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Gene: Mc2r (melanocortin 2 receptor) Rattus norvegicus
Symbol: Mc2r
Name: melanocortin 2 receptor
Description: Predicted to have G protein-coupled receptor activity. Involved in placenta development. Localizes to cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH ammonium chloride; bisphenol A; corticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adrenocorticotropic hormone receptor; melanocortin 2 receptor (adrenocorticotropic hormone)
Homo sapiens (human) : MC2R (melanocortin 2 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Mc2r (melanocortin 2 receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mc2r (melanocortin 2 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MC2R (melanocortin 2 receptor)
Canis lupus familiaris (dog) : MC2R (melanocortin 2 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mc2r (melanocortin 2 receptor)
Sus scrofa (pig) : MC2R (melanocortin 2 receptor)
Chlorocebus sabaeus (African green monkey) : MC2R (melanocortin 2 receptor)
Heterocephalus glaber (naked mole-rat) : Mc2r (melanocortin 2 receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01864,166,959 - 64,178,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1864,167,191 - 64,177,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01863,380,608 - 63,392,678 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,591,344 - 64,601,883 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11864,674,282 - 64,675,002 (+)NCBI
Celera1860,097,107 - 60,107,646 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mc2r
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628649
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.