1320438 | Art3 | ADP-ribosyltransferase 3 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in 1-cell stage embryo; 2-cell stage embryo; facial ganglion; glossopharyngeal ganglion; and vestibulo-cochlear ganglion. Orthologous to human ART3 (ADP-ribosy ltransferase 3 (inactive)). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 92479659 | 92562487 | Mouse | 108 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1315084 | ART4 | ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) | This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosp hatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008] | 12 | 14825569 | 14843526 | Human | 83 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1315085 | Art4 | ADP-ribosyltransferase 4 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; integumental system; liver; and sensory organ. Orthologous to human ART4 (ADP-rib osyltransferase 4 (inactive) (Dombrock blood group)). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 136825449 | 136834598 | Mouse | 85 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 628834 | Art5 | ADP-ribosyltransferase 5 | ENCODES a protein that exhibits NAD+ nucleosidase activity (ortholog); NAD+-protein-arginine ADP-ribosyltransferase activity (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 1 | 165885344 | 165895306 | Rat | 60 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1347628 | ART5 | ADP-ribosyltransferase 5 | The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] | 11 | 3638512 | 3642379 | Human | 57 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1550298 | Art5 | ADP-ribosyltransferase 5 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including heart; limb; male reproductive system; nose; and skeletal musculature. Orthologous to human ART5 (ADP-ribosyltransferase 5). [pro vided by Alliance of Genome Resources, Jul 2025] | 7 | 101746086 | 101752052 | Mouse | 62 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2053 | Parp1 | poly (ADP-ribose) polymerase 1 | ENCODES a protein that exhibits enzyme binding; histone deacetylase binding; NAD binding; INVOLVED IN carbohydrate biosynthetic process; cellular response to amyloid-beta; cellular response to nerve growth factor stimulus; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; base ex cision repair pathway; ASSOCIATED WITH Binge Drinking; borna disease; Carotid Artery Injuries; FOUND IN nucleus; chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (-)-anisomycin | 13 | 94839484 | 94871295 | Rat | 2342 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345118 | PARP1 | poly(ADP-ribose) polymerase 1 | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] | 1 | 226360691 | 226408093 | Human | 2337 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1551988 | Parp1 | poly (ADP-ribose) polymerase family, member 1 | Enables chromatin binding activity and pentosyltransferase activity. Involved in several processes, including decidualization; negative regulation of adipose tissue development; and negative regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and regulation of macromolecule metabolic process. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is active in chromatin; nucleus; and site of DNA damage. Is expressed in several structures, including brain; gonad; hemolymphoid system; intestine; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 180396456 | 180428564 | Mouse | 2367 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1344897 | PARP14 | poly(ADP-ribose) polymerase family member 14 | This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016 ] | 3 | 122680839 | 122730840 | Human | 184 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1613887 | Parp14 | poly (ADP-ribose) polymerase family, member 14 | Enables NAD+ poly-ADP-ribosyltransferase activity. Involved in NAD catabolic process; negative regulation of type II interferon-mediated signaling pathway; and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in hemolymphoid system; intestine; and u rogenital sinus. Orthologous to human PARP14 (poly(ADP-ribose) polymerase family member 14). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 35652262 | 35691904 | Mouse | 195 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1353381 | PARP15 | poly(ADP-ribose) polymerase family member 15 | Enables NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and protein poly-ADP-ribosylation. Predicted to be active in cytoplasm and nucleus. Biomarker of atherosclerosis. [provided by Al liance of Genome Resources, Jul 2025] | 3 | 122577650 | 122639047 | Human | 42 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1553525 | Parp2 | poly (ADP-ribose) polymerase family, member 2 | Enables NAD+ poly-ADP-ribosyltransferase activity. Involved in decidualization. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 51045347 | 51058758 | Mouse | 208 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1602134 | PARP2 | poly(ADP-ribose) polymerase 2 | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding doma in which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] | 14 | 20343635 | 20357904 | Human | 163 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1550140 | Parp3 | poly (ADP-ribose) polymerase family, member 3 | Predicted to enable pentosyltransferase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Is expressed in primordial germ cell of gonad. Orthologous to human PARP3 (poly(ADP-ribose) polymeras e family member 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 106347521 | 106354148 | Mouse | 138 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1604647 | PARP3 | poly(ADP-ribose) polymerase family member 3 | The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 3 | 51942363 | 51948867 | Human | 126 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1553510 | Parp4 | poly (ADP-ribose) polymerase family, member 4 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Predicted to be involved in inflammatory response and protein modification process. Predicted to be located in cytosol; nucleoplasm; and spindle microtubule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 56812982 | 56897256 | Mouse | 105 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1606845 | PARP4 | poly(ADP-ribose) polymerase family member 4 | This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-termina l catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008] | 13 | 24420931 | 24512778 | Human | 101 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1347584 | PARP9 | poly(ADP-ribose) polymerase family member 9 | Enables several functions, including ADP-D-ribose binding activity; STAT family protein binding activity; and pentosyltransferase activity. Involved in several processes, including DNA damage checkpoint signaling; regulation of defense response; and regulation of macromolecule metabolic process. Loc ated in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025] | 3 | 122527924 | 122564784 | Human | 180 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1552550 | Parp9 | poly (ADP-ribose) polymerase family, member 9 | Predicted to enable several functions, including ADP-D-ribose binding activity; STAT family protein binding activity; and pentosyltransferase activity. Involved in positive regulation of type II interferon-mediated signaling pathway. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; hemolymphoid system; nasal cavity; and urinary system. Orthologous to human PARP9 (poly(ADP-ribose) polymerase family member 9). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 35759360 | 35792975 | Mouse | 206 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1322405 | RAET1E | retinoic acid early transcript 1E | This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rathe r than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] | 6 | 149883179 | 149898113 | Human | 79 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 12034311 | TMEM181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (inferred); FOUND IN membrane (inferred) | 6 | 156431076 | 156529012 | Bonobo | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 12136668 | TMEM181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (inferred); FOUND IN membrane (inferred) | 1 | 47969247 | 48058207 | Dog | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 12572471 | Tmem181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (inferred); FOUND IN membrane (inferred) | NW_004936489 | 10275739 | 10328102 | Squirrel | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 13874777 | TMEM181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (inferred); FOUND IN membrane (inferred) | | | | Pig | 7 | description | gene, protein-coding, MODEL [RefSeq] |
| 18391920 | TMEM181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (inferred); FOUND IN membrane (inferred) | | | | Green Monkey | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 18925007 | Tmem181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (inferred); FOUND IN membrane (inferred) | | | | Naked Mole-Rat | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 1318757 | Tnks | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organizati on. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and oocyte. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 35296333 | 35432844 | Mouse | 217 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1343497 | TNKS | tankyrase | Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Acts upstream of or with in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 9555912 | 9782346 | Human | 167 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1312811 | TNKS2 | tankyrase 2 | Enables NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere main tenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 91798426 | 91865475 | Human | 145 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1552096 | Tnks2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. P redicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; eye; and genitourinary system. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 36811583 | 36870877 | Mouse | 147 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1550720 | Adgrl1 | adhesion G protein-coupled receptor L1 | Predicted to enable cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in growth cone and synapse. Predicted to be active in axon; glutamatergic synapse; and presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 84626598 | 84668583 | Mouse | 164 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348193 | PARP10 | poly(ADP-ribose) polymerase family member 10 | Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008] | 8 | 143977158 | 144012764 | Human | 115 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2311830 | Parp10 | poly (ADP-ribose) polymerase family, member 10 | Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; pentosyltransferase activity; and transcription corepressor activity. Predicted to be involved in several processes, including post-translational protein modification; regulatio n of macromolecule metabolic process; and translesion synthesis. Predicted to be located in Golgi apparatus; cytosol; and nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human PARP10 (poly(ADP-ribose) polymerase family member 10). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 76117195 | 76127640 | Mouse | 122 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1344916 | PARP11 | poly(ADP-ribose) polymerase family member 11 | Enables NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 3808861 | 3873399 | Human | 82 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1557039 | Parp11 | poly (ADP-ribose) polymerase family, member 11 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Acts upstream of or within nuclear envelope organization. Predicted to be located in cytosol; nuclear body; and nuclear envelope. Predicted to be part of nuclear pore. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; reproductive system; and thymus. Orthologous to human PARP11 (poly(ADP-ribose) polymerase family member 11). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 127423803 | 127491200 | Mouse | 100 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1318511 | PARP12 | poly(ADP-ribose) polymerase family member 12 | Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 140023749 | 140062951 | Human | 117 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1551043 | Parp12 | poly (ADP-ribose) polymerase family, member 12 | Predicted to enable NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. Is expressed in early conceptus; gallbladder; genitourinary system; and gut. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 39063346 | 39095283 | Mouse | 132 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1306243 | Parp16 | poly (ADP-ribose) polymerase family, member 16 | ENCODES a protein that exhibits kinase binding (ortholog); NAD+ poly-ADP-ribosyltransferase activity (ortholog); NAD+-protein mono-ADP-ribosyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); endoplasmic reticulum unfolded protein response (orth olog); IRE1-mediated unfolded protein response (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum tubular network (ortholog); nuclear envelope (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 74626399 | 74644610 | Rat | 123 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1350046 | PARP16 | poly(ADP-ribose) polymerase family member 16 | Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in IRE1-mediated unfolded protein response; negative regulation of cytoplasmic translation; and protein auto-ADP-ribosylation. Located in endoplasmic reticulum tubular netw ork and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 65230917 | 65286883 | Human | 109 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1551462 | Parp16 | poly (ADP-ribose) polymerase family, member 16 | Predicted to enable kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic retic ulum tubular network and nuclear envelope. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human PARP16 (poly(ADP-ribose) polymerase family member 16). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 65121918 | 65146502 | Mouse | 123 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1344996 | PARP6 | poly(ADP-ribose) polymerase family member 6 | Enables NAD+-protein-aspartate ADP-ribosyltransferase activity and NAD+-protein-cysteine ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 20 25] | 15 | 72241181 | 72272554 | Human | 78 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1553819 | Parp6 | poly (ADP-ribose) polymerase family, member 6 | Predicted to enable kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; positive regulation of dendrite morphogenesis; and protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Is expressed in nervous system and sensory organ. Orthologous to human PARP6 (poly(ADP-ribose) polymerase family member 6). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 59524473 | 59557573 | Mouse | 87 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1350347 | PARP8 | poly(ADP-ribose) polymerase family member 8 | Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 50665931 | 50846519 | Human | 99 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1550781 | Parp8 | poly (ADP-ribose) polymerase family, member 8 | Predicted to enable kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular ne twork and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PARP8 (poly(ADP-ribose) polymerase family member 8). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 116987378 | 117162549 | Mouse | 105 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1314636 | TIPARP | TCDD inducible poly(ADP-ribose) polymerase | This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by Ref Seq, May 2010] | 3 | 156674590 | 156706770 | Human | 268 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1314637 | Tiparp | TCDD-inducible poly(ADP-ribose) polymerase | Enables NAD+ poly-ADP-ribosyltransferase activity. Acts upstream of or within several processes, including face morphogenesis; steroid metabolic process; and vasculogenesis. Predicted to be active in nucleus. Is expressed in bladder; reproductive system; telencephalon; and tongue. Orthologous to hum an TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 65435868 | 65462939 | Mouse | 329 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628694 | Zc3hav1 | zinc finger CCCH-type containing, antiviral 1 | ENCODES a protein that exhibits identical protein binding; RNA binding; NAD+ binding (ortholog); INVOLVED IN cellular response to virus; negative regulation of viral genome replication; positive regulation of mRNA catabolic process; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylatio n; FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 4 | 67979055 | 68029353 | Rat | 162 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 736106 | ZC3HAV1 | zinc finger CCCH-type containing, antiviral 1 | This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Eb ola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021] | 7 | 139043515 | 139109720 | Human | 155 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 736107 | Zc3hav1 | zinc finger CCCH type, antiviral 1 | Predicted to enable DEAD/H-box RNA helicase binding activity; RNA binding activity; and identical protein binding activity. Acts upstream of or within cellular response to exogenous dsRNA and positive regulation of type I interferon production. Predicted to be located in cytosol. Predicted to be act ive in nucleus. Is expressed in early conceptus; liver lobe; meninges; oocyte; and thymus primordium. Orthologous to human ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 38282221 | 38332859 | Mouse | 174 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 16552360 | AL450338.1 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) pseudogene | | 6 | 85868944 | 85869499 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 621583 | A4galt | alpha 1,4-galactosyltransferase | ENCODES a protein that exhibits galactosyltransferase activity; lactosylceramide 4-alpha-galactosyltransferase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN globoside biosynthetic process (ortholog); plasma membrane organization (ortholog) ; PARTICIPATES IN globoside metabolic pathway; ASSOCIATED WITH Burkitt lymphoma (ortholog); Caffey disease (ortholog); NOR POLYAGGLUTINATION SYNDROME (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate | 7 | 116248571 | 116272917 | Rat | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9052103 | A4galt | alpha 1,4-galactosyltransferase (P1PK blood group) | ENCODES a protein that exhibits galactosyltransferase activity (ortholog); lactosylceramide 4-alpha-galactosyltransferase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN globoside biosynthetic process (ortholog); plasma membrane organization (ortholog); ASSOCIATED WITH Burkitt lymphoma (ortholog); Caffey disease (ortholog); NOR POLYAGGLUTINATION SYNDROME (ortholog); FOUND IN membrane (ortholog) | NW_004955413 | 28018363 | 28038359 | Chinchilla | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12606647 | A4galt | alpha 1,4-galactosyltransferase (P1PK blood group) | ENCODES a protein that exhibits galactosyltransferase activity (ortholog); lactosylceramide 4-alpha-galactosyltransferase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN globoside biosynthetic process (ortholog); plasma membrane organization (ortholog); ASSOCIATED WITH Burkitt lymphoma (ortholog); Caffey disease (ortholog); NOR POLYAGGLUTINATION SYNDROME (ortholog); FOUND IN membrane (ortholog) | NW_004936718 | 594462 | 630926 | Squirrel | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 18932756 | A4galt | alpha 1,4-galactosyltransferase (P1PK blood group) | ENCODES a protein that exhibits galactosyltransferase activity (ortholog); lactosylceramide 4-alpha-galactosyltransferase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN globoside biosynthetic process (ortholog); plasma membrane organization (ortholog); ASSOCIATED WITH Burkitt lymphoma (ortholog); Caffey disease (ortholog); NOR POLYAGGLUTINATION SYNDROME (ortholog); FOUND IN membrane (ortholog) | | | | Naked Mole-Rat | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 626131239 | A4galt | alpha 1,4-galactosyltransferase (P1PK blood group) | ENCODES a protein that exhibits galactosyltransferase activity (ortholog); lactosylceramide 4-alpha-galactosyltransferase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN globoside biosynthetic process (ortholog); plasma membrane organization (ortholog); ASSOCIATED WITH Burkitt lymphoma (ortholog); Caffey disease (ortholog); NOR POLYAGGLUTINATION SYNDROME (ortholog); FOUND IN membrane (ortholog) | | | | Black Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12063362 | ABCB1 | ATP binding cassette subfamily B member 1 | ENCODES a protein that exhibits transmembrane transporter activity (ortholog); INVOLVED IN adult heart development (ortholog); aldosterone secretion (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN axitinib pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; cl opidogrel pharmacokinetics pathway; ASSOCIATED WITH toxic encephalopathy; acquired immunodeficiency syndrome (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); brush border membrane (ortholog); INTERACTS WITH 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; allicin; digoxin | 14 | 13644891 | 13852829 | Dog | 331 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 10919 | Abcc1 | ATP-binding cassette, sub-family C member 1 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, G CN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011] | 16 | 14179317 | 14292743 | Mouse | 921 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620724 | Abtb2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitro toluene | 3 | 110409672 | 110563488 | Rat | 118 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 733617 | ABTB2 | ankyrin repeat and BTB domain containing 2 | Predicted to enable protein heterodimerization activity. Predicted to act upstream of or within cellular response to toxic substance. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 34150987 | 34358010 | Human | 117 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551708 | Abtb2 | ankyrin repeat and BTB domain containing 2 | Predicted to enable protein heterodimerization activity. Acts upstream of or within cellular response to toxic substance. Is expressed in several structures, including central nervous system; hindlimb long bone; limb segment; respiratory system cartilage; and se nsory organ. Orthologous to human ABTB2 (ankyrin repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 103396655 | 103548768 | Mouse | 123 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11999817 | ABTB2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (inferred) | 11 | 34127668 | 34335680 | Bonobo | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 12063585 | ABTB2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (inferred) | 18 | 33483925 | 33651165 | Dog | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 12673640 | Abtb2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (inferred) | NW_004936533 | 3705902 | 3866998 | Squirrel | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 14044780 | ABTB2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (inferred) | | | | Pig | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 18400431 | ABTB2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (inferred) | | | | Green Monkey | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 18910175 | Abtb2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 1553036 | Acy3 | aminoacylase 3 | This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of tox ;'>toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 19 | 4036570 | 4040007 | Mouse | 105 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 12299462 | ADAL | adenosine deaminase like | ENCODES a protein that exhibits deaminase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN nucleotide metabolic process (inferred); toxic metabolite repair (inferred) | 30 | 10191019 | 10214089 | Dog | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 1348641 | AHRR | aryl hydrocarbon receptor repressor | The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-depen dent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011] | 5 | 321714 | 438285 | Human | 201 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1557053 | Ahrr | aryl-hydrocarbon receptor repressor | This gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response ele ment (XRE) sequence in many genes. This protein is implicated in the regulation of cell growth and differentiation as well as mediating dioxin toxicity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015] | 13 | 74359237 | 74440450 | Mouse | 207 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1347108 | AKR1C4 | aldo-keto reductase family 1 member C4 | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping bu t distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008] | 10 | 5196837 | 5218949 | Human | 213 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1322469 | ALOX12 | arachidonate 12-lipoxygenase, 12S type | This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet fu nction. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017] | 17 | 6996049 | 7010754 | Human | 247 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1596307 | Aqp10 | aquaporin 10 | ENCODES a protein that exhibits glycerol channel activity (ortholog); water channel activity (ortholog); INVOLVED IN glycerol transmembrane transport (ortholog); protein homotetramerization (ortholog); response to toxic substance (ortholog); PARTICIPATES IN wate r transport pathway; FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH all-trans-retinoic acid (ortholog); ammonium hexachloroplatinate (ortholog); arsane (ortholog) | 2 | 177699717 | 177704620 | Rat | 62 | description | gene, protein-coding, MODEL [RefSeq] |
