CNR1 (cannabinoid receptor 1) - Rat Genome Database

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Gene: CNR1 (cannabinoid receptor 1) Homo sapiens
Analyze
Symbol: CNR1
Name: cannabinoid receptor 1
RGD ID: 735525
HGNC Page HGNC:2159
Description: Enables cannabinoid receptor activity and identical protein binding activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and cannabinoid signaling pathway. Located in actin cytoskeleton and plasma membrane. Implicated in obesity; schizophrenia; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CANN6; cannabinoid receptor 1 (brain); CB-R; CB1; CB1A; CB1K5; CB1R; central cannabinoid receptor; CNR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (ISO)
Alcohol Withdrawal Delirium  (IAGP)
Animal Disease Models  (EXP)
anxiety disorder  (EXP)
Ascites  (ISO)
attention deficit hyperactivity disorder  (EXP)
Binge-Eating Disorder  (EXP)
cannabis abuse  (EXP)
Catalepsy  (EXP)
cholestasis  (EXP)
Cocaine-Related Disorders  (EXP)
cognitive disorder  (EXP)
developmental coordination disorder  (EXP)
diabetic neuropathy  (ISO)
Endometrial Neoplasms  (EXP)
endometriosis  (EXP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Fever  (ISO)
focal epilepsy  (ISO)
genetic disease  (IAGP)
glucose intolerance  (EXP)
Hemorrhagic Shock  (ISO)
Huntington's disease  (EXP)
Hyperalgesia  (EXP)
hypertension  (ISO)
Hypotension  (EXP,ISO)
Hypothermia  (EXP)
impotence  (ISO)
Insulin Resistance  (ISO)
Intravenous Substance Abuse  (IAGP)
liver cirrhosis  (EXP)
Memory Disorders  (EXP)
morphine dependence  (ISO)
movement disease  (EXP)
multiple sclerosis  (EXP)
Muscle Spasticity  (EXP)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (EXP,ISO)
obesity  (EXP,IAGP,IDA,ISO)
Pain  (EXP,ISO)
pancreatic cancer  (EXP)
pancreatitis  (EXP)
Parkinsonism  (ISO)
peptic ulcer disease  (ISO)
post-traumatic stress disorder  (EXP)
Reperfusion Injury  (ISO)
rhabdomyosarcoma  (EXP)
schizophrenia  (EXP,IAGP,ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (EXP,ISO)
stress-related disorder  (ISO)
substance-related disorder  (EXP)
systemic scleroderma  (EXP)
temporal lobe epilepsy  (EXP)
type 2 diabetes mellitus  (IMP)
Weight Gain  (EXP)
Weight Loss  (EXP)
withdrawal disorder  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-nitropropanoic acid  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetaldehyde  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
Adb-fubinaca  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (EXP,ISO)
ammonium chloride  (ISO)
amphetamines  (EXP)
anandamide  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
Bromazepam  (ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
Cannabinol  (ISO)
capsaicin  (ISO)
carbazoles  (EXP)
CGP 52608  (EXP)
chaetocin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cytarabine  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazepam  (ISO)
diazoxon  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichlorvos  (ISO)
dioxygen  (EXP)
diprotium oxide  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
entinostat  (EXP)
ethanol  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
gemcitabine  (EXP)
gentamycin  (ISO)
ghrelin  (ISO)
glucose  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
imipramine  (ISO)
indazoles  (EXP)
indoles  (EXP)
indometacin  (EXP)
kainic acid  (ISO)
ketamine  (ISO)
L-ascorbic acid  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP)
methamphetamine  (ISO)
Methanandamide  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylphenidate  (ISO)
morphine  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-oleoyldopamine  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (EXP)
palmitoyl ethanolamide  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
parecoxib  (ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
phencyclidine  (ISO)
Phenol, 5-(1,1-dimethylheptyl)-2-[(1r,3s)-3-hydroxycyclohexyl]-  (ISO)
phenylmercury acetate  (EXP)
piperidines  (ISO)
poly(I:C)  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
pregabalin  (ISO)
pregnenolone  (ISO)
progesterone  (EXP)
pyrazoles  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quetiapine fumarate  (ISO)
reserpine  (ISO)
ricinoleic acid  (EXP)
rimonabant  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (ISO)
SB 431542  (EXP)
serotonin  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
SR 144528  (ISO)
streptozocin  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topiramate  (ISO)
tribufos  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triptonide  (ISO)
valproic acid  (EXP)
venlafaxine hydrochloride  (ISO)
water  (ISO)
WIN 55212-2  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA,IEA)
axonal fasciculation  (IEA,ISO)
cannabinoid signaling pathway  (IDA,IEA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (TAS)
glucose homeostasis  (IEA,ISO)
learning or memory  (IEA,ISO)
maternal process involved in female pregnancy  (IEA,ISO)
memory  (IEA,ISO)
negative regulation of action potential  (IEA,ISO)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of dopamine secretion  (IEA,ISO)
negative regulation of fatty acid beta-oxidation  (IEA,ISO)
negative regulation of mast cell activation  (IEA,ISO)
negative regulation of monoatomic ion transport  (IEA,ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of serotonin secretion  (IEA)
positive regulation of acute inflammatory response to antigenic stimulus  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of blood pressure  (IEA,ISO)
positive regulation of fever generation  (IEA,ISO)
positive regulation of neuron projection development  (IEA,ISO)
regulation of feeding behavior  (IEA,ISO)
regulation of insulin secretion  (IEA,ISO)
regulation of lipid metabolic process  (IEA,ISO)
regulation of metabolic process  (IBA,IEA)
regulation of penile erection  (IEA,ISO)
regulation of presynaptic cytosolic calcium ion concentration  (IEA)
regulation of synaptic transmission, GABAergic  (IEA,ISO)
regulation of synaptic transmission, glutamatergic  (IEA,ISO)
response to cocaine  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to nicotine  (IEA,ISO)
response to nutrient  (IEA,ISO)
retrograde trans-synaptic signaling by endocannabinoid  (IEA)
signal transduction  (IEA)
spermatogenesis  (IEA,ISO)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy. Bujalska M Pharmacology. 2008;82(3):193-200. Epub 2008 Sep 23.
