Mc2r (melanocortin 2 receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mc2r (melanocortin 2 receptor) Rattus norvegicus
Analyze
Symbol: Mc2r
Name: melanocortin 2 receptor
RGD ID: 628649
Description: Predicted to enable corticotropin receptor activity. Involved in placenta development. Located in cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH ammonium chloride; bisphenol A; corticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adrenocorticotropic hormone receptor; melanocortin 2 receptor (adrenocorticotropic hormone)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21862,001,980 - 62,015,567 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1862,004,948 - 62,015,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1864,080,111 - 64,090,647 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01864,772,227 - 64,782,780 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01862,617,456 - 62,627,960 (-)NCBIRnor_WKY
Rnor_6.01864,166,959 - 64,178,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1864,167,191 - 64,177,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01863,380,608 - 63,392,678 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,591,344 - 64,601,883 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,674,282 - 64,675,002 (+)NCBI
Celera1860,097,107 - 60,107,646 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
plasma membrane  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Metallothionein and zinc metabolism in endotoxin shock rats. Abe S, etal., Experientia Suppl. 1987;52:587-94.
2. The melanocortin system in control of inflammation. Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
3. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Clark AJ, etal., Lancet. 1993 Feb 20;341(8843):461-2.
4. Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay. Fluck CE, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4318-23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Immunohistochemical localization of the ACTH (MC-2) receptor in the rat placenta and adrenal gland. Izumi S, etal., Arch Histol Cytol. 2004 Dec;67(5):443-53.
8. Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms. Liu ZL, etal., Chin Med J (Engl). 2008 Sep 5;121(17):1627-32.
9. Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Adrenocorticotropic hormone (MC-2) receptor mRNA is expressed in rat sympathetic ganglia and up-regulated by stress. Nankova BB, etal., Neurosci Lett 2003 Jul 3;344(3):149-52.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Piedboeuf B, etal., Am J Respir Cell Mol Biol. 1994 Feb;10(2):123-32.
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:17947354   PMID:19329486   PMID:19808775   PMID:20042918   PMID:26868281   PMID:29140411   PMID:29943847  


Genomics

Comparative Map Data
Mc2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21862,001,980 - 62,015,567 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1862,004,948 - 62,015,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1864,080,111 - 64,090,647 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01864,772,227 - 64,782,780 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01862,617,456 - 62,627,960 (-)NCBIRnor_WKY
Rnor_6.01864,166,959 - 64,178,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1864,167,191 - 64,177,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01863,380,608 - 63,392,678 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,591,344 - 64,601,883 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,674,282 - 64,675,002 (+)NCBI
Celera1860,097,107 - 60,107,646 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
MC2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381813,882,044 - 13,915,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1813,882,044 - 13,915,707 (-)EnsemblGRCh38hg38GRCh38
GRCh371813,882,043 - 13,915,706 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361813,872,043 - 13,905,535 (-)NCBINCBI36Build 36hg18NCBI36
Build 341813,874,623 - 13,875,517NCBI
Celera1813,762,993 - 13,796,477 (-)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1813,835,653 - 13,869,147 (-)NCBIHuRef
CHM1_11813,881,179 - 13,914,672 (-)NCBICHM1_1
T2T-CHM13v2.01814,044,399 - 14,078,045 (-)NCBIT2T-CHM13v2.0
Mc2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391868,539,970 - 68,562,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1868,539,978 - 68,562,391 (-)EnsemblGRCm39 Ensembl
GRCm381868,406,899 - 68,429,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1868,406,907 - 68,429,320 (-)EnsemblGRCm38mm10GRCm38
MGSCv371868,566,561 - 68,588,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361868,532,276 - 68,554,628 (-)NCBIMGSCv36mm8
Celera1869,709,404 - 69,724,852 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1841.89NCBI
Mc2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955402190,513 - 225,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955402190,513 - 225,627 (+)NCBIChiLan1.0ChiLan1.0
MC2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1182,578,783 - 2,612,149 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl182,608,691 - 2,609,584 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v018409,141 - 442,578 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MC2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,351,219 - 24,390,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,388,280 - 24,389,170 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,333,175 - 25,372,054 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,250,353 - 24,289,508 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,287,716 - 24,288,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,304,147 - 24,343,019 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,190,528 - 24,229,405 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,463,475 - 24,502,476 (+)NCBIUU_Cfam_GSD_1.0
Mc2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049444,024,784 - 4,025,686 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366263,253,112 - 3,253,999 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366263,253,100 - 3,254,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MC2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,265,764 - 96,266,657 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,241,744 - 96,268,870 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,575,397 - 89,602,023 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MC2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11872,286,380 - 72,296,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1872,288,224 - 72,289,105 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,353,947 - 47,364,420 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mc2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477020,431,571 - 20,476,405 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mc2r
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:93
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000022347
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
Mc2r  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21862,005,033 - 62,005,149 (+)MAPPERmRatBN7.2
Rnor_6.01864,167,277 - 64,167,392NCBIRnor6.0
Rnor_5.01863,381,260 - 63,381,375UniSTSRnor5.0
RGSC_v3.41864,601,682 - 64,601,797UniSTSRGSC3.4
Celera1860,097,193 - 60,097,308UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 1
Low 1 1 4 4 8 9 16 18 11 8
Below cutoff 2 12 8 5 11 5 2 19 19 21