| 8927373 | Aqp10 | aquaporin 10 | ENCODES a protein that exhibits glycerol channel activity (ortholog); water channel activity (ortholog); INVOLVED IN glycerol transmembrane transport (ortholog); protein homotetramerization (ortholog); response to toxic substance (ortholog); PARTICIPATES IN wate r transport pathway; FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog) | NW_004955545 | 845749 | 848738 | Chinchilla | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 11855552 | AQP10 | aquaporin 10 | ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); urea transmembrane transporter activity (inferred); INVOLVED IN glycerol transmembrane transport (inferred); protein homotetramerization (inferred); response to tox >ic substance (inferred); PARTICIPATES IN water transport pathway; FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); membrane (inferred) | 1 | 129677969 | 129682681 | Bonobo | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 12059853 | AQP10 | aquaporin 10 | ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); water channel activity (inferred); INVOLVED IN glycerol transmembrane transport (inferred); protein homotetramerization (inferred); response to toxic substance (in ferred); PARTICIPATES IN water transport pathway; FOUND IN apical plasma membrane (inferred); membrane (inferred); plasma membrane (inferred) | 7 | 42961041 | 42964053 | Dog | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 12552000 | Aqp10 | aquaporin 10 | ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); urea transmembrane transporter activity (inferred); INVOLVED IN glycerol transmembrane transport (inferred); protein homotetramerization (inferred); response to tox >ic substance (inferred); PARTICIPATES IN water transport pathway; FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); membrane (inferred) | NW_004936580 | 3981254 | 3984895 | Squirrel | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 14297182 | AQP10 | aquaporin 10 | ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); water channel activity (inferred); INVOLVED IN glycerol transmembrane transport (inferred); protein homotetramerization (inferred); response to toxic substance (in ferred); PARTICIPATES IN water transport pathway; FOUND IN apical plasma membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 25 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18509656 | AQP10 | aquaporin 10 | ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); urea transmembrane transporter activity (inferred); INVOLVED IN glycerol transmembrane transport (inferred); protein homotetramerization (inferred); response to tox >ic substance (inferred); PARTICIPATES IN water transport pathway; FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); membrane (inferred) | | | | Green Monkey | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 18919724 | Aqp10 | aquaporin 10 | ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); urea transmembrane transporter activity (inferred); INVOLVED IN glycerol transmembrane transport (inferred); protein homotetramerization (inferred); response to tox >ic substance (inferred); PARTICIPATES IN water transport pathway; FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); membrane (inferred) | | | | Naked Mole-Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 625882964 | Aqp10 | aquaporin 10 | ENCODES a protein that exhibits glycerol channel activity (ortholog); water channel activity (ortholog); INVOLVED IN glycerol transmembrane transport (ortholog); protein homotetramerization (ortholog); response to toxic substance (ortholog); PARTICIPATES IN wate r transport pathway; FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 2313448 | Aqp10-ps | aquaporin 10, pseudogene | ENCODES a pseudogene that exhibits glycerol channel activity (ortholog); water channel activity (ortholog); INVOLVED IN glycerol transmembrane transport (ortholog); protein homotetramerization (ortholog); response to toxic substance (ortholog); PARTICIPATES IN w ater transport pathway; FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH triptonide; all-trans-retinoic acid (ortholog); ammonium hexachloroplatinate (ortholog) | 3 | 89870751 | 89877041 | Mouse | 39 | description | gene, pseudo, INFERRED [RefSeq] |
| 1353880 | ARF1 | ARF GTPase 1 | ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activat ors of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 228082708 | 228099212 | Human | 214 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1354397 | ARF3 | ARF GTPase 3 | ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. [provided by RefSeq, Oct 2022] | 12 | 48935723 | 48957487 | Human | 144 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1352328 | ARF4 | ARF GTPase 4 | This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. T he gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008] | 3 | 57571363 | 57597344 | Human | 157 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732462 | ARF5 | ARF GTPase 5 | This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activat ors of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010] | 7 | 127588411 | 127591700 | Human | 91 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 734181 | ARF6 | ARF GTPase 6 | This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular traffic king and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008] | 14 | 49893082 | 49897054 | Human | 230 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 2318374 | Arhgap33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of dendritic spine morphogenesis; response to toxic substance; regulation of postsynapse assembly (ortholog); ASSOCIATED WITH autism s pectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine; glutamatergic synapse; postsynaptic density; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 1 | 94903566 | 94917074 | Rat | 80 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8999737 | Arhgap33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); regulation of postsynapse assembly (ortholog); response to toxic substance (ortholog); AS SOCIATED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog) | NW_004955468 | 2769108 | 2783746 | Chinchilla | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 11694678 | ARHGAP33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (inferred); phosphatidylinositol binding (inferred); protein kinase binding (inferred); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); response to toxic substance (ortholog); ASSOCIAT ED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine (ortholog); postsynaptic density (ortholog) | 19 | 32704877 | 32710778 | Bonobo | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 12277376 | ARHGAP33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (inferred); phosphatidylinositol binding (inferred); protein kinase binding (inferred); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); response to toxic substance (ortholog); ASSOCIAT ED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine (ortholog) | 1 | 116851341 | 116864696 | Dog | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 12549617 | Arhgap33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (inferred); phosphatidylinositol binding (inferred); protein kinase binding (inferred); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); response to toxic substance (ortholog); ASSOCIAT ED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine (ortholog); postsynaptic density (ortholog) | NW_004936570 | 539839 | 553018 | Squirrel | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 14035340 | ARHGAP33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (inferred); phosphatidylinositol binding (inferred); protein kinase binding (inferred); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); response to toxic substance (ortholog); ASSOCIAT ED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine (ortholog) | | | | Pig | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 18419260 | ARHGAP33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (inferred); phosphatidylinositol binding (inferred); protein kinase binding (inferred); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); response to toxic substance (ortholog); ASSOCIAT ED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine (ortholog); postsynaptic density (ortholog) | | | | Green Monkey | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 18911254 | Arhgap33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); regulation of postsynapse assembly (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); postsynaptic density (ortholog) | | | | Naked Mole-Rat | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 625991837 | Arhgap33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of dendritic spine morphogenesis (ortholog); regulation of postsynapse assembly (ortholog); response to toxic substance (ortholog); AS SOCIATED WITH autism spectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN cytoplasm (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 732961 | ARL1 | ARF like GTPase 1 | The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulat e intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] | 12 | 101393116 | 101407820 | Human | 123 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 621325 | As3mt | arsenite methyltransferase | ENCODES a protein that exhibits arsenite methyltransferase activity; INVOLVED IN arsonoacetate metabolic process; response to arsenic-containing substance; toxin metabolic process; PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathwa y; ASSOCIATED WITH Arsenic Poisoning (ortholog); attention deficit hyperactivity disorder (ortholog); Birth Weight (ortholog); FOUND IN cytosol; INTERACTS WITH 1,4-dithiothreitol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 1 | 255536879 | 255569245 | Rat | 246 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 733292 | As3mt | arsenite methyltransferase | Predicted to enable arsenite methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; methylation; and toxin metabolic process. Predicted to act upstream of or within response to arsenic-containing substance. Located in mitochondr ion. Orthologous to human AS3MT (arsenite methyltransferase). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 46695124 | 46729538 | Mouse | 251 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12391639 | AS3MT | arsenite methyltransferase | ENCODES a protein that exhibits arsenite methyltransferase activity (ortholog); INVOLVED IN arsonoacetate metabolic process (ortholog); response to arsenic-containing substance (ortholog); toxin metabolic process (ortholog); PARTICIPATES IN homocysteine metaboli c pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); attention deficit hyperactivity disorder (ortholog); Birth Weight (ortholog); FOUND IN cytosol (inferred); lysosomal membrane (inferred) | 28 | 15334141 | 15350749 | Dog | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 2163 | Ass1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity; toxic substance binding; amino acid binding (ortholog); INVOLVED IN acute-phase response; argininosuccinate metabolic process; cellular response to amine stimulus; PARTICIPATES IN urea cycle pa thway; AGAT deficiency pathway; arginine and proline metabolic pathway; ASSOCIATED WITH Acute-Phase Reaction; Drug-Related Side Effects and Adverse Reactions; Endotoxemia; FOUND IN cell body fiber; mitochondrial outer membrane; neuronal cell body; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 35144765 | 35194632 | Rat | 431 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736137 | Ass1 | argininosuccinate synthetase 1 | Predicted to enable several functions, including argininosuccinate synthase activity; identical protein binding activity; and toxic substance binding activity. Involved in circadian rhythm. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Used to study citrullinemia. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 31360282 | 31410682 | Mouse | 516 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12018981 | ASS1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN acute-phase response (ortholog); argininosuccinate metabolic process (ortholog); cellular response to amine stimulus (ortholog); PARTI CIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-Phase Reaction (ortholog); adult-onset type II citrullinemia (ortholog); FOUND IN cell body fiber (ortholog); mitochondrial outer membrane (ortholog); mitochondrion (ortholog) | 9 | 101569442 | 101625899 | Bonobo | 126 | description | gene, protein-coding, MODEL [RefSeq] |
| 12157586 | ASS1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN acute-phase response (ortholog); argininosuccinate metabolic process (ortholog); cellular response to amine stimulus (ortholog); PARTI CIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-Phase Reaction (ortholog); adult-onset type II citrullinemia (ortholog); FOUND IN cell body fiber (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog); INTERACTS WITH clofibrate; phenobarbital | 9 | 53425228 | 53478007 | Dog | 128 | description | gene, protein-coding, MODEL [RefSeq] |
| 12556627 | Ass1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN acute-phase response (ortholog); argininosuccinate metabolic process (ortholog); cellular response to amine stimulus (ortholog); PARTI CIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-Phase Reaction (ortholog); adult-onset type II citrullinemia (ortholog); FOUND IN cell body fiber (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog) | NW_004936487 | 17482307 | 17527407 | Squirrel | 126 | description | gene, protein-coding, MODEL [RefSeq] |
| 14055601 | ASS1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN acute-phase response (ortholog); argininosuccinate metabolic process (ortholog); cellular response to amine stimulus (ortholog); PARTI CIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-Phase Reaction (ortholog); adult-onset type II citrullinemia (ortholog); FOUND IN cell body fiber (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog) | | | | Pig | 126 | description | gene, protein-coding, MODEL [RefSeq] |
| 18906227 | Ass1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN acute-phase response (ortholog); argininosuccinate metabolic process (ortholog); cellular response to amine stimulus (ortholog); PARTI CIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-Phase Reaction (ortholog); adult-onset type II citrullinemia (ortholog); FOUND IN cell body fiber (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 126 | description | gene, protein-coding, MODEL [RefSeq] |
| 1304668 | Blmh | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's d isease 1 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 10 | 62270170 | 62313349 | Rat | 107 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8925949 | Blmh | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's d isease 1 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | NW_004955481 | 3031283 | 3078678 | Chinchilla | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 11748045 | BLMH | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (inferred); cysteine-type aminopeptidase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 17 | 26476039 | 26519782 | Bonobo | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 12407493 | BLMH | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (inferred); cysteine-type aminopeptidase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 9 | 44271662 | 44319814 | Dog | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 12634036 | Blmh | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (inferred); cysteine-type aminopeptidase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936538 | 6251602 | 6298281 | Squirrel | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 14148118 | BLMH | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (inferred); cysteine-type aminopeptidase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Pig | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 18400272 | BLMH | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (inferred); cysteine-type aminopeptidase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 18926600 | Blmh | bleomycin hydrolase | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease 1 (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 626075348 | Blmh | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's d isease 1 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 1605303 | C8orf34 | chromosome 8 open reading frame 34 | This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing ch emotherapeutic treatment. [provided by RefSeq, Mar 2017] | 8 | 68330373 | 68819023 | Human | 35 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732740 | CAT | catalase | This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009] | 11 | 34438934 | 34472060 | Human | 3386 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 69069 | Ccl5 | C-C motif chemokine ligand 5 | ENCODES a protein that exhibits chemokine activity; heparin binding; CCR1 chemokine receptor binding (ortholog); INVOLVED IN cellular response to alkyl hydroperoxide; cellular response to amino acid stimulus; cellular response to cytokine stimulus; PARTICIPATES IN syndecan signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; ASSOCIATED WITH alcoholic hepatitis; allergic conjunctivitis; Animal Toxoplasmosis; FOUND IN extracellular space; cytoplasm (ortholog); membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 10 | 68820330 | 68824906 | Rat | 907 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561104 | Cd209d | CD209d molecule | ENCODES a protein that exhibits cell adhesion receptor activity (ortholog); D-mannose binding (ortholog); identical protein binding (ortholog); INVOLVED IN B cell adhesion (ortholog); defense response to bacterium (ortholog); dendritic cell migration (ortholog); ASSOCIATED WITH acquired immunodefici ency syndrome (ortholog); Animal Toxoplasmosis (ortholog); aspergillosis (ortholog); FOUND IN external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH alpha-Zearalanol; bisphenol A; pravastatin | 12 | 6689002 | 6695452 | Rat | 87 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 619745 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (ortholog); cadherin binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to toxic substance; cellular response to xenobiotic stimulus; calcium-dependent cell-cell adhesion (o rtholog); ASSOCIATED WITH abnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer; saccharin preference; ASSOCIATED WITH coronary restenosis; Lung Neoplasms; substance-related disorder; FOUND IN GABA-ergic synapse; perinuclear region of cytoplasm; synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-acetamidofluorene | 19 | 63258251 | 64296122 | Rat | 281 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8790851 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (ortholog); cadherin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcium-dependent cell-cell adhesion (ortholog); cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH amphetamine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN caveola (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog) | NW_004955564 | 407120 | 1549880 | Chinchilla | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 11879212 | CDH13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (inferred); beta-catenin binding (inferred); cadherin binding (inferred); INVOLVED IN cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH amphet amine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN GABA-ergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); synapse (ortholog) | 16 | 63255482 | 64418053 | Bonobo | 87 | description | gene, protein-coding, MODEL [RefSeq] |
| 12139493 | CDH13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (inferred); cadherin binding (inferred); calcium ion binding (inferred); INVOLVED IN cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH ampheta mine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN GABA-ergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); synapse (ortholog) | 5 | 68491156 | 69586119 | Dog | 86 | description | gene, protein-coding, MODEL [RefSeq] |