2. Cannabinoid receptor gene (CNR1): association with i.v. drug use. Comings DE, etal., Mol Psychiatry 1997 Mar;2(2):161-8.
3. Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Cota D, etal., Obesity (Silver Spring). 2009 Aug;17(8):1641-5. Epub 2009 Mar 26.
4. Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions. De March Z, etal., Neuroscience. 2008 Mar 27;152(3):734-40. doi: 10.1016/j.neuroscience.2007.11.044. Epub 2007 Dec 8.
5. Type 1 diabetes alters brain cannabinoid receptor expression and phosphorylation status in rats. Diaz-Asensio C, etal., Horm Metab Res. 2008 Jul;40(7):454-8. Epub 2008 Mar 27.
6. Cannabinoid type 1 receptor antagonism delays ascites formation in rats with cirrhosis. Domenicali M, etal., Gastroenterology. 2009 Jul;137(1):341-9. Epub 2009 Jan 14.
7. Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Falenski KW, etal., Brain Res. 2009 Mar 25;1262:64-72. Epub 2009 Jan 31.
8. Endogenous cannabinoids induce fever through the activation of CB1 receptors. Fraga D, etal., Br J Pharmacol. 2009 Aug;157(8):1494-501.
9. The endocannabinoid system is modulated in response to spinal cord injury in rats. Garcia-Ovejero D, etal., Neurobiol Dis. 2009 Jan;33(1):57-71. Epub 2008 Sep 30.
10. Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. Ghasemi M, etal., BJU Int. 2007 Dec;100(6):1385-90. Epub 2007 Sep 10.
11. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
12. Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. Ho WS and Gardiner SM, Br J Pharmacol. 2009 Jan;156(1):94-104.
13. CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats. Hou LC, etal., Chin Med J (Engl). 2009 Apr 20;122(8):950-4.
14. The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease. Kelsey JE, etal., Behav Brain Res. 2009 Nov 5;203(2):304-7. Epub 2009 May 3.
15. Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiiskaia akademiia nauk Lasukova OV, etal., Izv Akad Nauk Ser Biol. 2008 Jul-Aug;(4):471-8.
16. Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. Leroy S, etal., Am J Med Genet 2001 Dec 8;105(8):749-52.
17. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Marco EM, etal., Pharmacol Biochem Behav. 2017 Jan;152:68-80. doi: 10.1016/j.pbb.2016.11.005. Epub 2016 Nov 25.
18. No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents. Muller TD, etal., Mol Genet Metab. 2007 Apr;90(4):429-34. Epub 2007 Feb 8.
19. Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Pernia-Andrade AJ, etal., Science. 2009 Aug 7;325(5941):760-4.
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity. Pucci M, etal., Front Genet. 2019 Jun 14;10:523. doi: 10.3389/fgene.2019.00523. eCollection 2019.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat. Rizzo V, etal., Neurosci Lett. 2009 Sep 22;462(2):135-9. Epub 2009 Jul 10.
25. SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes. Rosenstock J, etal., Diabetes Care. 2008 Nov;31(11):2169-76. Epub 2008 Aug 4.
26. Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. Russo P, etal., J Clin Endocrinol Metab. 2007 Jun;92(6):2382-6. Epub 2007 Apr 3.
27. Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. Rutkowska M and Fereniec-Golebiewska L, Pharmazie. 2009 Sep;64(9):595-7.
28. Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Schmidt LG, etal., Drug Alcohol Depend. 2002 Feb 1;65(3):221-4.
29. Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats. Spano MS, etal., Eur Neuropsychopharmacol. 2009 Oct 22.
30. New perspectives in the studies on endocannabinoid and cannabis: cannabinoid receptors and schizophrenia. Ujike H and Morita Y, J Pharmacol Sci. 2004 Dec;96(4):376-81.
31. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Villanueva A, etal., Shock. 2009 Dec;32(6):614-20.
32. Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. Wang Q, etal., Stroke. 2009 Jun;40(6):2157-64. Epub 2009 Apr 16.
33. Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1, 5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice. Wu CH, etal., J Med Chem. 2009 Jul 23;52(14):4496-510.
34. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Zhang J, etal., Neurosci Lett. 2016 Sep 6;630:70-76. doi: 10.1016/j.neulet.2016.07.047. Epub 2016 Jul 25.