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022347   ⟹   ENSRNOP00000022347
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1862,004,948 - 62,015,488 (-)Ensembl
Rnor_6.0 Ensembl1864,167,191 - 64,177,729 (-)Ensembl
RefSeq Acc Id: NM_001100491   ⟹   NP_001093961
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21862,004,948 - 62,015,488 (-)NCBI
Rnor_6.01864,167,191 - 64,177,729 (-)NCBI
Rnor_5.01863,380,608 - 63,392,678 (-)NCBI
RGSC_v3.41864,591,344 - 64,601,883 (+)RGD
Celera1860,097,107 - 60,107,646 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772094   ⟹   XP_008770316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21862,001,980 - 62,015,567 (-)NCBI
Rnor_6.01864,166,959 - 64,178,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772095   ⟹   XP_008770317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21862,001,980 - 62,015,567 (-)NCBI
Rnor_6.01864,166,959 - 64,178,729 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001093961   ⟸   NM_001100491
- UniProtKB: G3V848 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770316   ⟸   XM_008772094
- Peptide Label: isoform X1
- UniProtKB: G3V848 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770317   ⟸   XM_008772095
- Peptide Label: isoform X1
- UniProtKB: G3V848 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022347   ⟸   ENSRNOT00000022347
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V848-F1-model_v2 AlphaFold G3V848 1-296 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628649 AgrOrtholog
BioCyc Gene G2FUF-7102 BioCyc
Ensembl Genes ENSRNOG00000016681 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022347 ENTREZGENE
  ENSRNOP00000022347.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022347 ENTREZGENE
  ENSRNOT00000022347.6 UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  ACTH_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Melcrt_ACTH_rcpt UniProtKB/TrEMBL
KEGG Report rno:282839 UniProtKB/TrEMBL
NCBI Gene 282839 ENTREZGENE
PANTHER PTHR22750:SF3 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Mc2r PhenoGen
PRINTS ACTROPHINR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
  MCRFAMILY UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt G3V848 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Mc2r  melanocortin 2 receptor  Mc2r  melanocortin 2 receptor (adrenocorticotropic hormone)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Mc2r  melanocortin 2 receptor (adrenocorticotropic hormone)  Mc2r  melanocortin 2 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-19 Mc2r  melanocortin 2 receptor  Mc2r  melanocortin 2 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mc2r  melanocortin 2 receptor      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Mc2r  melanocortin 2 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in sympathetic ganglia 724417