| 12592015 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (inferred); beta-catenin binding (inferred); cadherin binding (inferred); INVOLVED IN cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH amphet amine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN GABA-ergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); synapse (ortholog) | NW_004936641 | 3925185 | 4223421 | Squirrel | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 13952301 | CDH13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (inferred); cadherin binding (inferred); calcium ion binding (inferred); INVOLVED IN cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH ampheta mine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN GABA-ergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); synapse (ortholog) | | | | Pig | 86 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18794012 | CDH13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (inferred); beta-catenin binding (inferred); cadherin binding (inferred); INVOLVED IN cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH amphet amine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN GABA-ergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); synapse (ortholog) | | | | Green Monkey | 86 | description | gene, protein-coding, MODEL [RefSeq] |
| 18910881 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits lipoprotein particle binding (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); endothelial cell migra tion (ortholog); ASSOCIATED WITH amphetamine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN caveola (ortholog); extracellular space (ortholog); GABA-ergic synapse (ortholog) | | | | Naked Mole-Rat | 82 | description | gene, protein-coding, MODEL [RefSeq] |
| 626161614 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (ortholog); cadherin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcium-dependent cell-cell adhesion (ortholog); cellular response to toxic substance (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH amphetamine abuse (ortholog); arteriosclerosis (ortholog); Barrett's esophagus (ortholog); FOUND IN caveola (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog) | | | | Black Rat | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 736299 | Cnp | 2',3'-cyclic nucleotide 3' phosphodiesterase | Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within adult locomotory behavior; neurogenesis; and response to toxic substance. Located in cytoplasm; membrane; and myelin sheath. Is expressed in adrenal gland; gut; nervous sys tem; and reproductive system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 100465765 | 100472565 | Mouse | 385 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735525 | CNR1 | cannabinoid receptor 1 | This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009] | 6 | 88139864 | 88167349 | Human | 483 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732246 | CNR2 | cannabinoid receptor 2 | The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. The y inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008] | 1 | 23870515 | 23913362 | Human | 269 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 10389 | Cps1 | carbamoyl-phosphate synthetase 1 | This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Car bamoyl-phosphate is subsequently converted to urea that is excreted by the kidneys. Deficiency of the encoded enzyme leads to an accumulation of ammonia in the blood. High levels of ammonia are toxic to the central nervous system and result in neurological disorders. [provided by RefSeq, Oct 2013] | 1 | 67151294 | 67270426 | Mouse | 391 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 620860 | Crispld2 | cysteine-rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN lung development; extracellular matrix organization (ortholog); face morphogenesis (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); tox ;'>toxic encephalopathy (ortholog); FOUND IN extracellular matrix (ortholog); transport vesicle (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 19 | 64961764 | 65020099 | Rat | 172 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8769012 | Crispld2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); face morphogenesis (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); tox -weight:700;'>toxic encephalopathy (ortholog); FOUND IN extracellular matrix (ortholog); transport vesicle (ortholog) | NW_004955541 | 324623 | 369690 | Chinchilla | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 11810364 | CRISPLD2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); heparin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); toxic ence phalopathy (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); transport vesicle (inferred) | 16 | 65488965 | 65578502 | Bonobo | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 12202613 | CRISPLD2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); heparin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); toxic ence phalopathy (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); transport vesicle (inferred) | 5 | 67643225 | 67707438 | Dog | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12732308 | Crispld2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); heparin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); toxic ence phalopathy (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); transport vesicle (inferred) | NW_004936641 | 3228791 | 3277379 | Squirrel | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 13950311 | CRISPLD2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); heparin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); toxic ence phalopathy (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); transport vesicle (inferred); INTERACTS WITH deoxynivalenol; resveratrol | | | | Pig | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 18540139 | CRISPLD2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); heparin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); toxic ence phalopathy (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); transport vesicle (inferred) | | | | Green Monkey | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 18901470 | Crispld2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); face morphogenesis (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); tox -weight:700;'>toxic encephalopathy (ortholog); FOUND IN extracellular matrix (ortholog); transport vesicle (ortholog) | | | | Naked Mole-Rat | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 626141826 | Crispld2 | cysteine rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); face morphogenesis (ortholog); lung development (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); tox -weight:700;'>toxic encephalopathy (ortholog); FOUND IN extracellular matrix (ortholog); transport vesicle (ortholog) | | | | Black Rat | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 10436 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; respons e to toxic substance; and toxin metabolic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; maxillary process; spleen; and upper jaw. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 57595211 | 57611107 | Mouse | 2930 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351527 | CYP2F1 | cytochrome P450 family 2 subfamily F member 1 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is know n to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] | 19 | 41114432 | 41128381 | Human | 212 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11744115 | CYP2F1 | cytochrome P450 family 2 subfamily F member 1 | ENCODES a protein that exhibits monooxygenase activity (ortholog); INVOLVED IN naphthalene catabolic process (ortholog); response to toxic substance (ortholog); trichloroethylene metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum membrane (inferred) | 19 | 38124921 | 38137574 | Bonobo | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 12164501 | CYP2F1 | cytochrome P450 family 2 subfamily F member 1 | ENCODES a protein that exhibits monooxygenase activity (ortholog); INVOLVED IN naphthalene catabolic process (ortholog); response to toxic substance (ortholog); trichloroethylene metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 1 | 112973776 | 112986419 | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 13913747 | CYP2F1 | cytochrome P450 family 2 subfamily F member 1 | ENCODES a protein that exhibits monooxygenase activity (ortholog); INVOLVED IN naphthalene catabolic process (ortholog); response to toxic substance (ortholog); trichloroethylene metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Pig | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 733763 | Cyp2f2 | cytochrome P450, family 2, subfamily f, polypeptide 2 | Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within na phthalene catabolic process and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; nose; pharyngo-tympanic tube; respiratory system; and sublingual gland primordium. Orthologous to several human genes including CYP2F1 (cytochrome P450 family 2 subfamily F member 1). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 26819380 | 26833085 | Mouse | 212 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2476 | Cyp2f4 | cytochrome P450, family 2, subfamily f, polypeptide 4 | ENCODES a protein that exhibits monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (ortholog); INVOLVED IN trichloroethylene metabolic proc ess; naphthalene catabolic process (ortholog); response to toxic substance (ortholog); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH (+)-schisandrin B; 1,1-dichloroethene; 1-nitronaphthalene | 1 | 91543768 | 91557553 | Rat | 206 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621227 | Daxx | death-domain associated protein | ENCODES a protein that exhibits JUN kinase binding; kinesin binding; nuclear androgen receptor binding; INVOLVED IN cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; cellular response to type II interferon; PARTICIPATES IN aldosterone signaling pathway; histone modi fication pathway; p53 signaling pathway; ASSOCIATED WITH Brain Hypoxia-Ischemia; Heavy Metal Toxicity; transient cerebral ischemia; FOUND IN cell body; cell cortex; microtubule; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; acetamide | 20 | 4971973 | 4978062 | Rat | 317 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1344529 | DCPS | decapping enzyme, scavenger | This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes t he triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017] | 11 | 126304060 | 126350005 | Human | 160 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 10469 | Ddc | dopa decarboxylase | Enables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within gene expression; kidney development; and response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; r espiratory system; and sensory organ. Used to study aromatic L-amino acid decarboxylase deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 11764101 | 11848144 | Mouse | 392 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606338 | DFFA | DNA fragmentation factor subunit alpha | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 10456522 | 10472529 | Human | 167 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731033 | DFFB | DNA fragmentation factor subunit beta | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013] | 1 | 3857476 | 3885429 | Human | 161 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1308072 | Dhx15 | DEAH-box helicase 15 | ENCODES a protein that exhibits double-stranded RNA binding (ortholog); RNA binding (ortholog); RNA helicase activity (ortholog); INVOLVED IN response to alkaloid; response to toxic substance; antiviral innate immune response (ortholog); PARTICIPATES IN ribosome biogenesis pathway; spliceosome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); U12-type spliceosomal complex (ortholog); U2-type post-mRNA release spliceosomal complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 14 | 62999886 | 63037829 | Rat | 131 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11740237 | DHX15 | DEAH-box helicase 15 | ENCODES a protein that exhibits ATP binding (inferred); double-stranded RNA binding (inferred); helicase activity (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN ribosome biogenesis pathway; splice osome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (inferred); nucleus (inferred); spliceosomal complex (inferred) | 4 | 18931119 | 18988048 | Bonobo | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 12272054 | DHX15 | DEAH-box helicase 15 | ENCODES a protein that exhibits ATP binding (inferred); double-stranded RNA binding (inferred); helicase activity (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN ribosome biogenesis pathway; splice osome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (inferred); nucleus (inferred); U12-type spliceosomal complex (inferred) | 3 | 85549946 | 85609598 | Dog | 46 | description | gene, protein-coding, MODEL [RefSeq] |
| 13873867 | DHX15 | DEAH-box helicase 15 | ENCODES a protein that exhibits ATP binding (inferred); double-stranded RNA binding (inferred); helicase activity (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN ribosome biogenesis pathway; splice osome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (inferred); nucleus (inferred); U12-type spliceosomal complex (inferred) | | | | Pig | 49 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18615028 | DHX15 | DEAH-box helicase 15 | ENCODES a protein that exhibits ATP binding (inferred); double-stranded RNA binding (inferred); helicase activity (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN ribosome biogenesis pathway; splice osome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (inferred); nucleus (inferred); spliceosomal complex (inferred) | | | | Green Monkey | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 1343992 | DNAJB8 | DnaJ heat shock protein family (Hsp40) member B8 | The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012] | 3 | 128462437 | 128466890 | Human | 38 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1350551 | DNAJC24 | DnaJ heat shock protein family (Hsp40) member C24 | Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria tox 700;'>toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008] | 11 | 31369860 | 31432835 | Human | 54 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346924 | DPH3 | diphthamide biosynthesis 3 | This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the b acterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] | 3 | 16257061 | 16264943 | Human | 91 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1602122 | DPH5 | diphthamide biosynthesis 5 | This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 100989623 | 101025784 | Human | 138 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312556 | DPH7 | diphthamide biosynthesis 7 | Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016] | 9 | 137554444 | 137578925 | Human | 50 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731730 | DPYD | dihydropyrimidine dehydrogenase | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uracilu ria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] | 1 | 97077743 | 97921059 | Human | 761 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 10529 | Ephx1 | epoxide hydrolase 1, microsomal | Enables oxysterol binding activity. Acts upstream of or within hydrocarbon catabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Is expressed in several structures, including brain ventricle and choroid plexus; exocrine system; integumental system; nerv ous system; and nose. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 180817121 | 180845134 | Mouse | 657 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306518 | Fbxw4 | F-box and WD repeat domain containing 4 | INVOLVED IN cartilage development (ortholog); embryonic digit morphogenesis (ortholog); limb development (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); split hand-foot malformation (ortholog); split hand-foot malformation 3 (ortholog); INTERACTS WITH bisphenol A; flutamide; T-2 tox tyle='font-weight:700;'>toxin | 1 | 254375921 | 254465173 | Rat | 56 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606303 | FLVCR1 | FLVCR choline and heme transporter 1 | This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a r ole in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011] | 1 | 212858275 | 212899363 | Human | 244 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 14137184 | FMO1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits N,N-dimethylaniline monooxygenase activity; hypotaurine monooxygenase activity (ortholog); monooxygenase activity (ortholog); INVOLVED IN organic acid metabolic process; toxin metabolic process; energy homeostasis (ortholog); PART ICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane; INTERACTS WITH chlorpromazine; cysteamine; deoxynivalenol | | | | Pig | 48 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61845 | Gfer | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity; flavin adenine dinucleotide binding (ortholog); protein-disulfide reductase activity (ortholog); INVOLVED IN cellular response to actinomycin D; cellular response to lipopolysaccharide; cellular response to tox nt-weight:700;'>toxic substance; PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure; Chemical and Drug Induced Liver Injury; cryptorchidism; FOUND IN extracellular space; cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 14223023 | 14225736 | Rat | 135 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8947432 | Gfer | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin adenine dinucleotide binding (ortholog); flavin-dependent sulfhydryl oxidase activity (ortholog); protein-disulfide reductase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cel lular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); mitochondrion (ortholog) | NW_004955442 | 15280753 | 15283405 | Chinchilla | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 11676943 | GFER | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN extracellular space (ortholog) | 16 | 716640 | 720196 | Bonobo | 59 | description | gene, protein-coding, MODEL [RefSeq] |
| 12178935 | GFER | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); mitochondrion (ortholog) | 6 | 38948927 | 38951300 | Dog | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 12723350 | Gfer | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN extracellular space (ortholog) | NW_004936694 | 2051362 | 2053812 | Squirrel | 61 | description | gene, protein-coding, MODEL [RefSeq] |
| 14145059 | GFER | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); mitochondrion (ortholog) | | | | Pig | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 18392921 | GFER | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 59 | description | gene, protein-coding, MODEL [RefSeq] |
| 18909275 | Gfer | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 626130047 | Gfer | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin adenine dinucleotide binding (ortholog); flavin-dependent sulfhydryl oxidase activity (ortholog); protein-disulfide reductase activity (ortholog); INVOLVED IN cellular response to actinomycin D (ortholog); cellular response to lipopolysaccharide (ortholog); cel lular response to toxic substance (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); mitochondrion (ortholog) | | | | Black Rat | 48 | description | gene, protein-coding, MODEL [RefSeq] |
| 731694 | GGT7 | gamma-glutamyltransferase 7 | This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008] | 20 | 34844720 | 34872856 | Human | 74 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1623025 | Gjc2 | gap junction protein, gamma 2 | Enables gap junction channel activity. Acts upstream of or within cell-cell signaling and response to toxic substance. Located in gap junction and myelin sheath. Is expressed in brain; ovary; and spinal cord. Used to study hypomyelinating leukodystrophy 2. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 59066390 | 59074039 | Mouse | 165 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 736383 | GLRX | glutaredoxin | This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlli ng the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] | 5 | 95813849 | 95822726 | Human | 275 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11888119 | GLYAT | glycine-N-acyltransferase | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN benzoyl-CoA metabolic process (inferred); glycine metabolic process (inferred); response to tox >toxic substance (inferred); FOUND IN mitochondrion (inferred) | 11 | 53963676 | 53985965 | Bonobo | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 12107454 | GLYAT | glycine-N-acyltransferase | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN benzoyl-CoA metabolic process (inferred); glycine metabolic process (inferred); response to tox >toxic substance (inferred); FOUND IN mitochondrion (inferred) | 18 | 37689076 | 37715614 | Dog | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 18391353 | GLYAT | glycine-N-acyltransferase | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN benzoyl-CoA metabolic process (inferred); glycine metabolic process (inferred); response to tox >toxic substance (inferred); FOUND IN mitochondrion (inferred) | | | | Green Monkey | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 1317712 | GNA14 | G protein subunit alpha 14 | This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009] | 9 | 77423079 | 77648322 | Human | 187 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733341 | GNAZ | G protein subunit alpha z | The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluid s. [provided by RefSeq, Jul 2008] | 22 | 23070519 | 23125032 | Human | 141 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 734191 | GPT | glutamic--pyruvic transaminase | This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism o f glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009] | 8 | 144503068 | 144507172 | Human | 1397 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1349200 | GSTA1 | glutathione S-transferase alpha 1 | This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detox yle='font-weight:700;'>toxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] | 6 | 52791371 | 52803816 | Human | 397 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351230 | GSTA3 | glutathione S-transferase alpha 3 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight di stinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] | 6 | 52896646 | 52909698 | Human | 295 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309970 | Gsta4 | glutathione S-transferase alpha 4 | ENCODES a protein that exhibits toxic substance binding; glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to lithium ion; response to herbicide; response to nicotine; PARTICIPATES IN glutathione con jugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH Experimental Diabetes Mellitus; Experimental Liver Cirrhosis; Liver Injury; FOUND IN cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; (E)-4-hydroxynon-2-enal; (S)-nicotine | 8 | 87947247 | 87964490 | Rat | 422 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320601 | GSTA4 | glutathione S-transferase alpha 4 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight di stinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008] | 6 | 52977953 | 52995284 | Human | 267 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1320602 | Gsta4 | glutathione S-transferase, alpha 4 | Predicted to enable glutathione transferase activity and toxic substance binding activity. Acts upstream of or within response to caloric restriction. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 78099248 | 78116631 | Mouse | 337 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11943564 | GSTA4 | glutathione S-transferase alpha 4 | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotine (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arter iosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (inferred) | 6 | 52532942 | 52550404 | Bonobo | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12384201 | GSTA4 | glutathione S-transferase alpha 4 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotin e (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH clofibrate; masitinib; phenobarbital | 12 | 20426724 | 20443200 | Dog | 34 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 14045548 | GSTA4 | glutathione S-transferase alpha 4 | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotine (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arter iosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18909530 | Gsta4 | glutathione S-transferase alpha 4 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotin e (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 2758 | Gstp1 | glutathione S-transferase pi 1 | ENCODES a protein that exhibits protein kinase binding; toxic substance binding; dinitrosyl-iron complex binding (ortholog); INVOLVED IN animal organ regeneration; cellular response to cell-matrix adhesion; cellular response to epidermal growth factor stimulus; PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; glutathione metabolic pathway; ASSOCIATED WITH Cholangiofibrosis; cholestasis; Chronic Cerebral Hypoperfusion; FOUND IN cytosol (ortholog); mitochondrion (ortholog); protein-containing complex (ortholog); INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (E)-4-hydroxynon-2-enal; (R)-lipoic acid | 1 | 210767237 | 210770242 | Rat | 1183 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731775 | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HA AO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008] | 2 | 42767089 | 42792583 | Human | 242 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1323512 | HEMK2 | HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine | This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less tox 00;'>toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Mar 2023] | 21 | 28575598 | 28885367 | Human | 99 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736399 | Hspa1b | heat shock protein 1B | Enables protein folding chaperone. Involved in protein folding. Acts upstream of or within binding activity of sperm to zona pellucida; negative regulation of apoptotic process; and response to heat. Located in cell body and mitochondrion. Part of zona pellucida receptor complex. Is expressed in sev eral structures, including early conceptus; heart; humerus; and lung. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 35175405 | 35178214 | Mouse | 530 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 10746 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in negative regulation of serotonin secretion and phospholipase C-activating serotonin receptor signaling pathway. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signali ng pathway; bone remodeling; and response to toxic substance. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is active in presynaptic membrane and serotonergic synapse. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; eye; and gonad. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 81510344 | 81515885 | Mouse | 244 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 10747 | Htr1d | 5-hydroxytryptamine (serotonin) receptor 1D | Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Acts upstream of or within response to toxic substance. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and neuronal dense cor e vesicle. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; eye; and genitourinary system. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 136150835 | 136171716 | Mouse | 116 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11933967 | HTR1D | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits serotonin binding (ortholog); INVOLVED IN regulation of synaptic vesicle exocytosis (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive dis order (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog) | 1 | 22378262 | 22403918 | Bonobo | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18576531 | HTR1D | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits serotonin binding (ortholog); INVOLVED IN regulation of synaptic vesicle exocytosis (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive dis order (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog) | | | | Green Monkey | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 619989 | Ido1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding; indoleamine 2,3-dioxygenase activity; oxygen binding; INVOLVED IN L-tryptophan catabolic process to L-kynurenine; inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); PARTICIPATES IN tryptophan metabolic pathway; kynure nine metabolic pathway; sleeping sickness pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (ortholog); smooth muscle contractile fiber (ortholog); stereocilium bundle (ortholog); INTERACTS WITH ammonium chloride; atrazine; bisphenol A | 16 | 74133259 | 74145328 | Rat | 254 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8781560 | Ido1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); L-tryptophan 2,3-dioxygenase activity (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynureni ne (ortholog); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (ortholog); smooth muscle contractile fiber (ortholog); stereocilium bundle (ortholog) | NW_004955536 | 2944770 | 2955829 | Chinchilla | 68 | description | gene, protein-coding, MODEL [RefSeq] |
| 11974812 | IDO1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); oxygen binding (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynurenine (ortholog); PARTICIP ATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); smooth muscle contractile fiber (inferred) | 8 | 39108310 | 39123611 | Bonobo | 89 | description | gene, protein-coding, MODEL [RefSeq] |
| 12067734 | IDO1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); oxygen binding (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynurenine (ortholog); PARTICIP ATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN smooth muscle contractile fiber (ortholog); stereocilium bundle (ortholog) | 16 | 25391759 | 25407161 | Dog | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 12725468 | Ido1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); oxygen binding (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynurenine (ortholog); PARTICIP ATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); smooth muscle contractile fiber (inferred) | NW_004936843 | 658058 | 672662 | Squirrel | 89 | description | gene, protein-coding, MODEL [RefSeq] |
| 14108737 | IDO1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); oxygen binding (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynurenine (ortholog); PARTICIP ATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); smooth muscle contractile fiber (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 90 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18771773 | IDO1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); oxygen binding (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynurenine (ortholog); PARTICIP ATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); smooth muscle contractile fiber (inferred) | | | | Green Monkey | 89 | description | gene, protein-coding, MODEL [RefSeq] |
| 18912360 | Ido1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); oxygen binding (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynurenine (ortholog); PARTICIP ATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); smooth muscle contractile fiber (inferred) | | | | Naked Mole-Rat | 89 | description | gene, protein-coding, MODEL [RefSeq] |
| 626030159 | Ido1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding (ortholog); indoleamine 2,3-dioxygenase activity (ortholog); L-tryptophan 2,3-dioxygenase activity (ortholog); INVOLVED IN inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); L-tryptophan catabolic process to L-kynureni ne (ortholog); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (ortholog); smooth muscle contractile fiber (ortholog); stereocilium bundle (ortholog) | | | | Black Rat | 68 | description | gene, protein-coding, MODEL [RefSeq] |
| 12879433 | Ift140em1Kyo | intraflagellar transport 140; CRISPR/Cas9 induced mutant 1, Kyo | This allele was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 1 (em1) has 2-bp insertion (c.23_24insGG) in the exon 1 of Ift140 (intraflagellar transpor t 140) gene. | | | | Rat | | description | gene, allele |
| 12879435 | Ift140em2Kyo | intraflagellar transport 140; CRISPR/Cas9 induced mutant 2, Kyo | This allele was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 2 (em2) has 2-bp deletion (c.23_24del) in the exon 1 of Ift140 (intraflagellar transport 1 40) gene. | | | | Rat | | description | gene, allele |
| 1306896 | Igtp | interferon gamma induced GTPase | ENCODES a protein that exhibits GTP binding (inferred); hydrolase activity (inferred); nucleotide binding (inferred); PARTICIPATES IN toxoplasmosis pathway; FOUND IN membrane (inferred); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benz oate | 10 | 42875047 | 42882866 | Rat | 59 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307335 | Il20ra | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-S tat signaling pathway; ASSOCIATED WITH Spontaneous Abortions (ortholog); toxic shock syndrome (ortholog); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol; bisphenol A | 1 | 16243683 | 16313229 | Rat | 63 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8826103 | Il20ra | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spontaneous Abortions (ortholog); tox yle='font-weight:700;'>toxic shock syndrome (ortholog); FOUND IN interleukin-20 receptor complex (ortholog); receptor complex (ortholog) | NW_004955436 | 22281422 | 22323242 | Chinchilla | 9 | description | gene, protein-coding, MODEL [RefSeq] |
| 11938780 | IL20RA | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spo ntaneous Abortions (ortholog); toxic shock syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 6 | 134762355 | 134805937 | Bonobo | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12078940 | IL20RA | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits interleukin-20 binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spontaneous Abortions (ortholog); tox yle='font-weight:700;'>toxic shock syndrome (ortholog); FOUND IN membrane (inferred) | 1 | 29506582 | 29545882 | Dog | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12492532 | Il20ra | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spo ntaneous Abortions (ortholog); toxic shock syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936560 | 4384126 | 4397971 | Squirrel | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 13986982 | IL20RA | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits interleukin-20 binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spontaneous Abortions (ortholog); tox yle='font-weight:700;'>toxic shock syndrome (ortholog); FOUND IN membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 18601264 | IL20RA | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spo ntaneous Abortions (ortholog); toxic shock syndrome (ortholog); FOUND IN plasma membrane (inferred) | | | | Green Monkey | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 18908327 | Il20ra | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spo ntaneous Abortions (ortholog); toxic shock syndrome (ortholog); FOUND IN interleukin-20 receptor complex (ortholog); receptor complex (ortholog) | | | | Naked Mole-Rat | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 626156640 | Il20ra | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); ASSOCIATED WITH Spontaneous Abortions (ortholog); tox yle='font-weight:700;'>toxic shock syndrome (ortholog); FOUND IN interleukin-20 receptor complex (ortholog); receptor complex (ortholog) | | | | Black Rat | 9 | description | gene, protein-coding, MODEL [RefSeq] |
| 1566151 | Il20rb | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); PARTICIPATES IN cytokine mediated signaling pat hway; Jak-Stat signaling pathway; ASSOCIATED WITH toxic shock syndrome (ortholog); INTERACTS WITH alpha-Zearalanol; bisphenol A; gentamycin | 8 | 109858108 | 109896066 | Rat | 106 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8932474 | Il20rb | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIATED WITH tox toxic shock syndrome (ortholog); FOUND IN interleukin-20 receptor complex (ortholog); receptor complex (ortholog) | NW_004955501 | 1826687 | 1863261 | Chinchilla | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 12012737 | IL20RB | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIAT ED WITH toxic shock syndrome (ortholog); FOUND IN plasma membrane (inferred) | 3 | 133995863 | 134045206 | Bonobo | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12132843 | IL20RB | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (inferred); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIATED WITH tox toxic shock syndrome (ortholog) | 23 | 33384057 | 33421619 | Dog | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 14071771 | IL20RB | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (inferred); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIATED WITH tox toxic shock syndrome (ortholog); FOUND IN membrane (inferred) | | | | Pig | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 18726348 | IL20RB | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIAT ED WITH toxic shock syndrome (ortholog); FOUND IN plasma membrane (inferred) | | | | Green Monkey | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 18922169 | Il20rb | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-20 binding (inferred); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIAT ED WITH toxic shock syndrome (ortholog); FOUND IN interleukin-20 receptor complex (ortholog); receptor complex (ortholog) | | | | Naked Mole-Rat | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 626048292 | Il20rb | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); ASSOCIATED WITH tox toxic shock syndrome (ortholog); FOUND IN interleukin-20 receptor complex (ortholog); receptor complex (ortholog) | | | | Black Rat | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 8986303 | Il21 | interleukin 21 | ENCODES a protein that exhibits cytokine receptor binding (ortholog); interleukin-2 receptor binding (ortholog); INVOLVED IN cell maturation (ortholog); cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog) ; Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955428 | 18057096 | 18065492 | Chinchilla | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 11738170 | IL21 | interleukin 21 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN positive regulation of B cell proliferation (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of i nterleukin-10 production (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 4 | 114795979 | 114806936 | Bonobo | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 12167679 | IL21 | interleukin 21 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); positive regulation of B cell proliferation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 19 | 17641833 | 17651275 | Dog | 86 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12610946 | Il21 | interleukin 21 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN positive regulation of B cell proliferation (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of i nterleukin-10 production (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | NW_004936662 | 1689879 | 1696883 | Squirrel | 81 | description | gene, protein-coding, MODEL [RefSeq] |
| 14161755 | IL21 | interleukin 21 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); positive regulation of B cell proliferation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 94 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18390634 | IL21 | interleukin 21 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN positive regulation of B cell proliferation (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of i nterleukin-10 production (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | | | | Green Monkey | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 18930024 | Il21 | interleukin 21 | ENCODES a protein that exhibits interleukin-2 receptor binding (ortholog); INVOLVED IN cell maturation (ortholog); cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Tox '>Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 625880340 | Il21 | interleukin 21 | ENCODES a protein that exhibits cytokine receptor binding (ortholog); interleukin-2 receptor binding (ortholog); INVOLVED IN cell maturation (ortholog); cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog) ; Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 620873 | Il23a | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-23 receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cell surface receptor signaling pathway via STAT (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular space (ortholog); interleukin-23 complex (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 1306320 | 1308434 | Rat | 342 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8734119 | Il23a | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-23 receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cell surface receptor signaling pathway via STAT (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular space (ortholog); interleukin-23 complex (ortholog); interleukin-23 receptor complex (ortholog) | NW_004955458 | 3946964 | 3949180 | Chinchilla | 70 | description | gene, protein-coding, MODEL [RefSeq] |
| 11939345 | IL23A | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-23 receptor binding (inferred); INVOLVED IN positive regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PART ICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN interleukin-23 receptor complex (ortholog); plasma membrane (ortholog) | 12 | 32575321 | 32576856 | Bonobo | 86 | description | gene, protein-coding, MODEL [RefSeq] |
| 12246608 | IL23A | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-23 receptor binding (inferred); INVOLVED IN positive regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PART ICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN interleukin-23 receptor complex (ortholog); plasma membrane (ortholog) | 10 | 635384 | 640715 | Dog | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 12588208 | Il23a | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-23 receptor binding (inferred); INVOLVED IN positive regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PART ICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN interleukin-23 receptor complex (ortholog); plasma membrane (ortholog) | NW_004936646 | 743630 | 745998 | Squirrel | 86 | description | gene, protein-coding, MODEL [RefSeq] |
| 14093893 | IL23A | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-23 receptor binding (inferred); INVOLVED IN positive regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PART ICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN interleukin-23 receptor complex (ortholog); plasma membrane (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; deoxynivalenol | | | | Pig | 91 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18776259 | IL23A | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-23 receptor binding (inferred); INVOLVED IN positive regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PART ICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN interleukin-23 receptor complex (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 86 | description | gene, protein-coding, MODEL [RefSeq] |
| 18917088 | Il23a | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-23 receptor binding (inferred); INVOLVED IN positive regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PART ICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN interleukin-23 receptor complex (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 86 | description | gene, protein-coding, MODEL [RefSeq] |
| 625873700 | Il23a | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-23 receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cell surface receptor signaling pathway via STAT (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular space (ortholog); interleukin-23 complex (ortholog); interleukin-23 receptor complex (ortholog) | | | | Black Rat | 70 | description | gene, protein-coding, MODEL [RefSeq] |
| 2896 | Il2rb | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding; interleukin-2 receptor activity; coreceptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway; interleukin-15-mediated signaling pathway (ortholog); interleukin-2-mediated signaling pathway (ortholog); PARTICIPATES IN interleu kin-12 signaling pathway; interleukin-2 signaling pathway; cytokine mediated signaling pathway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface; external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 7 | 111913828 | 111928537 | Rat | 184 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8951949 | Il2rb | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits coreceptor activity (ortholog); interleukin-15 receptor activity (ortholog); interleukin-2 binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); interleukin-15-mediated signaling pathway (ortholog); interleukin-2-mediated signaling pathway (o rtholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); interleukin-15 receptor complex (ortholog) | NW_004955413 | 23623567 | 23640245 | Chinchilla | 52 | description | gene, protein-coding, MODEL [RefSeq] |