Additional References at PubMed
PMID:1718258   PMID:1931832   PMID:2165569   PMID:2263478   PMID:2834384   PMID:7876112   PMID:8889548   PMID:10454705   PMID:10762343   PMID:11140838   PMID:11168387   PMID:11214319  
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PMID:12497582   PMID:12511587   PMID:12690115   PMID:12752773   PMID:12767117   PMID:12920192   PMID:12970790   PMID:14574404   PMID:14580383   PMID:14628192   PMID:14714115   PMID:14749627  
PMID:14755457   PMID:14966196   PMID:14966476   PMID:15108190   PMID:15289816   PMID:15472222   PMID:15489334   PMID:15562018   PMID:15620723   PMID:15657045   PMID:15657046   PMID:15668727  
PMID:15688035   PMID:15728830   PMID:15927811   PMID:15952782   PMID:16204352   PMID:16263116   PMID:16314880   PMID:16344560   PMID:16365309   PMID:16623851   PMID:16634642   PMID:16712507  
PMID:16715087   PMID:16741937   PMID:16788767   PMID:16818376   PMID:16917946   PMID:16962033   PMID:17015679   PMID:17041005   PMID:17065342   PMID:17068343   PMID:17074588   PMID:17160086  
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PMID:18618671   PMID:18676872   PMID:18705688   PMID:18761332   PMID:18776593   PMID:18799087   PMID:18815063   PMID:18830626   PMID:18941231   PMID:19008645   PMID:19014633   PMID:19016476  
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PMID:20628086   PMID:20631561   PMID:20680268   PMID:20691427   PMID:20705472   PMID:20720046   PMID:20734064   PMID:20808855   PMID:20838400   PMID:20851297   PMID:20852034   PMID:20854251  
PMID:20862263   PMID:20863671   PMID:20885390   PMID:20929960   PMID:21034788   PMID:21041608   PMID:21044623   PMID:21050275   PMID:21062041   PMID:21129839   PMID:21148019   PMID:21156413  
PMID:21203460   PMID:21209828   PMID:21234731   PMID:21244428   PMID:21251115   PMID:21266946   PMID:21306178   PMID:21346174   PMID:21373835   PMID:21396980   PMID:21420833   PMID:21442624  
PMID:21443454   PMID:21450051   PMID:21459482   PMID:21471673   PMID:21471953   PMID:21472688   PMID:21472841   PMID:21477106   PMID:21480765   PMID:21513772   PMID:21543209   PMID:21590281  
PMID:21603976   PMID:21633404   PMID:21666969   PMID:21693703   PMID:21695734   PMID:21790903   PMID:21795705   PMID:21808284   PMID:21863215   PMID:21873635   PMID:21892520   PMID:21901119  
PMID:21908614   PMID:21931835   PMID:22029183   PMID:22033526   PMID:22035053   PMID:22037868   PMID:22085192   PMID:22087025   PMID:22138970   PMID:22244745   PMID:22256945   PMID:22334331  
PMID:22362764   PMID:22370152   PMID:22393204   PMID:22431736   PMID:22532560   PMID:22534181   PMID:22542985   PMID:22567136   PMID:22669173   PMID:22678129   PMID:22701012   PMID:22763024  
PMID:22776901   PMID:22789143   PMID:22826533   PMID:22827915   PMID:22846992   PMID:22850347   PMID:22868830   PMID:22926037   PMID:22940268   PMID:22944513   PMID:22948261   PMID:22976112  
PMID:22995906   PMID:23010766   PMID:23057570   PMID:23142606   PMID:23161546   PMID:23167744   PMID:23207972   PMID:23244427   PMID:23277241   PMID:23296780   PMID:23306084   PMID:23318578  
PMID:23337343   PMID:23407780   PMID:23408552   PMID:23422373   PMID:23441106   PMID:23449980   PMID:23453134   PMID:23541635   PMID:23585028   PMID:23620805   PMID:23624489   PMID:23687977  
PMID:23727505   PMID:23734559   PMID:23747361   PMID:23748922   PMID:23755281   PMID:23838176   PMID:23894352   PMID:23937487   PMID:23954414   PMID:24053617   PMID:24075694   PMID:24091169  
PMID:24092756   PMID:24126189   PMID:24148086   PMID:24152087   PMID:24172113   PMID:24190005   PMID:24322329   PMID:24349109   PMID:24366865   PMID:24373053   PMID:24391723   PMID:24418364  
PMID:24444427   PMID:24445906   PMID:24530395   PMID:24553924   PMID:24652077   PMID:24690898   PMID:24704332   PMID:24843137   PMID:24853061   PMID:24864249   PMID:24971918   PMID:24980155  
PMID:25014618   PMID:25031702   PMID:25093427   PMID:25111814   PMID:25116250   PMID:25139064   PMID:25252306   PMID:25258300   PMID:25270105   PMID:25444073   PMID:25533906   PMID:25542687  
PMID:25545857   PMID:25641513   PMID:25664923   PMID:25682784   PMID:25796352   PMID:25833345   PMID:25833408   PMID:25893829   PMID:26071625   PMID:26100912   PMID:26158621   PMID:26253623  
PMID:26331953   PMID:26343051   PMID:26459312   PMID:26467187   PMID:26475744   PMID:26527537   PMID:26634814   PMID:26717543   PMID:26775260   PMID:26833047   PMID:26948343   PMID:27034934  
PMID:27053685   PMID:27108777   PMID:27261878   PMID:27346075   PMID:27349320   PMID:27404285   PMID:27425766   PMID:27453054   PMID:27613640   PMID:27641999   PMID:27762084   PMID:27768894  
PMID:27895162   PMID:27936172   PMID:27976824   PMID:27984180   PMID:28011441   PMID:28099629   PMID:28102227   PMID:28108228   PMID:28215712   PMID:28245562   PMID:28246151   PMID:28315398  
PMID:28334603   PMID:28349993   PMID:28356298   PMID:28438833   PMID:28678776   PMID:28685667   PMID:28722168   PMID:28734930   PMID:28843453   PMID:28849159   PMID:28918320   PMID:28930056  
PMID:29058339   PMID:29108858   PMID:29145497   PMID:29294249   PMID:29328379   PMID:29352424   PMID:29431265   PMID:29870711   PMID:30016776   PMID:30073165   PMID:30121138   PMID:30239920  
PMID:30262909   PMID:30286717   PMID:30296558   PMID:30371142   PMID:30482253   PMID:30569804   PMID:30576341   PMID:30642005   PMID:30832539   PMID:30858399   PMID:30890410   PMID:31013550  
PMID:31291229   PMID:31342135   PMID:31599069   PMID:31608546   PMID:31614728   PMID:32064664   PMID:32114795   PMID:32367548   PMID:32414087   PMID:32433545   PMID:32578480   PMID:32696508  
