GSTA4 (glutathione S-transferase alpha 4) - Rat Genome Database

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Gene: GSTA4 (glutathione S-transferase alpha 4) Canis lupus familiaris
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Symbol: GSTA4
Name: glutathione S-transferase alpha 4
RGD ID: 12384201
Description: ENCODES a protein that exhibits identical protein binding (ortholog); organic cyclic compound binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotine (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); INTERACTS WITH clofibrate; masitinib; phenobarbital
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase A4
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC478400  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,426,724 - 20,443,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1220,426,726 - 20,443,200 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,321,558 - 20,337,691 (-)NCBI
ROS_Cfam_1.01220,924,034 - 20,940,269 (-)NCBI
ROS_Cfam_1.0 Ensembl1220,923,735 - 20,940,277 (-)Ensembl
UMICH_Zoey_3.11220,429,613 - 20,445,821 (-)NCBI
UNSW_CanFamBas_1.01220,534,140 - 20,550,406 (-)NCBI
UU_Cfam_GSD_1.01220,672,284 - 20,688,436 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
mitochondrion  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GSTA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,426,724 - 20,443,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1220,426,726 - 20,443,200 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,321,558 - 20,337,691 (-)NCBI
ROS_Cfam_1.01220,924,034 - 20,940,269 (-)NCBI
ROS_Cfam_1.0 Ensembl1220,923,735 - 20,940,277 (-)Ensembl
UMICH_Zoey_3.11220,429,613 - 20,445,821 (-)NCBI
UNSW_CanFamBas_1.01220,534,140 - 20,550,406 (-)NCBI
UU_Cfam_GSD_1.01220,672,284 - 20,688,436 (-)NCBI
GSTA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,977,953 - 52,995,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl652,977,948 - 52,995,304 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,842,751 - 52,860,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,950,710 - 52,968,099 (-)NCBINCBI36hg18NCBI36
Build 34652,950,709 - 52,968,099NCBI
Celera654,504,520 - 54,521,952 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,674,221 - 52,691,656 (-)NCBIHuRef
CHM1_1652,844,511 - 52,861,941 (-)NCBICHM1_1
T2T-CHM13v2.0652,817,518 - 52,834,853 (-)NCBI
Gsta4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2879,066,967 - 79,084,193 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl879,066,934 - 79,084,182 (+)Ensembl
Rnor_6.0885,497,557 - 85,514,732 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,062,036 - 85,078,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,165,139 - 83,183,055NCBIRGSC3.4rn4RGSC3.4
Celera878,811,797 - 78,829,038 (+)NCBICelera
Cytogenetic Map8q31NCBI
GSTA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1654,171,609 - 54,189,032 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,171,318 - 54,188,976 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0652,532,942 - 52,550,404 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101958062
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,071,901 - 56,087,021 (-)NCBI
SpeTri2.0NW_0049364767,873,218 - 7,888,301 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,635,902 - 46,656,450 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,635,903 - 46,656,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27134,379,987 - 134,400,475 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,575,835 - 19,591,713 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,575,876 - 19,591,919 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604452,829,812 - 52,845,691 (-)NCBIVero_WHO_p1.0
Gsta4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850201,592 - 216,680 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624850201,119 - 217,302 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 3 12 8 10 6
Low 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003532   ⟹   ENSCAFP00000003273
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1220,426,726 - 20,443,200 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060883   ⟹   ENSCAFP00000052145
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1220,428,629 - 20,433,754 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083711   ⟹   ENSCAFP00000059637
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1220,429,914 - 20,443,200 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017225   ⟹   ENSCAFP00845013424
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1220,923,735 - 20,940,250 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017264   ⟹   ENSCAFP00845013455
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1220,927,268 - 20,940,277 (-)Ensembl
RefSeq Acc Id: NM_001252224   ⟹   NP_001239153
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11220,426,726 - 20,443,200 (-)NCBI
Dog10K_Boxer_Tasha1220,321,558 - 20,337,691 (-)NCBI
ROS_Cfam_1.01220,924,036 - 20,940,269 (-)NCBI
UMICH_Zoey_3.11220,429,613 - 20,445,821 (-)NCBI
UNSW_CanFamBas_1.01220,534,140 - 20,550,406 (-)NCBI
UU_Cfam_GSD_1.01220,672,284 - 20,688,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038682731   ⟹   XP_038538659
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01220,924,034 - 20,940,178 (-)NCBI
RefSeq Acc Id: XM_038682732   ⟹   XP_038538660
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01220,924,034 - 20,939,768 (-)NCBI
RefSeq Acc Id: XM_038682733   ⟹   XP_038538661
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01220,924,034 - 20,939,847 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001239153 (Get FASTA)   NCBI Sequence Viewer  
  XP_038538659 (Get FASTA)   NCBI Sequence Viewer  
  XP_038538660 (Get FASTA)   NCBI Sequence Viewer  
  XP_038538661 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001239153   ⟸   NM_001252224
- UniProtKB: E2REA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000052145   ⟸   ENSCAFT00000060883
RefSeq Acc Id: ENSCAFP00000059637   ⟸   ENSCAFT00000083711
RefSeq Acc Id: ENSCAFP00000003273   ⟸   ENSCAFT00000003532
RefSeq Acc Id: XP_038538659   ⟸   XM_038682731
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038538661   ⟸   XM_038682733
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038538660   ⟸   XM_038682732
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845013455   ⟸   ENSCAFT00845017264
RefSeq Acc Id: ENSCAFP00845013424   ⟸   ENSCAFT00845017225
Protein Domains
GST C-terminal   GST N-terminal

Promoters
RGD ID:13685462
Promoter ID:EPDNEW_C3530
Type:multiple initiation site
Name:GSTA4_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11220,443,214 - 20,443,274EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000024066 Ensembl
  ENSCAFG00030017938 UniProtKB/TrEMBL
  ENSCAFG00040006291 UniProtKB/TrEMBL
  ENSCAFG00845009775 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030028884.1 UniProtKB/TrEMBL
  ENSCAFP00040010168 UniProtKB/TrEMBL
  ENSCAFP00845013424 ENTREZGENE
  ENSCAFP00845013424.1 UniProtKB/TrEMBL
  ENSCAFP00845013455.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030033106.1 UniProtKB/TrEMBL
  ENSCAFT00040011721 UniProtKB/TrEMBL
  ENSCAFT00845017225 ENTREZGENE
  ENSCAFT00845017225.1 UniProtKB/TrEMBL
  ENSCAFT00845017264.1 UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_alpha UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene GSTA4 ENTREZGENE
Pfam GST_C_3 UniProtKB/TrEMBL
  GST_N UniProtKB/TrEMBL
PRINTS GSTRNSFRASEA UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0NR48_CANLF UniProtKB/TrEMBL
  A0A8C0QFI4_CANLF UniProtKB/TrEMBL
  A0A8I3NBL2_CANLF UniProtKB/TrEMBL
  A0A8I3NCU9_CANLF UniProtKB/TrEMBL
  E2REA5 ENTREZGENE