| 12043423 | IL2RB | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding (ortholog); interleukin-2 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pat hway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog) | 22 | 18039469 | 18069952 | Bonobo | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 12343649 | IL2RB | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding (ortholog); interleukin-2 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pat hway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog) | 10 | 27370797 | 27388775 | Dog | 55 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12727798 | Il2rb | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding (ortholog); interleukin-2 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pat hway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog) | NW_004936492 | 3795940 | 3805822 | Squirrel | 53 | description | gene, protein-coding, MODEL [RefSeq] |
| 13934436 | IL2RB | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding (ortholog); interleukin-2 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pat hway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 18640889 | IL2RB | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding (ortholog); interleukin-2 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pat hway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog) | | | | Green Monkey | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 18913041 | Il2rb | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits coreceptor activity (ortholog); interleukin-15 receptor activity (ortholog); interleukin-2 binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); interleukin-15-mediated signaling pathway (ortholog); interleukin-2-mediated signaling pathway (o rtholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); interleukin-15 receptor complex (ortholog); interleukin-2 receptor complex (ortholog) | | | | Naked Mole-Rat | 56 | description | gene, protein-coding, MODEL [RefSeq] |
| 735606 | IVD | isovaleryl-CoA dehydrogenase | Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isoval eric acidemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017] | 15 | 40405795 | 40435947 | Human | 340 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 628829 | Kcnc2 | potassium voltage-gated channel subfamily C member 2 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; transmembrane transporter binding; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN cellular response to ammonium ion; cellular response to nitric oxide; c ellular response to toxic substance; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 103 (ortholog); epilepsy (ortholog); FOUND IN apical plasma membrane; axolemma; axon; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine | 7 | 49586274 | 49770212 | Rat | 186 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560601 | Kdm5c | lysine demethylase 5C | ENCODES a protein that exhibits histone H3K4 demethylase activity (ortholog); identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN response to toxic substance; gene expression (ortholog ); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; ASSOCIATED WITH schizophrenia; Abnormal Reflexes (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; bisphenol A | X | 24821568 | 24866423 | Rat | 123 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12607329 | Kdm5c | lysine demethylase 5C | ENCODES a protein that exhibits identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN gene expression (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); response to tox ;'>toxic substance (ortholog); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; ASSOCIATED WITH Abnormal Reflexes (ortholog); autistic disorder (ortholog); breast cancer (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004936751 | 159628 | 204136 | Squirrel | 58 | description | gene, protein-coding, MODEL [RefSeq] |
| 1310787 | Lao1 | L-amino acid oxidase 1 | ENCODES a protein that exhibits L-amino-acid oxidase activity (inferred); oxidoreductase activity (inferred); toxin activity (inferred); INVOLVED IN defense response to bacterium (inferred); modulation of process of another organism (inferred); PARTICIPATES IN a lanine, aspartate and glutamate metabolic pathway; cysteine and methionine metabolic pathway; phenylalanine metabolic pathway; FOUND IN extracellular region (inferred); INTERACTS WITH bisphenol A; fenvalerate | 5 | 137859033 | 137868926 | Rat | 19 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8792209 | Ldlr | low density lipoprotein receptor | ENCODES a protein that exhibits amyloid-beta binding (ortholog); identical protein binding (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); artery development (ortholog); P ARTICIPATES IN atherosclerosis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); caveola (ortholog) | NW_004955495 | 2114702 | 2135584 | Chinchilla | 294 | description | gene, protein-coding, MODEL [RefSeq] |
| 11979195 | LDLR | low density lipoprotein receptor | ENCODES a protein that exhibits low-density lipoprotein particle receptor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN artery development (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN atherosclerosis pathway; ASSO CIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); aortic atherosclerosis (ortholog); FOUND IN caveola (ortholog); plasma membrane (ortholog); recycling endosome membrane (ortholog) | 19 | 10640225 | 10683728 | Bonobo | 321 | description | gene, protein-coding, MODEL [RefSeq] |
| 12155481 | LDLR | low density lipoprotein receptor | ENCODES a protein that exhibits low-density lipoprotein particle receptor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN artery development (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN atherosclerosis pathway; ASSO CIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN caveola (ortholog); recycling endosome membrane (ortholog) | 20 | 50115175 | 50152443 | Dog | 300 | description | gene, protein-coding, MODEL [RefSeq] |
| 12529384 | Ldlr | low density lipoprotein receptor | ENCODES a protein that exhibits low-density lipoprotein particle receptor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN artery development (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN atherosclerosis pathway; ASSO CIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN caveola (ortholog); plasma membrane (ortholog); recycling endosome membrane (ortholog) | NW_004936659 | 1259405 | 1300545 | Squirrel | 301 | description | gene, protein-coding, MODEL [RefSeq] |
| 18405512 | LDLR | low density lipoprotein receptor | ENCODES a protein that exhibits low-density lipoprotein particle receptor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN artery development (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN atherosclerosis pathway; ASSO CIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN caveola (ortholog); plasma membrane (ortholog); recycling endosome membrane (ortholog) | | | | Green Monkey | 317 | description | gene, protein-coding, MODEL [RefSeq] |
| 18926082 | Ldlr | low density lipoprotein receptor | ENCODES a protein that exhibits amyloid-beta binding (ortholog); identical protein binding (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); artery development (ortholog); P ARTICIPATES IN atherosclerosis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); caveola (ortholog) | | | | Naked Mole-Rat | 299 | description | gene, protein-coding, MODEL [RefSeq] |
| 625856738 | Ldlr | low density lipoprotein receptor | ENCODES a protein that exhibits amyloid-beta binding (ortholog); identical protein binding (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); artery development (ortholog); P ARTICIPATES IN atherosclerosis pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Animal Toxoplasmosis (ortholog); aortic atherosclerosis (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); caveola (ortholog) | | | | Black Rat | 177 | description | gene, protein-coding, MODEL [RefSeq] |
| 13989877 | LOC100518109 | glycine N-acyltransferase | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN benzoyl-CoA metabolic process (inferred); glycine metabolic process (inferred); response to tox >toxic substance (inferred); FOUND IN mitochondrion (inferred) | | | | Pig | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 18906872 | LOC101706844 | solute carrier family 22 member 1 | ENCODES a protein that exhibits toxin transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); xenobiotic transmembrane transporter activity (inferred); INVOLVED IN cellular detoxificatio n (inferred); monoatomic ion transport (inferred); transmembrane transport (inferred); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); basolateral plasma membrane (inferred) | | | | Naked Mole-Rat | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 18918218 | LOC101711412 | glycine N-acyltransferase | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN glycine metabolic process (inferred); response to toxic substance (inferred); FOUND IN mitochondrion (inferred) | | | | Naked Mole-Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12471977 | LOC101958062 | glutathione S-transferase A4 | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotine (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arter iosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (inferred) | NW_004936476 | 7873218 | 7888301 | Squirrel | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12585153 | LOC101960208 | glycine N-acyltransferase-like | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN benzoyl-CoA metabolic process (inferred); glycine metabolic process (inferred); response to tox >toxic substance (inferred); FOUND IN mitochondrion (inferred) | NW_004936581 | 3572535 | 3582325 | Squirrel | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 12735364 | LOC101968779 | HLA class II histocompatibility antigen, DQ beta 1 chain-like | ENCODES a protein that exhibits protein antigen binding (inferred); toxic substance binding (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN adaptive immune response (inferred); antigen processing and presentation (inferred); antigen processi ng and presentation of peptide or polysaccharide antigen via MHC class II (inferred); FOUND IN cell surface (inferred); membrane (inferred); MHC class II protein complex (inferred) | NW_004936727 | 361446 | 368507 | Squirrel | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12649012 | LOC101969732 | dimethylaniline monooxygenase [N-oxide-forming] 1 | ENCODES a protein that exhibits flavin adenine dinucleotide binding (inferred); hypotaurine monooxygenase activity (inferred); monooxygenase activity (inferred); INVOLVED IN organic acid metabolic process (inferred); taurine biosynthetic process (inferred); toxi n metabolic process (inferred); FOUND IN endoplasmic reticulum membrane (inferred) | NW_004936481 | 15857556 | 15873883 | Squirrel | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12721511 | LOC101974333 | L-amino-acid oxidase-like | ENCODES a protein that exhibits L-amino-acid oxidase activity (inferred); oxidoreductase activity (inferred); toxin activity (inferred); INVOLVED IN amino acid catabolic process (inferred); defense response to bacterium (inferred); modulation of process of anoth er organism (inferred); FOUND IN extracellular region (inferred) | NW_004936474 | 24387001 | 24392258 | Squirrel | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 8944462 | LOC102004212 | cytochrome P450 2F3 | ENCODES a protein that exhibits monooxygenase activity (ortholog); oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (ortholog); INVOLVED IN naphthalene catabolic process (ortholog); response to toxic substance (ortholog); trichloroethylene metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog) | NW_004955578 | 530094 | 541951 | Chinchilla | 8 | description | gene, protein-coding, MODEL [RefSeq] |
| 14284030 | LOC102164585 | solute carrier family 22 member 9-like | ENCODES a protein that exhibits secondary active transmembrane transporter activity (ortholog); short-chain fatty acid transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN hormone transport (ortholog); o rganic anion transport (ortholog); short-chain fatty acid transmembrane transport (ortholog); ASSOCIATED WITH Lynch syndrome (ortholog); mismatch repair cancer syndrome (ortholog); FOUND IN basolateral plasma membrane (inferred); membrane (inferred) | | | | Pig | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 18735162 | LOC103221351 | glutathione S-transferase A4 | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotine (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arter iosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (inferred) | | | | Green Monkey | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 18619530 | LOC103235509 | cytochrome P450 2F1 | ENCODES a protein that exhibits monooxygenase activity (ortholog); oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (ortholog); INVOLVED IN naphthalene catabolic process (ortholog); response to toxic substance (ortholog); trichloroethylene metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog) | | | | Green Monkey | 8 | description | gene, protein-coding, MODEL [RefSeq] |
| 12336361 | LOC106559796 | uncharacterized LOC106559796 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); extracellular space (ortholog) | 15 | 18024375 | 18025871 | Dog | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12395171 | LOC476047 | solute carrier family 22 member 9 | ENCODES a protein that exhibits secondary active transmembrane transporter activity (ortholog); short-chain fatty acid transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN hormone transport (ortholog); o rganic anion transport (ortholog); short-chain fatty acid transmembrane transport (ortholog); ASSOCIATED WITH Lynch syndrome (ortholog); mismatch repair cancer syndrome (ortholog); FOUND IN basolateral plasma membrane (ortholog) | 18 | 53504102 | 53546354 | Dog | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12337847 | LOC482436 | L-amino-acid oxidase-like | ENCODES a protein that exhibits L-amino-acid oxidase activity (inferred); oxidoreductase activity (inferred); toxin activity (inferred); INVOLVED IN defense response to bacterium (inferred); modulation of process of another organism (inferred); FOUND IN extracel lular region (inferred) | 15 | 335458 | 342935 | Dog | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12365286 | LOC483462 | glycine N-phenylacetyltransferase-like | ENCODES a protein that exhibits acyltransferase activity (inferred); glycine N-acyltransferase activity (inferred); glycine N-benzoyltransferase activity (inferred); INVOLVED IN benzoyl-CoA metabolic process (inferred); glycine metabolic process (inferred); response to tox >toxic substance (inferred); FOUND IN mitochondrion (inferred) | 18 | 37626488 | 37676184 | Dog | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 12282410 | LOC611908 | phosphorylated adapter RNA export protein-like | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN snRNA export from nucleus (ortholog); FOUND IN neuronal cell body (ortholog) | 4 | 49155408 | 49157318 | Dog | 8 | description | gene, protein-coding, MODEL [RefSeq] |
| 1312479 | LOXHD1 | lipoxygenase homology PLAT domains 1 | This gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins to the plasma membrane. Studies in mice show that this gene is expressed in the mechanosensory ha ir cells in the inner ear, and mutations in this gene lead to auditory defects, indicating that this gene is essential for normal hair cell function. Screening of human families segregating deafness identified a mutation in this gene which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL). Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010] | 18 | 46476961 | 46657220 | Human | 203 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309329 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN response to peptide hormone; retina vasculature morphogenesis in camera-type eye; adipose tissue de velopment (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern; ASSOCIATED WITH autosomal dominant polycystic kidney disease; Femur Head Necrosis; osteoporosis; FOUND IN plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 210243499 | 210346886 | Rat | 322 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9040848 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regres sion (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog) | NW_004955422 | 17394371 | 17475244 | Chinchilla | 144 | description | gene, protein-coding, MODEL [RefSeq] |
| 11858708 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signali ng, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | 11 | 63396511 | 63534471 | Bonobo | 153 | description | gene, protein-coding, MODEL [RefSeq] |
| 12365689 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signali ng, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | 18 | 49439494 | 49555375 | Dog | 157 | description | gene, protein-coding, MODEL [RefSeq] |
| 12545303 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signali ng, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); receptor complex (inferred) | NW_004936599 | 1746309 | 1814471 | Squirrel | 136 | description | gene, protein-coding, MODEL [RefSeq] |
| 14030019 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signali ng, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 151 | description | gene, protein-coding, MODEL [RefSeq] |
| 18789018 | LRP5 | LDL receptor related protein 5 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signali ng, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 154 | description | gene, protein-coding, MODEL [RefSeq] |
| 18899907 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regression (ortholog); PARTICIPATES IN a ltered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN receptor complex (ortholog) | | | | Naked Mole-Rat | 154 | description | gene, protein-coding, MODEL [RefSeq] |
| 626149741 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regres sion (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); BCARD syndrome (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog) | | | | Black Rat | 136 | description | gene, protein-coding, MODEL [RefSeq] |
| 1312374 | Lrp6 | low density lipoprotein receptor-related protein 6 | Enables Wnt-protein binding activity; apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway; positive regulation of neuron projection development; and positive regulation of transcripti on by RNA polymerase II. Acts upstream of or within several processes, including central nervous system development; embryonic morphogenesis; and regionalization. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study neural tube defect and steatotic liver disease. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 134423439 | 134543876 | Mouse | 546 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11969005 | LRP6 | LDL receptor related protein 6 | ENCODES a protein that exhibits apolipoprotein binding (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (orthol og); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); autosomal dominant polycystic kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN membrane (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog) | 12 | 12121411 | 12288590 | Bonobo | 223 | description | gene, protein-coding, MODEL [RefSeq] |
| 12139753 | LRP6 | LDL receptor related protein 6 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); autosomal dominant polycystic kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN membrane (ortholog); neuronal cell body (ortholog); INTERACTS WITH bisphenol A | 27 | 34003334 | 34166334 | Dog | 226 | description | gene, protein-coding, MODEL [RefSeq] |
| 12669704 | Lrp6 | LDL receptor related protein 6 | ENCODES a protein that exhibits apolipoprotein binding (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (orthol og); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); autosomal dominant polycystic kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN membrane (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog) | NW_004936587 | 5065200 | 5143029 | Squirrel | 206 | description | gene, protein-coding, MODEL [RefSeq] |
| 14077567 | LRP6 | LDL receptor related protein 6 | ENCODES a protein that exhibits apolipoprotein binding (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (orthol og); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); autosomal dominant polycystic kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN neuronal cell body (ortholog); plasma membrane (ortholog); INTERACTS WITH warfarin | | | | Pig | 226 | description | gene, protein-coding, MODEL [RefSeq] |
| 18660664 | LRP6 | LDL receptor related protein 6 | ENCODES a protein that exhibits apolipoprotein binding (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (orthol og); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); autosomal dominant polycystic kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN membrane (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 223 | description | gene, protein-coding, MODEL [RefSeq] |
| 18904913 | Lrp6 | LDL receptor related protein 6 | ENCODES a protein that exhibits apolipoprotein binding (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (orthol og); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); autosomal dominant polycystic kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN membrane (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 228 | description | gene, protein-coding, MODEL [RefSeq] |
| 1302993 | Ly96 | lymphocyte antigen 96 | ENCODES a protein that exhibits lipopolysaccharide immune receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); detection of lipopolysaccharide (ortholog); lipopolysaccharide-mediated signaling pathway (ortholog); PARTICIPATES IN Toll-like receptor signaling p athway; toxoplasmosis pathway; ASSOCIATED WITH Bacterial Keratitis (ortholog); carcinoma (ortholog); cholestasis (ortholog); FOUND IN lipopolysaccharide receptor complex (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil | 5 | 7365536 | 7397864 | Rat | 198 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1359517 | Mapda | N6-Methyl-AMP deaminase | ENCODES a protein that exhibits N6-methyl-AMP deaminase activity (ortholog); INVOLVED IN toxic metabolite repair (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 128555604 | 128583809 | Rat | 68 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8831113 | Mapda | N6-Methyl-AMP deaminase | ENCODES a protein that exhibits N6-methyl-AMP deaminase activity (ortholog); INVOLVED IN toxic metabolite repair (ortholog) | NW_004955416 | 9892422 | 9913877 | Chinchilla | 5 | description | gene, protein-coding, MODEL [RefSeq] |
| 18902984 | Mapda | N6-Methyl-AMP deaminase | ENCODES a protein that exhibits N6-methyl-AMP deaminase activity (ortholog); INVOLVED IN toxic metabolite repair (ortholog) | | | | Naked Mole-Rat | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 625947544 | Mapda | N6-Methyl-AMP deaminase | ENCODES a protein that exhibits N6-methyl-AMP deaminase activity (ortholog); INVOLVED IN toxic metabolite repair (ortholog) | | | | Black Rat | 5 | description | gene, protein-coding, MODEL [RefSeq] |