PMID:32732136   PMID:33049367   PMID:33062722   PMID:33168583   PMID:33221340   PMID:33369277   PMID:33401515   PMID:33511667   PMID:33575982   PMID:33640608   PMID:33799104   PMID:33803075  
PMID:34190825   PMID:34199599   PMID:34284706   PMID:34299009   PMID:34315947   PMID:34337715   PMID:34355541   PMID:34453034   PMID:34526596   PMID:34713823   PMID:34785728   PMID:35481563  
PMID:35537858   PMID:35580523   PMID:35719011   PMID:35739093   PMID:35792570   PMID:36250246   PMID:36323143   PMID:36360283   PMID:36361721   PMID:36440544   PMID:36645680   PMID:36674826  
PMID:36716771   PMID:36869624   PMID:36918037   PMID:36972648   PMID:37611908   PMID:37633192   PMID:37693348   PMID:37700679   PMID:37739333   PMID:37970951   PMID:37984468   PMID:38069049  


Genomics

Comparative Map Data
CNR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBIT2T-CHM13v2.0
Cnr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,923,171 - 33,948,831 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm39 Ensembl
GRCm38433,923,171 - 33,948,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm38mm10GRCm38
MGSCv37434,011,607 - 34,035,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36434,253,245 - 34,277,444 (+)NCBIMGSCv36mm8
Celera433,679,304 - 33,703,476 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.28NCBI
Cnr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2548,408,543 - 48,436,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx550,575,033 - 50,597,155 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0552,174,251 - 52,196,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0552,110,881 - 52,132,920 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
Cnr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
CNR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16106,115,872 - 106,143,699 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0686,017,141 - 86,044,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1689,289,102 - 89,315,174 (-)NCBIpanpan1.1PanPan1.1panPan2
CNR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11247,537,240 - 47,560,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1247,509,583 - 47,560,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1247,344,588 - 47,368,064 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01248,342,012 - 48,365,459 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11247,639,694 - 47,663,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01247,561,070 - 47,584,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01247,752,753 - 47,776,234 (-)NCBIUU_Cfam_GSD_1.0
Cnr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365103,781,210 - 3,802,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,467,835 - 56,492,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11312,626,259 - 12,653,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1312,630,270 - 12,631,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040188,875,655 - 188,902,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247996,101,728 - 6,126,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247996,100,709 - 6,126,530 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CNR1
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q14.1-16.1(chr6:82569098-93753476)x1 copy number loss See cases [RCV000052192] Chr6:82569098..93753476 [GRCh38]
Chr6:83278815..94463194 [GRCh37]
Chr6:83335534..94519915 [NCBI36]
Chr6:6q14.1-16.1
pathogenic
NM_001160226.1(CNR1):c.919C>T (p.Arg307Cys) single nucleotide variant Malignant melanoma [RCV000067497] Chr6:88144356 [GRCh38]
Chr6:88854075 [GRCh37]
Chr6:88910794 [NCBI36]
Chr6:6q15
not provided
NM_001160226.1(CNR1):c.905A>C (p.His302Pro) single nucleotide variant Malignant melanoma [RCV000067498] Chr6:88144370 [GRCh38]
Chr6:88854089 [GRCh37]
Chr6:88910808 [NCBI36]
Chr6:6q15
not provided
NM_001160226.1(CNR1):c.754C>T (p.Leu252Phe) single nucleotide variant Malignant melanoma [RCV000067499] Chr6:88144521 [GRCh38]
Chr6:88854240 [GRCh37]
Chr6:88910959 [NCBI36]
Chr6:6q15
not provided
NM_001160226.1(CNR1):c.1050G>A (p.Val350=) single nucleotide variant Malignant melanoma [RCV000061496] Chr6:88144225 [GRCh38]
Chr6:88853944 [GRCh37]
Chr6:88910663 [NCBI36]
Chr6:6q15
not provided
NM_001160226.1(CNR1):c.468C>T (p.Ile156=) single nucleotide variant Malignant melanoma [RCV000061497] Chr6:88144807 [GRCh38]
Chr6:88854526 [GRCh37]
Chr6:88911245 [NCBI36]
Chr6:6q15
not provided
GRCh38/hg38 6q14.2-16.1(chr6:83838303-98822313)x1 copy number loss See cases [RCV000135773] Chr6:83838303..98822313 [GRCh38]
Chr6:84548022..99270189 [GRCh37]
Chr6:84604741..99376910 [NCBI36]
Chr6:6q14.2-16.1
pathogenic
GRCh38/hg38 6q14.3-16.1(chr6:85804273-93189258)x1 copy number loss See cases [RCV000135450] Chr6:85804273..93189258 [GRCh38]
Chr6:86513991..93898976 [GRCh37]
Chr6:86570710..93955697 [NCBI36]
Chr6:6q14.3-16.1
pathogenic
GRCh38/hg38 6q14.3-15(chr6:85370716-90669793)x1 copy number loss See cases [RCV000136757] Chr6:85370716..90669793 [GRCh38]
Chr6:86080434..91379512 [GRCh37]
Chr6:86137153..91436233 [NCBI36]
Chr6:6q14.3-15
pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q14.1-16.1(chr6:75926199-92710793)x1 copy number loss See cases [RCV000143505] Chr6:75926199..92710793 [GRCh38]
Chr6:76635916..93420511 [GRCh37]
Chr6:76692636..93477232 [NCBI36]
Chr6:6q14.1-16.1
pathogenic
GRCh37/hg19 6q14.1-16.1(chr6:78911022-98909173)x1 copy number loss See cases [RCV002292710] Chr6:78911022..98909173 [GRCh37]
Chr6:6q14.1-16.1
uncertain significance
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_016083.6(CNR1):c.256C>T (p.Leu86Phe) single nucleotide variant Inborn genetic diseases [RCV003267333] Chr6:88145019 [GRCh38]
