GNA14 (G protein subunit alpha 14) - Rat Genome Database

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Gene: GNA14 (G protein subunit alpha 14) Homo sapiens
Analyze
Symbol: GNA14
Name: G protein subunit alpha 14
RGD ID: 1317712
HGNC Page HGNC:4382
Description: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Located in extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: g alpha-14; G-protein subunit alpha-14; guanine nucleotide binding protein (G protein), alpha 14; guanine nucleotide-binding protein 14; guanine nucleotide-binding protein subunit alpha-14; heterotrimeric guanine nucleotide-binding protein 1I; HG1I
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38977,423,079 - 77,648,322 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl977,423,079 - 77,648,322 (-)EnsemblGRCh38hg38GRCh38
GRCh37980,037,995 - 80,263,238 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36979,228,368 - 79,453,043 (-)NCBINCBI36Build 36hg18NCBI36
Build 34977,268,102 - 77,492,777NCBI
Celera950,615,129 - 50,840,361 (-)NCBICelera
Cytogenetic Map9q21.2NCBI
HuRef949,869,436 - 50,095,508 (-)NCBIHuRef
CHM1_1980,184,787 - 80,410,463 (-)NCBICHM1_1
T2T-CHM13v2.0989,579,647 - 89,805,301 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyanocob(III)alamin  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (EXP)
dorsomorphin  (EXP)
endosulfan  (ISO)
enniatin  (EXP)
ethanol  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
furan  (ISO)
glycine betaine  (ISO)
GW 4064  (ISO)
hexane  (ISO)
L-methionine  (ISO)
mercury dibromide  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nitrofen  (ISO)
orphenadrine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
rotenone  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
Additional References at PubMed
PMID:1322796   PMID:7937899   PMID:8316840   PMID:8626727   PMID:8982657   PMID:10191087   PMID:10625681   PMID:10644457   PMID:11118617   PMID:12477932   PMID:15489334   PMID:16102047  
PMID:16115892   PMID:17620339   PMID:18240029   PMID:18360038   PMID:19687291   PMID:19913121   PMID:20379614   PMID:20467437   PMID:20628086   PMID:21873635   PMID:22711498   PMID:23455924  
PMID:23509962   PMID:23533145   PMID:23975421   PMID:25416956   PMID:26377666   PMID:26823487   PMID:27476652   PMID:28514442   PMID:29574926   PMID:29975248   PMID:30054423   PMID:30321592  
PMID:30387149   PMID:31189994   PMID:31501420   PMID:31586073   PMID:32814053   PMID:32913203   PMID:33500727   PMID:33892667   PMID:33961781   PMID:34657150   PMID:34709727   PMID:35944360  


Genomics

Comparative Map Data
GNA14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38977,423,079 - 77,648,322 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl977,423,079 - 77,648,322 (-)EnsemblGRCh38hg38GRCh38
GRCh37980,037,995 - 80,263,238 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36979,228,368 - 79,453,043 (-)NCBINCBI36Build 36hg18NCBI36
Build 34977,268,102 - 77,492,777NCBI
Celera950,615,129 - 50,840,361 (-)NCBICelera
Cytogenetic Map9q21.2NCBI
HuRef949,869,436 - 50,095,508 (-)NCBIHuRef
CHM1_1980,184,787 - 80,410,463 (-)NCBICHM1_1
T2T-CHM13v2.0989,579,647 - 89,805,301 (-)NCBIT2T-CHM13v2.0
Gna14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391916,413,031 - 16,590,706 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1916,413,126 - 16,588,184 (+)EnsemblGRCm39 Ensembl
GRCm381916,435,667 - 16,610,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1916,435,762 - 16,610,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv371916,510,157 - 16,685,308 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361916,502,781 - 16,677,839 (+)NCBIMGSCv36mm8
Celera1917,094,438 - 17,269,681 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map1911.29NCBI
Gna14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21213,714,993 - 213,900,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1213,716,020 - 213,897,423 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,045,687 - 222,225,954 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01228,978,868 - 229,161,277 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01221,800,246 - 221,980,512 (+)NCBIRnor_WKY
Rnor_6.01235,165,775 - 235,347,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1235,166,718 - 235,347,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,484,562 - 242,665,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,906,120 - 219,983,252 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1211,049,903 - 211,230,953 (+)NCBICelera
Cytogenetic Map1q43NCBI