| 3046 | Mapk3 | mitogen activated protein kinase 3 | ENCODES a protein that exhibits ATP binding; MAP kinase activity; scaffold protein binding; INVOLVED IN arachidonate metabolic process; cellular response to toxic substance; decidualization; PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signalin g pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH alcohol dependence; alcohol use disorder; cocaine abuse; FOUND IN caveola; cytoplasm; nucleoplasm; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine | 1 | 190797189 | 190803411 | Rat | 3590 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628649 | Mc2r | melanocortin 2 receptor | ENCODES a protein that exhibits corticotropin receptor activity (ortholog); INVOLVED IN placenta development; adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); positive regulation of glucocorticoid biosynthetic process (ortholog); PARTICIPATES IN G protein mediate d signaling pathway via Galphas family; melanocortin system pathway; ASSOCIATED WITH Acute-Phase Reaction; Disorders of Environmental Origin; toxic shock syndrome; FOUND IN plasma membrane (ortholog); INTERACTS WITH ammonium chloride; bis(2-butoxyethyl)phthalate; bisphenol A | 18 | 64279878 | 64291775 | Rat | 99 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735904 | MGMT | O-6-methylguanine-DNA methyltransferase | Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein cataly zes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015] | 10 | 129467241 | 129770983 | Human | 426 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737343 | MGST1 | microsomal glutathione S-transferase 1 | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] | 12 | 16347115 | 16593331 | Human | 350 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 18342017 | MHC-DQB1 | major histocompatibility complex, class II, DQ beta 1 | ENCODES a protein that exhibits protein antigen binding (inferred); toxic substance binding (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN adaptive immune response (inferred); antigen processing and presentation (inferred); antigen processi ng and presentation of peptide or polysaccharide antigen via MHC class II (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endosome membrane (inferred); lysosomal membrane (inferred); membrane (inferred) | | | | Green Monkey | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 620937 | Mlh1 | mutL homolog 1 | ENCODES a protein that exhibits chromatin binding (ortholog); enzyme activator activity (ortholog); enzyme binding (ortholog); INVOLVED IN response to hypoxia; response to toxic substance; response to xenobiotic stimulus; PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH lung carcinoma; bile duct cancer (ortholog); breast cancer (ortholog); FOUND IN synaptonemal complex; chiasma (ortholog); chromosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-hydroperoxycyclophosphamide | 8 | 120074871 | 120112109 | Rat | 500 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1349540 | MT-ND1 | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in several diseases, including MELAS syn drome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Parkinson's disease; and multiple sclerosis. [provided by Alliance of Genome Resources, Jul 2025] | MT | 3307 | 4262 | Human | 538 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1609862 | mt-Nd1 | NADH dehydrogenase 1, mitochondrial | Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; and response to hydroperoxide. Located in mitoch ondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | MT | 2751 | 3707 | Mouse | 228 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1352993 | MT1B | metallothionein 1B | The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016] | 16 | 56651886 | 56653204 | Human | 83 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606267 | MTARC2 | mitochondrial amidoxime reducing component 2 | The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxyla ted nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016] | 1 | 220748322 | 220784815 | Human | 115 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732527 | NAT2 | N-acetyltransferase 2 | This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polym orphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019] | 8 | 18386301 | 18401218 | Human | 302 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 12521068 | Nefh | neurofilament heavy chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); protein-macromolecule adaptor activity (ortholog); toxic substance binding (ortholog); INVOLVED IN axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ce llular response to hydroperoxide (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Anti-N-Methyl-D-Aspartate Receptor Encephalitis (ortholog); FOUND IN apical dendrite (ortholog); axon (ortholog); basal proximal dendrite (ortholog) | NW_004936657 | 3443406 | 3453096 | Squirrel | 101 | description | gene, protein-coding, MODEL [RefSeq] |
| 18656660 | NEFH | neurofilament heavy chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); protein-macromolecule adaptor activity (ortholog); toxic substance binding (ortholog); INVOLVED IN axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ce llular response to hydroperoxide (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Anti-N-Methyl-D-Aspartate Receptor Encephalitis (ortholog); FOUND IN apical dendrite (ortholog); axon (ortholog); basal proximal dendrite (ortholog) | | | | Green Monkey | 101 | description | gene, protein-coding, MODEL [RefSeq] |
| 3160 | Nefm | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding; signaling receptor binding; toxic substance binding; INVOLVED IN axon regeneration; cellular response to estradiol stimulus; cellular response to oxidative stress; PARTICIPATES IN amyotrophic la teral sclerosis pathway; ASSOCIATED WITH amyotrophic lateral sclerosis; congenital hypothyroidism; Experimental Diabetes Mellitus; FOUND IN axon; cytoskeleton; intermediate filament; INTERACTS WITH (-)-anisomycin; 2,5-hexanedione; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile | 15 | 46535857 | 46541161 | Rat | 243 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 10970 | Nefm | neurofilament, medium polypeptide | Predicted to enable signaling receptor binding activity and toxic substance binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter . Located in several cellular components, including neurofilament; neuromuscular junction; and postsynaptic density. Is active in postsynaptic intermediate filament cytoskeleton and presynaptic intermediate filament cytoskeleton. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urogenital ridge. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 68356994 | 68362453 | Mouse | 275 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8890055 | Nefm | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); cytoskeleton (ortholog); intermediate filament (ortholog) | NW_004955403 | 47920408 | 47926922 | Chinchilla | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 11905130 | NEFM | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); intermediate filament (ortholog); neurofilament (ortholog) | 8 | 24181335 | 24186701 | Bonobo | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 12428607 | NEFM | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); intermediate filament (ortholog); intermediate filament cytoskeleton (ortholog) | 25 | 32493517 | 32498615 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 12607176 | Nefm | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); intermediate filament (ortholog); neurofilament (ortholog) | NW_004936757 | 1662905 | 1668707 | Squirrel | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 14097832 | NEFM | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); intermediate filament (ortholog); intermediate filament cytoskeleton (ortholog) | | | | Pig | 63 | description | gene, protein-coding, MODEL [RefSeq] |
| 18398743 | NEFM | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); intermediate filament (ortholog); neurofilament (ortholog) | | | | Green Monkey | 66 | description | gene, protein-coding, MODEL [RefSeq] |
| 18927275 | Nefm | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); intermediate filament (ortholog); intermediate filament cytoskeleton (ortholog) | | | | Naked Mole-Rat | 70 | description | gene, protein-coding, MODEL [RefSeq] |
| 626004767 | Nefm | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); cytoskeleton (ortholog); intermediate filament (ortholog) | | | | Black Rat | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 1321571 | NPTX1 | neuronal pentraxin 1 | NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008] | 17 | 80466834 | 80476607 | Human | 173 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735862 | Nptxr | neuronal pentraxin receptor | This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008] | 15 | 79670552 | 79688910 | Mouse | 102 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1607068 | NPTXR | neuronal pentraxin receptor | This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008] | 22 | 38818452 | 38844028 | Human | 95 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 8762274 | Nr4a2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); nuclear glucocorticoid receptor binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular response to corticotropin-releasing hormone stim ulus (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); nuclear speck (ortholog); nucleus (ortholog) | NW_004955449 | 16928780 | 16944536 | Chinchilla | 93 | description | gene, protein-coding, MODEL [RefSeq] |
| 12026151 | NR4A2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN adult locomotory behavior (ortholog); cellular response to oxidative stress (ortholog); centr al nervous system neuron differentiation (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog) | 2B | 43584835 | 43593118 | Bonobo | 112 | description | gene, protein-coding, MODEL [RefSeq] |
| 12162165 | NR4A2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN adult locomotory behavior (ortholog); cellular response to oxidative stress (ortholog); centr al nervous system neuron differentiation (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); INTERACTS WITH bisphenol A | 36 | 2546237 | 2554559 | Dog | 112 | description | gene, protein-coding, MODEL [RefSeq] |
| 12478856 | Nr4a2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN adult locomotory behavior (ortholog); cellular response to oxidative stress (ortholog); centr al nervous system neuron differentiation (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog) | NW_004936469 | 21912118 | 21920486 | Squirrel | 110 | description | gene, protein-coding, MODEL [RefSeq] |
| 14144081 | NR4A2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN adult locomotory behavior (ortholog); cellular response to oxidative stress (ortholog); centr al nervous system neuron differentiation (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); INTERACTS WITH ammonia | | | | Pig | 113 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18742828 | NR4A2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN adult locomotory behavior (ortholog); cellular response to oxidative stress (ortholog); centr al nervous system neuron differentiation (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog) | | | | Green Monkey | 111 | description | gene, protein-coding, MODEL [RefSeq] |
| 18923657 | Nr4a2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular response to oxidative stress (ortholog); central nervous system neuron differentiation (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 103 | description | gene, protein-coding, MODEL [RefSeq] |
| 626083897 | Nr4a2 | nuclear receptor subfamily 4 group A member 2 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); nuclear glucocorticoid receptor binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular response to corticotropin-releasing hormone stim ulus (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Animal Toxoplasmosis (ortholog); Arsenic Poisoning (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); nuclear speck (ortholog); nucleus (ortholog) | | | | Black Rat | 93 | description | gene, protein-coding, MODEL [RefSeq] |
| 1321575 | NUDT14 | nudix hydrolase 14 | The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] | 14 | 105172939 | 105181312 | Human | 77 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317982 | NUDT15 | nudix hydrolase 15 | This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing tr ansversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016] | 13 | 48037726 | 48052755 | Human | 95 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605623 | NUDT18 | nudix hydrolase 18 | The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012] | 8 | 22106878 | 22110482 | Human | 87 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1350832 | NUDT7 | nudix hydrolase 7 | The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011] | 16 | 77722514 | 77742260 | Human | 168 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1344089 | OBP2A | odorant binding protein 2A | This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or tox ont-weight:700;'>toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] | 9 | 135546126 | 135549969 | Human | 61 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 3240 | P2rx1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding; extracellularly ATP-gated monoatomic cation channel activity; identical protein binding; INVOLVED IN monoatomic cation transmembrane transport; monoatomic ion transmembrane transport; neuronal action potential; PARTICIPATES IN calcium/calcium-mediated sig naling pathway; ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse; postsynaptic membrane; presynaptic active zone membrane; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1 | 10 | 58117107 | 58132167 | Rat | 169 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8970969 | P2rx1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN external side of plasma membrane (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | NW_004955467 | 12955663 | 12971547 | Chinchilla | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 11823762 | P2RX1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic active zone membrane (ortholog) | 17 | 3944636 | 3965260 | Bonobo | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 12104128 | P2RX1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic active zone membrane (ortholog) | 9 | 47674175 | 47694358 | Dog | 69 | description | gene, protein-coding, MODEL [RefSeq] |
| 12472413 | P2rx1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic active zone membrane (ortholog) | NW_004936677 | 530338 | 546742 | Squirrel | 75 | description | gene, protein-coding, MODEL [RefSeq] |
| 14116944 | P2RX1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic active zone membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 18508384 | P2RX1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic active zone membrane (ortholog) | | | | Green Monkey | 70 | description | gene, protein-coding, MODEL [RefSeq] |
| 18908505 | P2rx1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic active zone membrane (ortholog) | | | | Naked Mole-Rat | 70 | description | gene, protein-coding, MODEL [RefSeq] |
| 625850994 | P2rx1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding (ortholog); extracellularly ATP-gated monoatomic cation channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); insemination (ortholog); monoatomic cation transmembrane transport (ortholog); ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN external side of plasma membrane (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | | | | Black Rat | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 1618391 | Phax | phosphorylated adaptor for RNA export | Predicted to enable mRNA cap binding complex binding activity and toxic substance binding activity. Acts upstream of or within snRNA export from nucleus. Located in cytoplasm and nucleus. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provid ed by Alliance of Genome Resources, Jul 2025] | 18 | 56695641 | 56720784 | Mouse | 85 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9038540 | Phax | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits mRNA cap binding complex binding (ortholog); toxic substance binding (ortholog); INVOLVED IN RNA stabilization (ortholog); snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN cytoplasm (ortholog); neuronal cell body (ortholog); nucleoplasm (ortholog) | NW_004955521 | 4425382 | 4442668 | Chinchilla | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 11922530 | PHAX | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN neuronal cell body (ortholog) | 5 | 122005976 | 122032326 | Bonobo | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12606688 | Phax | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN neuronal cell body (ortholog) | NW_004936504 | 1585 | 14592 | Squirrel | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 13915310 | PHAX | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN neuronal cell body (ortholog) | | | | Pig | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 18384245 | PHAX | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits toxic substance binding (ortholog); INVOLVED IN snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN neuronal cell body (ortholog) | | | | Green Monkey | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 18932173 | Phax | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits mRNA cap binding complex binding (ortholog); toxic substance binding (ortholog); INVOLVED IN RNA stabilization (ortholog); snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN neuronal cell body (ortholog); nucleoplasm (ortholog); ribonucleoprotein complex (ortholog) | | | | Naked Mole-Rat | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 625896815 | Phax | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits mRNA cap binding complex binding (ortholog); toxic substance binding (ortholog); INVOLVED IN RNA stabilization (ortholog); snRNA export from nucleus (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN cytoplasm (ortholog); neuronal cell body (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 1352736 | PKD1L1 | polycystin 1 like 1, transient receptor potential channel interacting | This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive syst em. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] | 7 | 47774614 | 47960906 | Human | 120 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1343423 | PKD1L2 | polycystin 1 like 2 (gene/pseudogene) | This gene encodes a member of the polycystin protein family. This protein may function as a G-protein-coupled component or regulator of cation channel pores. The long isoform of this protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycyst in-1, lipoxygenase, alpha-toxin (PLAT) domain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene is a polymorphic pseudogene in humans. [provided by RefSeq, May 2022] | 16 | 81100875 | 81220394 | Human | 84 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1317476 | PKD1L3 | polycystin 1 like 3, transient receptor potential channel interacting | This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009] | 16 | 71929538 | 72000402 | Human | 57 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315287 | PKDREJ | polycystin family receptor for egg jelly | This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-tox in (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008] | 22 | 46255663 | 46263343 | Human | 41 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733240 | Pon1 | paraoxonase 1 | Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several s tructures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 5168101 | 5193824 | Mouse | 683 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551394 | Pon2 | paraoxonase 2 | Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Predicted to be involved in lactone catabolic process and response to toxic substance. Predicted to be located in plasma membra ne. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 5264620 | 5298408 | Mouse | 219 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628670 | Ppif | peptidylprolyl isomerase F | ENCODES a protein that exhibits cyclosporin A binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN regulation of apoptotic process; regulation of mitochondrial membrane permeability; apoptotic mitochondrial changes (ortholog); PARTICIPATES IN tox 00;'>toxoplasmosis pathway; ASSOCIATED WITH COVID-19 (ortholog); intestinal disease (ortholog); Ulcer (ortholog); FOUND IN mitochondrial inner membrane; mitochondrial matrix; mitochondrial permeability transition pore complex (ortholog); INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 16 | 1264001 | 1270722 | Rat | 255 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 632280 | Ppp1r9a | protein phosphatase 1, regulatory subunit 9A | ENCODES a protein that exhibits actin filament binding; GTPase binding; identical protein binding; INVOLVED IN cellular response to toxic substance; excitatory postsynaptic potential; negative regulation of long-term synaptic potentiation; ASSOCIATED WITH hepato cellular carcinoma; Pain; transient cerebral ischemia; FOUND IN actin cytoskeleton; cytoskeleton; dendrite; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 33936949 | 34258927 | Rat | 206 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8952810 | Ppp1r9a | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits actin filament binding (ortholog); GTPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic substance (o rtholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); cytoskeleton (ortholog) | NW_004955432 | 11607269 | 11891568 | Chinchilla | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 11722915 | PPP1R9A | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic sub stance (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); dendrite (ortholog) | 7 | 86863919 | 87251634 | Bonobo | 77 | description | gene, protein-coding, MODEL [RefSeq] |
| 12257533 | PPP1R9A | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic sub stance (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); dendrite (ortholog) | 14 | 20251791 | 20563315 | Dog | 76 | description | gene, protein-coding, MODEL [RefSeq] |
| 12466561 | Ppp1r9a | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic sub stance (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); cytoskeleton (ortholog) | NW_004936585 | 4981555 | 5277185 | Squirrel | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 14095051 | PPP1R9A | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic sub stance (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); dendrite (ortholog) | | | | Pig | 76 | description | gene, protein-coding, MODEL [RefSeq] |
| 18726131 | PPP1R9A | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic sub stance (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); dendrite (ortholog) | | | | Green Monkey | 77 | description | gene, protein-coding, MODEL [RefSeq] |