Chr6:88854738 [GRCh37]
Chr6:6q15
uncertain significance
GRCh37/hg19 6q14.1-16.1(chr6:81261418-97796269)x3 copy number gain not provided [RCV000682688] Chr6:81261418..97796269 [GRCh37]
Chr6:6q14.1-16.1
pathogenic
Single allele deletion not provided [RCV000677932] Chr6:83319012..91907669 [GRCh37]
Chr6:6q14.1-15
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q15(chr6:88843377-88866376)x3 copy number gain not provided [RCV000745893] Chr6:88843377..88866376 [GRCh37]
Chr6:6q15
benign
NM_016083.6(CNR1):c.261G>A (p.Ser87=) single nucleotide variant not provided [RCV000942986] Chr6:88145014 [GRCh38]
Chr6:88854733 [GRCh37]
Chr6:6q15
likely benign
NM_016083.6(CNR1):c.1401G>A (p.Thr467=) single nucleotide variant not provided [RCV000922489] Chr6:88143874 [GRCh38]
Chr6:88853593 [GRCh37]
Chr6:6q15
likely benign
GRCh37/hg19 6q14.3-15(chr6:86024761-90023713)x1 copy number loss not provided [RCV001005826] Chr6:86024761..90023713 [GRCh37]
Chr6:6q14.3-15
pathogenic
NM_016083.6(CNR1):c.1131G>T (p.Thr377=) single nucleotide variant not provided [RCV000944641] Chr6:88144144 [GRCh38]
Chr6:88853863 [GRCh37]
Chr6:6q15
likely benign
NM_016083.6(CNR1):c.1092G>A (p.Val364=) single nucleotide variant not provided [RCV000921629] Chr6:88144183 [GRCh38]
Chr6:88853902 [GRCh37]
Chr6:6q15
likely benign
NM_016083.6(CNR1):c.480G>A (p.Ala160=) single nucleotide variant not provided [RCV000922870] Chr6:88144795 [GRCh38]
Chr6:88854514 [GRCh37]
Chr6:6q15
likely benign
GRCh37/hg19 6q14.3-16.1(chr6:87627836-93698486)x1 copy number loss not provided [RCV000848967] Chr6:87627836..93698486 [GRCh37]
Chr6:6q14.3-16.1
uncertain significance
GRCh37/hg19 6q15-16.1(chr6:88783642-96282103)x3 copy number gain not provided [RCV000849950] Chr6:88783642..96282103 [GRCh37]
Chr6:6q15-16.1
uncertain significance
NM_016083.6(CNR1):c.191C>T (p.Ala64Val) single nucleotide variant Inborn genetic diseases [RCV003273175] Chr6:88145084 [GRCh38]
Chr6:88854803 [GRCh37]
Chr6:6q15
uncertain significance
NM_016083.6(CNR1):c.681T>A (p.Ile227=) single nucleotide variant not provided [RCV000975272] Chr6:88144594 [GRCh38]
Chr6:88854313 [GRCh37]
Chr6:6q15
likely benign
NM_016083.6(CNR1):c.912C>T (p.His304=) single nucleotide variant not provided [RCV000951263] Chr6:88144363 [GRCh38]
Chr6:88854082 [GRCh37]
Chr6:6q15
benign
GRCh37/hg19 6q15(chr6:88412786-89246061)x3 copy number gain See cases [RCV001007424] Chr6:88412786..89246061 [GRCh37]
Chr6:6q15
uncertain significance
GRCh37/hg19 6q12-16.1(chr6:69938252-94379210) copy number gain not specified [RCV002053581] Chr6:69938252..94379210 [GRCh37]
Chr6:6q12-16.1
pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687) copy number loss not specified [RCV002053595] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
NM_016083.6(CNR1):c.433C>A (p.Arg145Ser) single nucleotide variant Inborn genetic diseases [RCV002683595] Chr6:88144842 [GRCh38]
Chr6:88854561 [GRCh37]
Chr6:6q15
uncertain significance
NM_016083.6(CNR1):c.1129A>G (p.Thr377Ala) single nucleotide variant Inborn genetic diseases [RCV002718490] Chr6:88144146 [GRCh38]
Chr6:88853865 [GRCh37]
Chr6:6q15
uncertain significance
NM_016083.6(CNR1):c.871G>C (p.Val291Leu) single nucleotide variant Inborn genetic diseases [RCV003175023] Chr6:88144404 [GRCh38]
Chr6:88854123 [GRCh37]
Chr6:6q15
uncertain significance
NM_016083.6(CNR1):c.111G>A (p.Met37Ile) single nucleotide variant Inborn genetic diseases [RCV003181124] Chr6:88145164 [GRCh38]
Chr6:88854883 [GRCh37]
Chr6:6q15
uncertain significance
NM_016083.6(CNR1):c.1325T>G (p.Val442Gly) single nucleotide variant Inborn genetic diseases [RCV003342254] Chr6:88143950 [GRCh38]
Chr6:88853669 [GRCh37]
Chr6:6q15
uncertain significance
GRCh37/hg19 6q15-16.1(chr6:88018122-94565168)x1 copy number loss not provided [RCV003482926] Chr6:88018122..94565168 [GRCh37]
Chr6:6q15-16.1
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:8055
Count of miRNA genes:1185
Interacting mature miRNAs:1516
Transcripts:ENST00000362094, ENST00000369499, ENST00000369501, ENST00000428600, ENST00000468898, ENST00000535130, ENST00000537554, ENST00000549716, ENST00000549890, ENST00000551417
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH80958  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,849,629 - 88,849,859UniSTSGRCh37
Build 36688,906,348 - 88,906,578RGDNCBI36
Celera689,267,521 - 89,267,751RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,064,974 - 86,065,204UniSTS
D6S1243E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,851,593 - 88,851,792UniSTSGRCh37
Build 36688,908,312 - 88,908,511RGDNCBI36
Celera689,269,485 - 89,269,684RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,066,938 - 86,067,137UniSTS
PMC193595P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,853,724 - 88,853,923UniSTSGRCh37
Build 36688,910,443 - 88,910,642RGDNCBI36
Celera689,271,616 - 89,271,815RGD
HuRef686,069,069 - 86,069,268UniSTS
CNR1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,854,265 - 88,854,460UniSTSGRCh37
Build 36688,910,984 - 88,911,179RGDNCBI36
Celera689,272,157 - 89,272,352RGD
HuRef686,069,610 - 86,069,805UniSTS
D6S1909  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,851,266 - 88,851,518UniSTSGRCh37
Build 36688,907,985 - 88,908,237RGDNCBI36
Celera689,269,158 - 89,269,410RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,066,611 - 86,066,863UniSTS
Whitehead-RH Map6577.6UniSTS
Whitehead-YAC Contig Map6 UniSTS
SHGC-35377  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,853,281 - 88,853,480UniSTSGRCh37
Build 36688,910,000 - 88,910,199RGDNCBI36
Celera689,271,173 - 89,271,372RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,068,626 - 86,068,825UniSTS
