ARF4 (ARF GTPase 4) - Rat Genome Database

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Gene: ARF4 (ARF GTPase 4) Homo sapiens
Analyze
Symbol: ARF4
Name: ARF GTPase 4 (Ensembl:ADP ribosylation factor 4)
RGD ID: 1352328
HGNC Page HGNC:655
Description: Enables several functions, including GTP binding activity; NAD+-protein-arginine ADP-ribosyltransferase activity; and epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of cilium assembly; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Acts upstream of or within dendritic spine development. Located in several cellular components, including Golgi membrane; dendritic spine; and ruffle membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ADP ribosylation factor 4; ADP-ribosylation factor 2; ADP-ribosylation factor 4; ARF2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: ARF4P1   ARF4P2   ARF4P3   ARF4P4   ARF4P5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,571,363 - 57,597,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,571,363 - 57,598,220 (-)EnsemblGRCh38hg38GRCh38
GRCh37357,557,090 - 57,583,071 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,532,130 - 57,558,118 (-)NCBINCBI36Build 36hg18NCBI36
Build 34357,532,129 - 57,558,118NCBI
Celera357,570,930 - 57,583,662 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,654,526 - 57,680,689 (-)NCBIHuRef
CHM1_1357,507,192 - 57,533,313 (-)NCBICHM1_1
T2T-CHM13v2.0357,611,733 - 57,637,720 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dimethoxyphenol  (EXP)
2-nitrotoluene  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
azoxystrobin  (EXP)
beta-lapachone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A5  (EXP)
bromochloroacetic acid  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
clobetasol  (ISO)
cocaine  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
DDE  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dioxygen  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furfural  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (EXP)
indirubin  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methylmercury chloride  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium chloride  (EXP)
Soman  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tolcapone  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1447192   PMID:1899243   PMID:2105501   PMID:2107548   PMID:7956370   PMID:8355790   PMID:8491770   PMID:9180902   PMID:10099884   PMID:10524252   PMID:10593962   PMID:10828067  
PMID:11481332   PMID:12446727   PMID:12477932   PMID:12842896   PMID:15049518   PMID:15231747   PMID:15489334   PMID:16344560   PMID:17314511   PMID:17956946   PMID:18022941   PMID:19041174  
PMID:19167051   PMID:19299420   PMID:19322201   PMID:19615732   PMID:19946888   PMID:20360068   PMID:20458337   PMID:20467437   PMID:20881058   PMID:21145461   PMID:21280222   PMID:21319273  
PMID:21873635   PMID:21988832   PMID:22004728   PMID:22105072   PMID:22185782   PMID:22268729   PMID:22304920   PMID:22952844   PMID:23050017   PMID:23125841   PMID:23376485   PMID:23464991  
PMID:23783033   PMID:23979707   PMID:24163370   PMID:24185178   PMID:24337577   PMID:24561123   PMID:24768165   PMID:25281560   PMID:25416956   PMID:25673879   PMID:25737280   PMID:25959826  
PMID:25963833   PMID:26258637   PMID:26344197   PMID:26561776   PMID:26618866   PMID:26816005   PMID:27025967   PMID:27432908   PMID:27462432   PMID:27634302   PMID:27684187   PMID:28057486  
PMID:28117675   PMID:28515276   PMID:28533407   PMID:28760826   PMID:28840565   PMID:29128334   PMID:29149599   PMID:29331416   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29564676  
PMID:29568061   PMID:29955894   PMID:30194290   PMID:30459231   PMID:30463901   PMID:30575818   PMID:30619736   PMID:30833792   PMID:30884312   PMID:30948266   PMID:31068062   PMID:31073040  