| 18916088 | Ppp1r9a | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic sub stance (ortholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 626021336 | Ppp1r9a | protein phosphatase 1 regulatory subunit 9A | ENCODES a protein that exhibits actin filament binding (ortholog); GTPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium-mediated signaling (ortholog); cellular response to toxic substance (o rtholog); ASSOCIATED WITH Experimental Seizures (ortholog); hepatocellular carcinoma (ortholog); Huntington's disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog); cytoskeleton (ortholog) | | | | Black Rat | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 11170 | Prh1 | proline rich protein HaeIII subfamily 1 | This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mic e against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015] | 6 | 132546805 | 132549364 | Mouse | 26 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 20866852 | PRKN | parkin RBR E3 ubiquitin protein ligase | ENCODES a protein that exhibits actin binding (inferred); beta-catenin binding (inferred); cullin family protein binding (inferred); INVOLVED IN aggresome assembly (inferred); autophagy of mitochondrion (inferred); cellular response to toxic substance (inferred) ; FOUND IN aggresome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 99 | description | gene, protein-coding |
| 1312903 | Prp2 | proline rich protein 2 | This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mic e against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015] | 6 | 132572874 | 132577665 | Mouse | 15 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1563360 | Ptpn13 | protein tyrosine phosphatase, non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance; negative regulation of excitatory synapse assembly; negative regulation of protein phosphorylation; PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH transient cerebral ischemia; breast cancer (ortholog); colon cancer (ortholog); FOUND IN cell body; cytoplasm (ortholog); lamellipodium (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 6412841 | 6587238 | Rat | 193 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8923499 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); lamellipodium (ortholog) | NW_004955474 | 2988109 | 3140520 | Chinchilla | 60 | description | gene, protein-coding, MODEL [RefSeq] |
| 11714007 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation o f excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog) | 4 | 78893598 | 79118745 | Bonobo | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 12079637 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation o f excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog); INTERACTS WITH bisphenol A | 32 | 10125447 | 10328764 | Dog | 76 | description | gene, protein-coding, MODEL [RefSeq] |
| 12690157 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation o f excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog) | NW_004936920 | 313762 | 510334 | Squirrel | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 13892215 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation o f excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 78 | description | gene, protein-coding, MODEL [RefSeq] |
| 18401050 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation o f excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog) | | | | Green Monkey | 70 | description | gene, protein-coding, MODEL [RefSeq] |
| 18911115 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits hydrolase activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation o f excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); midbody (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 69 | description | gene, protein-coding, MODEL [RefSeq] |
| 625848696 | Ptpn13 | protein tyrosine phosphatase non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance (ortholog); negative regulation of excitatory synapse assembly (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH breast cancer (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); lamellipodium (ortholog) | | | | Black Rat | 60 | description | gene, protein-coding, MODEL [RefSeq] |
| 1342592 | RAC1P5 | Rac family small GTPase 1 pseudogene 5 | This locus encodes one of the pseudogenes of the functional ras-related C3 botulinum toxin substrate 1 gene (RAC1, GeneID:5879) located on chr 7. It is intronless, shares overall 93% sequence identity with the RAC1 gene, and has enough differences in the coding region so as not to be able to code for a functional protein. There is no evidence of transcription at this pseudogene locus on chr 4. [provided by RefSeq, Jul 2008] | 4 | 107202653 | 107204757 | Human | | old_gene_name , description | gene, pseudo, REVIEWED [RefSeq] |
| 1316030 | RHOG | ras homolog family member G | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011] | 11 | 3826978 | 3840959 | Human | 117 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303020 | Rnase6 | ribonuclease A family member 6 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A | 15 | 26827896 | 26830807 | Rat | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8903718 | Rnase6 | ribonuclease A family member 6 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); extracellular space (ortholog) | NW_004955550 | 1687068 | 1688160 | Chinchilla | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 11747854 | RNASE6 | ribonuclease A family member 6 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN defense response to virus (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN c ytoplasmic vesicle (inferred); extracellular region (inferred); extracellular space (inferred) | 14 | 1642819 | 1644582 | Bonobo | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 12637844 | Rnase6 | ribonuclease A family member 6 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN defense response to virus (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN c ytoplasmic vesicle (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936880 | 78532 | 79342 | Squirrel | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 14268051 | RNASE6 | ribonuclease A family member 6 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN defense response to virus (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN c ytoplasmic vesicle (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Pig | 27 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18687987 | RNASE6 | ribonuclease A family member 6 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN defense response to virus (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN c ytoplasmic vesicle (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 18933636 | Rnase6 | ribonuclease A family member 6 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); lyase activity (inferred); INVOLVED IN defense response to virus (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN cyto plasmic vesicle (ortholog) | | | | Naked Mole-Rat | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 625846778 | Rnase6 | ribonuclease A family member 6 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); extracellular space (ortholog) | | | | Black Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 9008811 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN adipose tissue development (ortholo g); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog); nucleus (ortholog) | NW_004955589 | 590653 | 616784 | Chinchilla | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 12028797 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | 1 | 127164725 | 127190479 | Bonobo | 83 | description | gene, protein-coding, MODEL [RefSeq] |
| 12421811 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | 17 | 60821498 | 60842485 | Dog | 80 | description | gene, protein-coding, MODEL [RefSeq] |
| 12632877 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | NW_004936580 | 1997640 | 2020649 | Squirrel | 81 | description | gene, protein-coding, MODEL [RefSeq] |
| 13982454 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 81 | description | gene, protein-coding, MODEL [RefSeq] |
| 18342812 | RORC | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adipose tissue development (ortholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Green Monkey | 81 | description | gene, protein-coding, MODEL [RefSeq] |
| 18931540 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); ligand-modulated transcription factor activity (ortholog); INVOLVED IN adipose tissue development (or tholog); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 78 | description | gene, protein-coding, MODEL [RefSeq] |
| 626048651 | Rorc | RAR related orphan receptor C | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN adipose tissue development (ortholo g); alpha-beta T cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH advanced sleep phase syndrome (ortholog); Animal Toxoplasmosis (ortholog); bacterial pneumonia (ortholog); FOUND IN external side of plasma membrane (ortholog); nuclear body (ortholog); nucleus (ortholog) | | | | Black Rat | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 1350281 | SCFD1 | sec1 family domain containing 1 | Predicted to enable syntaxin binding activity. Involved in negative regulation of autophagosome assembly; regulation of protein transport; and response to toxic substance. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 30622254 | 30735850 | Human | 108 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737152 | Scn9a | sodium channel, voltage-gated, type IX, alpha | Predicted to enable sodium ion binding activity and voltage-gated sodium channel activity. Involved in behavioral response to pain; circadian rhythm; and detection of stimulus involved in sensory perception. Acts upstream of or within inflammatory response; post-embryonic development; and response t o toxic substance. Predicted to be located in axon terminus and plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in several structures, including brain; gut; immune system; male reproductive gland or organ; and respiratory system epithelium. Human ortholog(s) of this gene implicated in erythromelalgia and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 66310424 | 66465456 | Mouse | 209 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316584 | Serpinc1 | serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in response to nutrient. Located in collagen-containing extracellular matrix. Is expressed in embryo; liver; neura l tube; and notochord. Used to study antithrombin III deficiency. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 160806153 | 160830113 | Mouse | 258 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552805 | Serping1 | serine (or cysteine) peptidase inhibitor, clade G, member 1 | Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Located in extracellular space. Is expressed in several structures, including cerebral cortex; genitourinary system; notocho rd; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 84595704 | 84605748 | Mouse | 262 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737198 | Sftpb | surfactant associated protein B | Predicted to be involved in respiratory gaseous exchange by respiratory system and sphingolipid metabolic process. Located in cytoplasm. Is expressed in lung surfactant and respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectiou s disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 72281594 | 72291354 | Mouse | 272 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 14124419 | SLA-DQB1 | SLA-DQ beta1 domain | ENCODES a protein that exhibits protein antigen binding (inferred); toxic substance binding (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN adaptive immune response (inferred); antigen processing and presentation (inferred); antigen processi ng and presentation of peptide or polysaccharide antigen via MHC class II (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN membrane (inferred); MHC class II protein complex (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 28 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12118936 | SLC17A2 | solute carrier family 17 member 2 | ENCODES a protein that exhibits efflux transmembrane transporter activity (inferred); symporter activity (inferred); toxin transmembrane transporter activity (inferred); INVOLVED IN monoatomic anion transmembrane transport (inferred); monoatomic ion transport (i nferred); organic anion transport (inferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); liver cirrhosis (ortholog); FOUND IN apical plasma membrane (inferred); cytoplasm (inferred); endoplasmic reticulum membrane (inferred) | 35 | 23839113 | 23919789 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 628815 | Slc17a3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic anion transport (ortholog); urate metabolic process (ort holog); urate transport (ortholog); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 17 | 41698679 | 41729057 | Rat | 132 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732000 | Slc17a3 | solute carrier family 17 (sodium phosphate), member 3 | Predicted to enable several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Predicted to be involved in urate metabolic process; urate transport; and xe nobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in endoplasmic reticulum membrane; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including liver and urinary system. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 24020905 | 24044701 | Mouse | 131 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8834197 | Slc17a3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic anion transport (ortholog); urate metabolic process (ort holog); urate transport (ortholog); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955483 | 1235122 | 1260161 | Chinchilla | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 11858057 | SLC17A3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic anion transport (ortholog); urate metabolic process (ort holog); urate transport (ortholog); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog) | 6 | 25678412 | 25707948 | Bonobo | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 12428989 | SLC17A3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (inferred); symporter activity (inferred); toxin transmembrane transporter activity (inferred); INVOLVED IN monoatomic anion transmembrane transport (inferred); monoatomic ion transport (i nferred); organic anion transport (inferred); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (inferred); cytoplasm (inferred); endoplasmic reticulum membrane (inferred) | 35 | 23792281 | 23831893 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 13852183 | SLC17A3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (inferred); symporter activity (inferred); toxin transmembrane transporter activity (inferred); INVOLVED IN monoatomic anion transmembrane transport (inferred); monoatomic ion transport (i nferred); organic anion transport (inferred); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (inferred); cytoplasm (inferred); endoplasmic reticulum membrane (inferred); INTERACTS WITH cadmium atom; deoxynivalenol | | | | Pig | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 18915728 | Slc17a3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (inferred); symporter activity (inferred); toxin transmembrane transporter activity (inferred); INVOLVED IN organic anion transport (ortholog); urate metabolic process (ortholog); xenobiot ic detoxification by transmembrane export across the plasma membrane (ortholog); ASSOCIATED WITH gout (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 625956285 | Slc17a3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic anion transport (ortholog); urate metabolic process (ort holog); urate transport (ortholog); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 11300 | Slc18a2 | solute carrier family 18 (vesicular monoamine), member 2 | Predicted to enable several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and monoamine transmembrane transporter activity. Involved in histamine secretion by mast cell; neurotransmitter loading into synaptic vesicle; and serotonin secretion by m ast cell. Acts upstream of or within several processes, including locomotory behavior; response to amphetamine; and response to toxic substance. Located in synaptic vesicle membrane. Is active in dopaminergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; blastocyst; brain; and eye. Human ortholog(s) of this gene implicated in Parkinson's disease; infantile parkinsonism-dystonia 2; and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 59249310 | 59284444 | Mouse | 441 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 732626 | SLC22A1 | solute carrier family 22 member 1 | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation t ransporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008] | 6 | 160121815 | 160158718 | Human | 463 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737278 | Slc22a1 | solute carrier family 22 (organic cation transporter), member 1 | Enables several functions, including organic cation transmembrane transporter activity; pyrimidine nucleoside transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; quaterna ry ammonium group transport; and spermidine transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 12867761 | 12894725 | Mouse | 517 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1353940 | SLC22A11 | solute carrier family 22 member 11 | The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, wher e it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] | 11 | 64555941 | 64572875 | Human | 135 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1322509 | SLC22A15 | solute carrier family 22 member 15 | Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solu te facilitators (ASFs).[supplied by OMIM, Apr 2004] | 1 | 115976513 | 116070054 | Human | 92 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628885 | Slc22a19 | solute carrier family 22, member 19 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN response to molecule of fungal origin; sodium-independent organic anion transport; organic anion transport (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); FOUND IN apical plasma membrane; INTERACTS WITH 17beta-estradiol; 4-methylumbelliferone sulfate; acetamide | 1 | 214339594 | 214394681 | Rat | 69 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735527 | Slc22a19 | solute carrier family 22 (organic anion transporter), member 19 | Enables organic anion transmembrane transporter activity and toxin transmembrane transporter activity. Acts upstream of or within organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in metanephros. Human ortholog(s) of t his gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 7650440 | 7688675 | Mouse | 134 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 62229 | Slc22a2 | solute carrier family 22 (organic cation transporter), member 2 | Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in cellular detoxification and xenobiotic transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane. Is expressed in several structures, including metanephros; nasal cavity mucosa; nervous system; placenta; and ureter. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 12803076 | 12847376 | Mouse | 670 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1342518 | SLC22A2 | solute carrier family 22 member 2 | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation t ransporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008] | 6 | 160216755 | 160258821 | Human | 608 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351828 | SLC22A3 | solute carrier family 22 member 3 | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation t ransporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008] | 6 | 160348378 | 160452577 | Human | 372 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11726005 | SLC22A3 | solute carrier family 22 member 3 | ENCODES a protein that exhibits dopamine:sodium symporter activity (ortholog); spermidine transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN dopamine transport (ortholog); histamine transport (ortholog ); histamine uptake (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH Coxsackievirus Infections (ortholog); Kidney Neoplasms (ortholog); myocarditis (ortholog); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); basolateral plasma membrane (inferred) | 6 | 158240390 | 158344338 | Bonobo | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 12398987 | SLC22A3 | solute carrier family 22 member 3 | ENCODES a protein that exhibits dopamine:sodium symporter activity (ortholog); spermidine transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN dopamine transport (ortholog); histamine transport (ortholog ); histamine uptake (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH Coxsackievirus Infections (ortholog); Kidney Neoplasms (ortholog); myocarditis (ortholog); FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); endomembrane system (inferred); INTERACTS WITH bisphenol A | 1 | 49407949 | 49496627 | Dog | 80 | description | gene, protein-coding, MODEL [RefSeq] |
| 12440170 | Slc22a3 | solute carrier family 22 member 3 | ENCODES a protein that exhibits dopamine:sodium symporter activity (ortholog); spermidine transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN dopamine transport (ortholog); histamine transport (ortholog ); histamine uptake (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH Coxsackievirus Infections (ortholog); Kidney Neoplasms (ortholog); myocarditis (ortholog); FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); endomembrane system (inferred) | NW_004936489 | 11693755 | 11774380 | Squirrel | 78 | description | gene, protein-coding, MODEL [RefSeq] |
| 13853364 | SLC22A3 | solute carrier family 22 member 3 | ENCODES a protein that exhibits dopamine:sodium symporter activity (ortholog); spermidine transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN dopamine transport (ortholog); histamine transport (ortholog ); histamine uptake (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH Coxsackievirus Infections (ortholog); Kidney Neoplasms (ortholog); myocarditis (ortholog); FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); endomembrane system (inferred) | | | | Pig | 80 | description | gene, protein-coding, MODEL [RefSeq] |