Gna14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555121,707,503 - 1,917,513 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555121,703,750 - 1,918,321 (+)NCBIChiLan1.0ChiLan1.0
LOC100987065
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1976,276,687 - 76,504,137 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0947,196,338 - 47,423,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GNA14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1180,992,992 - 81,178,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl180,992,863 - 81,177,674 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,455,728 - 81,642,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,404,645 - 81,590,940 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,405,467 - 81,590,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,190,051 - 81,376,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0180,911,720 - 81,098,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,641,964 - 81,827,205 (+)NCBIUU_Cfam_GSD_1.0
LOC101971412
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947128,116,262 - 128,313,527 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650312,859,715 - 13,056,244 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493650312,860,296 - 13,056,880 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNA14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1230,341,942 - 230,546,120 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11230,341,947 - 230,545,123 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21257,105,693 - 257,310,461 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNA14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11288,386,597 - 88,606,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1288,385,377 - 88,605,845 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603876,717,968 - 76,939,040 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gna14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248114,909,324 - 5,108,322 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248114,904,428 - 5,108,713 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GNA14
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q21.13-21.31(chr9:73706686-80370629)x1 copy number loss See cases [RCV000052907] Chr9:73706686..80370629 [GRCh38]
Chr9:76321602..82985544 [GRCh37]
Chr9:75511422..82175364 [NCBI36]
Chr9:9q21.13-21.31		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
NM_004297.3(GNA14):c.310-35641T>G single nucleotide variant Lung cancer [RCV000108400] Chr9:77470163 [GRCh38]
Chr9:80085079 [GRCh37]
Chr9:9q21.2		 uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q21.11-31.2(chr9:68420430-106579493)x3 copy number gain See cases [RCV000136788] Chr9:68420430..106579493 [GRCh38]
Chr9:71130848..109341774 [GRCh37]
Chr9:70225166..108381595 [NCBI36]
Chr9:9q21.11-31.2		 pathogenic
GRCh38/hg38 9q21.11-21.32(chr9:68499530-83670227)x1 copy number loss See cases [RCV000137963] Chr9:68499530..83670227 [GRCh38]
Chr9:71130848..86285142 [GRCh37]
Chr9:70304266..85474962 [NCBI36]
Chr9:9q21.11-21.32		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3		 pathogenic
GRCh38/hg38 9q21.2(chr9:77531690-78300187)x1 copy number loss See cases [RCV000140595] Chr9:77531690..78300187 [GRCh38]
Chr9:80146606..80915103 [GRCh37]
Chr9:79336426..80104923 [NCBI36]
Chr9:9q21.2		 likely pathogenic
GRCh38/hg38 9p24.3-q22.1(chr9:203861-88130444)x4 copy number gain See cases [RCV000141904] Chr9:203861..88130444 [GRCh38]
Chr9:203861..90745359 [GRCh37]
Chr9:193861..89935179 [NCBI36]
Chr9:9p24.3-q22.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q21.31(chr9:193412-79877816)x3 copy number gain See cases [RCV000143012] Chr9:193412..79877816 [GRCh38]
Chr9:204104..82492731 [GRCh37]
Chr9:194104..81682551 [NCBI36]
Chr9:9p24.3-q21.31		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-21.31(chr9:68734571-83557267)x3 copy number gain See cases [RCV000510725] Chr9:68734571..83557267 [GRCh37]
Chr9:9q21.11-21.31		 pathogenic
GRCh37/hg19 9q21.11-22.1(chr9:70966262-90761254)x4 copy number gain See cases [RCV000512280] Chr9:70966262..90761254 [GRCh37]
Chr9:9q21.11-22.1		 pathogenic
GRCh37/hg19 9p24.3-q21.33(chr9:203861-88189913)x3 copy number gain See cases [RCV000512431] Chr9:203861..88189913 [GRCh37]
Chr9:9p24.3-q21.33		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NM_004297.4(GNA14):c.614A>T (p.Gln205Leu) single nucleotide variant Kaposiform hemangioendothelioma [RCV000662310]|not provided [RCV002254301] Chr9:77429016 [GRCh38]
Chr9:80043932 [GRCh37]