PMID:31091453   PMID:31298480   PMID:31324722   PMID:31340145   PMID:31540324   PMID:31586073   PMID:31620119   PMID:31672844   PMID:31980649   PMID:32041737   PMID:32203420   PMID:32296183  
PMID:32687490   PMID:32786267   PMID:32807901   PMID:32828303   PMID:32913203   PMID:33022573   PMID:33024031   PMID:33144569   PMID:33194618   PMID:33301849   PMID:33306668   PMID:33416178  
PMID:33443570   PMID:33545068   PMID:33561610   PMID:33567341   PMID:33644029   PMID:33729478   PMID:33766124   PMID:33961781   PMID:34017080   PMID:34079125   PMID:34185411   PMID:34316702  
PMID:34373451   PMID:34383978   PMID:34428256   PMID:34556124   PMID:34662580   PMID:34687317   PMID:34709727   PMID:34857952   PMID:35063084   PMID:35216969   PMID:35256949   PMID:35271311  
PMID:35338135   PMID:35384245   PMID:35516420   PMID:35562734   PMID:35563538   PMID:35676659   PMID:35831314   PMID:35833506   PMID:35844135   PMID:35896951   PMID:35944360   PMID:36180527  
PMID:36215168   PMID:36244648   PMID:36305789   PMID:36517590   PMID:36526897   PMID:36574265   PMID:36610398   PMID:36634849   PMID:36779763   PMID:36931259   PMID:36964488   PMID:37167062  
PMID:37223481   PMID:37232246   PMID:37249651   PMID:37314216   PMID:37317656   PMID:37448957   PMID:37609425   PMID:37689310   PMID:37705046   PMID:37827155   PMID:38697112   PMID:38816950  
PMID:39238192  


Genomics

Comparative Map Data
ARF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,571,363 - 57,597,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,571,363 - 57,598,220 (-)EnsemblGRCh38hg38GRCh38
GRCh37357,557,090 - 57,583,071 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,532,130 - 57,558,118 (-)NCBINCBI36Build 36hg18NCBI36
Build 34357,532,129 - 57,558,118NCBI
Celera357,570,930 - 57,583,662 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,654,526 - 57,680,689 (-)NCBIHuRef
CHM1_1357,507,192 - 57,533,313 (-)NCBICHM1_1
T2T-CHM13v2.0357,611,733 - 57,637,720 (-)NCBIT2T-CHM13v2.0
Arf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,359,289 - 26,377,997 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,359,229 - 26,386,239 (+)EnsemblGRCm39 Ensembl
GRCm381426,638,134 - 26,656,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,638,074 - 26,665,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371427,457,683 - 27,476,744 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361425,471,381 - 25,490,442 (+)NCBIMGSCv36mm8
Celera1422,881,059 - 22,899,926 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Arf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,903,238 - 1,920,012 (+)NCBIGRCr8
mRatBN7.2161,896,692 - 1,913,267 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,896,546 - 1,913,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,903,319 - 1,919,895 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,049,015 - 3,065,591 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0161,909,772 - 1,926,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,338,333 - 2,354,909 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,338,333 - 2,354,909 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,313,358 - 2,330,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,955,745 - 1,972,321 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1161,955,744 - 1,972,321 (+)NCBI
Celera161,865,523 - 1,882,099 (+)NCBICelera
Cytogenetic Map16p16NCBI
Arf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554307,288,386 - 7,319,449 (-)NCBIChiLan1.0ChiLan1.0
ARF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,539,666 - 57,566,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,544,439 - 57,571,074 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,504,701 - 57,530,545 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,710,897 - 58,736,315 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,710,897 - 58,736,816 (-)Ensemblpanpan1.1panPan2
