Tox4 (TOX high mobility group box family member 4) - Rat Genome Database

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Gene: Tox4 (TOX high mobility group box family member 4) Heterocephalus glaber
Analyze
Symbol: Tox4
Name: TOX high mobility group box family member 4
RGD ID: 18916616
Description: ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); regulation of transcription elongation by RNA polymerase II (inferred); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); cone-rod dystrophy 13 (ortholog); purine nucleoside phosphorylase deficiency (ortholog); FOUND IN chromatin (inferred); chromosome, telomeric region (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,493,953 - 7,511,846 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,493,911 - 7,511,852 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tox4Naked Mole-RatBrain-Lung-Thyroid Syndrome  ISOTOX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
Tox4Naked Mole-Ratcone-rod dystrophy 13  ISOTOX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cone-rod dystrophy 13ClinVarPMID:11528500 more ...
Tox4Naked Mole-Ratpurine nucleoside phosphorylase deficiency  ISOTOX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Purine-nucleoside phosphorylase deficiencyClinVarPMID:24767876 and PMID:28492532


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tox4Naked Mole-Ratpositive regulation of transcription elongation by RNA polymerase II involved_inIEAUniProtKB:O94842 and ensembl:ENSP00000393080150520179 EnsemblGO_REF:0000107
Tox4Naked Mole-Ratregulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN000345697150520179 TreeGrafterGO_REF:0000118
Tox4Naked Mole-Ratregulation of transcription elongation by RNA polymerase II involved_inIEAUniProtKB:Q8BU11 and ensembl:ENSMUSP00000022766150520179 EnsemblGO_REF:0000107
Tox4Naked Mole-RatRNA polymerase II promoter clearance involved_inIEAUniProtKB:O94842 and ensembl:ENSP00000393080150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tox4Naked Mole-Ratchromatin is_active_inIEAUniProtKB:Q8BU11 and ensembl:ENSMUSP00000022766150520179 EnsemblGO_REF:0000107
Tox4Naked Mole-Ratchromatin located_inIEAUniProtKB:O94842 and ensembl:ENSP00000393080150520179 EnsemblGO_REF:0000107
Tox4Naked Mole-Ratchromosome, telomeric region located_inIEAUniProtKB:O94842 and ensembl:ENSP00000393080150520179 EnsemblGO_REF:0000107
Tox4Naked Mole-Ratnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
Tox4Naked Mole-Ratnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
Tox4Naked Mole-Ratnucleus located_inIEAUniRule:UR000400811150520179 UniProtGO_REF:0000104
Tox4Naked Mole-Ratnucleus located_inIEAPANTHER:PTN000345697150520179 TreeGrafterGO_REF:0000118
Tox4Naked Mole-RatPTW/PP1 phosphatase complex part_ofIEAUniProtKB:O94842 and ensembl:ENSP00000393080150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tox4Naked Mole-Ratchromatin DNA binding enablesIEAPANTHER:PTN000345697150520179 TreeGrafterGO_REF:0000118
Tox4Naked Mole-RatDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
Tox4Naked Mole-RatDNA binding enablesIEAUniRule:UR000400811150520179 UniProtGO_REF:0000104
Tox4Naked Mole-Ratprotein binding enablesISOUniProtKB:P542539068941 PMID:16713569 and PMID:32814053IntActPMID:16713569 and PMID:32814053
Tox4Naked Mole-Ratprotein binding enablesISOUniProtKB:O95947 more ...9068941 PMID:32296183IntActPMID:32296183
Tox4Naked Mole-Ratprotein binding enablesISOUniProtKB:O95947 more ...9068941 PMID:25416956IntActPMID:25416956
Tox4Naked Mole-Ratprotein binding enablesISOUniProtKB:O959479068941 PMID:24722188IntActPMID:24722188
Tox4Naked Mole-Ratprotein binding enablesISOUniProtKB:A0A0S2Z5G4 more ...9068941 PMID:26871637IntActPMID:26871637
Tox4Naked Mole-Ratprotein binding enablesISOUniProtKB:Q80W009068941 PMID:20516061UniProtPMID:20516061
1 to 9 of 9 rows