Stanford-G3 RH Map63785.0UniSTS
GeneMap99-GB4 RH Map6387.19UniSTS
Whitehead-RH Map6586.3UniSTS
NCBI RH Map61243.8UniSTS
GeneMap99-G3 RH Map64091.0UniSTS
RH70837  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,853,662 - 88,853,820UniSTSGRCh37
Build 36688,910,381 - 88,910,539RGDNCBI36
Celera689,271,554 - 89,271,712RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,069,007 - 86,069,165UniSTS
GeneMap99-GB4 RH Map6385.58UniSTS
RH79168  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,853,033 - 88,853,207UniSTSGRCh37
Build 36688,909,752 - 88,909,926RGDNCBI36
Celera689,270,925 - 89,271,099RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,068,378 - 86,068,552UniSTS
GeneMap99-GB4 RH Map6389.88UniSTS
WI-19695  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,849,618 - 88,849,886UniSTSGRCh37
Build 36688,906,337 - 88,906,605RGDNCBI36
Celera689,267,510 - 89,267,778RGD
Cytogenetic Map6q14-q15UniSTS
HuRef686,064,963 - 86,065,231UniSTS
GeneMap99-GB4 RH Map6383.9UniSTS
Whitehead-RH Map6569.7UniSTS
NCBI RH Map61194.9UniSTS
UniSTS:482039  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,853,540 - 88,855,031UniSTSGRCh37
Celera689,271,432 - 89,272,923UniSTS
HuRef686,068,885 - 86,070,376UniSTS
UniSTS:482606  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,853,575 - 88,854,993UniSTSGRCh37
Celera689,271,467 - 89,272,885UniSTS
HuRef686,068,920 - 86,070,338UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 958 610 518 3 322 2 1377 328 2060 13 160 328 1 964 818
Low 1276 1208 747 188 909 42 2591 1215 1518 162 1050 1071 149 240 1714 1 1
Below cutoff 71 1149 331 321 626 309 345 611 123 186 142 126 16 256 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001160226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001160258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001160259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF107262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL121835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY225225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY766182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY995204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM682178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA128033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA239984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA768458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA793373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA799263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ067455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM763227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC292264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF042592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X81120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X81121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000362094   ⟹   ENSP00000355418
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,145,274 (-)Ensembl
RefSeq Acc Id: ENST00000369499   ⟹   ENSP00000358511
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,164,343 (-)Ensembl
RefSeq Acc Id: ENST00000369501   ⟹   ENSP00000358513
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)Ensembl
RefSeq Acc Id: ENST00000428600   ⟹   ENSP00000412192
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,163,024 (-)Ensembl
RefSeq Acc Id: ENST00000468898   ⟹   ENSP00000420188
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,145,274 (-)Ensembl
RefSeq Acc Id: ENST00000549890   ⟹   ENSP00000446819
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,145,365 (-)Ensembl
RefSeq Acc Id: ENST00000551417   ⟹   ENSP00000446702
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)Ensembl
RefSeq Acc Id: NM_001160226   ⟹   NP_001153698
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
GRCh37688,849,583 - 88,876,063 (-)NCBI
HuRef686,064,928 - 86,090,983 (-)ENTREZGENE
CHM1_1688,947,341 - 88,973,526 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001160258   ⟹   NP_001153730
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
GRCh37688,849,583 - 88,876,063 (-)NCBI
HuRef686,064,928 - 86,090,983 (-)ENTREZGENE
CHM1_1688,947,341 - 88,973,526 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001160259   ⟹   NP_001153731
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
GRCh37688,849,583 - 88,876,063 (-)NCBI
HuRef686,064,928 - 86,090,983 (-)ENTREZGENE
CHM1_1688,947,341 - 88,973,526 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001365869   ⟹   NP_001352798
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001365870   ⟹   NP_001352799
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001365872   ⟹   NP_001352801
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001365874   ⟹   NP_001352803
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,163,024 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,371,516 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370545   ⟹   NP_001357474
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,652 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,144 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370546   ⟹   NP_001357475
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,167,349 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370547   ⟹   NP_001357476
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,167,349 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001424094   ⟹   NP_001411023
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,167,349 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBI
RefSeq Acc Id: NM_001424095   ⟹   NP_001411024
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,167,109 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,601 (-)NCBI
RefSeq Acc Id: NM_001424096   ⟹   NP_001411025
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,167,109 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,601 (-)NCBI
RefSeq Acc Id: NM_001424097   ⟹   NP_001411026
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,167,109 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,375,601 (-)NCBI
RefSeq Acc Id: NM_001424098   ⟹   NP_001411027
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
RefSeq Acc Id: NM_016083   ⟹   NP_057167
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
GRCh37688,849,583 - 88,876,063 (-)NCBI
Build 36688,906,302 - 88,911,775 (-)NCBI Archive
HuRef686,064,928 - 86,090,983 (-)ENTREZGENE
CHM1_1688,947,341 - 88,973,526 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033181   ⟹   NP_149421
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,145,337 (-)NCBI
GRCh37688,849,583 - 88,876,063 (-)NCBI
Build 36688,906,302 - 88,911,775 (-)NCBI Archive
HuRef686,064,928 - 86,090,983 (-)ENTREZGENE
CHM1_1688,947,341 - 88,952,815 (-)NCBI
T2T-CHM13v2.0689,348,358 - 89,353,832 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047418171   ⟹   XP_047274127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
RefSeq Acc Id: XM_047418172   ⟹   XP_047274128
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,152,129 (-)NCBI
RefSeq Acc Id: XM_047418173   ⟹   XP_047274129
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,139,864 - 88,166,347 (-)NCBI
RefSeq Acc Id: XM_054354204   ⟹   XP_054210179
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
RefSeq Acc Id: XM_054354205   ⟹   XP_054210180
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0689,348,358 - 89,360,624 (-)NCBI
RefSeq Acc Id: XM_054354206   ⟹   XP_054210181
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0689,348,358 - 89,374,839 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001153698 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153730 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153731 (Get FASTA)   NCBI Sequence Viewer  
  NP_001352798 (Get FASTA)   NCBI Sequence Viewer  
  NP_001352799 (Get FASTA)   NCBI Sequence Viewer  
  NP_001352801 (Get FASTA)   NCBI Sequence Viewer  
  NP_001352803 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357474 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357475 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357476 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411023 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411024 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411025 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411026 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411027 (Get FASTA)   NCBI Sequence Viewer  
  NP_057167 (Get FASTA)   NCBI Sequence Viewer  
  NP_149421 (Get FASTA)   NCBI Sequence Viewer  
  XP_047274127 (Get FASTA)   NCBI Sequence Viewer  
  XP_047274128 (Get FASTA)   NCBI Sequence Viewer  
  XP_047274129 (Get FASTA)   NCBI Sequence Viewer  
  XP_054210179 (Get FASTA)   NCBI Sequence Viewer  
  XP_054210180 (Get FASTA)   NCBI Sequence Viewer  
  XP_054210181 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB18200 (Get FASTA)   NCBI Sequence Viewer  
  AAD34320 (Get FASTA)   NCBI Sequence Viewer  
  AAG37765 (Get FASTA)   NCBI Sequence Viewer  
  AAH74811 (Get FASTA)   NCBI Sequence Viewer  
  AAH74812 (Get FASTA)   NCBI Sequence Viewer  
  AAH95513 (Get FASTA)   NCBI Sequence Viewer  
  AAI00969 (Get FASTA)   NCBI Sequence Viewer  
  AAI00970 (Get FASTA)   NCBI Sequence Viewer  
  AAI00971 (Get FASTA)   NCBI Sequence Viewer  
  AAI00972 (Get FASTA)   NCBI Sequence Viewer  
  AAO67710 (Get FASTA)   NCBI Sequence Viewer  
  AAV35030 (Get FASTA)   NCBI Sequence Viewer  
  AAY21179 (Get FASTA)   NCBI Sequence Viewer  
  AAY68486 (Get FASTA)   NCBI Sequence Viewer  
  AGS49222 (Get FASTA)   NCBI Sequence Viewer  
  AGW25490 (Get FASTA)   NCBI Sequence Viewer  
  BAG36631 (Get FASTA)   NCBI Sequence Viewer  
  CAA38699 (Get FASTA)   NCBI Sequence Viewer  
  CAA57018 (Get FASTA)   NCBI Sequence Viewer  
  CAA57019 (Get FASTA)   NCBI Sequence Viewer  
  EAW48574 (Get FASTA)   NCBI Sequence Viewer  
  EAW48575 (Get FASTA)   NCBI Sequence Viewer  
  EAW48576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000355418.5
  ENSP00000358511
  ENSP00000358511.2
  ENSP00000358513
  ENSP00000358513.2
  ENSP00000412192
  ENSP00000412192.2
  ENSP00000420188
  ENSP00000420188.1
  ENSP00000446702
  ENSP00000446702.2
  ENSP00000446819.1
GenBank Protein P21554 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_057167   ⟸   NM_016083
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153698   ⟸   NM_001160226
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153730   ⟸   NM_001160258
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153731   ⟸   NM_001160259
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_149421   ⟸   NM_033181
- Peptide Label: isoform b
- UniProtKB: V5KA96 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001357475   ⟸   NM_001370546
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357476   ⟸   NM_001370547
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357474   ⟸   NM_001370545
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001352799   ⟸   NM_001365870
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001352798   ⟸   NM_001365869
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001352801   ⟸   NM_001365872