ARF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,849,725 - 32,871,127 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,849,757 - 32,870,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,777,874 - 32,799,283 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,122,306 - 33,143,713 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,122,415 - 33,159,515 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,578,184 - 32,599,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,936,246 - 32,957,656 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,106,867 - 33,128,487 (+)NCBIUU_Cfam_GSD_1.0
Arf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,768,725 - 174,788,135 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364737,907,277 - 7,926,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,409,376 - 39,430,129 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,410,094 - 39,430,177 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,338,149 - 43,361,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,879,064 - 18,904,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,877,715 - 18,903,891 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,967,881 - 147,993,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624821346,579 - 362,021 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARF4
3 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.1-14.1(chr3:54045018-66060461)x1 copy number loss See cases [RCV000051081] Chr3:54045018..66060461 [GRCh38]
Chr3:54079045..66046136 [GRCh37]
Chr3:54054085..66021176 [NCBI36]
Chr3:3p21.1-14.1		 pathogenic
NM_001660.4(ARF4):c.290G>A (p.Arg97His) single nucleotide variant not specified [RCV004253710] Chr3:57577356 [GRCh38]
Chr3:57563083 [GRCh37]
Chr3:3p14.3		 uncertain significance
GRCh38/hg38 3p14.3-14.1(chr3:57430538-64884522)x1 copy number loss See cases [RCV000139570] Chr3:57430538..64884522 [GRCh38]
Chr3:57416265..64870197 [GRCh37]
Chr3:57391305..64845237 [NCBI36]
Chr3:3p14.3-14.1		 pathogenic
GRCh38/hg38 3p14.3-11.1(chr3:57140424-90259960)x1 copy number loss See cases [RCV000139626] Chr3:57140424..90259960 [GRCh38]
Chr3:57174452..90309110 [GRCh37]
Chr3:57149492..90391800 [NCBI36]
Chr3:3p14.3-11.1		 pathogenic
GRCh37/hg19 3p21.2-14.2(chr3:52086599-59689209)x1 copy number loss See cases [RCV000239886] Chr3:52086599..59689209 [GRCh37]
Chr3:3p21.2-14.2		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p14.3-14.1(chr3:57076136-65716956)x1 copy number loss not provided [RCV000846379] Chr3:57076136..65716956 [GRCh37]
Chr3:3p14.3-14.1		 pathogenic
NC_000003.11:g.(?_57130421)_(58520833_?)del deletion Pyruvate dehydrogenase E1-beta deficiency [RCV003105375] Chr3:57130421..58520833 [GRCh37]
Chr3:3p14.3		 uncertain significance
GRCh37/hg19 3p21.2-14.2(chr3:51149374-59265315)x1 copy number loss not specified [RCV003986409] Chr3:51149374..59265315 [GRCh37]
Chr3:3p21.2-14.2		 pathogenic
NM_001660.4(ARF4):c.289C>A (p.Arg97Ser) single nucleotide variant not specified [RCV004420229] Chr3:57577357 [GRCh38]
Chr3:57563084 [GRCh37]
Chr3:3p14.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2085
Count of miRNA genes:828
Interacting mature miRNAs:969
Transcripts:ENST00000303436, ENST00000463880, ENST00000483848, ENST00000486310, ENST00000488156, ENST00000489843, ENST00000493378, ENST00000495354, ENST00000496292
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298487BFD1_HBody fluid distribution QTL 1 (human)3.94Body fluid distributionimpedance ratio33638071262380712Human
597477048GWAS1573122_Hblood protein measurement QTL GWAS1573122 (human)8e-14blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)35757139757571398Human
597471512GWAS1567586_Hblood protein measurement QTL GWAS1567586 (human)5e-122blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)35759264657592647Human
597472731GWAS1568805_Hblood protein measurement QTL GWAS1568805 (human)1e-122blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)35759264657592647Human
597471515GWAS1567589_Hblood protein measurement QTL GWAS1567589 (human)9e-179blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)35759264657592647Human
597475220GWAS1571294_Hblood protein measurement QTL GWAS1571294 (human)2e-141blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)35759264657592647Human
1298489RA4_HRheumatoid arthritis QTL 4 (human)0.0283Joint/bone inflammationrheumatoid arthritis33638071262380712Human
597471511GWAS1567585_Hblood protein measurement QTL GWAS1567585 (human)2e-127blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)35759264657592647Human
1643509BW293_HBody Weight QTL 293 (human)1.42Body weightBMI33638071262380712Human
2289308BW392_HBody weight QTL 392 (human)1.42Body weightBMI33638071262380712Human
1331643COPD16_HChronic obstructive pulmonary disease QTL 16 (human)1.07Chronic airflow obstructionpost-BD FEV1 minus pre-BD FEV1/pre-BD FEV1 x 10034938065175380651Human

Markers in Region
D3S3904  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3713101,408,288 - 101,408,620UniSTSGRCh37
GRCh37357,557,433 - 57,557,762UniSTSGRCh37
Build 36357,532,473 - 57,532,802RGDNCBI36
Celera357,571,273 - 57,571,602RGD
Celera1382,252,474 - 82,252,806UniSTS
Cytogenetic Map13q32.3UniSTS
Cytogenetic Map3p21.2-p21.1UniSTS
HuRef357,654,869 - 57,655,198UniSTS
HuRef1382,004,103 - 82,004,435UniSTS
GeneMap99-GB4 RH Map3198.02UniSTS
Whitehead-RH Map3228.1UniSTS
GeneMap99-G3 RH Map32491.0UniSTS
D3S1637  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,582,885 - 57,583,044UniSTSGRCh37
GRCh37357,583,158 - 57,583,280UniSTSGRCh37
Build 36357,557,925 - 57,558,084RGDNCBI36
Cytogenetic Map3p21.2-p21.1UniSTS
HuRef357,680,632 - 57,680,754UniSTS
HuRef357,680,359 - 57,680,518UniSTS
D3S1623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,583,158 - 57,583,269UniSTSGRCh37
Build 36357,558,198 - 57,558,309RGDNCBI36
Cytogenetic Map3p21.2-p21.1UniSTS
HuRef357,680,632 - 57,680,743UniSTS
RH129652  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,557,120 - 57,557,312UniSTSGRCh37
Build 36357,532,160 - 57,532,352RGDNCBI36
Celera357,570,960 - 57,571,152RGD
HuRef357,654,556 - 57,654,748UniSTS
ARF4_55  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,556,984 - 57,557,848UniSTSGRCh37
Build 36357,532,024 - 57,532,888RGDNCBI36
Celera357,570,824 - 57,571,688RGD
HuRef357,654,420 - 57,655,284UniSTS
D3S4365  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,582,828 - 57,583,107UniSTSGRCh37
Build 36357,557,868 - 57,558,147RGDNCBI36
Cytogenetic Map3p21.2-p21.1UniSTS
HuRef357,680,302 - 57,680,581UniSTS
RH69960  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,557,176 - 57,557,368UniSTSGRCh37
Build 36357,532,216 - 57,532,408RGDNCBI36
Celera357,571,016 - 57,571,208RGD
Cytogenetic Map3p21.2-p21.1UniSTS
HuRef357,654,612 - 57,654,804UniSTS
GeneMap99-GB4 RH Map3191.54UniSTS
NCBI RH Map3544.7UniSTS
HUMD2F08NC  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37357,557,147 - 57,557,307UniSTSGRCh37
Build 36357,532,187 - 57,532,347RGDNCBI36
Celera357,570,987 - 57,571,147RGD
Cytogenetic Map3p21.2-p21.1UniSTS
HuRef357,654,583 - 57,654,743UniSTS
TNG Radiation Hybrid Map335605.0UniSTS
Stanford-G3 RH Map32619.0UniSTS
NCBI RH Map3538.7UniSTS
GeneMap99-G3 RH Map32517.0UniSTS
D3S1637  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p21.2-p21.1UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence


Ensembl Acc Id: ENST00000303436   ⟹   ENSP00000306010
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,571,363 - 57,597,344 (-)Ensembl
Ensembl Acc Id: ENST00000463880   ⟹   ENSP00000420254
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,575,623 - 57,597,508 (-)Ensembl
Ensembl Acc Id: ENST00000483848
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,575,548 - 57,597,198 (-)Ensembl