PMID:30032202  



Tox4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,493,953 - 7,511,846 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,493,911 - 7,511,852 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,477,195 - 21,499,170 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,476,597 - 21,499,175 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,945,354 - 21,967,314 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,015,175 - 21,037,159 (+)NCBINCBI36Build 36hg18NCBI36
Build 341421,015,245 - 21,036,880NCBI
Celera141,810,716 - 1,830,660 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef142,064,581 - 2,085,176 (+)NCBIHuRef
CHM1_11421,946,806 - 21,968,784 (+)NCBICHM1_1
T2T-CHM13v2.01415,674,564 - 15,696,534 (+)NCBIT2T-CHM13v2.0
Tox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,516,603 - 52,532,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,516,603 - 52,533,858 (+)EnsemblGRCm39 Ensembl
GRCm381452,279,146 - 52,295,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,279,146 - 52,296,401 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,898,821 - 52,915,184 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361451,201,595 - 51,216,463 (+)NCBIMGSCv36mm8
Celera1449,261,686 - 49,277,476 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.88NCBI
Tox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,462,735 - 27,476,320 (+)NCBIGRCr8
mRatBN7.21524,989,246 - 25,002,833 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,988,853 - 25,002,833 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,761,942 - 27,775,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,716,039 - 28,729,621 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,968,978 - 26,982,572 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,696,378 - 28,709,960 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,695,912 - 28,709,957 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,506,578 - 32,520,161 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,729,485 - 27,743,620 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,745,184 - 27,759,317 (+)NCBI
Celera1525,293,401 - 25,306,983 (+)NCBICelera
Cytogenetic Map15p14NCBI
Tox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555502,195,710 - 2,209,729 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555502,195,710 - 2,209,729 (+)NCBIChiLan1.0ChiLan1.0
TOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,932,579 - 22,952,483 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11422,149,066 - 22,168,973 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,294,892 - 2,316,901 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11420,371,820 - 20,393,696 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1420,371,820 - 20,393,696 (+)Ensemblpanpan1.1panPan2
TOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,512,270 - 18,528,293 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,512,327 - 18,528,516 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,996,794 - 19,012,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,771,256 - 18,787,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,771,289 - 18,788,953 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,453,331 - 18,469,249 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,509,388 - 18,525,329 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,638,257 - 18,654,205 (+)NCBIUU_Cfam_GSD_1.0
Tox4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,718,872 - 32,737,761 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880627,576 - 646,006 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880628,316 - 646,006 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl777,678,475 - 77,698,917 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1777,679,405 - 77,698,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,021,649 - 83,040,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,946,311 - 21,966,197 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,945,901 - 21,965,740 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,462,325 - 24,484,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000006341   ⟹   ENSHGLP00000006262
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248257,493,953 - 7,511,846 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000006342   ⟹   ENSHGLP00000006263
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248257,494,143 - 7,511,457 (+)Ensembl
RefSeq Acc Id: XM_004865050   ⟹   XP_004865107
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248257,493,911 - 7,511,852 (+)NCBI
Protein RefSeqs XP_004865107 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006262
GenBank Protein JAO03540 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004865107   ⟸   XM_004865050
- UniProtKB: A0A0P6K925 (UniProtKB/TrEMBL),   G5BFV0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006262   ⟸   ENSHGLT00000006341
Ensembl Acc Id: ENSHGLP00000006263   ⟸   ENSHGLT00000006342



1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000004570 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006341 ENTREZGENE
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  TOX_HMG-box_domain UniProtKB/TrEMBL
KEGG Report hgl:101700262 UniProtKB/TrEMBL
NCBI Gene Tox4 ENTREZGENE
PANTHER AGAP000281-PA UniProtKB/TrEMBL
  PTHR45781:SF2 UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
PRINTS HIGHMOBLTY12 UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A0P6K925 ENTREZGENE, UniProtKB/TrEMBL
  G5BFV0 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows