Cnr1 (cannabinoid receptor 1) - Rat Genome Database

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Pathways
Gene: Cnr1 (cannabinoid receptor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Cnr1
Name: cannabinoid receptor 1
RGD ID: 12612496
Description: ENCODES a protein that exhibits cannabinoid receptor activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); learning or memory (ortholog); maternal process involved in female pregnancy (ortholog); PARTICIPATES IN N-cadherin signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); FOUND IN membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cannabinoid receptor 1, transcript variant X1; cannabinoid receptor 1, transcript variant X2; cannabinoid receptor 1, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365103,781,210 - 3,802,693 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
Alcohol Withdrawal Delirium  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
Ascites  (ISO)
attention deficit hyperactivity disorder  (ISO)
Binge-Eating Disorder  (ISO)
cannabis abuse  (ISO)
Catalepsy  (ISO)
cholestasis  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
developmental coordination disorder  (ISO)
diabetic neuropathy  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fever  (ISO)
focal epilepsy  (ISO)
glucose intolerance  (ISO)
Hemorrhagic Shock  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
Intravenous Substance Abuse  (ISO)
liver cirrhosis  (ISO)
Memory Disorders  (ISO)
morphine dependence  (ISO)
movement disease  (ISO)
multiple sclerosis  (ISO)
Muscle Spasticity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinsonism  (ISO)
peptic ulcer disease  (ISO)
post-traumatic stress disorder  (ISO)
Reperfusion Injury  (ISO)
rhabdomyosarcoma  (ISO)
schizophrenia  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stress-related disorder  (ISO)
substance-related disorder  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IEA)
axonal fasciculation  (IEA)
cannabinoid signaling pathway  (IEA)
cell communication  (IEA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glucose homeostasis  (IEA)
learning or memory  (ISO)
maternal process involved in female pregnancy  (ISO)
memory  (ISO)
negative regulation of action potential  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of dopamine secretion  (ISO)
negative regulation of fatty acid beta-oxidation  (ISO)
negative regulation of mast cell activation  (ISO)
negative regulation of monoatomic ion transport  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of serotonin secretion  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of neuron projection development  (ISO)
regulation of feeding behavior  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of long-term synaptic depression  (ISO)
regulation of penile erection  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (IEA)
regulation of synaptic transmission, GABAergic  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
retrograde trans-synaptic signaling by endocannabinoid  (IEA)
signal transduction  (IEA)
signaling  (IEA)
spermatogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Cnr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365103,781,210 - 3,802,693 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)Ensemblhg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBIT2T-CHM13v2.0
Cnr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,923,171 - 33,948,831 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38433,923,171 - 33,948,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,924,593 - 33,948,831 (+)Ensemblmm10GRCm38
MGSCv37434,011,607 - 34,035,806 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36434,253,245 - 34,277,444 (+)NCBIMGSCv36mm8
Celera433,679,304 - 33,703,476 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.28NCBI
Cnr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8553,204,867 - 53,230,396 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl553,204,260 - 53,239,252 (+)EnsemblGRCr8
mRatBN7.2548,408,543 - 48,436,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx550,575,033 - 50,597,155 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0552,174,251 - 52,196,375 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0552,110,881 - 52,132,920 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)Ensemblrn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera547,168,709 - 47,190,724 (+)NCBICelera
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Cytogenetic Map5q21NCBI
Cnr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)Ensembl
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
CNR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25108,222,001 - 108,249,883 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16106,115,872 - 106,143,699 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0686,017,141 - 86,044,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1689,289,102 - 89,315,174 (-)NCBIPanPan1.1PanPan1.1panPan2
CNR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11247,537,240 - 47,560,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1247,509,583 - 47,560,983 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1247,344,588 - 47,368,064 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01248,342,012 - 48,365,459 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1248,346,226 - 48,363,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11247,639,694 - 47,663,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01247,561,070 - 47,584,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01247,752,753 - 47,776,234 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CNR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,467,835 - 56,492,602 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11312,626,259 - 12,653,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1312,630,270 - 12,631,688 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040188,875,655 - 188,902,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247996,101,728 - 6,126,520 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247996,100,709 - 6,126,530 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000020145   ⟹   ENSSTOP00000022582
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365103,781,210 - 3,802,693 (+)Ensembl
RefSeq Acc Id: XM_005324720   ⟹   XP_005324777
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494682,664,248 - 82,690,036 (-)NCBI
SpeTri2.0NW_0049365103,781,149 - 3,806,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726015   ⟹   XP_021581690
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494682,664,248 - 82,690,708 (-)NCBI
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726016   ⟹   XP_021581691
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494682,664,248 - 82,690,406 (-)NCBI
SpeTri2.0NW_0049365103,780,562 - 3,806,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040283080   ⟹   XP_040139014
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBI
RefSeq Acc Id: XP_005324777   ⟸   XM_005324720
- UniProtKB: I3NDY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581690   ⟸   XM_021726015
- UniProtKB: I3NDY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581691   ⟸   XM_021726016
- UniProtKB: I3NDY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139014   ⟸   XM_040283080
- UniProtKB: I3NDY5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000022582   ⟸   ENSSTOT00000020145

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020390 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020145.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Canbinoid_rcpt_1 UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report iti:101964948 UniProtKB/TrEMBL
NCBI Gene Cnr1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PIRSF Cnoid_rcpt_1 UniProtKB/TrEMBL
PRINTS CANABINOID1R UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt I3NDY5 ENTREZGENE, UniProtKB/TrEMBL
  Q6W9B7_ICTTR UniProtKB/TrEMBL