Ensembl Acc Id: ENST00000486310   ⟹   ENSP00000420655
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,571,405 - 57,597,366 (-)Ensembl
Ensembl Acc Id: ENST00000488156   ⟹   ENSP00000418388
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,597,074 - 57,598,220 (-)Ensembl
Ensembl Acc Id: ENST00000489843   ⟹   ENSP00000475828
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,571,398 - 57,597,334 (-)Ensembl
Ensembl Acc Id: ENST00000493378
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,583,925 - 57,597,404 (-)Ensembl
Ensembl Acc Id: ENST00000495354
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,596,606 - 57,597,368 (-)Ensembl
Ensembl Acc Id: ENST00000496292   ⟹   ENSP00000417501
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl357,571,392 - 57,597,325 (-)Ensembl
RefSeq Acc Id: NM_001660   ⟹   NP_001651
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38357,571,363 - 57,597,344 (-)NCBI
GRCh37357,557,090 - 57,583,215 (-)ENTREZGENE
Build 36357,532,130 - 57,558,118 (-)NCBI Archive
HuRef357,654,526 - 57,680,689 (-)ENTREZGENE
CHM1_1357,507,192 - 57,533,313 (-)NCBI
T2T-CHM13v2.0357,611,733 - 57,637,720 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001651   ⟸   NM_001660
- UniProtKB: P18085 (UniProtKB/Swiss-Prot),   B2R7J7 (UniProtKB/Swiss-Prot),   P21371 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000420254   ⟸   ENST00000463880
Ensembl Acc Id: ENSP00000417501   ⟸   ENST00000496292
Ensembl Acc Id: ENSP00000420655   ⟸   ENST00000486310
Ensembl Acc Id: ENSP00000418388   ⟸   ENST00000488156
Ensembl Acc Id: ENSP00000306010   ⟸   ENST00000303436
Ensembl Acc Id: ENSP00000475828   ⟸   ENST00000489843

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18085-F1-model_v2 AlphaFold P18085 1-180 view protein structure

Promoters
RGD ID:6800621
Promoter ID:HG_KWN:45360
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001660,   UC003DIY.2,   UC003DIZ.2,   UC010HND.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36357,558,056 - 57,558,752 (-)MPROMDB
RGD ID:6864798
Promoter ID:EPDNEW_H5564
Type:initiation region
Name:ARF4_1
Description:ADP ribosylation factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38357,597,344 - 57,597,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:655 AgrOrtholog
COSMIC ARF4 COSMIC
Ensembl Genes ENSG00000168374 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000303436 ENTREZGENE
  ENST00000303436.11 UniProtKB/Swiss-Prot
  ENST00000463880.1 UniProtKB/TrEMBL
  ENST00000486310.5 UniProtKB/TrEMBL
  ENST00000488156.1 UniProtKB/TrEMBL
  ENST00000489843.1 UniProtKB/TrEMBL
  ENST00000496292.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000168374 GTEx
HGNC ID HGNC:655 ENTREZGENE
Human Proteome Map ARF4 Human Proteome Map
InterPro Arf1_5_like UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:378 UniProtKB/Swiss-Prot
NCBI Gene 378 ENTREZGENE
OMIM 601177 OMIM
PANTHER PTHR11711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ARF4 RGD, PharmGKB
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot
  SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARF4_HUMAN UniProtKB/Swiss-Prot
  B2R7J7 ENTREZGENE
  C9J6P1_HUMAN UniProtKB/TrEMBL
  C9JAK5_HUMAN UniProtKB/TrEMBL
  C9JPM4_HUMAN UniProtKB/TrEMBL
  F8WDB3_HUMAN UniProtKB/TrEMBL
  P18085 ENTREZGENE
  P21371 ENTREZGENE
  U3KQF2_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R7J7 UniProtKB/Swiss-Prot
  P21371 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-10-31 ARF4  ARF GTPase 4  ARF4  ADP ribosylation factor 4  Symbol and/or name change 19259463 PROVISIONAL
2016-03-30 ARF4  ADP ribosylation factor 4  ARF2  ADP-ribosylation factor 2  Data merged from RGD:1345639 737654 PROVISIONAL
2015-11-24 ARF4  ADP ribosylation factor 4  ARF4  ADP-ribosylation factor 4  Symbol and/or name change 5135510 APPROVED