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001352803   ⟸   NM_001365874
- Peptide Label: isoform a
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000412192   ⟸   ENST00000428600
RefSeq Acc Id: ENSP00000420188   ⟸   ENST00000468898
RefSeq Acc Id: ENSP00000355418   ⟸   ENST00000362094
RefSeq Acc Id: ENSP00000446819   ⟸   ENST00000549890
RefSeq Acc Id: ENSP00000446702   ⟸   ENST00000551417
RefSeq Acc Id: ENSP00000358511   ⟸   ENST00000369499
RefSeq Acc Id: ENSP00000358513   ⟸   ENST00000369501
RefSeq Acc Id: XP_047274127   ⟸   XM_047418171
- Peptide Label: isoform X1
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047274129   ⟸   XM_047418173
- Peptide Label: isoform X1
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047274128   ⟸   XM_047418172
- Peptide Label: isoform X1
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054210179   ⟸   XM_054354204
- Peptide Label: isoform X1
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054210181   ⟸   XM_054354206
- Peptide Label: isoform X1
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054210180   ⟸   XM_054354205
- Peptide Label: isoform X1
- UniProtKB: Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q9UNN0 (UniProtKB/Swiss-Prot),   S5TLS4 (UniProtKB/TrEMBL),   Q506J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411023   ⟸   NM_001424094
- Peptide Label: isoform a
- UniProtKB: Q9UNN0 (UniProtKB/Swiss-Prot),   Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q506J9 (UniProtKB/TrEMBL),   S5TLS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411025   ⟸   NM_001424096
- Peptide Label: isoform a
- UniProtKB: Q9UNN0 (UniProtKB/Swiss-Prot),   Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q506J9 (UniProtKB/TrEMBL),   S5TLS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411026   ⟸   NM_001424097
- Peptide Label: isoform a
- UniProtKB: Q9UNN0 (UniProtKB/Swiss-Prot),   Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q506J9 (UniProtKB/TrEMBL),   S5TLS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411024   ⟸   NM_001424095
- Peptide Label: isoform a
- UniProtKB: Q9UNN0 (UniProtKB/Swiss-Prot),   Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q506J9 (UniProtKB/TrEMBL),   S5TLS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411027   ⟸   NM_001424098
- Peptide Label: isoform a
- UniProtKB: Q9UNN0 (UniProtKB/Swiss-Prot),   Q5UB37 (UniProtKB/Swiss-Prot),   Q5JVL5 (UniProtKB/Swiss-Prot),   Q4VBM6 (UniProtKB/Swiss-Prot),   Q4PLI4 (UniProtKB/Swiss-Prot),   Q495Z0 (UniProtKB/Swiss-Prot),   Q13949 (UniProtKB/Swiss-Prot),   P21554 (UniProtKB/Swiss-Prot),   E1P512 (UniProtKB/Swiss-Prot),   B2R9T4 (UniProtKB/Swiss-Prot),   Q506J9 (UniProtKB/TrEMBL),   S5TLS4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21554-F1-model_v2 AlphaFold P21554 1-472 view protein structure

Promoters
RGD ID:7208663
Promoter ID:EPDNEW_H10078
Type:initiation region
Name:CNR1_2
Description:cannabinoid receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10079  EPDNEW_H10081  EPDNEW_H10080  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,165,996 - 88,166,056EPDNEW
RGD ID:7208667
Promoter ID:EPDNEW_H10079
Type:multiple initiation site
Name:CNR1_1
Description:cannabinoid receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10078  EPDNEW_H10081  EPDNEW_H10080  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,166,347 - 88,166,407EPDNEW
RGD ID:7208673
Promoter ID:EPDNEW_H10080
Type:initiation region
Name:CNR1_3
Description:cannabinoid receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10078  EPDNEW_H10079  EPDNEW_H10081  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38688,166,652 - 88,166,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2159 AgrOrtholog
COSMIC CNR1 COSMIC
Ensembl Genes ENSG00000118432 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000362094.6 UniProtKB/TrEMBL
  ENST00000369499 ENTREZGENE
  ENST00000369499.3 UniProtKB/Swiss-Prot
  ENST00000369501 ENTREZGENE
  ENST00000369501.3 UniProtKB/Swiss-Prot
  ENST00000428600 ENTREZGENE
  ENST00000428600.3 UniProtKB/Swiss-Prot
  ENST00000468898 ENTREZGENE
  ENST00000468898.2 UniProtKB/Swiss-Prot
  ENST00000549890.2 UniProtKB/Swiss-Prot
  ENST00000551417 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000551417.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000118432 GTEx
HGNC ID HGNC:2159 ENTREZGENE
Human Proteome Map CNR1 Human Proteome Map
InterPro Canbinoid_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1268 ENTREZGENE
OMIM 114610 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22750:SF47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26681 PharmGKB
PIRSF Cnoid_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CANABINOID1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R9T4 ENTREZGENE
  CNR1_HUMAN UniProtKB/Swiss-Prot
  E1P512 ENTREZGENE
  F8W187_HUMAN UniProtKB/TrEMBL
  F8W908_HUMAN UniProtKB/TrEMBL
  P21554 ENTREZGENE
  Q13949 ENTREZGENE
  Q495Z0 ENTREZGENE
  Q4PLI4 ENTREZGENE
  Q4VBM6 ENTREZGENE
  Q506J9 ENTREZGENE, UniProtKB/TrEMBL
  Q5JVL5 ENTREZGENE
  Q5UB37 ENTREZGENE
  Q9BYY6_HUMAN UniProtKB/TrEMBL
  Q9UNN0 ENTREZGENE
  S5TLS4 ENTREZGENE, UniProtKB/TrEMBL
  V5KA96 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R9T4 UniProtKB/Swiss-Prot
  E1P512 UniProtKB/Swiss-Prot
  Q13949 UniProtKB/Swiss-Prot
  Q495Z0 UniProtKB/Swiss-Prot
  Q4PLI4 UniProtKB/Swiss-Prot
  Q4VBM6 UniProtKB/Swiss-Prot
  Q5JVL5 UniProtKB/Swiss-Prot
  Q5UB37 UniProtKB/Swiss-Prot
  Q9UNN0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 CNR1  cannabinoid receptor 1  CNR1  cannabinoid receptor 1 (brain)  Symbol and/or name change 5135510 APPROVED