| 18680640 | SLC22A3 | solute carrier family 22 member 3 | ENCODES a protein that exhibits dopamine:sodium symporter activity (ortholog); spermidine transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN dopamine transport (ortholog); histamine transport (ortholog ); histamine uptake (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH Coxsackievirus Infections (ortholog); Kidney Neoplasms (ortholog); myocarditis (ortholog); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); basolateral plasma membrane (inferred) | | | | Green Monkey | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 733281 | SLC22A4 | solute carrier family 22 member 4 | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation t ransporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008] | 5 | 132294394 | 132344190 | Human | 254 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733710 | SLC22A5 | solute carrier family 22 member 5 | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral m embrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015] | 5 | 132369710 | 132395612 | Human | 706 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 619572 | SLC22A6 | solute carrier family 22 member 6 | The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transc ript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 11 | 62976597 | 62984967 | Human | 352 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732686 | SLC22A7 | solute carrier family 22 member 7 | The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] | 6 | 43295714 | 43305538 | Human | 276 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732952 | SLC22A8 | solute carrier family 22 member 8 | This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidn ey. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010] | 11 | 62992824 | 63015841 | Human | 378 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11966990 | SLC22A9 | solute carrier family 22 member 9 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN organic anion transport (ortholog); ASSOCIATED WITH Lynch syndrome (ortholog); mismatch repair cancer syndrome (ortholog); FOUND IN basolateral plasma membrane (infe rred); membrane (inferred) | 11 | 58722649 | 58763800 | Bonobo | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 1558196 | Slc29a4 | solute carrier family 29 (nucleoside transporters), member 4 | Enables several functions, including monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including adenosine transport; monoamine transpor t; and xenobiotic transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including brain; eye; reproductive system; spinal cord; and trigeminal nerve. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 142678226 | 142708245 | Mouse | 177 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8807017 | Slc30a4 | solute carrier family 30 member 4 | ENCODES a protein that exhibits zinc ion transmembrane transporter activity (ortholog); INVOLVED IN lactation (ortholog); response to toxic substance (ortholog); response to vitamin A (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); COVID-19 (ortholog ); prostate carcinoma in situ (ortholog); FOUND IN cytoplasm (ortholog); endosome membrane (ortholog); late endosome (ortholog) | NW_004955409 | 7963454 | 7991600 | Chinchilla | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 18915580 | Slc30a4 | solute carrier family 30 member 4 | ENCODES a protein that exhibits zinc ion transmembrane transporter activity (ortholog); INVOLVED IN lactation (ortholog); response to toxic substance (ortholog); response to vitamin A (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); COVID-19 (ortholog ); prostate carcinoma in situ (ortholog); FOUND IN cytoplasm (ortholog); endosome membrane (ortholog); late endosome (ortholog) | | | | Naked Mole-Rat | 43 | description | gene, protein-coding, MODEL [RefSeq] |
| 625994895 | Slc30a4 | solute carrier family 30 member 4 | ENCODES a protein that exhibits zinc ion transmembrane transporter activity (ortholog); INVOLVED IN lactation (ortholog); response to toxic substance (ortholog); response to vitamin A (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); COVID-19 (ortholog ); prostate carcinoma in situ (ortholog); FOUND IN cytoplasm (ortholog); endosome membrane (ortholog); late endosome (ortholog) | | | | Black Rat | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 1317894 | SLC39A8 | solute carrier family 39 member 8 | This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008] | 4 | 102251041 | 102345482 | Human | 369 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 12273346 | SLC6A14 | solute carrier family 6 member 14 | ENCODES a protein that exhibits aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN amino acid import across plasma membrane (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH Acidoses (ortholog); celiac disease (ortho log); Experimental Sarcoma (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog) | X | 88939176 | 88965093 | Dog | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 12518597 | Slc6a14 | solute carrier family 6 member 14 | ENCODES a protein that exhibits aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN response to toxic substance (ortholog); ASSOCIATED WITH Acidoses (ortholog); celiac disease (ortholog); Experimental Sarcoma (ortholog); FOUND IN brush border membrane (ortholog) | NW_004936479 | 13024831 | 13051908 | Squirrel | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 13877357 | SLC6A14 | solute carrier family 6 member 14 | ENCODES a protein that exhibits aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN amino acid import across plasma membrane (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH Acidoses (ortholog); celiac disease (ortho log); Experimental Sarcoma (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog) | | | | Pig | 29 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18919792 | Slc6a14 | solute carrier family 6 member 14 | ENCODES a protein that exhibits aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN response to toxic substance (ortholog); ASSOCIATED WITH Acidoses (ortholog); celiac disease (ortholog); Experimental Sarcoma (ortholog); FOUND IN brush border membrane (ortholog) | | | | Naked Mole-Rat | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 736222 | SNN | stannin | Enables metal ion binding activity. Predicted to be involved in response to toxic substance. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 11668455 | 11679152 | Human | 97 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353757 | SQOR | sulfide quinone oxidoreductase | The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [pr ovided by RefSeq, Sep 2012] | 15 | 45631148 | 45691281 | Human | 150 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309495 | Srsf9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN response to alkaloid; response to toxic substance; negative regulation of mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Expe rimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; bisphenol A | 12 | 46938948 | 46945213 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8790510 | Srsf9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway ; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955455 | 11175760 | 11183597 | Chinchilla | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 12014409 | SRSF9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); protein domain specific binding (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCI ATED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 12 | 118043325 | 118052107 | Bonobo | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 12252825 | SRSF9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits nucleic acid binding (inferred); protein domain specific binding (inferred); RNA binding (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIA TED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 26 | 16363275 | 16369699 | Dog | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 12450116 | Srsf9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); protein domain specific binding (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCI ATED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936668 | 484922 | 491576 | Squirrel | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 14269707 | SRSF9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits nucleic acid binding (inferred); protein domain specific binding (inferred); RNA binding (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIA TED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 27 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18385839 | SRSF9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); protein domain specific binding (inferred); INVOLVED IN response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCI ATED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 18901509 | Srsf9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway ; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 625848976 | Srsf9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); response to alkaloid (ortholog); response to toxic substance (ortholog); PARTICIPATES IN spliceosome pathway ; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 3679 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN ganglioside metabolic pathway; glo boside metabolic pathway; lacto-series glycosphingolipid metabolic pathway; ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN Golgi membrane (inferred); INTERACTS WITH acetamide; alpha-Zearalanol; ammonium chloride | 4 | 177513966 | 177651553 | Rat | 85 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8816005 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity (ortholog); sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog) | NW_004955413 | 17667434 | 17810671 | Chinchilla | 7 | description | gene, protein-coding, MODEL [RefSeq] |
| 11693778 | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); F OUND IN Golgi membrane (inferred) | 12 | 63972127 | 64112083 | Bonobo | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12431997 | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); F OUND IN Golgi membrane (inferred) | 27 | 24879103 | 25027014 | Dog | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12541052 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); F OUND IN Golgi membrane (inferred) | NW_004936548 | 4671257 | 4797917 | Squirrel | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 13967629 | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); F OUND IN Golgi membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 18667159 | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); F OUND IN Golgi membrane (inferred) | | | | Green Monkey | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 18921049 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); F OUND IN Golgi membrane (inferred) | | | | Naked Mole-Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 626037926 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity (ortholog); sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog) | | | | Black Rat | 7 | description | gene, protein-coding, MODEL [RefSeq] |
| 1562552 | Sting1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding; cyclic-di-GMP binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of type I interferon production; activation of innate immune response (ortholog); antiviral innate immune response (ortholog); ASSOCIA TED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN autophagosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; arsane | 18 | 27606196 | 27612544 | Rat | 310 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9000943 | Sting1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (ortholog); cyclic-di-GMP binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); autophagosome assembly (ortholog); ASSOCIATED WIT H Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN autophagosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955418 | 1091022 | 1097064 | Chinchilla | 133 | description | gene, protein-coding, MODEL [RefSeq] |
| 11729943 | STING1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (inferred); cyclic-di-GMP binding (inferred); identical protein binding (inferred); INVOLVED IN cellular response to interferon-beta (ortholog); defense response to virus (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog) | 5 | 134845689 | 134852938 | Bonobo | 132 | description | gene, protein-coding, MODEL [RefSeq] |
| 12365509 | STING1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (inferred); cyclic-di-GMP binding (inferred); identical protein binding (inferred); INVOLVED IN cellular response to interferon-beta (ortholog); defense response to virus (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog); INTERACTS WITH masitinib | 2 | 34783947 | 34792204 | Dog | 135 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12663976 | Sting1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (inferred); cyclic-di-GMP binding (inferred); identical protein binding (inferred); INVOLVED IN cellular response to interferon-beta (ortholog); defense response to virus (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog) | NW_004936531 | 8555966 | 8562829 | Squirrel | 132 | description | gene, protein-coding, MODEL [RefSeq] |
| 13984414 | STING1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (ortholog); cyclic-di-GMP binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN activation of innate immune response (ortholog); autophagosome assembly (ortholog); cellular response to interferon-beta (ortholog); AS SOCIATED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 155 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18683645 | STING1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (inferred); cyclic-di-GMP binding (inferred); identical protein binding (inferred); INVOLVED IN cellular response to interferon-beta (ortholog); defense response to virus (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog) | | | | Green Monkey | 132 | description | gene, protein-coding, MODEL [RefSeq] |
| 18905600 | Sting1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); protein kinase binding (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to exogenous dsRNA (ortholog); cellular response to interferon-beta (ortho log); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 124 | description | gene, protein-coding, MODEL [RefSeq] |
| 626140236 | Sting1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (ortholog); cyclic-di-GMP binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); autophagosome assembly (ortholog); ASSOCIATED WIT H Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN autophagosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 132 | description | gene, protein-coding, MODEL [RefSeq] |
| 1603906 | SVOPL | SVOP like | The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016] | 7 | 138594285 | 138701362 | Human | 39 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 69494 | SYNJ2 | synaptojanin 2 | The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediat ed endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] | 6 | 157981296 | 158099176 | Human | 206 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 62207 | Tfpi | tissue factor pathway inhibitor | Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of blood coagulation. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 84263199 | 84307119 | Mouse | 304 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564460 | Tlr11 | toll-like receptor 11 | INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN toxoplasmosis pathway; ASSOCIATED WITH membranoproliferative glomerulonephritis (ortholog); FOUND IN membrane (inferred); INTERACTS WITH bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ort holog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog) | 15 | 26018987 | 26023426 | Rat | 23 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602315 | TM2D1 | TM2 domain containing 1 | The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been establi shed to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016] | 1 | 61681046 | 61725141 | Human | 75 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1566403 | Tmem181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 1 | 49235923 | 49290244 | Rat | 55 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1620723 | Tmem181a | transmembrane protein 181A | Predicted to enable toxic substance binding activity. Is expressed in several structures, including cardiovascular system; central nervous system; gut; reproductive system; and trachea. Orthologous to human TMEM181 (transmembrane protein 181). [provided by Allia nce of Genome Resources, Jul 2025] | 17 | 6307001 | 6358589 | Mouse | 57 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1350168 | TPMT | thiopurine S-methyltransferase | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] | 6 | 18128311 | 18155169 | Human | 197 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 18906973 | Trpm6 | transient receptor potential cation channel subfamily M member 6 | ENCODES a protein that exhibits calcium ion transmembrane transporter activity (ortholog); magnesium ion transmembrane transporter activity (ortholog); INVOLVED IN magnesium ion transmembrane transport (ortholog); metal ion transport (ortholog); response to toxi c substance (ortholog); ASSOCIATED WITH cone-rod dystrophy (ortholog); Eye Abnormalities (ortholog); genetic disease (ortholog); FOUND IN brush border membrane (ortholog) | | | | Naked Mole-Rat | 48 | description | gene, protein-coding, MODEL [RefSeq] |
| 1343349 | UGT2B15 | UDP glucuronosyltransferase family 2 member B15 | This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of si milar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016] | 4 | 68646597 | 68670652 | Human | 179 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351542 | UGT2B7 | UDP glucuronosyltransferase family 2 member B7 | The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome memb rane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017] | 4 | 69051375 | 69112987 | Human | 312 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8865835 | Xrcc1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); ADP-D-ribose modification-dependent protein binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PA RTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); acute lymphoblastic leukemia (ortholog); asphyxia neonatorum (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); ERCC4-ERCC1 complex (ortholog) | NW_004955555 | 1293416 | 1315839 | Chinchilla | 191 | description | gene, protein-coding, MODEL [RefSeq] |
| 11791631 | XRCC1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); ADP-D-ribose modification-dependent protein binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog ); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); acute lymphoblastic leukemia (ortholog); asphyxia neonatorum (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | 19 | 40485052 | 40522188 | Bonobo | 201 | description | gene, protein-coding, MODEL [RefSeq] |
| 12298741 | XRCC1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); ADP-D-ribose modification-dependent protein binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog ); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); acute lymphoblastic leukemia (ortholog); asphyxia neonatorum (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | 1 | 111548719 | 111571816 | Dog | 201 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12631110 | Xrcc1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); ADP-D-ribose modification-dependent protein binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog ); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); acute lymphoblastic leukemia (ortholog); asphyxia neonatorum (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | NW_004936706 | 752571 | 783746 | Squirrel | 201 | description | gene, protein-coding, MODEL [RefSeq] |
| 13937601 | XRCC1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); ADP-D-ribose modification-dependent protein binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog ); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); acute lymphoblastic leukemia (ortholog); asphyxia neonatorum (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred); INTERACTS WITH ochratoxin A | | | | Pig | 202 | description | gene, protein-coding, MODEL [RefSeq] |
| 18450074 | XRCC1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); ADP-D-ribose modification-dependent protein binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog ); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); asphyxia neonatorum (ortholog); autosomal recessive spinocerebellar ataxia 26 (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | | | | Green Monkey | 201 | description | gene, protein-coding, MODEL [RefSeq] |
| 18935618 | Xrcc1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); ADP-D-ribose modification-dependent protein binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog ); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); acute lymphoblastic leukemia (ortholog); asphyxia neonatorum (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); chromosome, telomeric region (inferred) | | | | Naked Mole-Rat | 201 | description | gene, protein-coding, MODEL [RefSeq] |
| 626104033 | Xrcc1 | X-ray repair cross complementing 1 | ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); ADP-D-ribose modification-dependent protein binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PA RTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); asphyxia neonatorum (ortholog); autosomal recessive spinocerebellar ataxia 26 (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); ERCC4-ERCC1 complex (ortholog) | | | | Black Rat | 191 | description | gene, protein-coding, MODEL [RefSeq] |
| 1602437 | ZFAND2B | zinc finger AN1-type containing 2B | This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encodi ng multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] | 2 | 219206782 | 219209648 | Human | 89 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315510 | B3GALT5 | beta-1,3-galactosyltransferase 5 | This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this ge ne. [provided by RefSeq, Sep 2017] | 21 | 39612940 | 39673137 | Human | 86 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1346791 | RAC1P1 | Rac family small GTPase 1 pseudogene 1 | | 18 | 24685478 | 24686365 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1342726 | RAC1P2 | Rac family small GTPase 1 pseudogene 2 | INTERACTS WITH lead diacetate | 4 | 46723670 | 46724607 | Human | 1 | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1352022 | RAC1P3 | Rac family small GTPase 1 pseudogene 3 | | 13 | 41287506 | 41288460 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1348059 | RAC1P4 | Rac family small GTPase 1 pseudogene 4 | | X | 137441047 | 137442031 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 5133143 | RAC1P6 | Rac family small GTPase 1 pseudogene 6 | | 7 | 115136576 | 115137162 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 6480980 | RAC1P7 | Rac family small GTPase 1 pseudogene 7 | | 1 | 234026873 | 234027227 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 6480997 | RAC1P8 | Rac family small GTPase 1 pseudogene 8 | | 13 | 61805150 | 61805676 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 8662683 | RAC1P9 | Rac family small GTPase 1 pseudogene 9 | | 7 | 53779749 | 53780263 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1605733 | HBEGF | heparin binding EGF like growth factor | Enables growth factor activity; heparin binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal t ransduction; and positive regulation of wound healing. Located in cell surface. Is active in extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 140332843 | 140346603 | Human | 402 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