Chr9:9q21.2		 pathogenic|likely pathogenic
GRCh37/hg19 9q21.13-21.31(chr9:74534790-84014155)x1 copy number loss not provided [RCV000683165] Chr9:74534790..84014155 [GRCh37]
Chr9:9q21.13-21.31		 pathogenic
GRCh37/hg19 9q21.11-21.32(chr9:68999534-84656998)x1 copy number loss not provided [RCV000683169] Chr9:68999534..84656998 [GRCh37]
Chr9:9q21.11-21.32		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-21.31(chr9:68838523-83340723)x1 copy number loss not provided [RCV000748447] Chr9:68838523..83340723 [GRCh37]
Chr9:9q21.11-21.31		 pathogenic
GRCh37/hg19 9q21.2(chr9:80185929-80207402)x1 copy number loss not provided [RCV000748485] Chr9:80185929..80207402 [GRCh37]
Chr9:9q21.2		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
Single allele complex Glioma [RCV000754871] Chr9:23524426..87359888 [GRCh37]
Chr9:9p21.3-q21.33		 likely pathogenic
NM_004297.4(GNA14):c.678del (p.Ala227fs) deletion High myopia [RCV000785696] Chr9:77428952 [GRCh38]
Chr9:80043868 [GRCh37]
Chr9:9q21.2		 uncertain significance
GRCh37/hg19 9q21.2-22.32(chr9:79520825-97201274) copy number gain not provided [RCV000767645] Chr9:79520825..97201274 [GRCh37]
Chr9:9q21.2-22.32		 pathogenic
GRCh37/hg19 9q21.13-21.31(chr9:78672613-83349616)x1 copy number loss not provided [RCV000848555] Chr9:78672613..83349616 [GRCh37]
Chr9:9q21.13-21.31		 uncertain significance
NM_004297.4(GNA14):c.195C>T (p.Asp65=) single nucleotide variant not provided [RCV000959073] Chr9:77529183 [GRCh38]
Chr9:80144099 [GRCh37]
Chr9:9q21.2		 benign
GRCh37/hg19 9q21.11-21.31(chr9:70974661-81829792)x1 copy number loss not provided [RCV000846367] Chr9:70974661..81829792 [GRCh37]
Chr9:9q21.11-21.31		 pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3		 pathogenic
NM_004297.4(GNA14):c.549C>T (p.Thr183=) single nucleotide variant not provided [RCV000955192] Chr9:77431365 [GRCh38]
Chr9:80046281 [GRCh37]
Chr9:9q21.2		 benign
NM_004297.4(GNA14):c.97C>T (p.Arg33Cys) single nucleotide variant not provided [RCV000891437] Chr9:77647697 [GRCh38]
Chr9:80262613 [GRCh37]
Chr9:9q21.2		 benign
NC_000009.11:g.12246100_101559378inv inversion Recurrent spontaneous abortion [RCV000999471] Chr9:12246100..101559378 [GRCh37]
Chr9:9p23-q22.33		 likely pathogenic
GRCh37/hg19 9p24.3-q21.32(chr9:203861-84155399) copy number gain not specified [RCV002053820] Chr9:203861..84155399 [GRCh37]
Chr9:9p24.3-q21.32		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-33.2(chr9:71349994-122603410) copy number gain not specified [RCV002053853] Chr9:71349994..122603410 [GRCh37]
Chr9:9q21.11-33.2		 likely pathogenic
NC_000009.11:g.(?_79792621)_(80944002_?)del deletion Neu-Laxova syndrome 2 [RCV001953529] Chr9:79792621..80944002 [GRCh37]
Chr9:9q21.2		 pathogenic
GRCh37/hg19 9p22.1-q33.1(chr9:19356861-119513311) copy number loss Distal tetrasomy 15q [RCV002280776] Chr9:19356861..119513311 [GRCh37]
Chr9:9p22.1-q33.1		 uncertain significance
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
NC_000009.12:g.77390734_77428010del deletion Chorea-acanthocytosis [RCV000004953] Chr9:77390734..77428010 [GRCh38]
Chr9:9q21.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:367
Count of miRNA genes:306
Interacting mature miRNAs:325
Transcripts:ENST00000341700, ENST00000464095
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH103280  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,038,509 - 80,038,755UniSTSGRCh37
Build 36979,228,329 - 79,228,575RGDNCBI36
Celera950,615,643 - 50,615,889RGD
Cytogenetic Map9q21UniSTS
HuRef949,869,950 - 49,870,196UniSTS
GeneMap99-GB4 RH Map9266.53UniSTS
SHGC-82681  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,216,885 - 80,217,159UniSTSGRCh37
Build 36979,406,705 - 79,406,979RGDNCBI36
Celera950,794,012 - 50,794,286RGD
Cytogenetic Map9q21UniSTS
HuRef950,049,231 - 50,049,505UniSTS
TNG Radiation Hybrid Map927511.0UniSTS
RH122457  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,114,058 - 80,114,344UniSTSGRCh37
Build 36979,303,878 - 79,304,164RGDNCBI36
Celera950,691,187 - 50,691,472RGD
Cytogenetic Map9q21UniSTS
HuRef949,946,166 - 49,946,451UniSTS
TNG Radiation Hybrid Map927547.0UniSTS
SHGC-143870  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,083,055 - 80,083,354UniSTSGRCh37
Build 36979,272,875 - 79,273,174RGDNCBI36
Celera950,660,188 - 50,660,487RGD
Cytogenetic Map9q21UniSTS
HuRef949,915,379 - 49,915,678UniSTS
TNG Radiation Hybrid Map927556.0UniSTS
SHGC-141947  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,196,212 - 80,196,547UniSTSGRCh37
Build 36979,386,032 - 79,386,367RGDNCBI36
Celera950,773,341 - 50,773,676RGD
Cytogenetic Map9q21UniSTS
HuRef950,028,102 - 50,028,437UniSTS
TNG Radiation Hybrid Map927517.0UniSTS
SHGC-155377  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,255,175 - 80,255,469UniSTSGRCh37
Build 36979,444,995 - 79,445,289RGDNCBI36
Celera950,832,298 - 50,832,592RGD
Cytogenetic Map9q21UniSTS
HuRef950,087,491 - 50,087,785UniSTS
TNG Radiation Hybrid Map927492.0UniSTS
GNA14_8966  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,038,445 - 80,039,021UniSTSGRCh37
Build 36979,228,265 - 79,228,841RGDNCBI36
Celera950,615,579 - 50,616,155RGD
HuRef949,869,886 - 49,870,462UniSTS
RH70085  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37980,038,017 - 80,038,166UniSTSGRCh37
Build 36979,227,837 - 79,227,986RGDNCBI36
Celera950,615,151 - 50,615,300RGD
Cytogenetic Map9q21UniSTS
HuRef949,869,458 - 49,869,607UniSTS
GeneMap99-GB4 RH Map9268.36UniSTS
NCBI RH Map9741.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 374 35 690 4 123 5 155 121 292 97 390 1110 71 4 1
Low 1988 2046 990 588 444 426 3567 1455 3139 271 970 368 163 1133 2280 1 2
Below cutoff 56 797 38 28 791 29 591 607 287 41 79 91 5 1 503 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011519224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047424110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF105201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF493903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI263118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI629022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL158159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OU666875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000341700   ⟹   ENSP00000365807
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl977,423,079 - 77,648,322 (-)Ensembl
RefSeq Acc Id: ENST00000464095
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl977,424,128 - 77,431,688 (-)Ensembl
RefSeq Acc Id: NM_004297   ⟹   NP_004288
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38977,423,079 - 77,648,322 (-)NCBI
GRCh37980,037,995 - 80,263,232 (-)ENTREZGENE
Build 36979,228,368 - 79,453,043 (-)NCBI Archive
HuRef949,869,436 - 50,095,508 (-)ENTREZGENE
CHM1_1980,184,787 - 80,410,463 (-)NCBI
T2T-CHM13v2.0989,579,647 - 89,805,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047424110   ⟹   XP_047280066
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38977,423,079 - 77,452,678 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_004288   ⟸   NM_004297
- UniProtKB: B1ALW3 (UniProtKB/Swiss-Prot),   O95837 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000365807   ⟸   ENST00000341700
RefSeq Acc Id: XP_047280066   ⟸   XM_047424110
- Peptide Label: isoform X1
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O95837-F1-model_v2 AlphaFold O95837 1-355 view protein structure

Promoters
RGD ID:7215285
Promoter ID:EPDNEW_H13389
Type:initiation region
Name:GNA14_1
Description:G protein subunit alpha 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13390  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38977,648,320 - 77,648,380EPDNEW
RGD ID:7215287
Promoter ID:EPDNEW_H13390
Type:initiation region
Name:GNA14_2
Description:G protein subunit alpha 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13389  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38977,648,692 - 77,648,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4382 AgrOrtholog
COSMIC GNA14 COSMIC
Ensembl Genes ENSG00000156049 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000365807 ENTREZGENE
  ENSP00000365807.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000341700 ENTREZGENE
  ENST00000341700.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
GTEx ENSG00000156049 GTEx
HGNC ID HGNC:4382 ENTREZGENE
Human Proteome Map GNA14 Human Proteome Map
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report hsa:9630 UniProtKB/Swiss-Prot
NCBI Gene 9630 ENTREZGENE
OMIM 604397 OMIM
PANTHER PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PharmGKB PA28767 PharmGKB
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAQ UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt B1ALW3 ENTREZGENE
  GNA14_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B1ALW3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 GNA14  G protein subunit alpha 14    guanine nucleotide binding protein (G protein), alpha 14  Symbol and/or name change 5135510 APPROVED
2011-08-17 GNA14  guanine nucleotide binding protein (G protein), alpha 14  GNA14  guanine nucleotide binding protein (G protein), alpha 14  Symbol and/or name change 5135510 APPROVED